Kallidin (BioDeep_00000004700)
代谢物信息卡片
化学式: C56H85N17O12 (1187.656329)
中文名称: LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG: KRPPGFSPFR
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(=O)O
InChI: InChI=1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
描述信息
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:6102
- KEGG: C01505
- PubChem: 5311111
- Metlin: METLIN65605
- MeSH: Kallidin
- CAS: 342-10-9
- PMhub: MS000017260
- PubChem: 4673
- NIKKAJI: J5.687A
- RefMet: Lysyl-bradykinin
- KNApSAcK: 6102
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yu-Ling Yin, Chenyu Ye, Fulai Zhou, Jia Wang, Dehua Yang, Wanchao Yin, Ming-Wei Wang, H Eric Xu, Yi Jiang. Molecular basis for kinin selectivity and activation of the human bradykinin receptors.
Nature structural & molecular biology.
2021 09; 28(9):755-761. doi:
10.1038/s41594-021-00645-y
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Analytical and bioanalytical chemistry.
2021 May; 413(11):2971-2984. doi:
10.1007/s00216-021-03231-9
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Neurourology and urodynamics.
2016 Jan; 35(1):115-21. doi:
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. [PMID: 25327836] - M V Varoni, D Palomba, S Gianorso, V Anania, M P Demontis. Involvement of the kallikrein-kinin system in a model of hyperalgesia in low kallikrein rats.
Veterinary research communications.
2009 Sep; 33 Suppl 1(?):217-9. doi:
10.1007/s11259-009-9272-x
. [PMID: 19578955] - Johan Duchene, Amrita Ahluwalia. The kinin B(1) receptor and inflammation: new therapeutic target for cardiovascular disease.
Current opinion in pharmacology.
2009 Apr; 9(2):125-31. doi:
10.1016/j.coph.2008.11.011
. [PMID: 19124274] - Xianming Zhang, Fulong Tan, Yongkang Zhang, Randal A Skidgel. Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists.
The Journal of biological chemistry.
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British journal of pharmacology.
2005 Dec; 146(7):958-63. doi:
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The Journal of biological chemistry.
2005 Apr; 280(15):14378-84. doi:
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American journal of physiology. Heart and circulatory physiology.
2003 May; 284(5):H1647-54. doi:
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Journal of the neurological sciences.
2002 Oct; 202(1-2):75-6. doi:
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. [PMID: 12220696] - Thierry Sabourin, Luc Bastien, Dimcho R Bachvarov, François Marceau. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts.
Molecular pharmacology.
2002 Mar; 61(3):546-53. doi:
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Clinical and experimental pharmacology & physiology.
2001 Dec; 28(12):1060-5. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2001 Oct; 281(4):R1059-70. doi:
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European journal of pharmacology.
2001 Jun; 421(3):191-9. doi:
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Mediators of inflammation.
2001 Jun; 10(3):163-7. doi:
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Journal of cellular biochemistry.
2001 Apr; 82(1):163-70. doi:
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. [PMID: 11400173] - M R Loureiro-Silva, H M Molina, D R Borges. Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors.
Journal of gastroenterology and hepatology.
2001 Jan; 16(1):41-5. doi:
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1999 Aug; 42(17):3369-77. doi:
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European journal of pharmacology.
1999 Jun; 374(3):423-33. doi:
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Hypertension (Dallas, Tex. : 1979).
1999 Mar; 33(3):823-9. doi:
10.1161/01.hyp.33.3.823
. [PMID: 10082494] - U Hilgenfeldt, T Puschner, U Riester, J Finsterle, J Hilgenfeldt, E Ritz. Low-salt diet downregulates plasma but not tissue kallikrein-kinin system.
The American journal of physiology.
1998 07; 275(1):F88-93. doi:
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The American journal of physiology.
1998 03; 274(3):H752-9. doi:
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. [PMID: 9530185] - R M Vianna, J B Calixto. Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy.
British journal of pharmacology.
1998 Jan; 123(2):281-91. doi:
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Biochemistry and molecular biology international.
1997 Oct; 43(2):279-90. doi:
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. [PMID: 9350335] - F C Portaro, M H Cezari, M A Juliano, L Juliano, A R Walmsley, E S Prado. Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites.
The Biochemical journal.
1997 Apr; 323 ( Pt 1)(?):167-71. doi:
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. [PMID: 9173877] - L M Chen, J x Ma, Y M Liang, L Chao, J Chao. Tissue kallikrein-binding protein reduces blood pressure in transgenic mice.
The Journal of biological chemistry.
1996 Nov; 271(44):27590-4. doi:
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. [PMID: 8910346] - U Hilgenfeldt, R Linke, U Riester, W König, G Breipohl. Strategy of measuring bradykinin and kallidin and their concentration in plasma and urine.
Analytical biochemistry.
1995 Jun; 228(1):35-41. doi:
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The Biochemical journal.
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Journal of immunoassay.
1993 Dec; 14(4):227-40. doi:
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FEBS letters.
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The Journal of pharmacology and experimental therapeutics.
1993 Jul; 266(1):192-9. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1993 Mar; 48(3):253-60. doi:
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Agents and actions. Supplements.
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1991 Jun; 69(6):818-25. doi:
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General pharmacology.
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Biochemical pharmacology.
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The American journal of physiology.
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Society of General Physiologists series.
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Clinica chimica acta; international journal of clinical chemistry.
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The Journal of clinical investigation.
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Kidney international.
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