L-Dopa (BioDeep_00000000461)
Secondary id: BioDeep_00000027616, BioDeep_00000405310
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019
代谢物信息卡片
化学式: C9H11NO4 (197.0688046)
中文名称: 左旋多巴, 3-(3,4-二羟苯基)-DL-丙氨酸, 左旋多巴(DOPA)
谱图信息:
最多检出来源 Homo sapiens(feces) 31.14%
Last reviewed on 2024-07-01.
Cite this Page
L-Dopa. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/l-dopa (retrieved
2024-12-04) (BioDeep RN: BioDeep_00000000461). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)O)O
InChI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
描述信息
L-dopa is an optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinsons disease It has a role as a prodrug, a hapten, a neurotoxin, an antiparkinson drug, a dopaminergic agent, an antidyskinesia agent, an allelochemical, a plant growth retardant, a human metabolite, a mouse metabolite and a plant metabolite. It is a dopa, a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a L-dopa(1-). It is an enantiomer of a D-dopa. It is a tautomer of a L-dopa zwitterion.
Levodopa is a prodrug of dopamine that is administered to patients with Parkinsons due to its ability to cross the blood-brain barrier. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinsons. The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975.
3,4-Dihydroxy-L-phenylalanine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Levodopa is an Aromatic Amino Acid.
Levodopa is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinsons disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.
L-Dopa is used for the treatment of Parkinsonian disorders and Dopa-Responsive Dystonia and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. Peripheral tissue conversion may be the mechanism of the adverse effects of levodopa. It is standard clinical practice to co-administer a peripheral DOPA decarboxylase inhibitor - carbidopa or benserazide - and often a catechol-O-methyl transferase (COMT) inhibitor, to prevent synthesis of dopamine in peripheral tissue.The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. [PubChem]L-Dopa is the naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, L-Dopa can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. In particular, it is metabolized to dopamine by aromatic L-amino acid decarboxylase. Pyridoxal phosphate (vitamin B6) is a required cofactor for this decarboxylation, and may be administered along with levodopa, usually as pyridoxine.
The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside ...
L-DOPA, also known as levodopa or 3,4-dihydroxyphenylalanine is an alpha amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). L-DOPA is found naturally in both animals and plants. It is made via biosynthesis from the amino acid L-tyrosine by the enzyme tyrosine hydroxylase.. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines. The Swedish scientist Arvid Carlsson first showed in the 1950s that administering L-DOPA to animals with drug-induced (reserpine) Parkinsonian symptoms caused a reduction in the intensity of the animals symptoms. Unlike dopamine itself, L-DOPA can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. In particular, it is metabolized to dopamine by aromatic L-amino acid decarboxylase. Pyridoxal phosphate (vitamin B6) is a required cofactor for this decarboxylation, and may be administered along with levodopa, usually as pyridoxine. As a result, L-DOPA is a drug that is now used for the treatment of Parkinsonian disorders and DOPA-Responsive Dystonia. It is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. It is standard clinical practice in treating Parkinsonism to co-administer a peripheral DOPA decarboxylase inhibitor - carbidopa or benserazide - and often a catechol-O-methyl transferase (COMT) inhibitor, to prevent synthesis of dopamine in peripheral tissue. Side effects of L-DOPA treatment may include: hypertension, arrhythmias, nausea, gastrointestinal bleeding, disturbed respiration, hair loss, disorientation and confusion. L-DOPA can act as an L-tyrosine mimetic and be incorporated into proteins by mammalian cells in place of L-tyrosine, generating protease-resistant and aggregate-prone proteins in vitro and may contribute to neurotoxicity with chronic L-DOPA administration. L-phenylalanine, L-tyrosine, and L-DOPA are all precursors to the biological pigment melanin. The enzyme tyrosinase catalyzes the oxidation of L-DOPA to the reactive intermediate dopaquinone, which reacts further, eventually leading to melanin oligomers.
An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinsons disease
DOPA. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=59-92-7 (retrieved 2024-07-01) (CAS RN: 59-92-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
DL-Dopa is a beta-hydroxylated derivative of phenylalanine.
DL-Dopa is a beta-hydroxylated derivative of phenylalanine.
同义名列表
232 个代谢物同义名
L-Methyldopa ; (2S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; 3-(3,4-Dihydroxyphenyl)-?-methyl-L-alanine; 3-Hydroxy-a-methyl-L-tyrosine; 3,4-Dihydroxy-L-phenylalanine, certified reference material, TraceCERT(R); Levodopa, Pharmaceutical Secondary Standard; Certified Reference Material; Levodopa, United States Pharmacopeia (USP) Reference Standard; 3,4-Dihydroxy-L-phenylalanine, Vetec(TM) reagent grade, 98\\%; LEVODOPA COMPONENT OF LEVODOPA/CARBIDOPA/ENTACAPONE ORION; Levodopa, European Pharmacopoeia (EP) Reference Standard; (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acidL-dopa; Levodopa, British Pharmacopoeia (BP) Reference Standard; LEVODOPA/CARBIDOPA/ENTACAPONE ORION COMPONENT LEVODOPA; (S)-2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid; (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid; (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoicacid; (S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid; (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate; 3,4-Dihydroxy-L-phenylalanine, >=98\\% (TLC); L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine; beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine; beta-(3,4-Dihydroxyphenyl)-alpha-alanine; Alanine, 3-(3, 4-dihydroxyphenyl)-, (-)-; L-(3, 4-Dihydroxyphenyl)-.alpha.-alanine; L-(3,4-Dihydroxyphenyl)-.alpha.-alanine; Alanine, 3-(3,4-dihydroxyphenyl)-, (-)-; .beta.-(3,4-Dihydroxyphenyl)-L-alanine; (-)-3-(3,4-Dihydroxyphenyl)-L-alanine; alanine, 3-(3,4-dihydroxyphenyl)-, L-; L-.beta.-(3,4-Dihydroxyphenyl)alanine; beta-(3,4-Dihydroxyphenyl)-L-alanine; 1E83F927-C221-46AA-B90A-81B33C5F3868; Inbrija (levodopa inhalation powder); .beta.-(3, 4-Dihydroxyphenyl)alanine; L-beta-(3,4-Dihydroxyphenyl)alanine; .beta.-(3,4-Dihydroxyphenyl)alanine; L-DOPA (3,4-Dihydroxyphenylalanine); Levodopa;3,4-Dihydroxyphenylalanine; L-b-(3,4-Dihydroxyphenyl)-a-alanine; b-(3,4-Dihydroxyphenyl)-a-L-alanine; beta-(3,4-Dihydroxyphenyl)alanine; Β-(3,4-dihydroxyphenyl)-L-alanine; L-3-(3,4-dihydroxyphenyl)-Alanine; 3-(3,4-Dihydroxyphenyl)-L-alanine; b-(3,4-Dihydroxyphenyl)-L-alanine; L-3-(3,4-dihydroxy-phenyl)alanine; Alanine,4-dihydroxyphenyl)-, (-)-; Alanine, 3-(3,4-dihydroxyphenyl)-; L-Β-(3,4-dihydroxyphenyl)alanine; L-b-(3,4-Dihydroxyphenyl)alanine; 3,4-Dihydroxyphenylalanine (VAN); (-)-(3,4-Dihydroxyphenyl)alanine; L-3-(3,4-Dihydroxyphenyl)alanine; Levodopa [USAN:USP:INN:BAN:JAN]; L-(3, 4-Dihydroxyphenyl)alanine; Alanine,4-dihydroxyphenyl)-, L-; Levodopa (USAN:USP:INN:BAN:JAN); LEVODOPA COMPONENT OF CORBILTA; b-(3,4-Dihydroxyphenyl)alanine; L-(3,4-Dihydroxyphenyl)alanine; LEVODOPA COMPONENT OF DOPASNAP; LEVODOPA COMPONENT OF CARBILEV; Β-(3,4-dihydroxyphenyl)alanine; 3, 4-Dihydroxy-L-phenylalanine; 3,4-Dihydroxyphenyl-L-alanine; LEVODOPA COMPONENT OF SINEMET; 3,4-dihydroxy-L-phenylalanine; LEVODOPA COMPONENT OF PARCOPA; LEVODOPA COMPONENT OF STALEVO; LEVODOPA COMPONENT OF RYTARY; L 3,4 Dihydroxyphenylalanine; L-3,4-Dihydroxyphenylalanine; L-4-5-Dihydroxyphenylalanine; L-(o-Dihydroxyphenyl)alanine; CORBILTA COMPONENT LEVODOPA; 3, 4-Dihydroxyphenylalanine; LEVODOPA COMPONENT OF DUOPA; CARBILEV COMPONENT LEVODOPA; LEVODOPA COMPONENT OF DHIVY; Alanine,4-dihydroxyphenyl)-; DOPASNAP COMPONENT LEVODOPA; STALEVO COMPONENT LEVODOPA; 3,4-Dihydroxyphenylalanine; L-O-Dihydroxyphenylalanine; Medphano brand OF levodopa; L-3,4-Dihydrophenylalanine; PARCOPA COMPONENT LEVODOPA; RYTARY COMPONENT LEVODOPA; Roberts brand OF levodopa; Dihydroxy-L-phenylalanine; LEVODOPA (USP MONOGRAPH); DUOPA COMPONENT LEVODOPA; LEVODOPUM [WHO-IP LATIN]; DHIVY COMPONENT LEVODOPA; LEVODOPA [USP MONOGRAPH]; L-Dihydroxyphenylalanine; 4-dihydroxyphenylalanine; Carbidopa EP Impurity A; Roche brand OF levodopa; LEVODOPA [EP MONOGRAPH]; Levodopa (JP17/USP/INN); LEVODOPA (EP MONOGRAPH); LEVODOPA (EP IMPURITY); L-Tyrosine, 3-hydroxy-; dihydroxyphenylalanine; LEVODOPA [ORANGE BOOK]; LEVODOPA [EP IMPURITY]; Levodopum (INN-Latin); Levodopum [INN-Latin]; 3 Hydroxy L tyrosine; component of Sinemet; WLN: QVYZ1R CQ DQ -L; 3-Hydroxy-L-tyrosine; H-Phe{3,4-(OH)2}-OH; L-o-Hydroxytyrosine; Levodopa (JP15/USP); LEVODOPA [EMA EPAR]; L-3-Hydroxytyrosine; Levodopa (Sinemet); WLN: QVYZ1R CQ DQ; LEVODOPA (USP-RS); Prestwick2_000017; Prestwick1_000017; LEVODOPA [WHO-DD]; Madopa (Salt/Mix); LEVODOPA [WHO-IP]; LEVODOPA [USP-RS]; Prestwick3_000017; Prestwick0_000017; LEVODOPA [VANDF]; L-DOPA; Levodopa; Spectrum5_001899; Spectrum2_000496; LEVODOPA (MART.); LEVODOPA [MART.]; Spectrum4_000539; LEVODOPA [USAN]; LEVODOPA [HSDB]; LEVODOPA [JAN]; LEVODOPA [INN]; BPBio1_000059; DivK1c_000452; Lopac0_000454; LEVODOPA [MI]; KBio1_000452; Tox21_500454; PDSP2_001525; PDSP1_001541; KBio2_003502; KBio2_006070; Tox21_110338; KBio2_000934; CAS-59-92-7; Dopaston SE; IDI1_000452; Insulamina; L-(-)-Dopa; Dopal-fher; Helfo-Dopa; Helfo DOPA; Dopar (TN); Cidandopa; Levodopum; Ro 4-6316; Sobiodopa; Dopastone; L(-)-Dopa; Doparkine; Maipedopa; Eldopatec; Brocadopa; Dopastral; Levedopa; Larodopa; Dopaston; Dopaflex; Dopalina; Laradopa; DOPA, L-; C9H11NO4; Dopaidan; Levodopa; (-)-Dopa; Eurodopa; Eldopar; Inbrija; Bendopa; Syndopa; Cerepap; Biodopa; Prolopa; Weldopa; Eldopal; Deadopa; N04BA01; Veldopa; Prodopa; Pardopa; Dopicar; Dopasol; L Dopa; L-DOPA; Atamet; Doparl; Ledopa; Doprin; Levopa; Dopar; DOPAL; Parda; Dopa; L-3; α-amino-3,4-dihydroxy-Benzenepropanoic acid; 2-amino-3-(3,4-Dihydroxyphenyl)propanoic acid; α-amino-3,4-dihydroxy-Benzenepropanoate; β-(3,4-Dihydroxyphenyl)-α-alanine; a-amino-3,4-Dihydroxy-benzenepropanoic acid; (±s;) 3-(3,4-Dihydroxyphenyl)alanine; 2-amino-3-(3,4-Dihydroxyphenyl)propanoate; a-amino-3,4-Dihydroxy-benzenepropanoate; DL-β-(3,4-Dihydroxyphenyl)alanine; L-β-(3,4-Dihydroxyphenyl)alanine; 3-(3,4-Dihydroxyphenyl)-DL-alanine; DL-b-(3,4-Dihydroxyphenyl)alanine; b-(3,4-Dihydroxyphenyl)-a-alanine; α-amino-Hydrocaffeic acid; 3,4-Dihydroxy-DL-phenylalanine; DL-3,4-Dihydroxyphenylalanine; DL-4,5-Dihydroxyphenylalanine; DL-Dioxyphenylalanine; DL-3-Hydroxytyrosine; DL-Dopa; Dopa; 3,4-Dihydroxy-L-phenylalanine; Levodopa
数据库引用编号
50 个数据库交叉引用编号
- ChEBI: CHEBI:15765
- ChEBI: CHEBI:49168
- KEGG: C00355
- KEGGdrug: D00059
- KEGGdrug: D70595
- PubChem: 6047
- PubChem: 836
- HMDB: HMDB0000181
- Metlin: METLIN64960
- Metlin: METLIN42
- DrugBank: DB01235
- ChEMBL: CHEMBL1009
- ChEMBL: CHEMBL351042
- Wikipedia: Levodopa
- Wikipedia: L-DOPA
- MeSH: Levodopa
- MeSH: Dihydroxyphenylalanine
- ChemIDplus: 0000059927
- MetaCyc: L-DIHYDROXY-PHENYLALANINE
- KNApSAcK: C00001357
- foodb: FDB000567
- chemspider: 5824
- CAS: 59-92-7
- MoNA: KNA00576
- MoNA: KNA00578
- MoNA: KNA00579
- MoNA: PR100091
- MoNA: KNA00175
- MoNA: KNA00577
- MoNA: PR100092
- MoNA: KNA00285
- MoNA: PS015501
- MoNA: KNA00173
- MoNA: PS015502
- MoNA: KNA00284
- MoNA: PS015507
- MoNA: KNA00685
- MoNA: KNA00684
- PMhub: MS000000012
- MetaboLights: MTBLC15765
- PDB-CCD: DAH
- 3DMET: B01224
- NIKKAJI: J9.225H
- medchemexpress: HY-113404
- LOTUS: LTS0258042
- wikidata: Q3738328
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-69
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-877
- PubChem: 3648
- KNApSAcK: 15765
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
59 个相关的代谢反应过程信息。
Reactome(20)
- Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP
- Signaling by GPCR:
H2O + cAMP ⟶ AMP
- GPCR downstream signalling:
H2O + cAMP ⟶ AMP
- G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive)
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT
- Catecholamine biosynthesis:
DA + Oxygen + VitC ⟶ DHA + H2O + NAd
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amine-derived hormones:
Dopa ⟶ DA + carbon dioxide
- Catecholamine biosynthesis:
Dopa ⟶ DA + carbon dioxide
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amine-derived hormones:
Dopa ⟶ DA + carbon dioxide
- Catecholamine biosynthesis:
Dopa ⟶ DA + carbon dioxide
- Amine ligand-binding receptors:
H0ZMX8 + PEA ⟶ Trace amine-associated receptor:PEA
- Melanin biosynthesis:
Dopa + Oxygen ⟶ H2O + L-Dopaquinone
- GPCR ligand binding:
Ade-Rib + H0YT13 ⟶ ADORA1,3:Ade-Rib
- Class A/1 (Rhodopsin-like receptors):
Ade-Rib + H0YT13 ⟶ ADORA1,3:Ade-Rib
BioCyc(0)
WikiPathways(7)
- Parkinson's disease:
L-Tyrosine ⟶ L-DOPA
- Biogenic amine synthesis:
Norepinephrine ⟶ Epinephrine
- Dopamine metabolism:
Dopamine ⟶ 3-Methoxytyramine
- Parkinson's disease pathway:
L-Tyrosine ⟶ L-DOPA
- Dopamine metabolism:
Dopamine ⟶ 3-Methoxytyramine
- Biogenic amine synthesis:
Choline ⟶ Acetylcholine
- 17p13.3 (YWHAE) copy number variation:
Dopamine ⟶ Noradrenaline
Plant Reactome(0)
INOH(1)
- Tyrosine metabolism ( Tyrosine metabolism ):
4-Hydroxy-phenyl-acetaldehyde + H2O + NAD+ ⟶ 4-Hydroxy-phenyl-acetic acid + NADH
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(31)
- Disulfiram Action Pathway:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosinemia, Transient, of the Newborn:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosine Hydroxylase Deficiency:
Ascorbic acid + Dopamine + Oxygen ⟶ Dehydroascorbic acid + Norepinephrine + Water
- Dopamine beta-Hydroxylase Deficiency:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Monoamine Oxidase-A Deficiency (MAO-A):
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Isoquinoline Alkaloid Biosynthesis:
Dopamine + Oxygen + Water ⟶ 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide
- Catecholamine Biosynthesis:
Ascorbic acid + Dopamine + Oxygen ⟶ Dehydroascorbic acid + Norepinephrine + Water
- Tyrosine Metabolism:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Alkaptonuria:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Hawkinsinuria:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosinemia Type I:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosinemia, Transient, of the Newborn:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Dopamine beta-Hydroxylase Deficiency:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Monoamine Oxidase-A Deficiency (MAO-A):
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosine Metabolism:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosine Metabolism:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Catecholamine Biosynthesis:
Ascorbic acid + Dopamine + Oxygen ⟶ Dehydroascorbic acid + Norepinephrine + Water
- Tyrosine Metabolism:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Alkaptonuria:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Aromatic L-Aminoacid Decarboxylase Deficiency:
Ascorbic acid + Dopamine + Oxygen ⟶ Dehydroascorbic acid + Norepinephrine + Water
- Hawkinsinuria:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosinemia Type I:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosinemia, Transient, of the Newborn:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosine Metabolism:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Dopamine beta-Hydroxylase Deficiency:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Monoamine Oxidase-A Deficiency (MAO-A):
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Aromatic L-Aminoacid Decarboxylase Deficiency:
Ascorbic acid + Dopamine + Oxygen ⟶ Dehydroascorbic acid + Norepinephrine + Water
- Alkaptonuria:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Hawkinsinuria:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosinemia Type I:
Homovanillin + NADP + Water ⟶ NADPH + p-Hydroxyphenylacetic acid
- Tyrosine Hydroxylase Deficiency:
Ascorbic acid + Dopamine + Oxygen ⟶ Dehydroascorbic acid + Norepinephrine + Water
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Meng Hao, Yufeng He, Tingting Song, Huimin Guo, Margaret P Rayman, Jinsong Zhang. Dopamine and its precursor levodopa inactivate SARS-CoV-2 main protease by forming a quinoprotein.
Free radical biology & medicine.
2024 Aug; 220(?):167-178. doi:
10.1016/j.freeradbiomed.2024.05.008
. [PMID: 38718952] - Ziqiong Zhou, Yan Li, Fangyuan Wang, Guanghao Zhu, Shenglan Qi, Haonan Wang, Yuhe Ma, Rong Zhu, Yuejuan Zheng, Guangbo Ge, Ping Wang. Bioactive components and mechanisms of Pu-erh tea in improving levodopa metabolism in rats through COMT inhibition.
Food & function.
2024 May; 15(10):5287-5299. doi:
10.1039/d4fo00538d
. [PMID: 38639730] - Eriton E L Valente, James L Klotz, Ryana C Markmann, Ronald J Trotta, J Lannett Edwards, John B May, David L Harmon. Levodopa attenuates the feed intake reduction caused by ergot alkaloids in cattle.
Journal of animal science.
2024 Jan; 102(?):. doi:
10.1093/jas/skae078
. [PMID: 38502533] - Felix U Enemali, Kingsley Afoke Iteire, Raphael E Uweigho, Ogunberi Blessing, Gbayisomore Tolulope Judah. Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats.
Journal of chemical neuroanatomy.
2024 Jan; 135(?):102365. doi:
10.1016/j.jchemneu.2023.102365
. [PMID: 38030098] - Hend A Sabry, Mai M Zahra. Icariin attenuates dopaminergic neural loss in haloperidol-induced Parkinsonism in rats via GSK-3β and tyrosine hydroxylase regulation mechanism.
Journal of chemical neuroanatomy.
2023 Dec; 136(?):102385. doi:
10.1016/j.jchemneu.2023.102385
. [PMID: 38160784] - Shanthi Pandurengan Parthasarathy, Sathiyanarayanan Anusuya, Subramaniyan Rajalakshmi, Davis Megha, Chinnaswamy Appunu, Subramaniyam Alagumanian, Markandan Manickavasagam. Elucidating the efficacy of functionalized multi-walled carbon nanotube in the biogenesis of L-Dopa and antioxidant metabolites in cell cultures of Hybanthus enneaspermus.
Plant physiology and biochemistry : PPB.
2023 Dec; 206(?):108310. doi:
10.1016/j.plaphy.2023.108310
. [PMID: 38169226] - Peishan Li, Ning Yang, Weifeng Guo, Houxu Ning, Wenhao Cheng, Haidong Wang. Effect of Gushen shetuo decoction in improving motor and non-motor symptoms and the expression of PERK, ATF4 and CHOP in patients with Parkinson's disease.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Dec; 69(13):174-179. doi:
10.14715/cmb/2023.69.13.27
. [PMID: 38158670] - Jiayuan Li, Jiahe Yu, Jianyou Guo, Jinfeng Liu, Guohui Wan, Xiaojia Wei, Xue Yang, Jinli Shi. Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways.
Pharmaceutical biology.
2023 Dec; 61(1):1175-1185. doi:
10.1080/13880209.2023.2244176
. [PMID: 37559448] - Kenichiro Sato, Ayumi Hida, Yoshiki Niimi, Atsushi Iwata, Takeshi Iwatsubo. [Survey on the Current Advertising and Sales of Mucuna pruriens in Consumer-to-consumer Internet Trading in Japan].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2023 Dec; 143(12):1057-1067. doi:
10.1248/yakushi.23-00145
. [PMID: 37839871] - Neha S L, Ashwini Kumar Mishra, Laxmi Rani, Shweta Paroha, Hitesh Kumar Dewangan, Pravat Kumar Sahoo. Design and evaluations of a nanostructured lipid carrier loaded with dopamine hydrochloride for intranasal bypass drug delivery in Parkinson's disease.
Journal of microencapsulation.
2023 Oct; ?(?):1-14. doi:
10.1080/02652048.2023.2264386
. [PMID: 37787159] - Mostafa A Abdel-Kawy, Basma Emad Aboulhoda, Camilia G Michel, Mohamed S Sedeek, Farid N Kirollos, Marwa A Masoud. Ameliorating effect of Citrus trifoliata L. fruits extract on motor incoordination, neurodegeneration and oxidative stress in Parkinson's disease model.
Nutritional neuroscience.
2023 Sep; ?(?):1-13. doi:
10.1080/1028415x.2023.2253026
. [PMID: 37658797] - Zhang Wenbo, Ma Zhigang, Zhang Jiren, Zhang Ce, Li Ting, Zhang Pinyuan, Wang Tian. Antinociceptive effects of carbidopa levodopa on normal rats and Parkinson's disease mice.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5):1489-1495. doi:
"
. [PMID: 37869925] - M Alejandra Guerrero-Rubio, Nathanael Walker-Hale, Rui Guo, Hester Sheehan, Alfonso Timoneda, Fernando Gandia-Herrero, Samuel F Brockington. Are seven amino acid substitutions sufficient to explain the evolution of high l-DOPA 4,5-dioxygenase activity leading to betalain pigmentation? Revisiting the gain-of-function mutants of Bean et al. (2018).
The New phytologist.
2023 09; 239(6):2265-2276. doi:
10.1111/nph.18981
. [PMID: 37243529] - Yiyu Wang, Xinyu Wang, Xingxun Liu, Chunqing Niu, Guiting Yu, Yuanjing Hou, Chao Hu, Kai Zhao, Jian Shi. Fabrication, characterization and potential application of biodegradable polydopamine-modified scaffolds based on natural macromolecules.
International journal of biological macromolecules.
2023 Aug; 253(Pt 1):126596. doi:
10.1016/j.ijbiomac.2023.126596
. [PMID: 37648129] - Yifei Wang, Sheereen Majd. Charged Lipids Modulate the Phase Separation in Multicomponent Membranes.
Langmuir : the ACS journal of surfaces and colloids.
2023 08; 39(32):11371-11378. doi:
10.1021/acs.langmuir.3c01199
. [PMID: 37485979] - Hangzhen Li, Fancai Zeng, Cancan Huang, Qiqi Pu, Elizabeth Rosalind Thomas, Yan Chen, Xiang Li. The potential role of glucose metabolism, lipid metabolism, and amino acid metabolism in the treatment of Parkinson's disease.
CNS neuroscience & therapeutics.
2023 Aug; ?(?):. doi:
10.1111/cns.14411
. [PMID: 37577934] - Karuppiah Nagaraj, Pilavadi Thangamuniyandi, Subramaniam Kamalesu, Snehal Lokhandwala, Nikhil M Parekh, Swapna Rekha Panda, Subramanian Sakthinathan, Te-Wei Chiu, Karuppiah Chelladurai, Ammasai Karthikeyan, Iruthaya Kalai Selvam. Metallo-Surfactant assisted silver nanoparticles: A new approach for the colorimetric detection of amino acids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2023 Aug; 296(?):122693. doi:
10.1016/j.saa.2023.122693
. [PMID: 37028097] - Xiaolu Hu, Lan Yu, Yatong Li, Xiaoxi Li, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Qijun Chen, Xing Wang, Xiaoqing Chen, Yinying Ba, Yaonan Wang, Xia Wu. Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase.
CNS neuroscience & therapeutics.
2023 Aug; ?(?):. doi:
10.1111/cns.14383
. [PMID: 37528534] - Tomer Goldberg, Yonatan Redlich, David Yogev, Tsvia Fay-Karmon, Sharon Hassin-Baer, Saar Anis. Long-term safety of medical cannabis in Parkinson's disease: A retrospective case-control study.
Parkinsonism & related disorders.
2023 Jul; 112(?):105406. doi:
10.1016/j.parkreldis.2023.105406
. [PMID: 37211456] - Emile F van Vliet, Maarten J Knol, Raymond M Schiffelers, Massimiliano Caiazzo, Marcel H A M Fens. Levodopa-loaded nanoparticles for the treatment of Parkinson's disease.
Journal of controlled release : official journal of the Controlled Release Society.
2023 Jun; 360(?):212-224. doi:
10.1016/j.jconrel.2023.06.026
. [PMID: 37343725] - Subham Preetam, Swathi Jonnalagadda, Lamha Kumar, Rajeswari Rath, Soham Chattopadhyay, Badrah S Alghamdi, Adel Mohammad Abuzenadahg, Niraj Jha, Akash Gautam, Sumira Malik, Ghulam Md Ashraf. Therapeutic potential of Lipid Nanosystems for the treatment of Parkinson's disease: an updated review.
Ageing research reviews.
2023 May; ?(?):101965. doi:
10.1016/j.arr.2023.101965
. [PMID: 37268112] - Xufan Guo, Xinxin Wu, He Ma, Huayi Liu, Yunzi Luo. Yeast: A platform for the production of L -tyrosine derivatives.
Yeast (Chichester, England).
2023 Apr; ?(?):. doi:
10.1002/yea.3850
. [PMID: 37078622] - Jie Dong, Wan Jiang, Peng Gao, Tao Yang, Wuhua Zhang, Minge Huangfu, Jinzhu Zhang, Daidi Che. Comparison of betalain compounds in two Beta vulgaris var. cicla and BvCYP76AD27 function identification in betalain biosynthesis.
Plant physiology and biochemistry : PPB.
2023 Apr; 199(?):107711. doi:
10.1016/j.plaphy.2023.107711
. [PMID: 37116227] - Adedayo Oluwaseun Ademiluyi, Opeyemi Babatunde Ogunsuyi, Josephine Oluwaseun Akinduro, Olayemi Philemon Aro, Ganiyu Oboh. Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model.
Drug and chemical toxicology.
2023 Mar; 46(2):236-246. doi:
10.1080/01480545.2021.2021928
. [PMID: 35315297] - Pasquale Cascone, Jozsef Vuts, Michael A Birkett, Sarah Dewhirst, Sergio Rasmann, John A Pickett, Emilio Guerrieri. L-DOPA functions as a plant pheromone for belowground anti-herbivory communication.
Ecology letters.
2023 Mar; 26(3):460-469. doi:
10.1111/ele.14164
. [PMID: 36708055] - Chayarit Vilairat, Khwanlada Kobtrakul, Sornkanok Vimolmangkang. Enhanced Physicochemical Stability of the L-DOPA Extract of Mucuna pruriens Seeds by Adding Phyllanthus emblica.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041573
. [PMID: 36838562] - Angel Lai, Peter M Macdonald. Phospholipid lateral diffusion in the presence of cationic peptides as measured via 31P CODEX NMR.
Biophysical chemistry.
2023 Feb; 295(?):106964. doi:
10.1016/j.bpc.2023.106964
. [PMID: 36764129] - Kern Hast, M Rhia L Stone, Zhaojun Jia, Melih Baci, Tushar Aggarwal, Enver Cagri Izgu. Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules.
ACS applied materials & interfaces.
2023 Feb; 15(4):4996-5009. doi:
10.1021/acsami.2c20942
. [PMID: 36649474] - Natália de Matos Balsalobre, Elisangela Dos Santos, Sidney Mariano Dos Santos, Arielle Cristina Arena, Elisabete Castelon Konkiewitz, Edward Benjamin Ziff, Anelise Samara Nazari Formagio, Candida Aparecida Leite Kassuya. Potential anti-arthritic and analgesic properties of essential oil and viridiflorol obtained from Allophylus edulis leaves in mice.
Journal of ethnopharmacology.
2023 Jan; 301(?):115785. doi:
10.1016/j.jep.2022.115785
. [PMID: 36223847] - Ruizhi Han, Ke Gao, Yulin Jiang, Jieyu Zhou, Guochao Xu, Jinjun Dong, Ulrich Schwaneberg, Yu Ji, Ye Ni. Self-Sufficient In Vitro Multi-Enzyme Cascade for Efficient Synthesis of Danshensu from l-DOPA.
ACS synthetic biology.
2023 01; 12(1):277-286. doi:
10.1021/acssynbio.2c00552
. [PMID: 36412006] - Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A Alananzeh, Mohd Nizam Mordi. Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies.
Journal of ethnopharmacology.
2023 Jan; 300(?):115753. doi:
10.1016/j.jep.2022.115753
. [PMID: 36162546] - Gang Xiang, Xiansen He, Yuxia Liu, Qing Huang, Wei Huang, Cuizhong Zhang, Jinyun Peng. A Sensitive Photoelectrochemical Sensor for Levodopa Detection Using Benzothiadiazole-Based Conjugated Microporous Polymer-Coated Graphene Heterostructures.
ACS applied materials & interfaces.
2022 Nov; 14(45):51329-51340. doi:
10.1021/acsami.2c15516
. [PMID: 36326124] - Carmen Tesoro, Rosanna Ciriello, Filomena Lelario, Angela Di Capua, Raffaella Pascale, Giuliana Bianco, Mario Dell'Agli, Stefano Piazza, Antonio Guerrieri, Laura Scrano, Sabino A Bufo, Maria Assunta Acquavia. Development and Validation of a Reversed-Phase HPLC Method with UV Detection for the Determination of L-Dopa in Vicia faba L. Broad Beans.
Molecules (Basel, Switzerland).
2022 Nov; 27(21):. doi:
10.3390/molecules27217468
. [PMID: 36364292] - Meijun Pang, Rui Peng, Yiwen Wang, Yi Zhu, Peng Wang, Bernard Moussian, Yanfang Su, Xiuyun Liu, Dong Ming. Molecular understanding of the translational models and the therapeutic potential natural products of Parkinson's disease.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Nov; 155(?):113718. doi:
10.1016/j.biopha.2022.113718
. [PMID: 36152409] - Yajun Bai, Pu Jia, Ye Zhao, Lingjian Yang, Xiaoxiao Wang, Xue Wang, Jing Wang, Ni'er Zhong, Huaxiang Deng, Linxiang Du, Jiacheng Fang, Yanbo Xue, Yongyong Chen, Shuomo Gao, Ying Feng, Yi Yan, Tianzheng Xiong, Jinbin Liu, Ying Sun, Jing Xie, Xirui He, Xuexia An, Pei Liu, Jinjin Xu, Fanggang Qin, Xue Meng, Qian Yin, Qiuxiang Yang, Rong Gao, Xiaokang Gao, Kai Luo, Qiannan Li, Xing Wang, Jing Liang, Puye Yang, Yajun Zhang, Sha Liao, Shixiang Wang, Xinfeng Zhao, Chaoni Xiao, Jie Yu, Qinshe Liu, Rui Wang, Ning Peng, Xiaowen Wang, Jianbo Guo, Xia Li, Haijing Liu, Yan Bai, Zijian Li, Youyi Zhang, Yefei Nan, Qunzheng Zhang, Xunli Zhang, Jin'e Lei, Erna Alberts, Angélique de Man, Hye Kyong Kim, Su-Jung Hsu, Yu Sheng Jia, Joerg Riener, Jianbin Zheng, Wanbin Zhang, Xiaopu Zheng, Yujie Cai, Mei Wang, Tai-Ping Fan, Xiaohui Zheng. Discovery and therapeutic implications of bioactive dihydroxylated phenolic acids in patients with severe heart disease and conditions associated with inflammation and hypoxia.
Pharmacological research.
2022 Nov; 185(?):106458. doi:
10.1016/j.phrs.2022.106458
. [PMID: 36152740] - Ke Shun Hu, Chong Le Chen, Huan Ru Ding, Tian Yu Wang, Qin Zhu, Yi Chen Zhou, Jia Min Chen, Jia Qi Mei, Sheng Hu, Jun Huang, Wei Rui Zhao, Le He Mei. Production of Salvianic Acid A from l-DOPA via Biocatalytic Cascade Reactions.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27186088
. [PMID: 36144828] - Shijie Hao, Qijin Ge, Yunchang Shao, Benqin Tang, Guangyi Fan, Canyu Qiu, Xue Wu, Liangwei Li, Xiaochuan Liu, Chengcheng Shi, Simon Ming-Yuen Lee. Chromosomal-level genome of velvet bean (Mucuna pruriens) provides resources for L-DOPA synthetic research and development.
DNA research : an international journal for rapid publication of reports on genes and genomes.
2022 Aug; 29(5):. doi:
10.1093/dnares/dsac031
. [PMID: 35980175] - Samantha Smith, Jordan Sergio, Michael Coyle, Kayla Elder, Ashley Centner, Sophie Cohen, Michelle Terry, Natalie Lipari, John Glinski, Emily Wheelis, Carla Budrow, Christopher Bishop. The effects of Vilazodone, YL-0919 and Vortioxetine in hemiparkinsonian rats.
Psychopharmacology.
2022 Jul; 239(7):2119-2132. doi:
10.1007/s00213-022-06078-9
. [PMID: 35275226] - Yi-Tong Xiong, Man-Hua Liu, Han-Ying Gu, Kai Li, Jin-Ru Zhang, Xiao-Yu Cheng, Hong Jin, Jing Chen, Cheng-Jie Mao, Chun-Feng Liu. Fiber selectivity of peripheral neuropathy in patients with Parkinson's disease.
Acta neurologica Scandinavica.
2022 Jul; 146(1):75-81. doi:
10.1111/ane.13624
. [PMID: 35466436] - Nareelak Tangsrisakda, Therachon Kamollerd, Chayakorn Taoto, Sudtida Bunsueb, Chadaporn Chaimontri, Pannawat Choowong-In, Natthapol Lapyuneyong, Alexander Th Wu, Wipawee Thukhammee, Jintanaporn Wattanathorn, Supatcharee Arun, Tarinee Sawatpanich, Sitthichai Iamsaard. Seed extract of Thai Mucuna pruriens (L.) DC. var. pruriens enhances sexual performance and improves male reproductive damages in ethanol-induced rats.
Journal of ethnopharmacology.
2022 Jun; 292(?):115219. doi:
10.1016/j.jep.2022.115219
. [PMID: 35339625] - Wolf-Dieter Rausch, Feixue Wang, Khaled Radad. From the tyrosine hydroxylase hypothesis of Parkinson's disease to modern strategies: a short historical overview.
Journal of neural transmission (Vienna, Austria : 1996).
2022 06; 129(5-6):487-495. doi:
10.1007/s00702-022-02488-3
. [PMID: 35460433] - Jordan T Lloyd, Andrew G Yee, Prasanna K Kalligappa, Anower Jabed, Pang Y Cheung, Kathryn L Todd, Rashika N Karunasinghe, Srdjan M Vlajkovic, Peter S Freestone, Janusz Lipski. Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model.
Neuroscience.
2022 05; 491(?):43-64. doi:
10.1016/j.neuroscience.2022.03.019
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Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103131
. [PMID: 35630617] - Murat Gultekin, Zeynep Tufekcioglu. COVID-19 infection presented as severe dyskinesia in a patient with Parkinson's disease: a case with daily video recording.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2022 05; 43(5):2961-2963. doi:
10.1007/s10072-022-05912-4
. [PMID: 35137350] - Shikha Upreti, Seema Sen, Tapas Chandra Nag, Madhumita P Ghosh. Insulin like growth factor-1 works synergistically with dopamine to attenuate diabetic retinopathy by downregulating vascular endothelial growth factor.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 May; 149(?):112868. doi:
10.1016/j.biopha.2022.112868
. [PMID: 35378500] - Thomas Müller, Eugen Schlegel, Stephanie Zingler, Hans Michael Thiede. Effects of One-Day Application of Levodopa/Carbidopa/Entacapone versus Levodopa/Carbidopa/Opicapone in Parkinson's Disease Patients.
Cells.
2022 04; 11(9):. doi:
10.3390/cells11091511
. [PMID: 35563817] - Savvas Dimiou, Rui M Lopes, Ilona Kubajewska, Ryan D Mellor, Corinna S Schlosser, Manjunath S Shet, Hugh Huang, Ozgur Akcan, Garth T Whiteside, Andreas G Schätzlein, Ijeoma F Uchegbu. Particulate levodopa nose-to-brain delivery targets dopamine to the brain with no plasma exposure.
International journal of pharmaceutics.
2022 Apr; 618(?):121658. doi:
10.1016/j.ijpharm.2022.121658
. [PMID: 35292396] - Kyle C Chesler, Cara T Motz, Katie L Bales, Rachael A Allen, Harrison K Vo, Machelle T Pardue. Voluntary oral dosing for precise experimental compound delivery in adult rats.
Laboratory animals.
2022 Apr; 56(2):147-156. doi:
10.1177/00236772211016926
. [PMID: 34392713] - Abha Harfouche, Wael Alata, Karine Leblanc, Ghislain Heslaut, Bruno Figadère, Alexandre Maciuk. Label-free LC-HRMS-based enzymatic activity assay for the detection of DDC, MAO and COMT inhibitors.
Journal of pharmaceutical and biomedical analysis.
2022 Apr; 212(?):114598. doi:
10.1016/j.jpba.2022.114598
. [PMID: 35152005] - Nikolina Kalčec, Nikolina Peranić, Rinea Barbir, Christopher R Hall, Trevor A Smith, Marc Antoine Sani, Ruža Frkanec, Frances Separovic, Ivana Vinković Vrček. Spectroscopic study of L-DOPA and dopamine binding on novel gold nanoparticles towards more efficient drug-delivery system for Parkinson's disease.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Mar; 268(?):120707. doi:
10.1016/j.saa.2021.120707
. [PMID: 34902692] - Buse Cagla Ari, Fusun Mayda Domac, Gulay Ozgen Kenangil, Nergis Imamova, Aysegul Cinar Kuskucu. The Influence of ADORA2A on Levodopa-Induced Dyskinesia.
Neurology India.
2022 Mar; 70(2):633-637. doi:
10.4103/0028-3886.344646
. [PMID: 35532631] - Masahiro Nagai, Madoka Kubo, Rina Ando, Masayuki Ikeda, Hiroshi Iwamoto, Yasuhiro Takeda, Masahiro Nomoto. Comparative examination of levodopa pharmacokinetics during simultaneous administration with lactoferrin in healthy subjects and the relationship between lipids and COMT inhibitory activity in vitro.
Nutritional neuroscience.
2022 Mar; 25(3):462-471. doi:
10.1080/1028415x.2020.1760532
. [PMID: 32441567] - Azza A Ali, Mona M Kamal, Mona G Khalil, Shimaa A Ali, Hemat A Elariny, Amany Bekhit, Ahmed Wahid. Behavioral, Biochemical and Histopathological effects of Standardised Pomegranate extract with Vinpocetine, Propolis or Cocoa in a rat model of Parkinson's disease.
Experimental aging research.
2022 Mar; 48(2):191-210. doi:
10.1080/0361073x.2021.1959823
. [PMID: 34384037] - Margherita Fabbri, Joaquim J Ferreira, Olivier Rascol. COMT Inhibitors in the Management of Parkinson's Disease.
CNS drugs.
2022 03; 36(3):261-282. doi:
10.1007/s40263-021-00888-9
. [PMID: 35217995] - Yan Lin, Lin Ma, Nan Zhang, Ruihua Li, Wenjing Jiang. Neuroleptic malignant-like syndrome associated multiple system atrophy: report on three cases.
BMC neurology.
2022 Feb; 22(1):67. doi:
10.1186/s12883-022-02583-8
. [PMID: 35216572] - Jacopo Manso, Loris Bertazza, Susi Barollo, Alberto Mondin, Simona Censi, Sofia Carducci, Alfonso Massimiliano Ferrara, Isabella Merante Boschin, Stefania Zovato, Francesca Schiavi, Michele Gregianin, Gianmaria Pennelli, Maurizio Iacobone, Caterina Mian. Overexpression of miR-375 and L-type Amino Acid Transporter 1 in Pheochromocytoma and Their Molecular and Functional Implications.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052413
. [PMID: 35269556] - Katarzyna Jodko-Piórecka, Bożena Sikora, Monika Kluzek, Paweł Przybylski, Grzegorz Litwinienko. Antiradical Activity of Dopamine, L-DOPA, Adrenaline, and Noradrenaline in Water/Methanol and in Liposomal Systems.
The Journal of organic chemistry.
2022 02; 87(3):1791-1804. doi:
10.1021/acs.joc.1c02308
. [PMID: 34871499] - Marianne Oldehinkel, Alberto Llera, Myrthe Faber, Ismael Huertas, Jan K Buitelaar, Bastiaan R Bloem, Andre F Marquand, Rick C Helmich, Koen V Haak, Christian F Beckmann. Mapping dopaminergic projections in the human brain with resting-state fMRI.
eLife.
2022 02; 11(?):. doi:
10.7554/elife.71846
. [PMID: 35113016] - Bruno L Santos-Lobato, Luiz Gustavo Gardinassi, Mariza Bortolanza, Ana Paula Ferranti Peti, Ângela V Pimentel, Lúcia Helena Faccioli, Elaine A Del-Bel, Vitor Tumas. Metabolic Profile in Plasma AND CSF of LEVODOPA-induced Dyskinesia in Parkinson's Disease: Focus on Neuroinflammation.
Molecular neurobiology.
2022 Feb; 59(2):1140-1150. doi:
10.1007/s12035-021-02625-1
. [PMID: 34855116] - Jacek Kubica, Małgorzata Ostrowska, Wioleta Stolarek, Michał Kasprzak, Klaudyna Grzelakowska, Jacek Kryś, Aldona Kubica, Piotr Adamski, Przemysław Podhajski, Eliano Pio Navarese, Edyta Anielska-Michalak, Oliwia Brycht, Andrzej Curzytek, Aneta Dudek, Leszek Gromadziński, Paweł Grzelakowski, Leszek Kamiński, Andrzej Kleinrok, Marcin Kostkiewicz, Marek Koziński, Paweł Król, Tomasz Kulawik, Gleb Minczew, Marcin Mindykowski, Agnieszka Pawlak, Janusz Prokopczuk, Grzegorz Skonieczny, Bożena Sobkowicz, Sergiusz Sowiński, Sebastian Stankala, Paweł Szymański, Andrzej Wester, Przemysław Wilczewski, Stanisław Bartuś, Andrzej Budaj, Mariusz Gąsior, Marcin Gruchała, Jarosław Drożdż, Miłosz Jaguszewski, Piotr Jankowski, Jacek Legutko, Maciej Lesiak, Przemysław Leszek, Przemysław Mitkowski, Jadwiga Nessler, Anna Tomaszuk-Kazberuk, Agnieszka Tycińska, Tomasz Zdrojewski, Jarosław Kaźmierczak. Impact of COVID-19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV-HF-SIRIO 6 study).
ESC heart failure.
2022 Feb; 9(1):721-728. doi:
10.1002/ehf2.13680
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ACS chemical neuroscience.
2022 01; 13(1):158-165. doi:
10.1021/acschemneuro.1c00693
. [PMID: 34939797] - Jacek Kubica, Przemysław Podhajski, Przemysław Magielski, Aldona Kubica, Piotr Adamski, Roman Junik, Jarosław Pinkas, Eliano P Navarese. IMPACT of PCSK9 inhibition on clinical outcome in patients during the inflammatory stage of the SARS-COV-2 infection: Rationale and protocol of the IMPACT-SIRIO 5 study.
Cardiology journal.
2022 ; 29(1):140-147. doi:
10.5603/cj.a2021.0148
. [PMID: 34787891] - Min Zhong, Sha Zhu, Ruxin Gu, Yaxi Wang, Yinyin Jiang, Yu Bai, Xu Jiang, Bo Shen, Jun Yan, Yang Pan, Jun Zhu, Li Zhang. Elevation of Plasma Homocysteine and Minor Hallucinations in Parkinson's Disease: A Cross-Sectional Study.
Behavioural neurology.
2022; 2022(?):4797861. doi:
10.1155/2022/4797861
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Pest management science.
2022 Jan; 78(1):344-354. doi:
10.1002/ps.6648
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Journal of neural transmission (Vienna, Austria : 1996).
2022 01; 129(1):55-63. doi:
10.1007/s00702-021-02447-4
. [PMID: 34940921] - You Wu, Yi-Wen Yang, Si-Chun Gu, Yu Zhang, Rong Shi, Chang-De Wang, Can-Xing Yuan, Qing Ye. The Importance of Early Identification for Parkinson's Disease Patients with Postural Instability and Gait Disturbance.
Computational intelligence and neuroscience.
2022; 2022(?):6701519. doi:
10.1155/2022/6701519
. [PMID: 36438683] - Dingqiang Fu, Yi Yuan, Fengming Qin, Yan Xu, Xin Cui, Guangxun Li, Shaohua Yao, Yun Deng, Zhuo Tang. Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs.
European journal of medicinal chemistry.
2021 Dec; 226(?):113850. doi:
10.1016/j.ejmech.2021.113850
. [PMID: 34628235] - Maja Zorovic, Kaja Kolmančič, Marko Živin. Effects of L-dopa on expression of prolactin and synaptotagmin IV in 17-beta-estradiol-induced prolactinomas of ovariectomized hemiparkinsonian rats.
Bosnian journal of basic medical sciences.
2021 Dec; 21(6):702-711. doi:
10.17305/bjbms.2021.5491
. [PMID: 33823126] - Shwu-Jiuan Lin, Lily Tai, Yu-Jie Huang, Yow-Shieng Uang, Yih Ho, Kuang-Yang Hsu, Li-Hsuan Wang. Effect of catechin and commercial preparation of green tea essence on the pharmacokinetics of l-dopa in rabbits.
Biomedical chromatography : BMC.
2021 Dec; 35(12):e5227. doi:
10.1002/bmc.5227
. [PMID: 34388856] - Tu-Hsueh Yeh, Han-Fang Liu, Ching-Chi Chiu, Mei-Ling Cheng, Guo-Jen Huang, Yin-Cheng Huang, Yu-Chien Liu, Ying-Zu Huang, Chin-Song Lu, Yi-Chieh Chen, Hao-Yuan Chen, Yi-Chuan Cheng. PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models.
Experimental neurology.
2021 12; 346(?):113863. doi:
10.1016/j.expneurol.2021.113863
. [PMID: 34520727] - K Amande M Pauls, Jussi Toppila, Maija Koivu, Johanna Eerola-Rautio, Marianne Udd, Eero Pekkonen. Polyneuropathy monitoring in Parkinson's disease patients treated with levodopa/carbidopa intestinal gel.
Brain and behavior.
2021 12; 11(12):e2408. doi:
10.1002/brb3.2408
. [PMID: 34758207] - Uzma Saleem, Shabana Bibi, Muhammad Ajmal Shah, Bashir Ahmad, Ammara Saleem, Zunera Chauhdary, Fareeha Anwar, Nimra Javaid, Sundas Hira, Muhammad Furqan Akhtar, Ghulam Mujtaba Shah, Muhammad Saad Khan, Haji Muhammad, Muhammad Qasim, Mohammad Alqarni, Majed A Algarni, Renald Blundell, Celia Vargas-De-La-Cruz, Oscar Herrera-Calderon, Reem Hasaballah Alhasani. Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals.
Frontiers in bioscience (Landmark edition).
2021 11; 26(11):1031-1051. doi:
10.52586/5007
. [PMID: 34856751] - Hirofumi Matsuyama, Keita Matsuura, Hidehiro Ishikawa, Yoshinori Hirata, Natsuko Kato, Atsushi Niwa, Yugo Narita, Hidekazu Tomimoto. Correlation between Serum Zinc Levels and Levodopa in Parkinson's Disease.
Nutrients.
2021 Nov; 13(11):. doi:
10.3390/nu13114114
. [PMID: 34836369] - Anna Michalicha, Agata Roguska, Agata Przekora, Barbara Budzyńska, Anna Belcarz. Poly(levodopa)-modified β-glucan as a candidate for wound dressings.
Carbohydrate polymers.
2021 Nov; 272(?):118485. doi:
10.1016/j.carbpol.2021.118485
. [PMID: 34420744] - Imane Frouni, Sébastien Belliveau, Shawn Maddaford, Stephen G Nuara, Jim C Gourdon, Philippe Huot. Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.
European journal of pharmacology.
2021 Nov; 910(?):174452. doi:
10.1016/j.ejphar.2021.174452
. [PMID: 34480885] - Yan Wang, De-Qi Jiang, Cheng-Shu Lu, Ming-Xing Li, Li-Lin Jiang. Efficacy and safety of combination therapy with pramipexole and levodopa vs levodopa monotherapy in patients with Parkinson disease: A systematic review and meta-analysis.
Medicine.
2021 Nov; 100(44):e27511. doi:
10.1097/md.0000000000027511
. [PMID: 34871213] - Michael M Lipp, Anthony J Hickey, Robert Langer, Peter A LeWitt. A technology evaluation of CVT-301 (Inbrija): an inhalable therapy for treatment of Parkinson's disease.
Expert opinion on drug delivery.
2021 11; 18(11):1559-1569. doi:
10.1080/17425247.2021.1960820
. [PMID: 34311641] - Nahid Shahabadi, Mahtab Razlansari. Exploring the binding mechanisms of inorganic magnetic nanocarrier containing L-Dopa with HSA protein utilizing multi spectroscopic techniques.
Journal of biomolecular structure & dynamics.
2021 11; 39(18):7160-7167. doi:
10.1080/07391102.2020.1806929
. [PMID: 32795166] - Josef Finsterer, Carla A Scorza, Antonio-Carlos G de Almeida, Antônio Márcio Rodrigues, Fulvio A Scorza. Parkinson's disease: Research puts spotlight on thiamine deficiency and cardiovascular health.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 Nov; 93(?):270-271. doi:
10.1016/j.jocn.2021.06.024
. [PMID: 34167881] - Catalina Cioates Negut, Sorin Sebastian Gheorghe, Raluca-Ioana Stefan-van Staden, Jacobus Frederick van Staden. Fast screening test for molecular recognition of levodopa and dopamine in biological samples using 3D printed stochastic microsensors.
Journal of pharmaceutical and biomedical analysis.
2021 Oct; 205(?):114292. doi:
10.1016/j.jpba.2021.114292
. [PMID: 34375784] - Tan Hu, Omer Agazani, Sivan Nir, Mor Cohen, Siyi Pan, Meital Reches. Antiviral Activity of Peptide-Based Assemblies.
ACS applied materials & interfaces.
2021 Oct; 13(41):48469-48477. doi:
10.1021/acsami.1c16003
. [PMID: 34623127] - M Y Zhang, J W Ni, J J Ge, Y H Guan, Z Pei, C J Sun, J Wu, Z R Xu, L Yang, F H Luo, R Q Cheng. [Clinical features of 123 patients with hyperinsulinemic hypoglycemia auxiliarily diagnosed by 18F-DOPA-PET CT scanning].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2021 Oct; 59(10):853-858. doi:
10.3760/cma.j.cn112140-20210417-00326
. [PMID: 34587682] - Roberto Erro, Antonio Riccardo Buonomo, Paolo Barone, Maria Teresa Pellecchia. Severe Dyskinesia After Administration of SARS-CoV2 mRNA Vaccine in Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society.
2021 10; 36(10):2219. doi:
10.1002/mds.28772
. [PMID: 34368991] - Sidrah Tariq Khan, Sagheer Ahmed, Saima Gul, Ajmal Khan, Ahmed Al-Harrasi. Search for safer and potent natural inhibitors of Parkinson's disease.
Neurochemistry international.
2021 10; 149(?):105135. doi:
10.1016/j.neuint.2021.105135
. [PMID: 34271080] - Elze R Timmers, Martijn van Faassen, Marenka Smit, Anouk Kuiper, Ingrid H Hof, Ido P Kema, Marina A J Tijssen, Klary E Niezen-Koning, Tom J de Koning. Dopaminergic and serotonergic alterations in plasma in three groups of dystonia patients.
Parkinsonism & related disorders.
2021 10; 91(?):48-54. doi:
10.1016/j.parkreldis.2021.08.019
. [PMID: 34482194] - Noriyuki Miyaue, Yuko Hosokawa, Akira Yoshida, Yuki Yamanishi, Satoshi Tada, Rina Ando, Hayato Yabe, Masahiro Nagai. Fasting state is one of the factors associated with plasma levodopa fluctuations during levodopa‒carbidopa intestinal gel treatment.
Parkinsonism & related disorders.
2021 10; 91(?):55-58. doi:
10.1016/j.parkreldis.2021.09.001
. [PMID: 34509136] - Riccardo Viaro, Francesco Longo, Fabrizio Vincenzi, Katia Varani, Michele Morari. l-DOPA promotes striatal dopamine release through D1 receptors and reversal of dopamine transporter.
Brain research.
2021 10; 1768(?):147583. doi:
10.1016/j.brainres.2021.147583
. [PMID: 34284020] - Nir Giladi, Tanya Gurevich, Ruth Djaldetti, Liat Adar, Ryan Case, Shelly Leibman-Barak, Nissim Sasson, Yoseph Caraco. ND0612 (levodopa/carbidopa for subcutaneous infusion) in patients with Parkinson's disease and motor response fluctuations: A randomized, placebo-controlled phase 2 study.
Parkinsonism & related disorders.
2021 10; 91(?):139-145. doi:
10.1016/j.parkreldis.2021.09.024
. [PMID: 34619438] - Akane Kasei, Hanako Watanabe, Natsumi Ishiduka, Kyoko Noda, Masatsune Murata, Masaaki Sakuta. Comparative Analysis of the Extradiol Ring-Cleavage Dioxygenase LigB from Arabidopsis and 3,4-Dihydroxyphenylalanine Dioxygenase from Betalain-Producing Plants.
Plant & cell physiology.
2021 Sep; 62(4):732-740. doi:
10.1093/pcp/pcab031
. [PMID: 33638982] - George D Degen, Keila C Cunha, Zachary A Levine, J Herbert Waite, Joan-Emma Shea. Molecular Context of Dopa Influences Adhesion of Mussel-Inspired Peptides.
The journal of physical chemistry. B.
2021 09; 125(35):9999-10008. doi:
10.1021/acs.jpcb.1c05218
. [PMID: 34459591] - De-Qi Jiang, Qing-Min Zang, Li-Lin Jiang, Yan Wang, Ming-Xing Li, Jing-Yi Qiao. Comparison of pramipexole and levodopa/benserazide combination therapy versus levodopa/benserazide monotherapy in the treatment of Parkinson's disease: a systematic review and meta-analysis.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 09; 394(9):1893-1905. doi:
10.1007/s00210-021-02089-z
. [PMID: 33959780] - Peter Jenner, José-Francisco Rocha, Joaquim J Ferreira, Olivier Rascol, Patrício Soares-da-Silva. Redefining the strategy for the use of COMT inhibitors in Parkinson's disease: the role of opicapone.
Expert review of neurotherapeutics.
2021 09; 21(9):1019-1033. doi:
10.1080/14737175.2021.1968298
. [PMID: 34525893] - Faezeh Shahdost-Fard, Arafeh Bigdeli, Mohammad Reza Hormozi-Nezhad. A Smartphone-Based Fluorescent Electronic Tongue for Tracing Dopaminergic Agents in Human Urine.
ACS chemical neuroscience.
2021 09; 12(17):3157-3166. doi:
10.1021/acschemneuro.1c00160
. [PMID: 34382769] - Ramón Cacabelos, Iván Carrera, Olaia Martínez, Ramón Alejo, Lucía Fernández-Novoa, Pablo Cacabelos, Lola Corzo, Susana Rodríguez, Margarita Alcaraz, Laura Nebril, Iván Tellado, Natalia Cacabelos, Rocío Pego, Vinogran Naidoo, Juan C Carril. Atremorine in Parkinson's disease: From dopaminergic neuroprotection to pharmacogenomics.
Medicinal research reviews.
2021 09; 41(5):2841-2886. doi:
10.1002/med.21838
. [PMID: 34106485] - G Saranya, D Sruthi, K S Jayakumar, M V Jiby, R Aswati Nair, Padmesh P Pillai, C Jayabaskaran. Polyphenol oxidase (PPO) arm of catecholamine pathway catalyzes the conversion of L-tyrosine to L-DOPA in Mucuna pruriens (L.) DC var. pruriens: An integrated pathway analysis using field grown and in vitro callus cultures.
Plant physiology and biochemistry : PPB.
2021 Sep; 166(?):1032-1043. doi:
10.1016/j.plaphy.2021.06.053
. [PMID: 34274890] - Grigorios Megariotis, Nikolaos Romanos, Aggelos Avramopoulos, Georgios Mikaelian, Doros N Theodorou. In silico study of levodopa in hydrated lipid bilayers at the atomistic level.
Journal of molecular graphics & modelling.
2021 09; 107(?):107972. doi:
10.1016/j.jmgm.2021.107972
. [PMID: 34174554] - Aimee Rodica Chis, Alexandra Ioana Moatar, Cristina Dijmarescu, Cecilia Rosca, Ruxandra Julia Vorovenci, Inge Krabbendam, Amalia Dolga, Cristina Bejinar, Catalin Marian, Ioan Ovidiu Sirbu, Mihaela Simu. Plasma hsa-mir-19b is a potential LevoDopa therapy marker.
Journal of cellular and molecular medicine.
2021 09; 25(18):8715-8724. doi:
10.1111/jcmm.16827
. [PMID: 34328686] - Jong-Min Moon, Hazhir Teymourian, Ernesto De la Paz, Juliane R Sempionatto, Kuldeep Mahato, Thitaporn Sonsa-Ard, Nickey Huang, Katherine Longardner, Irene Litvan, Joseph Wang. Non-Invasive Sweat-Based Tracking of L-Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration.
Angewandte Chemie (International ed. in English).
2021 08; 60(35):19074-19078. doi:
10.1002/anie.202106674
. [PMID: 34145703] - Alexander M Goldberg, Miranda K Robinson, Erykah S Starr, Ryan N Marasco, Alexa C Alana, C Skyler Cochrane, Kameron L Klugh, David J Strzeminski, Muxue Du, Keri L Colabroy, Larryn W Peterson. L-DOPA Dioxygenase Activity on 6-Substituted Dopamine Analogues.
Biochemistry.
2021 08; 60(32):2492-2507. doi:
10.1021/acs.biochem.1c00310
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