3-Iodothyronamine (BioDeep_00000054123)
human metabolite Endogenous blood metabolite
代谢物信息卡片
3-IODOTHYRONAMINE-[ETHYLAMINO-1,1,2,2-2H4] HYDROCHLORIDE
化学式: C14H14INO2 (355.0069254)
中文名称: 3-碘类甲腺质-[D4]
谱图信息:
最多检出来源 Homo sapiens(blood) 80%
分子结构信息
SMILES: C1=CC(=CC=C1O)OC2=C(C=C(C=C2)CCN)I
InChI: InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2
描述信息
3-Iodothyronamine is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1, a recently discovered G protein-coupled receptor. T1AM is the most potent TAAR1 agonist yet discovered. (Wikipedia)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:89700
- PubChem: 9950514
- HMDB: HMDB0060524
- ChEMBL: CHEMBL1182312
- Wikipedia: 3-Iodothyronamine
- CAS: 712349-95-6
- RefMet: 3-Iodothyronamine
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhong-Min Li, Manuel Miller, Sogol Gachkar, Jens Mittag, Sonja C Schriever, Paul T Pfluger, Karl-Werner Schramm, Meri De Angelis. Determination of 3-iodothyronamine (3-T1AM) in mouse liver using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Feb; 1165(?):122553. doi:
10.1016/j.jchromb.2021.122553. [PMID: 33503577] - Riccardo Zucchi. Thyroid Hormone Analogues: An Update.
Thyroid : official journal of the American Thyroid Association.
2020 08; 30(8):1099-1105. doi:
10.1089/thy.2020.0071. [PMID: 32098589] - M Kim, K Park, I Choi. The metabolic suppressor 3-iodothyronamine enhances lipolysis in 3T3-L1 adipocytes via activation of the adenosine monophosphate-activated protein kinase/forkhead box O1 signaling pathway.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Jun; 71(3):. doi:
10.26402/jpp.2020.3.12. [PMID: 33077693] - Haiyan Zhou, Bailong Hu, Xingde Liu. Thyroid Hormone Metabolite 3-Iodothyronamine (T1AM) Alleviates Hypoxia/Reoxygenation-Induced Cardiac Myocyte Apoptosis via Akt/FoxO1 Pathway.
Medical science monitor : international medical journal of experimental and clinical research.
2020 Mar; 26(?):e923195. doi:
10.12659/msm.923195. [PMID: 32162616] - Lorenza Bellusci, Massimiliano Runfola, Vittoria Carnicelli, Simona Sestito, Federica Fulceri, Filippo Santucci, Paola Lenzi, Francesco Fornai, Simona Rapposelli, Nicola Origlia, Riccardo Zucchi, Grazia Chiellini. Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6.
Molecules (Basel, Switzerland).
2020 Feb; 25(5):. doi:
10.3390/molecules25051054. [PMID: 32110992] - Zhou Haiyan, Hu Bailong, Zhang Bei, Wang Yiming, Liu Xingde. Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM).
BioMed research international.
2020; 2020(?):1302453. doi:
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International journal of molecular sciences.
2019 Aug; 20(16):. doi:
10.3390/ijms20164054. [PMID: 31434215] - Josef Köhrle, Heike Biebermann. 3-Iodothyronamine-A Thyroid Hormone Metabolite With Distinct Target Profiles and Mode of Action.
Endocrine reviews.
2019 04; 40(2):602-630. doi:
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The Journal of clinical endocrinology and metabolism.
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
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Experimental biology and medicine (Maywood, N.J.).
2014 Feb; 239(2):151-8. doi:
10.1177/1535370213510252. [PMID: 24302559] - Veronica Mariotti, Erika Melissari, Caterina Iofrida, Marco Righi, Manuela Di Russo, Riccardo Donzelli, Alessandro Saba, Sabina Frascarelli, Grazia Chiellini, Riccardo Zucchi, Silvia Pellegrini. Modulation of gene expression by 3-iodothyronamine: genetic evidence for a lipolytic pattern.
PloS one.
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Obesity (Silver Spring, Md.).
2013 Dec; 21(12):2538-44. doi:
10.1002/oby.20391. [PMID: 23512955] - Maria Elena Manni, Gaetano De Siena, Alessandro Saba, Maja Marchini, Elisa Landucci, Elisabetta Gerace, Marina Zazzeri, Claudia Musilli, Domenico Pellegrini-Giampietro, Rosanna Matucci, Riccardo Zucchi, Laura Raimondi. Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold.
British journal of pharmacology.
2013 Jan; 168(2):354-62. doi:
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The Journal of endocrinology.
2012 Jun; 213(3):223-30. doi:
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2012 Jan; 287(3):1790-800. doi:
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