13-Demethyl tacrolimus (BioDeep_00000054200)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


(1R,9S,12S,13R,14S,17R,18Z,21S,23S,24S,25S,27R)-1,14,25-trihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23-methoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-ene-2,3,10,16-tetrone

化学式: C43H67NO12 (789.4663022)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: [H][C@]12O[C@](O)([C@H](C)C[C@@H]1O)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)\C=C(C)/C[C@H](C)C[C@@H]2OC)C(\C)=C\[C@@H]1CC[C@@H](O)[C@@H](C1)OC
InChI: InChI=1S/C43H67NO12/c1-9-12-30-18-24(2)17-25(3)19-37(54-8)39-35(48)21-27(5)43(52,56-39)40(49)41(50)44-16-11-10-13-31(44)42(51)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)36(22-29)53-7/h9,18,20,25,27-33,35-39,45-46,48,52H,1,10-17,19,21-23H2,2-8H3/b24-18-,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35-,36+,37-,38+,39-,43+/m0/s1

描述信息

13-Demethyl tacrolimus is a metabolite of tacrolimus. Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patients immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis, severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, and the skin condition vitiligo. (Wikipedia)

同义名列表

62 个代谢物同义名

(1R,9S,12S,13R,14S,17R,18Z,21S,23S,24S,25S,27R)-1,14,25-trihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23-methoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-ene-2,3,10,16-tetrone; Pharmachemie brand OF fluorouracil monosodium salt; Ribosepharm brand OF fluorouracil; Dermatech brand OF fluorouracil; Fluorouracil monopotassium salt; Onkoworks brand OF fluorouracil; Allergan brand OF fluorouracil; Riemser brand OF fluorouracil; Neocorp brand OF fluorouracil; Haemato brand OF fluorouracil; Dakota brand OF fluorouracil; Biosyn brand OF fluorouracil; Fluorouracil monosodium salt; Ferrer brand OF fluorouracil; 5-Fluoropyrimidine-2,4-dione; Dermik brand OF fluorouracil; Roche brand OF fluorouracil; Fluorouracil potassium salt; Hexal brand OF fluorouracil; Medac brand OF fluorouracil; Teva brand OF fluorouracil; ICN brand OF fluorouracil; CSP Brand OF fluorouracil; Gry brand OF fluorouracil; Fluorouracilo ferrer far; Fluorouracil mononitrate; Fluorouracil teva brand; 13-Demethyl tacrolimus; 5 Fluorouracil biosyn; Dakota, fluorouracile; 5-Fluorouracil-biosyn; Fluorouracile dakota; Fluoro uracile icn; Fluoro-uracile icn; Fluorouracil gry; Fluorouracil-gry; 5-Fluorouracil; Fluorouracilum; 5 Fluorouracil; Fluorouracilo; 5 FU lederle; 5-FU lederle; Fluoruracil; 5-Fluoracil; 5 FU medac; Fluracedyl; Haemato fu; Haemato-fu; 5-HU hexal; Fluoroplex; 5-FU medac; 5 HU hexal; Ribofluor; Onkofluor; Flurodex; Neofluor; Adrucil; Efudex; Efudix; Carac; 5-FU; 5FU



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表