4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+) (BioDeep_00000054414)
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C21H18ClFNO+ (354.106088)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 13.33%
分子结构信息
SMILES: C1=CC(=CC=C1C2=CC=[N+](C=C2)CCCC(=O)C3=CC=C(C=C3)F)Cl
InChI: InChI=1S/C21H18ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-12,14-15H,1-2,13H2/q+1
描述信息
4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+) is a metabolite of haloperidol. Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines. Haloperidol is an older antipsychotic used in the treatment of schizophrenia and acute psychotic states and delirium. (Wikipedia)
同义名列表
11 个代谢物同义名
(4-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,4-dihydropyridin-4-ylidene}cyclohexa-2,5-dien-1-ylidene)-lambda3-chloranylium; (4-{1-[4-(4-fluorophenyl)-4-oxobutyl]pyridin-4-ylidene}cyclohexa-2,5-dien-1-ylidene)-lambda3-chloranylium; 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+); N-(4-Fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium perchlorate; N-(4-Fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium chloride; 4-(4-Chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)pyridinium; N-(4-Fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium iodide; N-(4-Fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium; 4-CFOBP; BCPP(+); HPP(+)
数据库引用编号
分类词条
相关代谢途径
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代谢反应
1 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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PathBank(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hidekazu Kawashima, Yasuhiko Iida, Youji Kitamura, Hideo Saji. Binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP+), a metabolite of haloperidol, to synthetic melanin: implications for the dopaminergic neurotoxicity of HPP+.
Neurotoxicity research.
2004; 6(7-8):535-42. doi:
10.1007/bf03033449. [PMID: 15639785] - Amit S Kalgutkar, Timothy J Taylor, Karthik Venkatakrishnan, Emre M Isin. Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.
Drug metabolism and disposition: the biological fate of chemicals.
2003 Mar; 31(3):243-9. doi:
10.1124/dmd.31.3.243. [PMID: 12584149] - D W Eyles, K M Avent, T J Stedman, S M Pond. Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem.
Life sciences.
1997; 60(8):529-34. doi:
10.1016/s0024-3205(96)00656-x. [PMID: 9042387] - D W Eyles, J J McGrath, S M Pond. Formation of pyridinium species of haloperidol in human liver and brain.
Psychopharmacology.
1996 Jun; 125(3):214-9. doi:
10.1007/bf02247331. [PMID: 8815956] - K Igarashi, F Kasuya, M Fukui, E Usuki, N Castagnoli. Studies on the metabolism of haloperidol (HP): the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP.
Life sciences.
1995 Nov; 57(26):2439-46. doi:
10.1016/0024-3205(95)02240-5. [PMID: 8847965] - D W Eyles, H R McLennan, A Jones, J J McGrath, T J Stedman, S M Pond. Quantitative analysis of two pyridinium metabolites of haloperidol in patients with schizophrenia.
Clinical pharmacology and therapeutics.
1994 Nov; 56(5):512-20. doi:
10.1038/clpt.1994.172. [PMID: 7955815]