4'-Hydroxyflurbiprofen (BioDeep_00000054361)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


2-[3-fluoro-4-(4-hydroxyphenyl)phenyl]propanoic acid

化学式: C15H13FO3 (260.08486800000003)
中文名称: 4-羟基氟吡洛芬
谱图信息: 最多检出来源 Homo sapiens(blood) 11.76%

分子结构信息

SMILES: CC(C(O)=O)C1=CC(F)=C(C=C1)C1=CC=C(O)C=C1
InChI: InChI=1S/C15H13FO3/c1-9(15(18)19)11-4-7-13(14(16)8-11)10-2-5-12(17)6-3-10/h2-9,17H,1H3,(H,18,19)

描述信息

4-Hydroxyflurbiprofen is a metabolite of flurbiprofen. Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis. It is known by the following tradenames: Urbifen marketed by General Pharmaceuticals, Ansaid, marketed by Pfizer, Flurwood by W. Woodward and Froben, by Abbott. Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges. (Wikipedia)

同义名列表

6 个代谢物同义名

2-[3-fluoro-4-(4-hydroxyphenyl)phenyl]propanoic acid; 4-Hydroxyflurbiprofen, (+-)-isomer; 4-Hydroxyflurbiprofen, (R)-isomer; 4-Hydroxyflurbiprofen, (S)-isomer; 4-Hydroxy Flurbiprofen; 4-Hydroxyflurbiprofen



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yun-Jeong Lee, Ji-Yeong Byeon, Young-Hoon Kim, Se-Hyung Kim, Chang-Ik Choi, Jung-Woo Bae, Uy-Dong Sohn, Choon-Gon Jang, Jeongmi Lee, Seok-Yong Lee. Effects of CYP2C9*1/*3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects. Archives of pharmacal research. 2015 Jun; 38(6):1232-7. doi: 10.1007/s12272-015-0580-0. [PMID: 25712887]
  • Hye-In Lee, Chang-Ik Choi, Ji-Yeong Byeon, Jung-Eun Lee, So-Young Park, Young-Hoon Kim, Se-Hyung Kim, Yun-Jeong Lee, Choon-Gon Jang, Seok-Yong Lee. Simultaneous determination of flurbiprofen and its hydroxy metabolite in human plasma by liquid chromatography-tandem mass spectrometry for clinical application. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Nov; 971(?):58-63. doi: 10.1016/j.jchromb.2014.09.007. [PMID: 25264913]
  • Melanie S Joy, Reginald F Frye, Thomas D Nolin, Brittney V Roberts, Mary K La, Jinzhao Wang, Kim L R Brouwer, Mary Anne Dooley, Ronald J Falk. In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases. Pharmacotherapy. 2014 Feb; 34(2):114-22. doi: 10.1002/phar.1347. [PMID: 24038489]
  • Ilaria Peretto, Stefano Radaelli, Carlo Parini, Michele Zandi, Luca F Raveglia, Giulio Dondio, Laura Fontanella, Paola Misiano, Chiara Bigogno, Andrea Rizzi, Benedetta Riccardi, Marcello Biscaioli, Silvia Marchetti, Paola Puccini, Silvia Catinella, Ivano Rondelli, Valentina Cenacchi, Pier Tonino Bolzoni, Paola Caruso, Gino Villetti, Fabrizio Facchinetti, Elda Del Giudice, Nadia Moretto, Bruno P Imbimbo. Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. Journal of medicinal chemistry. 2005 Sep; 48(18):5705-20. doi: 10.1021/jm0502541. [PMID: 16134939]
  • Craig R Lee, John A Pieper, Reginald F Frye, Alan L Hinderliter, Joyce A Blaisdell, Joyce A Goldstein. Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes. European journal of clinical pharmacology. 2003 Apr; 58(12):791-4. doi: 10.1007/s00228-003-0574-6. [PMID: 12698304]
  • J M Hutzler, R F Frye, K R Korzekwa, R A Branch, S M Huang, T S Tracy. Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2001 Aug; 14(1):47-52. doi: 10.1016/s0928-0987(01)00144-0. [PMID: 11457649]
  • J M Hutzler, R F Frye, T S Tracy. Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma. Journal of chromatography. B, Biomedical sciences and applications. 2000 Nov; 749(1):119-25. doi: 10.1016/s0378-4347(00)00393-5. [PMID: 11129071]
  • E A Cefali, W J Poynor, D Sica, S Cox. Pharmacokinetic comparison of flurbiprofen in end-stage renal disease subjects and subjects with normal renal function. Journal of clinical pharmacology. 1991 Sep; 31(9):808-14. doi: 10.1002/j.1552-4604.1991.tb01916.x. [PMID: 1804864]
  • R E Small, S R Cox, W J Adams. Influence of H2 receptor antagonists on the disposition of flurbiprofen enantiomers. Journal of clinical pharmacology. 1990 Jul; 30(7):660-4. doi: 10.1002/j.1552-4604.1990.tb01870.x. [PMID: 2391398]