dapsone hydroxylamine (BioDeep_00000054405)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


4-Amino-4-hydroxylaminodiphenylsulfone, T-labeled CPD

化学式: C12H12N2O3S (264.0568602)
中文名称: 羟胺氨苯砜
谱图信息: 最多检出来源 Mus musculus(blood) 66.67%

分子结构信息

SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)NO
InChI: InChI=1S/C12H12N2O3S/c13-9-1-5-11(6-2-9)18(16,17)12-7-3-10(14-15)4-8-12/h1-8,14-15H,13H2

描述信息

dapsone hydroxylamine is a metabolite of dapsone. Dapsone (diamino-diphenyl sulfone) is a medication most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections. It is also second-line treatment for prophylaxis (prevention) against Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly P. carinii) in HIV patients in whom CD4 counts are below 200/mm. (Wikipedia)

同义名列表

8 个代谢物同义名

4-Amino-4-hydroxylaminodiphenylsulfone, T-labeled CPD; 4-[4-(hydroxyamino)benzenesulfonyl]aniline; 4-Amino-4-hydroxylaminodiphenylsulfone; 4-Hydroxylamino-4-aminophenyl sulfone; Dapsone hydroxylamine; N-Hydroxydapsone; DDS-NOH; HADS



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Luis M Veggi, Luciana Pretto, Elena J Ochoa, Viviana A Catania, Marcelo G Luquita, Diego R Taborda, Enrique J Sánchez Pozzi, Shin-ichi Ikushiro, Michael D Coleman, Marcelo G Roma, Aldo D Mottino. Dapsone induces oxidative stress and impairs antioxidant defenses in rat liver. Life sciences. 2008 Aug; 83(5-6):155-63. doi: 10.1016/j.lfs.2008.05.016. [PMID: 18602405]
  • Sanjoy Roychowdhury, Piyush M Vyas, Craig K Svensson. Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells. Drug metabolism and disposition: the biological fate of chemicals. 2007 Apr; 35(4):676-81. doi: 10.1124/dmd.106.013680. [PMID: 17220235]
  • David C McMillan, Christine L Powell, Zachary S Bowman, Jason D Morrow, David J Jollow. Lipids versus proteins as major targets of pro-oxidant, direct-acting hemolytic agents. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Nov; 88(1):274-83. doi: 10.1093/toxsci/kfi290. [PMID: 16107547]
  • Helen R Winter, Carol B Trapnell, John T Slattery, Mark Jacobson, Debra L Greenspan, Thomas M Hooton, Jashvant D Unadkat. The effect of clarithromycin, fluconazole, and rifabutin on dapsone hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283). Clinical pharmacology and therapeutics. 2004 Dec; 76(6):579-87. doi: 10.1016/j.clpt.2004.08.016. [PMID: 15592329]
  • D J Jollow, D C McMillan. Oxidative stress, glucose-6-phosphate dehydrogenase and the red cell. Advances in experimental medicine and biology. 2001; 500(?):595-605. doi: 10.1007/978-1-4615-0667-6_88. [PMID: 11765001]
  • D C McMillan, C B Jensen, D J Jollow. Role of lipid peroxidation in dapsone-induced hemolytic anemia. The Journal of pharmacology and experimental therapeutics. 1998 Dec; 287(3):868-76. doi: ". [PMID: 9864266]
  • M D Tingle, R Mahmud, J L Maggs, M Pirmohamed, B K Park. Comparison of the metabolism and toxicity of dapsone in rat, mouse and man. The Journal of pharmacology and experimental therapeutics. 1997 Nov; 283(2):817-23. doi: . [PMID: 9353403]
  • A K Mitra, K E Thummel, T F Kalhorn, E D Kharasch, J D Unadkat, J T Slattery. Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. Clinical pharmacology and therapeutics. 1995 Nov; 58(5):556-66. doi: 10.1016/0009-9236(95)90176-0. [PMID: 7586950]
  • M D Coleman, D P Jacobus. Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro--II. Movement of dapsone across a semipermeable membrane into erythrocytes and plasma. Biochemical pharmacology. 1993 Oct; 46(8):1363-8. doi: 10.1016/0006-2952(93)90100-b. [PMID: 8240384]
  • M Haas, J H Harrison. Stimulation of K-C1 cotransport in rat red cells by a hemolytic anemia-producing metabolite of dapsone. The American journal of physiology. 1989 Feb; 256(2 Pt 1):C265-72. doi: 10.1152/ajpcell.1989.256.2.c265. [PMID: 2919657]