Dimethylthiophosphate (BioDeep_00000054831)

   

human metabolite blood metabolite


代谢物信息卡片


dimethoxy(sulfanylidene)phosphinous acid

化学式: C2H7O3PS (141.98535220000002)
中文名称: O,O-二甲基氢硫代磷酸酯
谱图信息: 最多检出来源 Homo sapiens(blood) 1.3%

分子结构信息

SMILES: COP(=S)(O)OC
InChI: InChI=1S/C2H7O3PS/c1-4-6(3,7)5-2/h1-2H3,(H,3,7)

描述信息

Dimethylthiophosphate, also known as O,O-dimethyl phosphorothionate or O,O-dimethylthiophosphoric acid, is classified as a member of the thiophosphoric acid esters. Thiophosphoric acid esters are organic compounds containing the thiophosphoric acid functional group or a derivative thereof, with the general structure ROP(OR)(OR)=S, where at least one R-group is an organyl group. Dimethylthiophosphate is considered to be slightly soluble (in water) and acidic. (ChemoSummarizer)

同义名列表

6 个代谢物同义名

dimethoxy(sulfanylidene)phosphinous acid; O,O-Dimethyl Hydrogen Phosphorothioate; DIMETHYL thiophosphoric acid; Dimethylthiophosphoric acid; dimethyl thiophosphate; Dimethylthiophosphate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Claire Philippat, Jacqueline Barkoski, Daniel J Tancredi, Bill Elms, Dana Boyd Barr, Sally Ozonoff, Deborah H Bennett, Irva Hertz-Picciotto. Prenatal exposure to organophosphate pesticides and risk of autism spectrum disorders and other non-typical development at 3 years in a high-risk cohort. International journal of hygiene and environmental health. 2018 04; 221(3):548-555. doi: 10.1016/j.ijheh.2018.02.004. [PMID: 29478806]
  • Sunwook Kim, Maury A Nussbaum, Paul J Laurienti, Haiying Chen, Sara A Quandt, Dana Boyd Barr, Thomas A Arcury. Exploring Associations Between Postural Balance and Levels of Urinary Organophosphorus Pesticide Metabolites. Journal of occupational and environmental medicine. 2018 02; 60(2):174-179. doi: 10.1097/jom.0000000000001194. [PMID: 29023345]
  • Yiwen Wang, Limei Chen, Caifeng Wang, Yi Hum, Yu Gao, Yijun Zhou, Rong Shi, Yan Zhang, Michihiro Kamijima, Jun Ueyama, Ying Tian. Association Between Organophosphate Pesticide Exposure and Thyroid Hormones in Pregnant Women. Epidemiology (Cambridge, Mass.). 2017 10; 28 Suppl 1(?):S35-S40. doi: 10.1097/ede.0000000000000721. [PMID: 29028673]
  • Zhijing Feng, Xiaowei Sun, Jindan Yang, Dongfang Hao, Longfei Du, Hong Wang, Wei Xu, Xiujuan Zhao, Changhao Sun. Metabonomics analysis of urine and plasma from rats given long-term and low-dose dimethoate by ultra-performance liquid chromatography-mass spectrometry. Chemico-biological interactions. 2012 Sep; 199(3):143-53. doi: 10.1016/j.cbi.2012.07.004. [PMID: 22884955]
  • Panpan Jiang, Jiguo He. Preparation and identification of generic antigens and broad-spectrum monoclonal antibodies for detection of organophosphorus pesticides. Journal of AOAC International. 2011 Nov; 94(6):1911-7. doi: 10.5740/jaoacint.10-203. [PMID: 22320100]
  • Yan Zhang, Sha Zhu, Yu Gao, Xiao-jin Wang, Tao Chen, You Yang, Guo-quan Wang, Guo-hua Hu, Rong Shi, Ping Jin, Ying Tian. [A case-control study on correlation of pesticide exposure with childhood acute leukemia]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2011 Jan; 45(1):41-6. doi: . [PMID: 21418818]
  • Maryse F Bouchard, David C Bellinger, Robert O Wright, Marc G Weisskopf. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics. 2010 Jun; 125(6):e1270-7. doi: 10.1542/peds.2009-3058. [PMID: 20478945]
  • G K Hemakanthi De Alwis, Larry L Needham, Dana B Barr. Automated solid phase extraction, on-support derivatization and isotope dilution-GC/MS method for the detection of urinary dialkyl phosphates in humans. Talanta. 2009 Jan; 77(3):1063-7. doi: 10.1016/j.talanta.2008.08.007. [PMID: 19064092]
  • Gayanga Weerasekera, Kimberly D Smith, Larry L Needham, Dana B Barr. A rapid, cost-effective method for analyzing organophosphorus pesticide metabolites in human urine for counter-terrorism response. Journal of analytical toxicology. 2008 Jan; 32(1):106-15. doi: 10.1093/jat/32.1.106. [PMID: 18269802]
  • Wei-Chao Lin, Chang-Yuan Hsieh, Ho-Yuan Chang. Improved analysis of dialkylphosphates in urine using strong anion exchange disk extraction and in-vial derivatization. Journal of separation science. 2007 Jun; 30(9):1326-33. doi: 10.1002/jssc.200600302. [PMID: 17623475]
  • Gloria D Coronado, Eric M Vigoren, Beti Thompson, William C Griffith, Elaine M Faustman. Organophosphate pesticide exposure and work in pome fruit: evidence for the take-home pesticide pathway. Environmental health perspectives. 2006 Jul; 114(7):999-1006. doi: 10.1289/ehp.8620. [PMID: 16835050]
  • Richard A Fenske, Chensheng Lu, Cynthia L Curl, Jeffry H Shirai, John C Kissel. Biologic monitoring to characterize organophosphorus pesticide exposure among children and workers: an analysis of recent studies in Washington State. Environmental health perspectives. 2005 Nov; 113(11):1651-7. doi: 10.1289/ehp.8022. [PMID: 16263526]
  • C Aprea, B Terenzoni, V De Angelis, G Sciarra, L Lunghini, G Borzacchi, D Vasconi, D Fani, A Quercia, A Salvan, L Settimi. Evaluation of skin and respiratory doses and urinary excretion of alkylphosphates in workers exposed to dimethoate during treatment of olive trees. Archives of environmental contamination and toxicology. 2005 Jan; 48(1):127-34. doi: 10.1007/s00244-004-0073-5. [PMID: 15657814]
  • F Hernández, J V Sancho, O J Pozo. An estimation of the exposure to organophosphorus pesticides through the simultaneous determination of their main metabolites in urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Sep; 808(2):229-39. doi: 10.1016/j.jchromb.2004.05.019. [PMID: 15261816]
  • N Kupfermann, A Schmoldt, H Steinhart. Rapid and sensitive quantitative analysis of alkyl phosphates in urine after organophosphate poisoning. Journal of analytical toxicology. 2004 May; 28(4):242-8. doi: 10.1093/jat/28.4.242. [PMID: 15189674]
  • Shalini Roy, Sharmila Roy, Reena Kumar, C B Sharma, Ben J Pereira. Biodegradation and bioaccumulation of fenitrothion in rat liver. Biomedical chromatography : BMC. 2004 Mar; 18(2):132-6. doi: 10.1002/bmc.318. [PMID: 15039966]
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