Beclomethasone 17-Propionate (BioDeep_00000446751)

   


代谢物信息卡片


17-Beclomethasone monopropionate(17-BMP)

化学式: C25H33ClO6 (464.19655480000006)
中文名称: 倍氯米松17-丙酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)Cl)O)C)C)C(=O)CO
InChI: InChI=1S/C25H33ClO6/c1-5-21(31)32-25(20(30)13-27)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,26)19(29)12-23(18,25)4/h8-9,11,14,17-19,27,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid

同义名列表

3 个代谢物同义名

Beclomethasone 17-monopropionate; Beclomethasone 17-Propionate; 17-Beclomethasone monopropionate(17-BMP)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Amira Sa Said, Salahdein AbuRuz, Henry Chrystyn. Bioavailability of Beclometasone From Two HFA-BDP Formulations With a Spacer. Respiratory care. 2019 Oct; 64(10):1222-1230. doi: 10.4187/respcare.06689. [PMID: 31138731]
  • Calvin J Small, Michael Gillespie. Pharmacokinetics of Beclomethasone Dipropionate Delivered by Breath-Actuated Inhaler and Metered-Dose Inhaler in Healthy Subjects. Journal of aerosol medicine and pulmonary drug delivery. 2018 06; 31(3):182-190. doi: 10.1089/jamp.2017.1397. [PMID: 28937845]
  • Vipul Yadav, Simon Gaisford, Hamid A Merchant, Abdul W Basit. Colonic bacterial metabolism of corticosteroids. International journal of pharmaceutics. 2013 Nov; 457(1):268-74. doi: 10.1016/j.ijpharm.2013.09.007. [PMID: 24055438]
  • Sarita D Boyd, Colleen Hadigan, Maryellen McManus, Cheryl Chairez, Lynnette K Nieman, Alice K Pau, Raul M Alfaro, Joseph A Kovacs, Monica M Calderon, Scott R Penzak. Influence of low-dose ritonavir with and without darunavir on the pharmacokinetics and pharmacodynamics of inhaled beclomethasone. Journal of acquired immune deficiency syndromes (1999). 2013 Jul; 63(3):355-61. doi: 10.1097/qai.0b013e31829260d6. [PMID: 23535292]
  • Amira S A Said, Lindsay P Harding, Henry Chrystyn. Urinary pharmacokinetic methodology to determine the relative lung bioavailability of inhaled beclometasone dipropionate. British journal of clinical pharmacology. 2012 Sep; 74(3):456-64. doi: 10.1111/j.1365-2125.2012.04210.x. [PMID: 22299644]
  • Clyde Schultz, Jason Breaux, Jerome Schentag, Douglas Morck. Drug delivery to the posterior segment of the eye through hydrogel contact lenses. Clinical & experimental optometry. 2011 Mar; 94(2):212-8. doi: 10.1111/j.1444-0938.2010.00553.x. [PMID: 21175822]
  • J E Esposito-Festen, P Zanen, H A W M Tiddens, J-W J Lammers. Pharmacokinetics of inhaled monodisperse beclomethasone as a function of particle size. British journal of clinical pharmacology. 2007 Sep; 64(3):328-34. doi: 10.1111/j.1365-2125.2007.02894.x. [PMID: 17439539]
  • O Holz, I Zühlke, M Einhaus, L Welker, F Kanniess, D Branscheid, M Nakashima, L I Harrison, R A Jörres, K Richter, H Magnussen. Direct measurement of BDP and 17-BMP in bronchial and peripheral lung tissue after inhalation of HFA- vs CFC-driven aerosols. Pulmonary pharmacology & therapeutics. 2004; 17(4):233-8. doi: 10.1016/j.pupt.2004.04.004. [PMID: 15219268]
  • L Agertoft, L W Laulund, L I Harrison, S Pedersen. Influence of particle size on lung deposition and pharmacokinetics of beclomethasone dipropionate in children. Pediatric pulmonology. 2003 Mar; 35(3):192-9. doi: 10.1002/ppul.10238. [PMID: 12567387]
  • Lester I Harrison, Sarala Kurup, Craig Wagner, Bruce P Ekholm, Julie S Larson, Harold B Kaiser. Pharmacokinetics of beclomethasone 17-monopropionate from a beclomethasone dipropionate extrafine aerosol in adults with asthma. European journal of clinical pharmacology. 2002 Jun; 58(3):197-201. doi: 10.1007/s00228-002-0466-1. [PMID: 12107606]
  • P T Daley-Yates, A C Price, J R Sisson, A Pereira, N Dallow. Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man. British journal of clinical pharmacology. 2001 May; 51(5):400-9. doi: 10.1046/j.0306-5251.2001.01374.x. [PMID: 11421996]
  • K Foe, K F Brown, J P Seale. Comparative kinetics of metabolism of beclomethasone propionate esters in human lung homogenates and plasma. Journal of pharmaceutical sciences. 2000 Sep; 89(9):1143-50. doi: 10.1002/1520-6017(200009)89:9<1143::aid-jps6>3.0.co;2-c. [PMID: 10944379]
  • N Esmailpour, P Högger, P Rohdewald. Binding of glucocorticoids to human nasal tissue in vitro. International archives of allergy and immunology. 2000 Jun; 122(2):151-4. doi: 10.1159/000024371. [PMID: 10878494]
  • K Foe, K F Brown, J P Seale. Decomposition of beclomethasone propionate esters in human plasma. Biopharmaceutics & drug disposition. 1998 Jan; 19(1):1-8. doi: 10.1002/(sici)1099-081x(199801)19:1<1::aid-bdd67>3.0.co;2-3. [PMID: 9510979]
  • J Girault, B Istin, J M Malgouyat, A M Brisson, J B Fourtillan. Simultaneous determination of beclomethasone, beclomethasone monopropionate and beclomethasone dipropionate in biological fluids using a particle beam interface for combining liquid chromatography with negative-ion chemical ionization mass spectrometry. Journal of chromatography. 1991 Mar; 564(1):43-53. doi: 10.1016/0378-4347(91)80068-n. [PMID: 1860934]
  • G Würthwein, P Rohdewald. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharmaceutics & drug disposition. 1990 Jul; 11(5):381-94. doi: 10.1002/bdd.2510110503. [PMID: 2207292]