Dextrorphan (BioDeep_00000054135)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,9S,10S)-17-methyl-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2(7),3,5-trien-4-ol

化学式: C17H23NO (257.1779548)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.66%

分子结构信息

SMILES: CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O
InChI: InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1

描述信息

Dextrorphan is a metabolite of Dextromethorphan. Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextro-stereoisomer of racemorphan, the levo-half being levorphanol. Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the psychoactive effects of dextromethorphan. (Wikipedia)
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D020011 - Protective Agents

同义名列表

7 个代谢物同义名

(1S,9S,10S)-17-methyl-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2(7),3,5-trien-4-ol; (+)-3-Hydroxy-N-methylmorphinan; D-3-Hydroxy-N-methylmorphinan; (+-)-17-Methylmorphinan-3-ol; Dextrorphanum; Dextrorphane; dextrorphan



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

65 个相关的代谢反应过程信息。

Reactome(65)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sara Shum, Aprajita Yadav, Emily Fay, Sue Moreni, Jennie Mao, Lindsay Czuba, Celine Wang, Nina Isoherranen, Mary F Hebert. Infant Dextromethorphan and Dextrorphan Exposure via Breast Milk From Mothers Who Are CYP2D6 Extensive Metabolizers. Journal of clinical pharmacology. 2022 06; 62(6):747-755. doi: 10.1002/jcph.2012. [PMID: 34889461]
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  • Marina V Antunes, Rafael Linden, Tamyris V Santos, Pierre Wallemacq, Vincent Haufroid, Jean-François Classen, Huander Andreolla, Nathalia Costa, Tiago O Fontanive, Daniela D Rosa. Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy. Therapeutic drug monitoring. 2012 Aug; 34(4):422-31. doi: 10.1097/ftd.0b013e318260b46e. [PMID: 22777153]
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