Norcisapride (BioDeep_00000501908)
代谢物信息卡片
化学式: C14H20ClN3O3 (313.1193)
中文名称: 顺式-4-氨基-5-氯-2-甲氧基-N-(3-甲氧基-哌啶-4-基)-苯甲酰胺, 去甲西沙必利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1CNCCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl
InChI: InChI=1S/C14H20ClN3O3/c1-20-12-6-10(16)9(15)5-8(12)14(19)18-11-3-4-17-7-13(11)21-2/h5-6,11,13,17H,3-4,7,16H2,1-2H3,(H,18,19)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:186415
- PubChem: 3019427
- Metlin: METLIN1780
- ChEMBL: CHEMBL1748
- CAS: 84946-16-7
- CAS: 83863-69-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Gregory L Kearns, Patricia K Robinson, John T Wilson, Deanna Wilson-Costello, Gail R Knight, Robert M Ward, John N van den Anker. Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Clinical pharmacology and therapeutics.
2003 Oct; 74(4):312-25. doi:
10.1016/s0009-9236(03)00225-x. [PMID: 14534518] - Jennifer A Lowry, Gregory L Kearns, Susan M Abdel-Rahman, Anne N Nafziger, Irim S Khan, Angela D M Kashuba, Erin G Schuetz, Joseph S Bertino, John N van den Anker, J Steven Leeder. Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Clinical pharmacology and therapeutics.
2003 Mar; 73(3):209-22. doi:
10.1067/mcp.2003.29. [PMID: 12621386] - R E Pearce, R R Gotschall, G L Kearns, J S Leeder. Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Drug metabolism and disposition: the biological fate of chemicals.
2001 Dec; 29(12):1548-54. doi:
. [PMID: 11717173] - E M Offman, D J Freeman, G K Dresser, C Munoz, J R Bend, D G Bailey. Red wine-cisapride interaction: comparison with grapefruit juice.
Clinical pharmacology and therapeutics.
2001 Jul; 70(1):17-23. doi:
10.1067/mcp.2001.116892. [PMID: 11452240] - R S Addison, S L Duffy, S R Mathers. A simple high-performance liquid chromatography assay for the major cisapride metabolite, norcisapride, in human urine.
Journal of chromatographic science.
1999 Mar; 37(3):61-4. doi:
10.1093/chromsci/37.3.61. [PMID: 10089595] - S Cisternino, J Schlatter, J L Saulnier. Determination of cisapride and norcisapride in human plasma using high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Sep; 714(2):395-8. doi:
10.1016/s0378-4347(98)00213-8. [PMID: 9766883] - U Gladziwa, R Bares, U Klotz, K V Dakshinamurty, T H Ittel, K U Seiler, H G Sieberth. Pharmacokinetics and pharmacodynamics of cisapride in patients undergoing hemodialysis.
Clinical pharmacology and therapeutics.
1991 Dec; 50(6):673-81. doi:
10.1038/clpt.1991.206. [PMID: 1752111]
