Buserelin (BioDeep_00000467274)
代谢物信息卡片
化学式: C60H86N16O13 (1238.6559946000002)
中文名称: 布塞林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
InChI: InChI=1S/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1
描述信息
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AE - Gonadotropin releasing hormone analogues
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1910 - Gonadotropin-releasing Hormone Analog
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D012102 - Reproductive Control Agents > D005299 - Fertility Agents
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:135907
- KEGGdrug: D07259
- PubChem: 50225
- Metlin: METLIN1448
- ChEMBL: CHEMBL2110824
- MeSH: Buserelin
- CAS: 57982-77-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Jingyuan Kong, Fuqin Su, Yu Liu, Yuxin Yang, Yuying Cao, Jicheng Qiu, Yue Wang, Lu Zhang, Jianzhong Wang, Xingyuan Cao. The pharmacokinetics of buserelin after intramuscular administration in pigs and cows.
BMC veterinary research.
2022 Apr; 18(1):136. doi:
10.1186/s12917-022-03237-0
. [PMID: 35410205] - Diana Fanelli, Matteo Tesi, Alessandra Rota, Massimiliano Beltramo, Giuseppe Conte, Mario Giorgi, Giovanni Barsotti, Francesco Camillo, Duccio Panzani. hCG is more effective than the GnRH agonist buserelin for inducing the first ovulation of the breeding season in mares.
Equine veterinary journal.
2022 Mar; 54(2):306-311. doi:
10.1111/evj.13455
. [PMID: 33884659] - A S El-Shalofy, M G Hedia. Effects of buserelin administration on testicular blood flow and plasma concentrations of testosterone and estradiol-17β in rams.
Domestic animal endocrinology.
2021 10; 77(?):106646. doi:
10.1016/j.domaniend.2021.106646
. [PMID: 34175682] - Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana, Kok-Yong Chin. The effects of gonadotropin-releasing hormone agonist (buserelin) and orchidectomy on bone turnover markers and histomorphometry in rats.
The aging male : the official journal of the International Society for the Study of the Aging Male.
2020 Dec; 23(5):327-334. doi:
10.1080/13685538.2018.1446075
. [PMID: 29495911] - Miguel Russo, Kimberly Liu, Crystal Chan. Suboptimal response to GnRH-agonist trigger during oocyte cryopreservation: a case series.
Reproductive biology and endocrinology : RB&E.
2020 Jun; 18(1):59. doi:
10.1186/s12958-020-00614-y
. [PMID: 32503566] - Julia Giriboni, Özdal Gökdal, Vadullah Eren, Engin Yaralı, Julián Santiago-Moreno, Rodolfo Ungerfeld. Daily administration of a GnRH analogue enhances sperm quality in bucks during the non-breeding season.
Animal reproduction science.
2019 Jan; 200(?):43-50. doi:
10.1016/j.anireprosci.2018.11.009
. [PMID: 30473147] - Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin. Effects of tocotrienol from Bixa orellana (annatto) on bone histomorphometry in a male osteoporosis model induced by buserelin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jul; 103(?):453-462. doi:
10.1016/j.biopha.2018.04.083
. [PMID: 29674281] - C P Bianchi, M A Benavente, M Simonetti, M A Aba. Synchronization of time of ovarian follicular development in llamas (Lama glama) using a protocol based on GnRH and PGF2α.
Animal reproduction science.
2018 May; 192(?):200-205. doi:
10.1016/j.anireprosci.2018.03.011
. [PMID: 29550272] - Dayane Priscila Vrisman, Natália Marins Bastos, Guilherme Fazan Rossi, Naiara Nantes Rodrigues, Luisa Pucci Bueno Borges, Augusto Ryonosuke Taira, Cláudia Cristina Paro de Paz, Guilherme de Paula Nogueira, Pedro Paulo Maia Teixeira, Fábio Morato Monteiro, Maria Emília Franco Oliveira. Corpus luteum dynamics after ovulation induction with or without previous exposure to progesterone in prepubertal Nellore heifers.
Theriogenology.
2018 Jan; 106(?):60-68. doi:
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Drug design, development and therapy.
2018; 12(?):555-564. doi:
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Theriogenology.
2018 Jan; 105(?):184-188. doi:
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Theriogenology.
2017 Jul; 97(?):104-112. doi:
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Theriogenology.
2017 Jun; 95(?):83-88. doi:
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European journal of drug metabolism and pharmacokinetics.
2017 Apr; 42(2):251-259. doi:
10.1007/s13318-016-0342-5
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Theriogenology.
2016 Dec; 86(9):2312-2322. doi:
10.1016/j.theriogenology.2016.07.029
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Reproduction in domestic animals = Zuchthygiene.
2016 Aug; 51(4):478-84. doi:
10.1111/rda.12705
. [PMID: 27170495] - L Casares-Crespo, J S Vicente, A M Talaván, M P Viudes-de-Castro. Does the inclusion of protease inhibitors in the insemination extender affect rabbit reproductive performance?.
Theriogenology.
2016 Mar; 85(5):928-932. doi:
10.1016/j.theriogenology.2015.10.044
. [PMID: 26639641] - Bodil Ohlsson. Gonadotropin-Releasing Hormone and Its Physiological and Pathophysiological Roles in Relation to the Structure and Function of the Gastrointestinal Tract.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.
2016; 57(1-2):22-33. doi:
10.1159/000445717
. [PMID: 27089503] - Atsushi Imai, Kazutoshi Matsunami, Satoshi Ichigo, Hiroshi Takagi. Minodronic acid suppresses gonadotropin-releasing hormone agonist-induced bone remodeling biomarkers: a retrospective pilot study.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2016; 32(3):250-2. doi:
10.3109/09513590.2015.1112783
. [PMID: 26503621] - Elin Sand, Caroline Linninge, Liudmyla Lozinska, Emil Egecioglu, Bodil Roth, Göran Molin, Björn Weström, Eva Ekblad, Bodil Ohlsson. Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum.
BMC research notes.
2015 Dec; 8(?):824. doi:
10.1186/s13104-015-1800-x
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Reproduction, fertility, and development.
2015 Nov; 27(8):1181-6. doi:
10.1071/rd14037
. [PMID: 24965784] - A K Pandey, G S Dhaliwal, S P S Ghuman, S K Agarwal. Impact of buserelin acetate or hCG administration on day 5 post-ovulation on subsequent luteal profile and conception rate in Murrah buffalo (Bubalus bubalis).
Animal reproduction science.
2015 Nov; 162(?):80-7. doi:
10.1016/j.anireprosci.2015.09.013
. [PMID: 26471839] - N Picard-Hagen, G Lhermie, S Florentin, D Merle, P Frein, V Gayrard. Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle.
Theriogenology.
2015 Jul; 84(2):177-83. doi:
10.1016/j.theriogenology.2015.03.004
. [PMID: 25890780] - Mufeed A Alnimer, Ahmad I Shamoun. Treatment with hCG 4 or 6 days after TAI to improve pregnancy outcomes in repeat-breeding dairy cows.
Animal reproduction science.
2015 Jun; 157(?):63-70. doi:
10.1016/j.anireprosci.2015.03.016
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Theriogenology.
2015 Mar; 83(5):817-21. doi:
10.1016/j.theriogenology.2014.11.016
. [PMID: 25499088] - Elin Sand, Bodil Roth, Björn Weström, Peter Bonn, Eva Ekblad, Bodil Ohlsson. Structural and functional consequences of buserelin-induced enteric neuropathy in rat.
BMC gastroenterology.
2014 Dec; 14(?):209. doi:
10.1186/s12876-014-0209-7
. [PMID: 25496312] - M Saint-Dizier, A-C Legendre, M-A Driancourt, S Chastant-Maillard. The induction of a secondary corpus luteum on day 12 post-ovulation can delay the time of luteolysis in high-producing Holstein cows.
Reproduction in domestic animals = Zuchthygiene.
2014 Dec; 49(6):920-5. doi:
10.1111/rda.12401
. [PMID: 25219366] - M P Viudes-de-Castro, E Mocé, R Lavara, F Marco-Jiménez, J S Vicente. Aminopeptidase activity in seminal plasma and effect of dilution rate on rabbit reproductive performance after insemination with an extender supplemented with buserelin acetate.
Theriogenology.
2014 Jun; 81(9):1223-8. doi:
10.1016/j.theriogenology.2014.02.003
. [PMID: 24629591] - Alejandro Cabrera-Wrooman, Jo Ann Janovick, P Michael Conn. Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system.
Molecular and cellular endocrinology.
2013 Dec; 381(1-2):1-7. doi:
10.1016/j.mce.2013.07.012
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Fertility and sterility.
2013 Oct; 100(4):994-1001. doi:
10.1016/j.fertnstert.2013.05.038
. [PMID: 23856575] - Elin Sand, Ulrikke Voss, Oskar Hammar, Ragnar Alm, Gunilla Nordin Fredrikson, Bodil Ohlsson, Eva Ekblad. Gonadotropin-releasing hormone analog buserelin causes neuronal loss in rat gastrointestinal tract.
Cell and tissue research.
2013 Mar; 351(3):521-34. doi:
10.1007/s00441-012-1534-1
. [PMID: 23254679] - A K Pandey, S P S Ghuman, G S Dhaliwal, Ajeet Kumar, S K Agarwal. Impact of buserelin acetate or hCG administration on day 12 post-ovulation on subsequent luteal profile and conception rate in buffalo (Bubalus bubalis).
Animal reproduction science.
2013 Jan; 136(4):260-7. doi:
10.1016/j.anireprosci.2012.10.021
. [PMID: 23201300] - M Rohlertz, B Ström Holst, E Axnér. Comparison of the GnRH-stimulation test and a semiquantitative quick test for LH to diagnose presence of ovaries in the female domestic cat.
Theriogenology.
2012 Dec; 78(9):1901-6. doi:
10.1016/j.theriogenology.2012.06.027
. [PMID: 22979964] - Arturo Aguilar-Rojas, Maira Huerta-Reyes, Guadalupe Maya-Núñez, Fabián Arechavaleta-Velásco, P Michael Conn, Alfredo Ulloa-Aguirre, Jesús Valdés. Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231.
BMC cancer.
2012 Nov; 12(?):550. doi:
10.1186/1471-2407-12-550
. [PMID: 23176180] - G García Romero, G Mattioli, D Rosa, J D Diaz, M Abeyá, C Gobello. A single administration of the GnRH antagonist acyline inhibits basal and GnRH-stimulated serum testosterone concentrations in male dogs.
Reproduction in domestic animals = Zuchthygiene.
2012 Jun; 47(3):e32-5. doi:
10.1111/j.1439-0531.2011.01898.x
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The Journal of clinical endocrinology and metabolism.
2012 May; 97(5):1712-9. doi:
10.1210/jc.2011-2939
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Reproduction in domestic animals = Zuchthygiene.
2012 Apr; 47(2):230-7. doi:
10.1111/j.1439-0531.2011.01833.x
. [PMID: 21883507] - Lena Persson, Peter Henriksson, Eli Westerlund, Outi Hovatta, Bo Angelin, Mats Rudling. Endogenous estrogens lower plasma PCSK9 and LDL cholesterol but not Lp(a) or bile acid synthesis in women.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Mar; 32(3):810-4. doi:
10.1161/atvbaha.111.242461
. [PMID: 22207727] - Eiichi Kawakami, Tomoko Yagi, Masanori Kobayashi, Tatsuya Hori. Therapeutic effect of frequent injections of GnRH analogue in a beagle with knobbed acrosome abnormality of sperm.
The Journal of veterinary medical science.
2012 Feb; 74(2):201-4. doi:
10.1292/jvms.11-0272
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Theriogenology.
2012 Jan; 77(2):292-8. doi:
10.1016/j.theriogenology.2011.07.041
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Reproduction, fertility, and development.
2012; 24(7):932-44. doi:
10.1071/rd11290
. [PMID: 22935154] - C M Kershaw-Young, X Druart, J Vaughan, W M C Maxwell. β-Nerve growth factor is a major component of alpaca seminal plasma and induces ovulation in female alpacas.
Reproduction, fertility, and development.
2012; 24(8):1093-7. doi:
10.1071/rd12039
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Journal of chromatography. A.
2011 Dec; 1218(48):8701-7. doi:
10.1016/j.chroma.2011.09.080
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Theriogenology.
2011 Oct; 76(6):1120-5. doi:
10.1016/j.theriogenology.2011.05.020
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Molecular and cellular endocrinology.
2011 Jun; 339(1-2):63-71. doi:
10.1016/j.mce.2011.03.017
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Electrophoresis.
2011 Jun; 32(11):1273-81. doi:
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Molecular and cellular endocrinology.
2011 Apr; 337(1-2):16-23. doi:
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Journal of chromatography. A.
2011 Jan; 1218(2):205-10. doi:
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The Journal of endocrinology.
2010 Dec; 207(3):289-300. doi:
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Archives of gynecology and obstetrics.
2010 Sep; 282(3):319-25. doi:
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Animal reproduction science.
2010 Sep; 121(3-4):279-85. doi:
10.1016/j.anireprosci.2010.06.004
. [PMID: 20663621] - Krishna Mohan, B S Prakash. Changes in endogenous estrogens and expression of behaviors associated with estrus during the periovulatory period in Heatsynch treated Murrah buffaloes (Bubalus bubalis).
Tropical animal health and production.
2010 Jun; 42(5):947-52. doi:
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Reproduction in domestic animals = Zuchthygiene.
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BMC gastroenterology.
2010 May; 10(?):48. doi:
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Animal reproduction science.
2010 Apr; 118(2-4):377-87. doi:
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. [PMID: 19892498] - Andrea Staňová, Jozef Marák, Vítězslav Maier, Václav Ranc, Joanna Znaleziona, Juraj Ševčík, Dušan Kaniansky. Analysis of buserelin in urine by online combination of capillary zone electrophoresis with electrospray mass spectrometry.
Electrophoresis.
2010 Apr; 31(7):1234-1240. doi:
10.1002/elps.200900422
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Molecular endocrinology (Baltimore, Md.).
2010 Feb; 24(2):423-35. doi:
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Australian veterinary journal.
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