Propranolol glucuronide (BioDeep_00000543902)

   


代谢物信息卡片


Propranolol glucuronide

化学式: C22H29NO8 (435.1893074)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)OC3C(C(C(C(O3)C(=O)O)O)O)O
InChI: InChI=1S/C22H29NO8/c1-12(2)23-10-14(11-29-16-9-5-7-13-6-3-4-8-15(13)16)30-22-19(26)17(24)18(25)20(31-22)21(27)28/h3-9,12,14,17-20,22-26H,10-11H2,1-2H3,(H,27,28)/t14?,17-,18-,19+,20-,22+/m0/s1

描述信息

同义名列表

1 个代谢物同义名

Propranolol glucuronide



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(1)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Lian-Jun Luan, Qing Shao, Jian-Yin Ma, Su Zeng. Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral administration of RS-propranolol in Chinese Han subjects. World journal of gastroenterology. 2005 Mar; 11(12):1822-4. doi: 10.3748/wjg.v11.i12.1822. [PMID: 15793873]
  • V G Belolipetskaia, D S Rumiantsev, V K Piotrovskiĭ, V I Metelitsa, S G Duda, T P Ostrovskaia, E V Kokurina, S Iu Martseva, E V Bochkareva, N P Filatova. [The pharmacokinetics of propranolol and its conjugated metabolites in patients with chronic ischemic heart disease and arterial hypertension with a one-time and course intake of the drug]. Eksperimental'naia i klinicheskaia farmakologiia. 1995 Nov; 58(6):56-9. doi: NULL. [PMID: 8704616]
  • C Pham-Huy, A Sahui-Gnassi, V Saada, J P Gramond, H Galons, S Ellouk-Achard, V Levresse, D Fompeydie, J R Claude. Microassay of propranolol enantiomers and conjugates in human plasma and urine by high-performance liquid chromatography after chiral derivatization for pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 1994 Sep; 12(9):1189-98. doi: 10.1016/0731-7085(94)e0028-y. [PMID: 7803571]
  • T Walle, K Walle, R S Mathur, Y Y Palesch, E C Conradi. Propranolol metabolism in normal subjects: association with sex steroid hormones. Clinical pharmacology and therapeutics. 1994 Aug; 56(2):127-32. doi: 10.1038/clpt.1994.115. [PMID: 8062488]
  • V G Belolipetskaja, V K Piotrovskii, V I Metelitsa, S A Pavlinov. Ion-exchange high-performance liquid chromatography in drug assay in biological fluids. V. Propranolol and metabolites. Journal of chromatography. 1989 Jul; 491(2):507-12. doi: 10.1016/s0378-4347(00)82873-x. [PMID: 2808636]
  • T Walle, U K Walle, T D Cowart, E C Conradi, T E Gaffney. Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites. The Journal of pharmacology and experimental therapeutics. 1987 Jun; 241(3):928-33. doi: NULL. [PMID: 3598909]
  • S A Bai, T Walle. Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites. Drug metabolism and disposition: the biological fate of chemicals. 1984 Nov; 12(6):749-54. doi: NULL. [PMID: 6150825]
  • M W Lo, S M Pond, D J Effeney, B M Silber, S Riegelman, T N Tozer. Nonlinear formation of propranolol metabolites in dogs after portacaval transpositions. Journal of pharmacokinetics and biopharmaceutics. 1984 Aug; 12(4):401-12. doi: 10.1007/bf01062665. [PMID: 6527232]
  • M T Smith, I Livingstone, W D Hooper, M J Eadie, E J Triggs. Propranolol, propranolol glucuronide, and naphthoxylactic acid in breast milk and plasma. Therapeutic drug monitoring. 1983; 5(1):87-93. doi: 10.1097/00007691-198303000-00008. [PMID: 6845404]
  • T Walle, E C Conradi, U K Walle, T C Fagan, T E Gaffney. Propranolol glucuronide cumulation during long-term propranolol therapy: a proposed storage mechanism for propranolol. Clinical pharmacology and therapeutics. 1979 Dec; 26(6):686-95. doi: 10.1002/cpt1979266686. [PMID: 498710]