Cycloguanil (BioDeep_00000539112)
代谢物信息卡片
Cycloguanil
化学式: C11H14ClN5 (251.0938)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C
InChI: InChI=1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
D007004 - Hypoglycemic Agents > D001645 - Biguanides
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135029
- PubChem: 9049
- Metlin: METLIN2129
- DrugBank: DB14763
- ChEMBL: CHEMBL747
- CAS: 516-21-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ryohkan Funakoshi, Yukana Tomoda, Toshiyuki Kudo, Kenichi Furihata, Hiroyuki Kusuhara, Kiyomi Ito. Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers.
British journal of clinical pharmacology.
2019 07; 85(7):1454-1463. doi:
10.1111/bcp.13914. [PMID: 30845361] - Pablo Villoslada, Gemma Vila, Valeria Colafrancesco, Beatriz Moreno, Begoña Fernandez-Diez, Raquel Vazquez, Inna Pertsovskaya, Irati Zubizarreta, Irene Pulido-Valdeolivas, Joaquin Messeguer, Gloria Vendrell-Navarro, Jose Maria Frade, Noelia López-Sánchez, Meritxell Teixido, Ernest Giralt, Mar Masso, Jason C Dugas, Dmitri Leonoudakis, Karen D Lariosa-Willingham, Lawrence Steinman, Angel Messeguer. Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2019 07; 16(3):808-827. doi:
10.1007/s13311-019-00717-4. [PMID: 30815844] - Maarten van der Velden, Albert Bilos, Jeroen J M W van den Heuvel, Sanna R Rijpma, Evelien G E Hurkmans, Robert W Sauerwein, Frans G M Russel, Jan B Koenderink. Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates.
Malaria journal.
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Scientific reports.
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Journal of natural products.
2016 Apr; 79(4):978-83. doi:
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Fundamental & clinical pharmacology.
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2004 Jun; 3(?):16. doi:
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2002 Nov; 58(8):537-42. doi:
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2002 Apr; 58(1):19-27. doi:
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1999 Sep; 20(5):737-43. doi:
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1999 Jun; 55(4):311-5. doi:
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Acta dermato-venereologica.
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
1998 Mar; 92(2):201-6. doi:
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Acta tropica.
1997 Sep; 66(3):127-35. doi:
10.1016/s0001-706x(97)00044-2. [PMID: 9210963] - U Jeppesen, B B Rasmussen, K Brøsen. Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide.
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1997 Sep; 62(3):279-86. doi:
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The American journal of tropical medicine and hygiene.
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British journal of clinical pharmacology.
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