1-Hydroxypyrene glucuronide (BioDeep_00000053832)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(pyren-1-yloxy)oxane-2-carboxylic acid

化学式: C22H18O7 (394.1052478)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 83.33%

分子结构信息

SMILES: C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)OC5C(C(C(C(O5)C(=O)O)O)O)O
InChI: InChI=1S/C22H18O7/c23-17-18(24)20(21(26)27)29-22(19(17)25)28-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17-20,22-25H,(H,26,27)/t17-,18-,19+,20-,22+/m0/s1

描述信息

1-Hydroxypyrene glucuronide belongs to the family of Pyrenes. These are compounds containing a pyrene moiety, which consists four fused benzene rings, resulting in a flat aromatic system

同义名列表

5 个代谢物同义名

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(pyren-1-yloxy)oxane-2-carboxylic acid; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(pyren-1-yloxy)oxane-2-carboxylate; 1-Hydroxypyrene-glucuronide; 1-Hydroxypyrene glucuronide; 1-OHP-Gluc



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Biban Gill, Karl Jobst, Philip Britz-McKibbin. Rapid Screening of Urinary 1-Hydroxypyrene Glucuronide by Multisegment Injection-Capillary Electrophoresis-Tandem Mass Spectrometry: A High-Throughput Method for Biomonitoring of Recent Smoke Exposures. Analytical chemistry. 2020 10; 92(19):13558-13564. doi: 10.1021/acs.analchem.0c03212. [PMID: 32901481]
  • Kamau O Peters, D' Ann L Williams, Salahadin Abubaker, Jean Curtin-Brosnan, Meredith C McCormack, Roger Peng, Patrick N Breysse, Elizabeth C Matsui, Nadia N Hansel, Gregory B Diette, Paul T Strickland. Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. Journal of exposure science & environmental epidemiology. 2017 05; 27(3):290-298. doi: 10.1038/jes.2016.57. [PMID: 27966668]
  • Mingxin Li, Qian Wang, Jing Zhu, Nana Li, Xiaoli Zou. A simple analytical method of determining 1-hydroxypyrene glucuronide in human urine by isotope dilution with ultra performance liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. 2017 Feb; 409(6):1513-1518. doi: 10.1007/s00216-016-0083-y. [PMID: 27888306]
  • Qun Miao, Michèle Bouchard, Dongmei Chen, Igor Burstyn, John J Spinelli, Kristan J Aronson. Assessing traffic and polycyclic aromatic hydrocarbon exposure in Montreal, Canada. The Science of the total environment. 2014 Feb; 470-471(?):945-53. doi: 10.1016/j.scitotenv.2013.10.030. [PMID: 24239815]
  • Jonathan N Hofmann, Linda M Liao, Paul T Strickland, Xiao-Ou Shu, Gong Yang, Bu-Tian Ji, Hong-Lan Li, Nathaniel Rothman, Farin Kamangar, Yu-Tang Gao, Wei Zheng, Wong-Ho Chow. Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study. BMC cancer. 2013 Jun; 13(?):282. doi: 10.1186/1471-2407-13-282. [PMID: 23758680]
  • Hyung-Suk Yoon, Kyoung-Mu Lee, Kyoung-Ho Lee, Sungkyoon Kim, Kyungho Choi, Daehee Kang. Polycyclic aromatic hydrocarbon (1-OHPG and 2-naphthol) and oxidative stress (malondialdehyde) biomarkers in urine among Korean adults and children. International journal of hygiene and environmental health. 2012 Jul; 215(4):458-64. doi: 10.1016/j.ijheh.2012.02.007. [PMID: 22436105]
  • Han-Bin Huang, Ching-Huang Lai, Guan-Wen Chen, Yong-Yang Lin, Jouni J K Jaakkola, Saou-Hsing Liou, Shu-Li Wang. Traffic-related air pollution and DNA damage: a longitudinal study in Taiwanese traffic conductors. PloS one. 2012; 7(5):e37412. doi: 10.1371/journal.pone.0037412. [PMID: 22629390]
  • Robert A Wilson, Carl J Seliskar, Glenn Talaska, William R Heineman. Spectroelectrochemical sensing of pyrene metabolites 1-hydroxypyrene and 1-hydroxypyrene-glucuronide. Analytical chemistry. 2011 May; 83(10):3725-9. doi: 10.1021/ac200161s. [PMID: 21504209]
  • Adriana H Nudi, Angela de L R Wagener, Eleine Francioni, Carla B Sette, André V Sartori, Arthur de L Scofield. Biomarkers of PAHs exposure in crabs Ucides cordatus: laboratory assay and field study. Environmental research. 2010 Feb; 110(2):137-45. doi: 10.1016/j.envres.2009.10.014. [PMID: 20034625]
  • Kyoung-Ho Lee, Roel Vermeulen, Virissa Lenters, Soo-Hun Cho, Paul T Strickland, Daehee Kang. Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children. International archives of occupational and environmental health. 2009 Aug; 82(8):961-8. doi: 10.1007/s00420-008-0385-2. [PMID: 19020893]
  • Christian C Abnet, Renato B Fagundes, Paul T Strickland, Farin Kamangar, Mark J Roth, Philip R Taylor, Sanford M Dawsey. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. Carcinogenesis. 2007 Jan; 28(1):112-7. doi: 10.1093/carcin/bgl131. [PMID: 16864595]
  • Robert B Gunier, Peggy Reynolds, Susan E Hurley, Sauda Yerabati, Andrew Hertz, Paul Strickland, Pamela L Horn-Ross. Estimating exposure to polycyclic aromatic hydrocarbons: a comparison of survey, biological monitoring, and geographic information system-based methods. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2006 Jul; 15(7):1376-81. doi: 10.1158/1055-9965.epi-05-0799. [PMID: 16835339]
  • Y Hu, Z Zhou, X Xue, X Li, J Fu, B Cohen, A A Melikian, M Desai, M -S Tang, X Huang, N Roy, J Sun, P Nan, Q Qu. Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2006 Jul; 11(4):306-18. doi: 10.1080/13547500600626883. [PMID: 16908438]
  • Renato B Fagundes, Christian C Abnet, Paul T Strickland, Farin Kamangar, Mark J Roth, Philip R Taylor, Sanford M Dawsey. Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil. BMC cancer. 2006 May; 6(?):139. doi: 10.1186/1471-2407-6-139. [PMID: 16729889]
  • C-H Lai, S-H Liou, H-C Lin, T-S Shih, P-J Tsai, J-S Chen, T Yang, J J K Jaakkola, P T Strickland. Exposure to traffic exhausts and oxidative DNA damage. Occupational and environmental medicine. 2005 Apr; 62(4):216-22. doi: 10.1136/oem.2004.015107. [PMID: 15778253]
  • Farin Kamangar, Paul T Strickland, Akram Pourshams, Reza Malekzadeh, Paolo Boffetta, Mark J Roth, Christian C Abnet, Mitra Saadatian-Elahi, Nasser Rakhshani, Paul Brennan, Arash Etemadi, Sanford M Dawsey. High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran. Anticancer research. 2005 Jan; 25(1B):425-8. doi: NULL. [PMID: 15816606]
  • Ching-Huang Lai, Saou-Hsing Liou, Tung-Sheng Shih, Perng-Jy Tsai, Hsiao-Lung Chen, Timothy J Buckley, Paul T Strickland, Jouni J K Jaakkola. Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan. Archives of environmental health. 2004 Feb; 59(2):61-9. doi: 10.3200/aeoh.59.2.61-69. [PMID: 16075899]
  • Kyoung-Ho Lee, Masayoshi Ichiba, Jiusong Zhang, Katsumaro Tomokuni, Yun-Chul Hong, Mina Ha, Ho Jang Kwon, Sang-Back Koh, Hong-Ryul Choi, Kwan-Hee Lee, Chung-Gyu Park, Soo-Hun Cho, Ari Hirvonen, Paul T Strickland, Roel Vermeulen, Richard B Hayes, Daehee Kang. Multiple biomarkers study in painters in a shipyard in Korea. Mutation research. 2003 Sep; 540(1):89-98. doi: 10.1016/s1383-5718(03)00173-6. [PMID: 12972061]
  • Kyoung-Ho Lee, Soo-Hun Cho, Yun-Chul Hong, Kwan-Hee Lee, Ho-Jang Kwan, Inmi Choi, Daehee Kang. Urinary PAH metabolites influenced by genetic polymorphisms of GSTM1 in male hospital incinerator workers. Journal of occupational health. 2003 May; 45(3):168-71. doi: 10.1539/joh.45.168. [PMID: 14646292]
  • Eivor Elovaara, Virpi Väänänen, Jouni Mikkola. Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with beta-naphthoflavone induction in the rat. Archives of toxicology. 2003 Apr; 77(4):183-93. doi: 10.1007/s00204-003-0436-0. [PMID: 12698233]
  • Kyoung-Ho Lee, Jeongmi Lee, Mina Ha, Jae-Wook Choi, Soo-Hun Cho, Eung-Soo Hwang, Chung-Gyu Park, Paul T Strickland, Ari Hirvonen, Daehee Kang. Influence of polymorphism of GSTM1 gene on association between glycophorin a mutant frequency and urinary PAH metabolites in incineration workers. Journal of toxicology and environmental health. Part A. 2002 Mar; 65(5-6):355-63. doi: 10.1080/15287390252808028. [PMID: 11936216]
  • Jeongmi Lee, Daehee Kang, Kyoung-Ho Lee, Masayoshi Ichiba, Jiusong Zhang, Katsumaro Tomokuni, Eung Soo Hwang, Chung-Gyu Park, Mina Ha, SungGyun Kim, Sang-Beom Han, Jae Wook Choi, Eunil Lee, Jae-yeon Jang, Paul T Strickland, Ari Hirvonen, Soo-Hun Cho. Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers. Mutation research. 2002 Feb; 514(1-2):213-21. doi: 10.1016/s1383-5718(01)00340-0. [PMID: 11815259]
  • P Strickland, D Kang. Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure to environmental PAH in air particulate matter. Toxicology letters. 1999 Sep; 108(2-3):191-9. doi: 10.1016/s0378-4274(99)00089-2. [PMID: 10511262]
  • Y C Hong, J H Leem, H S Park, K H Lee, S J Lee, C K Lee, D Kang. Variations in urinary 1-hydroxypyrene glucuronide in relation to smoking and the modification effects of GSTM1 and GSTT1. Toxicology letters. 1999 Sep; 108(2-3):217-23. doi: 10.1016/s0378-4274(99)00092-2. [PMID: 10511265]
  • C K Lee, S H Cho, J W Kang, S J Lee, Y S Ju, J Sung, P T Strickland, D Kang. Comparison of three analytical methods for 1-hydroxypyrene glucuronide in urine after non-occupational exposure to polycyclic aromatic hydrocarbons. Toxicology letters. 1999 Sep; 108(2-3):209-15. doi: 10.1016/s0378-4274(99)00091-0. [PMID: 10511264]
  • R Singh, M Tucek, K Maxa, J Tenglerová, E H Weyand. A rapid and simple method for the analysis of 1-hydroxypyrene glucuronide: a potential biomarker for polycyclic aromatic hydrocarbon exposure. Carcinogenesis. 1995 Dec; 16(12):2909-15. doi: 10.1093/carcin/16.12.2909. [PMID: 8603463]
  • D Kang, N Rothman, S H Cho, H S Lim, H J Kwon, S M Kim, B Schwartz, P T Strickland. Association of exposure to polycyclic aromatic hydrocarbons (estimated from job category) with concentration of 1-hydroxypyrene glucuronide in urine from workers at a steel plant. Occupational and environmental medicine. 1995 Sep; 52(9):593-9. doi: 10.1136/oem.52.9.593. [PMID: 7550799]
  • D H Kang, N Rothman, M C Poirier, A Greenberg, C H Hsu, B S Schwartz, M E Baser, J D Groopman, A Weston, P T Strickland. Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells after charbroiled beef consumption. Carcinogenesis. 1995 May; 16(5):1079-85. doi: 10.1093/carcin/16.5.1079. [PMID: 7767968]