Dextrorphan (BioDeep_00000054135)
human metabolite Endogenous blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
(1S,9S,10S)-17-methyl-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2(7),3,5-trien-4-ol
化学式: C17H23NO (257.1779548)
中文名称: 右啡肽
谱图信息:
最多检出来源 Homo sapiens(blood) 0.61%
分子结构信息
SMILES: CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O
InChI: InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1
描述信息
Dextrorphan is a metabolite of Dextromethorphan. Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextro-stereoisomer of racemorphan, the levo-half being levorphanol. Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the psychoactive effects of dextromethorphan. (Wikipedia)
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D020011 - Protective Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:29133
- PubChem: 5360697
- HMDB: HMDB0060552
- DrugBank: DB14682
- ChEMBL: CHEMBL1254766
- Wikipedia: Dextrorphan
- MeSH: Dextrorphan
- CAS: 125-73-5
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
65 个相关的代谢反应过程信息。
Reactome(65)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Cytochrome P450 - arranged by substrate type:
ANDST + H+ + Oxygen + TPNH ⟶ H2O + HCOOH + TPN + estrone - Xenobiotics:
EtOH + H+ + Oxygen + TPNH ⟶ CH3CHO + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Cytochrome P450 - arranged by substrate type:
EtOH + H+ + Oxygen + TPNH ⟶ CH3CHO + H2O + TPN - Xenobiotics:
EtOH + H+ + Oxygen + TPNH ⟶ CH3CHO + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Phase I - Functionalization of compounds:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH - Cytochrome P450 - arranged by substrate type:
ANDST + H+ + Oxygen + TPNH ⟶ H2O + HCOOH + TPN + estrone - Xenobiotics:
DEXM + H+ + Oxygen + TPNH ⟶ CH2O + DEXT + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
CAF + H+ + Oxygen + TPNH ⟶ CH2O + H2O + Paraxanthine + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sara Shum, Aprajita Yadav, Emily Fay, Sue Moreni, Jennie Mao, Lindsay Czuba, Celine Wang, Nina Isoherranen, Mary F Hebert. Infant Dextromethorphan and Dextrorphan Exposure via Breast Milk From Mothers Who Are CYP2D6 Extensive Metabolizers.
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Archives of medical science : AMS.
2011 Jun; 7(3):465-9. doi:
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The Journal of surgical research.
2011 May; 167(2):e231-43. doi:
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Clinical pharmacokinetics.
2011 May; 50(5):319-29. doi:
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Journal of separation science.
2011 May; 34(10):1102-10. doi:
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Journal of pharmaceutical and biomedical analysis.
2011 Jan; 54(2):387-94. doi:
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Neuro endocrinology letters.
2011; 32(5):727-32. doi:
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2011; 27(6):663-6. doi:
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The Annals of pharmacotherapy.
2011 Jan; 45(1):e1. doi:
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Clinical pharmacology and therapeutics.
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2010 Mar; 878(7-8):682-8. doi:
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Human psychopharmacology.
2010 Jan; 25(1):71-9. doi:
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Drug metabolism letters.
2010 Jan; 4(1):51-5. doi:
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Biomedical chromatography : BMC.
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The pharmacogenomics journal.
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British journal of clinical pharmacology.
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Neuro endocrinology letters.
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Acta poloniae pharmaceutica.
2008 Sep; 65(5):611-5. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Aug; 871(1):78-89. doi:
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Clinical pharmacology and therapeutics.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jan; 861(1):56-63. doi:
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Acta poloniae pharmaceutica.
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European journal of pharmacology.
2007 Nov; 573(1-3):55-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Nov; 859(1):141-6. doi:
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Pharmacological reports : PR.
2007 Nov; 59(6):734-8. doi:
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Basic & clinical pharmacology & toxicology.
2007 Nov; 101(5):350-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 853(1-2):287-93. doi:
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Basic & clinical pharmacology & toxicology.
2007 Apr; 100(4):269-72. doi:
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Journal of postgraduate medicine.
2006 Oct; 52(4):253-6. doi:
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Forensic science international.
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Clinical pharmacology and therapeutics.
2005 Dec; 78(6):664-74. doi:
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European journal of clinical pharmacology.
2005 Dec; 61(11):821-9. doi:
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2005 Nov; 45(11):1230-5. doi:
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Life sciences.
2005 Oct; 77(23):2911-26. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2005 Jul; 33(7):1052-5. doi:
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2005 Apr; 818(2):147-57. doi:
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International journal of clinical pharmacology and therapeutics.
2005 Mar; 43(3):150-3. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Feb; 816(1-2):297-308. doi:
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European journal of clinical pharmacology.
2005 Feb; 60(12):849-54. doi:
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Pain.
2005 Feb; 113(3):360-368. doi:
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European journal of mass spectrometry (Chichester, England).
2005; 11(2):199-208. doi:
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Rapid communications in mass spectrometry : RCM.
2005; 19(15):2144-50. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Dec; 813(1-2):217-25. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2004 Dec; 32(12):1333-6. doi:
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2004 Oct; 44(10):1132-42. doi:
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Journal of pharmaceutical and biomedical analysis.
2004 Sep; 35(5):1179-89. doi:
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2004 Jun; 39(6):449-52. doi:
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The Journal of pharmacology and experimental therapeutics.
2004 May; 309(2):515-22. doi:
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2004 Apr; 802(2):317-22. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2004 Apr; 32(4):460-7. doi:
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British journal of clinical pharmacology.
2004 Apr; 57(4):456-63. doi:
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Journal of veterinary pharmacology and therapeutics.
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Acta anaesthesiologica Scandinavica.
2004 Mar; 48(3):328-36. doi:
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