2-Ketohexanoic acid (BioDeep_00000004512)

 

Secondary id: BioDeep_00001868581

human metabolite Endogenous Volatile Flavor Compounds


代谢物信息卡片


alpha-Ketocaproic acid, sodium salt

化学式: C6H10O3 (130.062991)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.11%

分子结构信息

SMILES: CCCCC(=O)C(=O)O
InChI: InChI=1S/C6H10O3/c1-2-3-4-5(7)6(8)9/h2-4H2,1H3,(H,8,9)

描述信息

2-Ketohexanoic acid is a potent insulin secretagogue (PMID 7045091). 2-Ketohexanoic acid directly inhibits the ATP-sensitive K+ channel (KATP channel) in pancreatic beta-cells (stimulated in isolated mouse islets), but it is unknown whether direct KATP channel inhibition contributes to insulin release by 2-ketohexanoic acid and related alpha-keto acid anions, which are generally believed to act via beta-cell metabolism (PMID 16014804).
2-Ketohexanoic acid is a potent insulin secretagogue. (PMID 7045091)

同义名列表

26 个代谢物同义名

alpha-Ketocaproic acid, sodium salt; alpha-Ketohexanoic acid; alpha-Ketocaproic acid; 2-keto-n-caproic acid; alpha-Ketohexanoate; 2-oxo-hexanoic acid; a-Ketohexanoic acid; 2-Ketohexanoic acid; Α-ketohexanoic acid; alpha-Ketocaproate; Α-ketocaproic acid; 2-Oxohexanoic acid; 2-Ketocaproic acid; a-Ketocaproic acid; 2-Keto-N-caproate; a-Ketohexanoate; 2-Ketohexanoate; 2-oxo-Hexanoate; Α-ketohexanoate; a-Ketocaproate; 2-Ketocaproate; 2-Oxohexanoate; Α-ketocaproate; 2-oxo C6:0; 2-oxo 6:0; 2-Oxohexanoic acid



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jan-Willem de Kraker, Jonathan Gershenzon. From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis. The Plant cell. 2011 Jan; 23(1):38-53. doi: 10.1105/tpc.110.079269. [PMID: 21205930]
  • Jan-Willem de Kraker, Katrin Luck, Susanne Textor, James G Tokuhisa, Jonathan Gershenzon. Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine. Plant physiology. 2007 Feb; 143(2):970-86. doi: 10.1104/pp.106.085555. [PMID: 17189332]
  • Albert L Shroads, George N Henderson, Jang Cheung, Margaret O James, Peter W Stacpoole. Unified gas chromatographic-mass spectrometric method for quantitating tyrosine metabolites in urine and plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Sep; 808(2):153-61. doi: 10.1016/j.jchromb.2004.05.005. [PMID: 15261808]
  • C M O'Flaherty, N B Beorlegui, M T Beconi. Lactate dehydrogenase-C4 is involved in heparin- and NADH-dependent bovine sperm capacitation. Andrologia. 2002 Apr; 34(2):91-7. doi: 10.1046/j.0303-4569.2001.00481.x. [PMID: 11966575]
  • P Duez, A Kumps, Y Mardens. GC-MS profiling of urinary organic acids evaluated as a quantitative method. Clinical chemistry. 1996 Oct; 42(10):1609-15. doi: . [PMID: 8855143]
  • T Nakahara, J Ishida, M Yamaguchi, M Nakamura. Determination of alpha-keto acids including phenylpyruvic acid in human plasma by high-performance liquid chromatography with chemiluminescence detection. Analytical biochemistry. 1990 Nov; 190(2):309-13. doi: 10.1016/0003-2697(90)90199-j. [PMID: 2291475]
  • S Nissen, M Van Koevering, D Webb. Analysis of beta-hydroxy-beta-methyl butyrate in plasma by gas chromatography and mass spectrometry. Analytical biochemistry. 1990 Jul; 188(1):17-9. doi: 10.1016/0003-2697(90)90522-b. [PMID: 2221358]
  • G L Loy, A N Quick, C C Teng, W W Hay, P V Fennessey. Versatile stable isotope technique for the measurement of amino acids and keto acids: comparison with radioactive isotope and its use in measuring in vivo disposal rates. Analytical biochemistry. 1990 Feb; 185(1):1-9. doi: 10.1016/0003-2697(90)90246-6. [PMID: 2344035]
  • S A Metz. p-Hydroxymercuribenzoic acid inhibits arachidonic acid esterification into two distinct pools and stimulates insulin release in intact rat islets. The Journal of pharmacology and experimental therapeutics. 1986 Sep; 238(3):809-18. doi: . [PMID: 3091809]
  • G François, A Calderon, F Rose, M Blanc, P Lena. [Inhibition of postoperative muscular proteolysis by sodium alpha-ketoisocaproate: does a dose-effect relation exist?]. Annales francaises d'anesthesie et de reanimation. 1985; 4(4):351-4. doi: 10.1016/s0750-7658(85)80104-0. [PMID: 4037442]
  • W J Malaisse. Insulin release : the fuel concept. Diabete & metabolisme. 1983 Dec; 9(4):313-20. doi: NULL. [PMID: 6365644]
  • G P Butrimovitz, F Farina, I Sharlip. Micromethod for determination of lactate dehydrogenase isoenzyme C4 activity in human seminal plasma. Clinical chemistry. 1983 Aug; 29(8):1518-21. doi: . [PMID: 6872212]