Gentamicin C2 (BioDeep_00000004830)
代谢物信息卡片
化学式: C20H41N5O7 (463.30058360000004)
中文名称:
谱图信息:
最多检出来源 Macaca mulatta(otcml) 0.04%
分子结构信息
SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)N
InChI: InChI=1S/C20H41N5O7/c1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19/h8-19,25-28H,4-7,21-24H2,1-3H3
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D005839 - Gentamicins
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- KEGG: C02033
- PubChem: 588785
- PubChem: 72397
- Metlin: METLIN3054
- ChEMBL: CHEMBL1254452
- ChEMBL: CHEMBL117044
- CAS: 287916-51-2
- CAS: 25876-11-3
- PMhub: MS000017438
- ChEBI: CHEBI:28292
- PubChem: 5126
- NIKKAJI: J37.114I
- RefMet: Gentamicin C2
- KNApSAcK: 28292
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaotang Chen, Hui Zhang, Shaotong Zhou, Mingjun Bi, Shizhou Qi, Huiyuan Gao, Xianpu Ni, Huanzhang Xia. The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3',4'-di-deoxygenation via reduction and transamination activities.
Microbial cell factories.
2020 Mar; 19(1):62. doi:
10.1186/s12934-020-01317-0. [PMID: 32156271] - Alexander V Birk, Edward J Dubovi, Xianchao Zhang, Hazel H Szeto. Antiviral activity of geneticin against bovine viral diarrhoea virus.
Antiviral chemistry & chemotherapy.
2008; 19(1):33-40. doi:
10.1177/095632020801900105. [PMID: 18610556] - Yves Babin, Serge Fortier. A high-throughput analytical method for determination of aminoglycosides in veal tissues by liquid chromatography/tandem mass spectrometry with automated cleanup.
Journal of AOAC International.
2007 Sep; 90(5):1418-26. doi:
10.1093/jaoac/90.5.1418. [PMID: 17955988] - Eliangiringa Kaale, Yinhua Long, Humphrey Azambeh Fonge, Cindy Govaerts, Koenraad Desmet, Ann Van Schepdael, Jos Hoogmartens. Gentamicin assay in human serum by solid-phase extraction and capillary electrophoresis.
Electrophoresis.
2005 Feb; 26(3):640-7. doi:
10.1002/elps.200410012. [PMID: 15690437] - Kozo Takamoto, Manabu Kawada, Takayuki Usui, Masaaki Ishizuka, Daishiro Ikeda. Aminoglycoside antibiotics reduce glucose reabsorption in kidney through down-regulation of SGLT1.
Biochemical and biophysical research communications.
2003 Sep; 308(4):866-71. doi:
10.1016/s0006-291x(03)01502-x. [PMID: 12927799] - Wojciech Lesniak, Wesley R Harris, Joslyn Yudenfreund Kravitz, Jochen Schacht, Vincent L Pecoraro. Solution chemistry of copper(II)-gentamicin complexes: relevance to metal-related aminoglycoside toxicity.
Inorganic chemistry.
2003 Mar; 42(5):1420-9. doi:
10.1021/ic025965t. [PMID: 12611506] - N Isoherranen, S Soback. Determination of gentamicins C(1), C(1a), and C(2) in plasma and urine by HPLC.
Clinical chemistry.
2000 Jun; 46(6 Pt 1):837-42. doi:
10.1093/clinchem/46.6.837. [PMID: 10839773] - N Isoherranen, E Lavy, S Soback. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose.
Antimicrobial agents and chemotherapy.
2000 Jun; 44(6):1443-7. doi:
10.1128/aac.44.6.1443-1447.2000. [PMID: 10817690] - S J Kohlhepp, M O Loveless, P W Kohnen, D C Houghton, W M Bennett, D N Gilbert. Nephrotoxicity of the constituents of the gentamicin complex.
The Journal of infectious diseases.
1984 Apr; 149(4):605-14. doi:
10.1093/infdis/149.4.605. [PMID: 6725992]