alpha-hydroxysalmeterol (BioDeep_00000054442)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


4-(1-hydroxy-2-{[6-(4-hydroxy-4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol

化学式: C25H37NO5 (431.26715920000004)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 15.22%

分子结构信息

SMILES: C1=CC=C(C=C1)C(CCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)O
InChI: InChI=1S/C25H37NO5/c27-19-22-17-21(12-13-24(22)29)25(30)18-26-14-6-1-2-7-15-31-16-8-11-23(28)20-9-4-3-5-10-20/h3-5,9-10,12-13,17,23,25-30H,1-2,6-8,11,14-16,18-19H2

描述信息

alpha-hydroxysalmeterol is a metabolite of salmeterol. Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease(COPD). It is currently available as a dry powder inhaler that releases a powdered form of the drug. Before 2008, it was also available as a metered-dose inhaler (MDI). (Wikipedia)

同义名列表

4 个代谢物同义名

4-(1-hydroxy-2-{[6-(4-hydroxy-4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol; alpha-hydroxysalmeterol; a-Hydroxysalmeterol; Α-hydroxysalmeterol



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Panagiotis Sakellariou, Michael Petrou, Emmanouil Lyris, Maria Tsivou, Argyro Fragkaki, Polyxeni Kiousi, Yiannis S Angelis, Constantinos Pistos. Determination of salmeterol, α-hydroxysalmeterol and fluticasone propionate in human urine and plasma for doping control using UHPLC-QTOF-MS. Biomedical chromatography : BMC. 2021 Aug; 35(8):e5114. doi: 10.1002/bmc.5114. [PMID: 33720401]
  • Søren Jessen, Victoria Becker, Sebastian Rzeppa, Vibeke Backer, Kasper Høtoft Bengtsen, Ingunn Hullstein, Yvette Dehnes, Morten Hostrup. Pharmacokinetics of salmeterol and its main metabolite α-hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance-trained men: Implications for doping control. Drug testing and analysis. 2021 Apr; 13(4):747-761. doi: 10.1002/dta.2978. [PMID: 33210444]