4-Chloro-5-sulfamoylanthranilic acid (BioDeep_00000054240)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


2-amino-4-chloro-5-sulfamoylbenzoic acid

化学式: C7H7ClN2O4S (249.9815052)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 4.55%

分子结构信息

SMILES: C1=C(C(=CC(=C1S(=O)(=O)N)Cl)N)C(=O)O
InChI: InChI=1S/C7H7ClN2O4S/c8-4-2-5(9)3(7(11)12)1-6(4)15(10,13)14/h1-2H,9H2,(H,11,12)(H2,10,13,14)

描述信息

4-Chloro-5-sulfamoylanthranilic acid is a metabolite of furosemide. Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races. Along with some other diuretics, furosemide is also included on the World Anti-Doping Agencys banned drug list due to its alleged use as a masking agent for other drugs. (Wikipedia)

同义名列表

5 个代谢物同义名

2-amino-4-chloro-5-sulfamoylbenzoic acid; 4-Chloro-5-sulphamoylanthranilic acid; 4-Chloro-5-sulfamoylanthranilic acid; 4-Chloro-5-sulphamoylanthranilate; 4-Chloro-5-sulfamoylanthranilate



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S Carda-Broch, J Esteve-Romero, M J Ruiz-Angel, M C García-Alvarez-Coque. Determination of furosemide in urine samples by direct injection in a micellar liquid chromatographic system. The Analyst. 2002 Jan; 127(1):29-34. doi: 10.1039/b108358a. [PMID: 11827392]
  • H Nakahama, Y Fukuhara, Y Orita, A Yamauchi, T Takama, T Kamada. Furosemide accelerates gentamicin accumulation in cultured renal cells (LLC-PK1 cells). Nephron. 1989; 53(2):138-41. doi: 10.1159/000185726. [PMID: 2812167]
  • Y Miwa, A Yamaji, H Nakahama, Y Orita, Y Fukuhara, T Kamada, M Ishibashi, Y Ichikawa, S Takahara, T Sonoda. [Determination of furosemide and its metabolic products in plasma and urine by high performance liquid chromatography and clinical application]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1988 Nov; 108(11):1087-92. doi: 10.1248/yakushi1947.108.11_1087. [PMID: 3251019]
  • H Nakahama, Y Miwa, A Yamaji, Y Orita, Y Fukuhara, M Yanase, T Kamada, T Sonoda, M Ishibasi, Y Ichikawa. The urinary excretion of frusemide and its metabolites by kidney transplant patients. European journal of clinical pharmacology. 1987; 32(3):313-5. doi: 10.1007/bf00607581. [PMID: 3297734]
  • L Z Benet, D E Smith, E T Lin, F Vincenti, J G Gambertoglio. Furosemide assays and disposition in healthy volunteers and renal transplant patients. Federation proceedings. 1983 Apr; 42(6):1695-8. doi: NULL. [PMID: 6339277]
  • B Wesley-Hadzija, A M Mattocks. Thin-layer chromatographic determination of furosemide and 4-chloro-5-sulfamoyl anthranilic acid in plasma and urine. Journal of chromatography. 1982 May; 229(2):425-32. doi: 10.1016/s0378-4347(00)84285-1. [PMID: 7096477]
  • F Andreasen, C K Christensen, F K Jakobsen, C E Mogensen. The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products. Acta pharmacologica et toxicologica. 1981 Sep; 49(3):223-9. doi: 10.1111/j.1600-0773.1981.tb00897.x. [PMID: 7336980]
  • D E Smith, E T Lin, L Z Benet. Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay. Drug metabolism and disposition: the biological fate of chemicals. 1980 Sep; 8(5):337-42. doi: NULL. [PMID: 6107232]
  • F Andreasen, S Husted. The binding of furosemide to serum proteins in elderly patients: displacing effect of phenprocoumon. Acta pharmacologica et toxicologica. 1980 Sep; 47(3):202-7. doi: 10.1111/j.1600-0773.1980.tb01560.x. [PMID: 7446136]
  • M L MacDougall, D W Shoeman, D L Azarnoff. Separation and quantitative analysis of furosemide and 4-chloro-5-sulfamoylanthranilic adid (CSA) by high pressure liquid chromatography. Research communications in chemical pathology and pharmacology. 1975 Feb; 10(2):285-92. doi: NULL. [PMID: 1153837]