Kallidin (BioDeep_00000004700)

   


代谢物信息卡片


Lys-Bradykinin acetate salt

化学式: C56H85N17O12 (1187.656329)
中文名称: LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG: KRPPGFSPFR
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(=O)O
InChI: InChI=1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1

描述信息

D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

6 个代谢物同义名

Lys-Bradykinin acetate salt; Kallidin; Lysyl-bradykinin; Lysylbradykinin; Lys-Bradykinin; Kallidin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Ling Yin, Chenyu Ye, Fulai Zhou, Jia Wang, Dehua Yang, Wanchao Yin, Ming-Wei Wang, H Eric Xu, Yi Jiang. Molecular basis for kinin selectivity and activation of the human bradykinin receptors. Nature structural & molecular biology. 2021 09; 28(9):755-761. doi: 10.1038/s41594-021-00645-y. [PMID: 34518695]
  • Tanja Gangnus, Bjoern B Burckhardt. Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system. Analytical and bioanalytical chemistry. 2021 May; 413(11):2971-2984. doi: 10.1007/s00216-021-03231-9. [PMID: 33693976]
  • S De Maat, Z L M Hofman, C Maas. Hereditary angioedema: the plasma contact system out of control. Journal of thrombosis and haemostasis : JTH. 2018 09; 16(9):1674-1685. doi: 10.1111/jth.14209. [PMID: 29920929]
  • Ana S F Ribeiro, Vítor S Fernandes, María Pilar Martínez, María Elvira López-Oliva, María Victoria Barahona, Paz Recio, Ana Cristina Martínez, Igor Blaha, Luis M Orensanz, Salvador Bustamante, Albino García-Sacristán, Dolores Prieto, Medardo Hernández. Pre- and post-junctional bradykinin B2 receptors regulate smooth muscle tension to the pig intravesical ureter. Neurourology and urodynamics. 2016 Jan; 35(1):115-21. doi: 10.1002/nau.22685. [PMID: 25327836]
  • M V Varoni, D Palomba, S Gianorso, V Anania, M P Demontis. Involvement of the kallikrein-kinin system in a model of hyperalgesia in low kallikrein rats. Veterinary research communications. 2009 Sep; 33 Suppl 1(?):217-9. doi: 10.1007/s11259-009-9272-x. [PMID: 19578955]
  • Johan Duchene, Amrita Ahluwalia. The kinin B(1) receptor and inflammation: new therapeutic target for cardiovascular disease. Current opinion in pharmacology. 2009 Apr; 9(2):125-31. doi: 10.1016/j.coph.2008.11.011. [PMID: 19124274]
  • Xianming Zhang, Fulong Tan, Yongkang Zhang, Randal A Skidgel. Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists. The Journal of biological chemistry. 2008 Mar; 283(12):7994-8004. doi: 10.1074/jbc.m709837200. [PMID: 18187413]
  • Hong Dong, Hong Sun, Ella Magal, Xiao Ding, Gondi N Kumar, Jian Jeffrey Chen, Eileen J Johnson, Barton H Manning. Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw. Journal of neuroscience methods. 2008 Feb; 168(1):76-87. doi: 10.1016/j.jneumeth.2007.09.028. [PMID: 18022246]
  • Jon E Hawkinson, Balazs G Szoke, Albert W Garofalo, Dennis S Hom, Hongbing Zhang, Mark Dreyer, Juri Y Fukuda, Linda Chen, Bhushan Samant, Stellanie Simmonds, Karla P Zeitz, Angie Wadsworth, Anna Liao, Raymond A Chavez, Wes Zmolek, Lany Ruslim, Michael P Bova, Ryan Holcomb, Eduardo R Butelman, Mei-Chuan Ko, Annika B Malmberg. Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958. The Journal of pharmacology and experimental therapeutics. 2007 Aug; 322(2):619-30. doi: 10.1124/jpet.107.120352. [PMID: 17470643]
  • Wanda Nowak, Ezequiel Dario Goldschmidt, Alejandra Georgina Falcioni, Mariana Ines Pugliese, Andrea Emilse Errasti, Facundo German Pelorosso, Federico Manuel Daray, Juan Ezequiel Gago, Rodolfo Pedro Rothlin. Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein. Naunyn-Schmiedeberg's archives of pharmacology. 2007 May; 375(3):221-9. doi: 10.1007/s00210-007-0145-y. [PMID: 17372720]
  • Sinisa Stanisavljevic, Tatjana Ignjatovic, Peter A Deddish, Viktor Brovkovych, Kai Zhang, Ervin G Erdös, Randal A Skidgel. Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells. The Journal of pharmacology and experimental therapeutics. 2006 Mar; 316(3):1153-8. doi: 10.1124/jpet.105.093849. [PMID: 16282523]
  • Ulrich Hilgenfeldt, Christina Stannek, Martina Lukasova, Martina Schnölzer, Sabina Lewicka. Rat tissue kallikrein releases a kallidin-like peptide from rat low-molecular-weight kininogen. British journal of pharmacology. 2005 Dec; 146(7):958-63. doi: 10.1038/sj.bjp.0706409. [PMID: 16231010]
  • José R Romero, Alicia Rivera, Vasco Lança, Manuel D P Bicho, Paul R Conlin, Dennis A Ricupero. Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin-stimulated myofibroblasts. The Journal of biological chemistry. 2005 Apr; 280(15):14378-84. doi: 10.1074/jbc.m410052200. [PMID: 15703175]
  • Fernando Boix, Cecilie Røe, Laila Rosenborg, Stein Knardahl. Kinin peptides in human trapezius muscle during sustained isometric contraction and their relation to pain. Journal of applied physiology (Bethesda, Md. : 1985). 2005 Feb; 98(2):534-40. doi: 10.1152/japplphysiol.01340.2003. [PMID: 15475593]
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  • Jean-Philippe Fortin, Johanne Bouthillier, François Marceau. High agonist-independent clearance of rabbit kinin B1 receptors in cultured cells. American journal of physiology. Heart and circulatory physiology. 2003 May; 284(5):H1647-54. doi: 10.1152/ajpheart.00884.2002. [PMID: 12521931]
  • Simone Wagner, Pamela Kalb, Martina Lukosava, Ulrich Hilgenfeldt, Markus Schwaninger. Activation of the tissue kallikrein-kinin system in stroke. Journal of the neurological sciences. 2002 Oct; 202(1-2):75-6. doi: 10.1016/s0022-510x(02)00208-3. [PMID: 12220696]
  • Thierry Sabourin, Luc Bastien, Dimcho R Bachvarov, François Marceau. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Molecular pharmacology. 2002 Mar; 61(3):546-53. doi: 10.1124/mol.61.3.546. [PMID: 11854434]
  • D J Campbell. The kallikrein-kinin system in humans. Clinical and experimental pharmacology & physiology. 2001 Dec; 28(12):1060-5. doi: 10.1046/j.1440-1681.2001.03564.x. [PMID: 11903316]
  • D J Campbell, B Dixon, A Kladis, M Kemme, J D Santamaria. Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans. American journal of physiology. Regulatory, integrative and comparative physiology. 2001 Oct; 281(4):R1059-70. doi: 10.1152/ajpregu.2001.281.4.r1059. [PMID: 11557611]
  • P Ganju, A Davis, S Patel, X Núñez, A Fox. p38 stress-activated protein kinase inhibitor reverses bradykinin B(1) receptor-mediated component of inflammatory hyperalgesia. European journal of pharmacology. 2001 Jun; 421(3):191-9. doi: 10.1016/s0014-2999(01)01048-2. [PMID: 11516436]
  • P R Wille, R Vitor, N H Gabilan, M Nicolau. Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues. Mediators of inflammation. 2001 Jun; 10(3):163-7. doi: 10.1080/09629350124164. [PMID: 11545253]
  • X Yang, L Taylor, J Yu, M J Fenton, P Polgar. Mediator caused induction of a human bradykinin B1 receptor minigene: participation of c-Jun in the process. Journal of cellular biochemistry. 2001 Apr; 82(1):163-70. doi: 10.1002/jcb.1116. [PMID: 11400173]
  • M R Loureiro-Silva, H M Molina, D R Borges. Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors. Journal of gastroenterology and hepatology. 2001 Jan; 16(1):41-5. doi: 10.1046/j.1440-1746.2001.02397.x. [PMID: 11206315]
  • D J Campbell. Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2000 Jun; 33(6):665-77. doi: 10.1590/s0100-879x2000000600008. [PMID: 10829095]
  • A M Duncan, A Kladis, G L Jennings, A M Dart, M Esler, D J Campbell. Kinins in humans. American journal of physiology. Regulatory, integrative and comparative physiology. 2000 Apr; 278(4):R897-904. doi: 10.1152/ajpregu.2000.278.4.r897. [PMID: 10749777]
  • M Pellegrini, M Tancredi, P Rovero, D F Mierke. Probing the topological arrangement of the N- and C-terminal residues of bradykinin for agonist activity at the B1 receptor. Journal of medicinal chemistry. 1999 Aug; 42(17):3369-77. doi: 10.1021/jm9901069. [PMID: 10464023]
  • C Jones, E Phillips, C Davis, J Arbuckle, M Yaqoob, G M Burgess, R J Docherty, M Webb, S J Bevan, P McIntyre. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. European journal of pharmacology. 1999 Jun; 374(3):423-33. doi: 10.1016/s0014-2999(99)00315-5. [PMID: 10422787]
  • F Gobeil, S Charland, C Filteau, S I Perron, W Neugebauer, D Regoli. Kinin B1 receptor antagonists containing alpha-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension (Dallas, Tex. : 1979). 1999 Mar; 33(3):823-9. doi: 10.1161/01.hyp.33.3.823. [PMID: 10082494]
  • U Hilgenfeldt, T Puschner, U Riester, J Finsterle, J Hilgenfeldt, E Ritz. Low-salt diet downregulates plasma but not tissue kallikrein-kinin system. The American journal of physiology. 1998 07; 275(1):F88-93. doi: 10.1152/ajprenal.1998.275.1.f88. [PMID: 9689009]
  • T L Pallone, E P Silldorff, J Y Cheung. Response of isolated rat descending vasa recta to bradykinin. The American journal of physiology. 1998 03; 274(3):H752-9. doi: 10.1152/ajpheart.1998.274.3.h752. [PMID: 9530185]
  • R M Vianna, J B Calixto. Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy. British journal of pharmacology. 1998 Jan; 123(2):281-91. doi: 10.1038/sj.bjp.0701590. [PMID: 9489617]
  • P Rajasekariah, R S Warlow, R S Walls. High affinity bradykinin binding to human inflammatory cells. Biochemistry and molecular biology international. 1997 Oct; 43(2):279-90. doi: 10.1080/15216549700204061. [PMID: 9350335]
  • F C Portaro, M H Cezari, M A Juliano, L Juliano, A R Walmsley, E S Prado. Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites. The Biochemical journal. 1997 Apr; 323 ( Pt 1)(?):167-71. doi: 10.1042/bj3230167. [PMID: 9173877]
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  • J R Chagas, F C Portaro, I Y Hirata, P C Almeida, M A Juliano, L Juliano, E S Prado. Determinants of the unusual cleavage specificity of lysyl-bradykinin-releasing kallikreins. The Biochemical journal. 1995 Feb; 306 ( Pt 1)(?):63-9. doi: 10.1042/bj3060063. [PMID: 7864830]
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