Methylprednisolon (BioDeep_00000445846)

PANOMIX_OTCML-2023

代谢物信息卡片

(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione

化学式: C22H30O5 (374.2093)
中文名称: 甲基泼尼松龙标准溶液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
InChI: InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1

描述信息

H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids
D - Dermatologicals > D10 - Anti-acne preparations > D10A - Anti-acne preparations for topical use > D10AA - Corticosteroids, combinations for treatment of acne
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AA - Corticosteroids, weak (group i)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
COVID info from DrugBank, clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D000893 - Anti-Inflammatory Agents
D020011 - Protective Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

8 个代谢物同义名

(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione; 6α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dione; 11β,17,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione; δ(1)-6α-methylhydrocortisone; 1-dehydro-6α-methylhydrocortisone; 6α-methylprednisolone; Methylprednisolone; Methylprednisolon

数据库引用编号

9 个数据库交叉引用编号

ChEBI: CHEBI:6888
KEGG: C16437
KEGGdrug: D00407
PubChem: 6741
Metlin: METLIN1234
DrugBank: DB00959
ChEMBL: CHEMBL650
MeSH: Methylprednisolone
CAS: 83-43-2

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Jinwen Min, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Cepharanthine synergistically promotes methylprednisolone pharmacodynamics against human peripheral blood mononuclear cells possibly via regulation of P-glycoprotein/glucocorticoid receptor translocation. BMC complementary medicine and therapies. 2024 May; 24(1):186. doi: 10.1186/s12906-024-04489-z. [PMID: 38734604]
Gordana Taleska Štupica, Maja Šoštarič, Matej Jenko, Matej Podbregar. Methylprednisolone Does Not Enhance Paraoxonase 1 Activity During Cardiopulmonary Bypass Surgery-A Randomized, Controlled Clinical Trial. Journal of cardiothoracic and vascular anesthesia. 2024 Apr; 38(4):946-956. doi: 10.1053/j.jvca.2023.12.035. [PMID: 38311492]
Qingwu Yang, Changwei Guo, Chengsong Yue, Jiaxing Song, Jie Yang, Zhouzhou Peng, Nizhen Yu, Jiacheng Huang, Linyu Li, Jiandi Huang, Yifei Chen, Chong Zheng, Shunfu Jiang, Zhongfan Ruan, Min Zhang, Dengwen Song, Xiaojun Luo, Yaoyu Tian, Mei Yang, Shenglin Deng, Shirong Wei, Youlin Wu, Yufeng Tang, De Yang, Xiaolin Tan, Guoyong Zeng, Daoyou Cheng, Wenhua Liu, Wencheng He, Tieying Cai, Chengde Pan, Jiasheng Liao, Bo Lei, Shengxiong Pu, Zhenglong Jin, Jinglun Li, Zhongbin Xia, Guling Zhang, Jun Luo, Yaxuan Sun, Xiaoping Xiong, Jian Wang, Bo Li, Yuqi Peng, Kechun Chen, Yuanjun Shan, Peiyang Zhou, Xinyuan Huang, Shiwei Luo, Jie Zhang, Chang Liu, Lin Jiang, Dahong Yang, Yan Tian, Jinrong Hu, Zhongming Qiu, Jinfu Ma, Xu Xu, Shitao Fan, Xiang Liu, Dongjing Xie, Jianqin Niu, Hongting Zheng, Qin Ouyang, Duolao Wang, Thanh N Nguyen, Jeffrey L Saver, Raul G Nogueira, Fengli Li, Wenjie Zi. Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: The MARVEL Randomized Clinical Trial. JAMA. 2024 03; 331(10):840-849. doi: 10.1001/jama.2024.0626. [PMID: 38329440]
Limin Yao, Xiaoli Cai, Xiaoqing Du, Yuxin Ma. Adalimumab induced exacerbation of psoriasis in patients with combined pemphigus: A case report. Medicine. 2024 Jan; 103(4):e36988. doi: 10.1097/md.0000000000036988. [PMID: 38277534]
Seyed Reza Mousavi, Majid Reza Farrokhi, Mahdi Khorsand Ghaffari, Fatemeh Karimi, Somaye Keshavarz, Amir Reza Dehghanian, Maryam Naseh. The combination treatment of methylprednisolone and growth factor-rich serum ameliorates the structural and functional changes after spinal cord injury in rat. Spinal cord. 2024 Jan; 62(1):17-25. doi: 10.1038/s41393-023-00942-x. [PMID: 38001173]
Nader Hejrati, Bizhan Aarabi, Chris J Neal, Beatrice Ugiliweneza, Shekar N Kurpad, Christopher I Shaffrey, James D Guest, Elizabeth G Toups, James S Harrop, Michael G Fehlings. Trends in the Use of Corticosteroids in the Management of Acute Spinal Cord Injury in North American Clinical Trials Network Sites. Journal of neurotrauma. 2023 09; 40(17-18):1938-1947. doi: 10.1089/neu.2022.0409. [PMID: 36597351]
Hao Wang, Feng Lin, Yi Wu, Wei Guo, Xuesi Chen, Chunsheng Xiao, Meiwan Chen. Carrier-Free Nanodrug Based on Co-Assembly of Methylprednisolone Dimer and Rutin for Combined Treatment of Spinal Cord Injury. ACS nano. 2023 07; 17(13):12176-12187. doi: 10.1021/acsnano.3c00360. [PMID: 37387550]
Yi Zhang, Lei Fang, Yi Zhou, Yongqing Zhang, Bing Liang, Chuanzhu Yan, Ling Li. A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing. BMC neurology. 2023 May; 23(1):192. doi: 10.1186/s12883-023-03227-1. [PMID: 37194001]
Hui Li, Yufei Zhang, Yangquan Hao, Peng Xu, Xingyu Wang, Bin Zhu, Chao Lu, Ke Xu. Proanthocyanidins Inhibit Osteoblast Apoptosis via the PI3K/AKT/Bcl-xL Pathway in the Treatment of Steroid-Induced Osteonecrosis of the Femoral Head in Rats. Nutrients. 2023 Apr; 15(8):. doi: 10.3390/nu15081936. [PMID: 37111155]
Ying Chen, Cai Shi, Haiyan Zhan, Boning Yang, Jun Liu, Peipei Rong, Yi Luo, Jian Yang. Drug-induced liver injury in COVID-19 patients during hospitalization. Medicine. 2023 Mar; 102(11):e33294. doi: 10.1097/md.0000000000033294. [PMID: 36930097]
Dan Chen, Duming Zhong, Runhong Mei, Shida Qian, Peng Wang, Kaiyun Chen, Xuefeng Yu. Screening and identification of potential key biomarkers for glucocorticoid-induced osteonecrosis of the femoral head. Journal of orthopaedic surgery and research. 2023 Jan; 18(1):28. doi: 10.1186/s13018-022-03465-y. [PMID: 36631868]
Chuanyang Dai, Xianyue Guan, Guannan Qin. Targeted Therapy of Tuberculous Meningitis in Rats with Methylprednisolone Composite Nanoparticles. Cellular and molecular biology (Noisy-le-Grand, France). 2022 Dec; 68(12):61-67. doi: 10.14715/cmb/2022.68.12.12. [PMID: 37130179]
Kie Okajima, Itaru Hayakawa, Norihiko Tsuboi, Kisho Shimura, Akira Ishiguro, Yuichi Abe. Early therapeutic plasma exchange may lead to complete neurological recovery in moderate to severe influenza-associated acute necrotizing encephalopathy. Brain & development. 2022 Aug; 44(7):492-497. doi: 10.1016/j.braindev.2022.03.004. [PMID: 35337691]
Md Asaduzzaman, Bidrum Purkayastha, M M Jahangir Alam, Shishir Ranjan Chakraborty, Soumitra Roy, Nasad Ahmed. COVID-19 mRNA vaccine-associated encephalopathy, myocarditis, and thrombocytopenia with excellent response to methylprednisolone: A case report. Journal of neuroimmunology. 2022 Jul; 368(?):577883. doi: 10.1016/j.jneuroim.2022.577883. [PMID: 35561428]
Jia-Ying Lei, Han Chen, Dun-Hua Zhou, Lu-Hong Xu, Jian-Pei Fang, You-Gang Mai. Pneumocystis jirovecii-associated immune reconstitution inflammatory syndrome-like phenomenon in a child with leukaemia: a case report and literature review. BMC pediatrics. 2022 07; 22(1):410. doi: 10.1186/s12887-022-03441-9. [PMID: 35820900]
Reimi Mizushima, Kotaro Haruhara, Nei Fukasawa, Mari Satake, Akira Fukui, Kentaro Koike, Nobuo Tsuboi, Hiroyuki Takahashi, Takashi Yokoo. Two entities in pulmonary nodules of a diabetic patient receiving corticosteroid therapy for bullous pemphigoid: an autopsy case report. BMC infectious diseases. 2022 Jul; 22(1):597. doi: 10.1186/s12879-022-07566-1. [PMID: 35799119]
Arthi Sridhar, Binoy Yohannan, Johncy John Kachira, Sameeksha Bhama. Severe pulmonary toxicity related to carfilzomib use: a rare but serious side effect. BMJ case reports. 2022 Jul; 15(7):. doi: 10.1136/bcr-2022-251173. [PMID: 35787495]
Takashi Ichiyama, Masamichi Komatsu, Yosuke Wada, Masayuki Hanaoka. Report of a combination of remdesivir, intravenous methylprednisolone pulse, and tocilizumab for severe coronavirus disease: 20-case series at a single institution. Respiratory investigation. 2022 Jul; 60(4):604-606. doi: 10.1016/j.resinv.2022.04.001. [PMID: 35501265]
Marta Ponzano, Irene Schiavetti, Francesca Bovis, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Margherita Monti Bragadin, Eleonora Cocco, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Paolo Confalonieri, Paola Perini, Roberto Bergamaschi, Matilde Inglese, Maria Petracca, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Rana Karabudak, Husnu Efendi, Roberto Furlan, Marco Salvetti, Maria Pia Sormani. A multiparametric score for assessing the individual risk of severe Covid-19 among patients with Multiple Sclerosis. Multiple sclerosis and related disorders. 2022 Jul; 63(?):103909. doi: 10.1016/j.msard.2022.103909. [PMID: 35675744]
Shukun Hong, Hongye Wang, Zhaolong Zhang, Lujun Qiao. The roles of methylprednisolone treatment in patients with COVID-19: A systematic review and meta-analysis. Steroids. 2022 Jul; 183(?):109022. doi: 10.1016/j.steroids.2022.109022. [PMID: 35346661]
Yue Liu, Xiaoting Hao, Dong Zhou, Zhen Hong. Relapsing and Immune-Responsive Paroxysmal Jaw Clonus With Blepharospasm and Sialorrhea Associated With D2R Autoantibodies. Neurology(R) neuroimmunology & neuroinflammation. 2022 07; 9(4):. doi: 10.1212/nxi.0000000000001172. [PMID: 35459715]
Shohei Beppu, Taiki Yabumoto, Makoto Kinoshita, Tatsusada Okuno, Kenichi Todo, Naoki Tani, Haruhiko Kishima, Yuichi Motoyama, Eiichi Morii, Hideki Mochizuki. [A case of IgG4-related disease exclusively affecting pia matter and cerebral parenchyma]. Rinsho shinkeigaku = Clinical neurology. 2022 Jun; 62(6):469-474. doi: 10.5692/clinicalneurol.cn-001712. [PMID: 35644582]
Tadeusz Płusa. Treatment of patients with asthma during COVID-19. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2022 Jun; 50(297):195-197. doi: NULL. [PMID: 35801604]
Ko Takamatsu, Yasuyoshi Kusanagi, Hideyuki Horikoshi, Takashi Nakanishi, Akinori Wada, Shunsuke Koumoto, Yuka Katsurada, Hitoshi Tsuda, Ryota Hokari, Fumihiko Kimura, Kenji Itoh. Acute pancreatitis coincided with multiple arteriolar aneurysms in a patient with polyarteritis nodosa. Modern rheumatology case reports. 2022 06; 6(2):234-238. doi: 10.1093/mrcr/rxab052. [PMID: 34878139]
Hadia R Ahmad, Victoria M Timmermans, Tarek Dakakni. Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination. The American journal of case reports. 2022 Jun; 23(?):e936574. doi: 10.12659/ajcr.936574. [PMID: 35717556]
Ladan Abbasian, Negar Toroghi, Hamid Rahmani, Hossein Khalili, Malihe Hasannezhad, Fereshteh Ghiasvand, Sirous Jafari, Mohammadreza Salehi, Faeze Salahshour, Mahsa Azadbakhsh Kanaf Gorabi, Fateme Alizade, Sara Ghaderkhani, Maryam Nakhostin. Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19. International immunopharmacology. 2022 Jun; 107(?):108689. doi: 10.1016/j.intimp.2022.108689. [PMID: 35313272]
Phei Ching Lim, Kar Loon Wong, Retha Rajah, Meng Fei Chong, Ting Soo Chow, Sivasangari Subramaniam, Chong Yew Lee. Comparing the efficacy of tocilizumab with corticosteroid therapy in treating COVID-19 patients: a systematic review and meta-analysis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2022 Jun; 30(1):211-228. doi: 10.1007/s40199-021-00430-8. [PMID: 35084705]
I Duman, J B Celik, M S Iyisoy, S Degirmencioglu, A Korkmaz, A Duman. Evaluation of personalized methylprednisolone therapy in critically ill COVID-19 patients: an observational comparative study using real-life data. European review for medical and pharmacological sciences. 2022 Jun; 26(12):4497-4508. doi: 10.26355/eurrev_202206_29089. [PMID: 35776051]
Suiting Ao, Xuemei Gao, Jipang Zhan, Lu Ai, Minyi Li, Huilin Su, Xuhua Tang, Coco Chu, Jiande Han, Fang Wang. Inhibition of tumor necrosis factor improves conventional steroid therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis in a cohort of patients. Journal of the American Academy of Dermatology. 2022 06; 86(6):1236-1245. doi: 10.1016/j.jaad.2022.01.039. [PMID: 35121075]
Priyankar Pal, Jigna N Bathia, Hriday De, Debapoma Biswas, Mohini Bhelo, Anurag Mondal. A retrospective analysis of the need for methylprednisolone in addition to IVIG for treating multisystem inflammatory syndrome in children. Rheumatology (Oxford, England). 2022 05; 61(6):e141-e142. doi: 10.1093/rheumatology/keac086. [PMID: 35166768]
Shukun Hong, Hongye Wang, Jian Liu, Lujun Qiao. Effects of different doses of methylprednisolone on clinical outcomes in patients with severe community-acquired pneumonia: a study protocol for a randomized controlled trial. Trials. 2022 May; 23(1):423. doi: 10.1186/s13063-022-06404-8. [PMID: 35598005]
Jicheng Lv, Muh Geot Wong, Michelle A Hladunewich, Vivekanand Jha, Lai Seong Hooi, Helen Monaghan, Minghui Zhao, Sean Barbour, Meg J Jardine, Heather N Reich, Daniel Cattran, Richard Glassock, Adeera Levin, David C Wheeler, Mark Woodward, Laurent Billot, Sandrine Stepien, Kris Rogers, Tak Mao Chan, Zhi-Hong Liu, David W Johnson, Alan Cass, John Feehally, Jürgen Floege, Giuseppe Remuzzi, Yangfeng Wu, Rajiv Agarwal, Hong Zhang, Vlado Perkovic. Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial. JAMA. 2022 05; 327(19):1888-1898. doi: 10.1001/jama.2022.5368. [PMID: 35579642]
Taira Yamamoto, Daisuke Endo, Akie Shimada, Satoshi Matsushita, Tohru Asai, Atsushi Amano. Surgical treatment of acute aortic dissection in a patient with SLE and prior antiphospholipid syndrome on therapy for over 30 years: a case report. BMC cardiovascular disorders. 2022 05; 22(1):216. doi: 10.1186/s12872-022-02659-w. [PMID: 35562652]
Takeshi Imai, Kensuke Shinohara, Kenji Uchino, Hirohisa Okuma, Futaba Maki, Kiyoshi Hiruma, Yasushi Ariizumi, Yoshihisa Yamano. Paraneoplastic cerebellar degeneration with anti-Yo antibodies and an associated submandibular gland tumor: a case report. BMC neurology. 2022 May; 22(1):165. doi: 10.1186/s12883-022-02684-4. [PMID: 35501715]
Azizullah Beran, Hazem Ayesh, Mohammed Mhanna, Omar Srour, Rami Musallam, Wasef Sayeh, Waleed Khokher, Nehaya Altorok, Zaid Noori, Ragheb Assaly, Nezam Altorok. Methylprednisolone Versus Dexamethasone in COVID-19: A Meta-Analysis of Nonrandomized Studies. American journal of therapeutics. 2022 May; 29(3):e354-e357. doi: 10.1097/mjt.0000000000001506. [PMID: 35533326]
S Benguerfi, F Reizine, F Eugène, P Tattevin, A Maamar. Remarkable resolution of COVID-19-associated cerebral vasculitis with methylprednisolone. Infectious diseases now. 2022 May; 52(3):181-182. doi: 10.1016/j.idnow.2022.01.008. [PMID: 35172219]
Azizullah Beran, Hazem Ayesh, Mohammed Mhanna, Omar Srour, Rami Musallam, Wasef Sayeh, Waleed Khokher, Nehaya Altorok, Zaid Noori, Ragheb Assaly, Nezam Altorok. Methylprednisolone May Be Superior to Dexamethasone in COVID-19: A Meta-Analysis of Randomized Controlled Trials. American journal of therapeutics. 2022 May; 29(3):e351-e354. doi: 10.1097/mjt.0000000000001507. [PMID: 35533325]
Hiroaki Fujita, Mukuto Shioda, Keisuke Suzuki. Anti-LGI1 encephalitis recurring 3 years after the first episode: a case report. BMC neurology. 2022 Apr; 22(1):148. doi: 10.1186/s12883-022-02674-6. [PMID: 35448972]
Satoshi Yamatani, Keiji Kono, Hideki Fujii, Ken Hirabayashi, Mao Shimizu, Kentaro Watanabe, Shunsuke Goto, Shinichi Nishi. Comparison of two protocols for steroid pulse therapy in patients with IgA nephropathy: a retrospective observational study. BMC nephrology. 2022 04; 23(1):153. doi: 10.1186/s12882-022-02791-x. [PMID: 35436909]
Kenji Matsui, Wataru Kamata, Yasuhiro Mochida, Kunihiro Ishioka, Hidekazu Moriya, Sumi Hidaka, Takayasu Ohtake, Yotaro Tamai, Shuzo Kobayashi. Acquired aplastic anemia complicated with anti-glomerular basement membrane disease successfully treated with immunosuppressive therapy: a case report. BMC nephrology. 2022 04; 23(1):136. doi: 10.1186/s12882-022-02772-0. [PMID: 35392836]
Ping Jiang, Shuang-Hua Wu, Ting Zhu, Yuan Guo, Yi He. A rare case of drug-induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID-19. Journal of medical virology. 2022 04; 94(4):1745-1747. doi: 10.1002/jmv.27525. [PMID: 34911144]
Nagaraju Poola, Bryan Due, Dale Wright, Leah R Brooks, Fahima Zaman. Pharmacokinetics and Pharmacodynamics of Repository Corticotropin Injection Compared With Synthetic ACTH1-24 Depot and Methylprednisolone in Healthy Subjects. Clinical pharmacology in drug development. 2022 04; 11(4):502-515. doi: 10.1002/cpdd.1020. [PMID: 34528408]
Priyadharshini Krishnaswamy, Nagaraja Bs, Shubha Vishnu Hegde. A Comparison of the Efficacy of Adjuvant Parenteral Methylprednisolone and Dexamethasone in Reducing Covid-19 Disease Severity and Mortality among the Moderate to Critical Patients -A Retrospective Study. The Journal of the Association of Physicians of India. 2022 Apr; 70(4):11-12. doi: NULL. [PMID: 35443522]
Sean Bujarski, Christine Sutanto, Tanya M Spektor, Jennifer To, Regina A Swift, Tracy Green, Benjamin R Eades, Marsiye Emamy-Sadr, Eric Souther, James R Berenson. Use of serum B-cell maturation antigen levels to predict outcomes for myeloma patients treated with ruxolitinib, lenalidomide and methylprednisolone. Hematological oncology. 2022 Apr; 40(2):243-248. doi: 10.1002/hon.2961. [PMID: 34982491]
Zhiwei Huang, Fenghuan Hu, Haibo Liu, Man Wang. A Retrospective Study to Compare the Effects of Methylprednisolone and Dexamethasone in 35 Patients with Anaphylactic Shock Due to Iodinated Contrast Media During Cardiac Catheterization. Medical science monitor : international medical journal of experimental and clinical research. 2022 Mar; 28(?):e934703. doi: 10.12659/msm.934703. [PMID: 35304433]
Ronaldo C Go, Themba Nyirenda, Maryam Bojarian, Davood K Hosseini, Kevin Kim, Mehek Rahim, Elli G Paleoudis, Anna C Go, Zhiyong Han, Steven J Sperber, Anjali Gupta. Racial/ethnic disparities on inflammation and response to methylprednisolone in severe COVID-19 pneumonia. BMC infectious diseases. 2022 Mar; 22(1):254. doi: 10.1186/s12879-022-07237-1. [PMID: 35287602]
Esther Park, Jihye You. A Case Report for Using Methylprednisolone for Severe ARDS Caused by SARS-CoV-2 Delta Variant in a Pediatric Patient With Lennox-Gastaut Syndrome. Journal of Korean medical science. 2022 Mar; 37(10):e82. doi: 10.3346/jkms.2022.37.e82. [PMID: 35289141]
Daniel Traila, Monica Steluta Marc, Camelia Pescaru, Diana Manolescu, Ovidiu Fira-Mladinescu. ANCA-associated vasculitis in idiopathic pulmonary fibrosis: A case report and brief review of the literature. Medicine. 2022 Mar; 101(9):e29008. doi: 10.1097/md.0000000000029008. [PMID: 35244078]
Emrah Keskin, Özlem Elmas, Havva Hande Keser Şahin, Berrak Güven. Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES. 2022 Mar; 28(3):233-241. doi: 10.14744/tjtes.2021.70728. [PMID: 35485570]
Snezana Zivancevic-Simonovic, Danijela Jovanovic, Vojislav Cupurdija, Olivera Milosevic-Djordjevic, Marijana Stanojevic, Milos Marinkovic, Nebojsa Igrutinovic, Ivan Stanojevic, Danilo Vojvodic, Olgica Mihaljevic. Cytokine producing ability of peripheral blood cells from COVID-19 patients after unspecific in vitro stimulation. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2022 Mar; 71(3):331-341. doi: 10.1007/s00011-022-01543-9. [PMID: 35157090]
Rumeysa Yalçinkaya, Fatma Nur Öz, Meltem Polat, Berna Uçan, Türkan Aydin Teke, Ayşe Kaman, Suna Özdem, Zeynep Savaş Şen, Rüveyda Gümüşer Cinni, Gönül Tanir. A Case of Multisystem Inflammatory Syndrome in a 12-Year-old Male After COVID-19 mRNA Vaccine. The Pediatric infectious disease journal. 2022 03; 41(3):e87-e89. doi: 10.1097/inf.0000000000003432. [PMID: 34978781]
Qingquan Chen, Qiongxiu Yang, Yingying Fang, Gongping Chen, Xiaoting Lv. Potential benefits of precise corticosteroid therapy for critical COVID-19. Respiratory physiology & neurobiology. 2022 03; 297(?):103813. doi: 10.1016/j.resp.2021.103813. [PMID: 34801741]
Ramazan Danis, Emrah Gunay, Enver Yuksel, Seyhmus Kaya, Jehat Kılıc, Emrah Kacar, Ayhan Senol, Derya Deniz Altıntas, Mehmet Serdar Yıldırım. Successful Treatment of COVID-19-Related Immune- Complex Glomerulonephritis, Case Report. Iranian journal of kidney diseases. 2022 03; 16(2):147-151. doi: NULL. [PMID: 35489083]
Lu Cheng, Shen-Ju Gou. Whether the addition of high-dosage methylprednisolone to plasma exchange was more effective than plasma exchange in the treatment for severe antineutrophil cytoplasmic antibody-associated vasculitis?. Kidney international. 2022 03; 101(3):647-648. doi: 10.1016/j.kint.2021.11.025. [PMID: 35190039]
Takahito Endo, Takeshi Ishimura, Shun Nishioka, Naoki Yokoyama, Satoshi Ogawa, Masato Fujisawa. No Influence of Everolimus on Mycophenolic Acid Area Under the Concentration-Time Curve: Limited Sampling Strategy for Mycophenolic Acid in Japanese Kidney Transplant Recipients Treated With Tacrolimus, Mycophenolate Mofetil, Steroid, and Everolimus. Transplantation proceedings. 2022 Mar; 54(2):286-292. doi: 10.1016/j.transproceed.2021.08.066. [PMID: 35034789]
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Murat Bektaş, Gökhan Özdemir. Protracted or recurrent COVID-19 associated cytokine storm in a patient with chronic lymphocytic leukemia receiving rituximab-based chemotherapy. Clinical immunology (Orlando, Fla.). 2022 03; 236(?):108936. doi: 10.1016/j.clim.2022.108936. [PMID: 35091103]
Joshua DeJong, Rebecca Sainato, Melissa Forouhar, David Robinson, Anjali Kunz. Multisystem Inflammatory Syndrome in a Previously Vaccinated Adolescent Female With Sickle Cell Disease. The Pediatric infectious disease journal. 2022 03; 41(3):e104-e105. doi: 10.1097/inf.0000000000003444. [PMID: 34955521]
Hyunjong Eom, Seung Woo Kim, Minkyoung Kim, Ye Eun Kim, Ji Hyun Kim, Ha Young Shin, Hye Lim Lee. Case Reports of Acute Transverse Myelitis Associated With mRNA Vaccine for COVID-19. Journal of Korean medical science. 2022 Feb; 37(7):e52. doi: 10.3346/jkms.2022.37.e52. [PMID: 35191229]
Shanshan Jin, Danqiong Wang, Jian Luo, Weiwen Zhang, Meng Wu. Diffuse alveolar hemorrhage in a patient with anti-neutrophil cytoplasm antibody-associated vasculitis successfully treated with immunoadsorption combined with methylprednisolone. Medicina clinica. 2022 02; 158(3):133-136. doi: 10.1016/j.medcli.2021.08.004. [PMID: 34666904]
En-Shuo Chang, Han-Hua Yu, Chiao-En Wu, Tien-Ming Chan. Acute respiratory distress syndrome associated with macrophage activation syndrome in systemic lupus erythematosus: A case report and literature review. Medicine. 2022 Feb; 101(5):e28612. doi: 10.1097/md.0000000000028612. [PMID: 35119005]
Varun Chalasani, Padmini Parameswaran, Adriani Cherico, Vipin Villgran, Holly Lowther, Joanna Marco. SARS-CoV-2 multisystem inflammatory syndrome in an adult presenting with polyarthritis treated with anakinra. Rheumatology (Oxford, England). 2022 02; 61(2):e33-e34. doi: 10.1093/rheumatology/keab697. [PMID: 34508552]
Alexander Ghincea, Changwan Ryu, Erica L Herzog. An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination: A Case Report. Chest. 2022 02; 161(2):e71-e73. doi: 10.1016/j.chest.2021.07.2160. [PMID: 35131075]
Alexsander K Bressan, Susan Isherwood, Oliver F Bathe, Elijah Dixon, Francis R Sutherland, Chad G Ball. Preoperative Single-dose Methylprednisolone Prevents Surgical Site Infections After Major Liver Resection: A Randomized Controlled Trial. Annals of surgery. 2022 02; 275(2):281-287. doi: 10.1097/sla.0000000000004720. [PMID: 33351452]
Stephanie P Schwartz, Tracie C Walker, Margaret Kihlstrom, Mubina Isani, Melissa M Smith, Rebecca L Smith, Sean E McLean, Katherine C Clement, Michael R Phillips. Extracorporeal Membrane Oxygenation for COVID-19-Associated Multisystem Inflammatory Syndrome in a 5-year-old. The American surgeon. 2022 Feb; 88(2):174-176. doi: 10.1177/0003134820983198. [PMID: 33372818]
Kritchai Vutipongsatorn, Anthony Isaacs, Ziad Farah. Inflammatory myopathy occurring shortly after severe acute respiratory syndrome coronavirus 2 vaccination: two case reports. Journal of medical case reports. 2022 Jan; 16(1):57. doi: 10.1186/s13256-022-03266-1. [PMID: 35094715]
Mengjun Liang, Liping Xiong, Aihua Li, Jiafan Zhou, Yajuan Huang, Miaofang Huang, Xing Zhang, Hongrui Shi, Ning Su, Yi Wei, Zongpei Jiang. The effectiveness and safety of corticosteroid therapy for IgA nephropathy with crescents: a prospective, randomized, controlled study. BMC nephrology. 2022 01; 23(1):40. doi: 10.1186/s12882-022-02661-6. [PMID: 35062886]
Yan Li, Rongguo Fu, Jie Gao, Li Wang, Zhaoyang Duan, Lifang Tian, Heng Ge, Xiaotao Ma, Yuzhan Zhang, Ke Li, Peihao Xu, Xuefei Tian, Zhao Chen. Effect of pulsed intravenous methylprednisolone with alternative low-dose prednisone on high-risk IgA nephropathy: a 18-month prospective clinical trial. Scientific reports. 2022 01; 12(1):255. doi: 10.1038/s41598-021-03691-0. [PMID: 34996948]
Ronaldo C Go, Themba Nyirenda, Maryam Bojarian, Davood K Hosseini, Mehek Rahim, Kevin Kim, Keith M Rose. Methylprednisolone, venous thromboembolism, and association with heparin to 30 days in hospital survival in severe Covid-19 pneumonia. BMC pulmonary medicine. 2022 Jan; 22(1):6. doi: 10.1186/s12890-021-01810-1. [PMID: 34986821]
Yeter Eylul Bayram, Dilek Yildiz-Sevgi, Ayse Yavuz, Merve Cancetin, Mehmet Yavuz Gurler. Management skin manifestation of multisystem inflammatory syndrome associated with SARS-CoV-2. Virology journal. 2022 01; 19(1):9. doi: 10.1186/s12985-021-01736-4. [PMID: 34991644]
Manisha Thakur, Ashok Kumar Datusalia, Anoop Kumar. Use of steroids in COVID-19 patients: A meta-analysis. European journal of pharmacology. 2022 Jan; 914(?):174579. doi: 10.1016/j.ejphar.2021.174579. [PMID: 34678244]
Akitake Suzuki, Shigeki Morita, Miho Ohshima, Nobuyoshi Minemura, Takeshi Suzuki, Masanobu Yoshida, Rikuo Machinami, Shuji Sakai, Chikao Torikata. Simultaneous occurrence of accelerated nodulosis in lungs, liver, and kidneys, and acute exacerbation of interstitial pneumonia in a patient with rheumatoid arthritis: an autopsy case report. BMC pulmonary medicine. 2022 Jan; 22(1):10. doi: 10.1186/s12890-021-01806-x. [PMID: 34983485]
Mustafa Fatih Dasci, Elif Yaprak Sarac, Asiye Gok Yurttas, Tolgahan Atci, Muhammed Uslu, Abdurrahman Acar, Mehmet Akif Gulec, Ender Alagoz. The effects of thymoquinone on steroid-induced femoral head osteonecrosis: An experimental study in rats. Joint diseases and related surgery. 2022; 33(3):553-566. doi: 10.52312/jdrs.2022.752. [PMID: 36345183]
Rashmi Ranjan Mohanty, Biswa Mohan Padhy, Bikash Ranjan Meher. Effectiveness of pulse dose methyl prednisolone in management of COVID 19: A systematic review and meta-analysis of observational studies. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2022; 25(?):110-123. doi: 10.18433/jpps32430. [PMID: 35364003]
Nihal Akçay, Mustafa Oğur, Mehmet Emin Menentoğlu, Kübra Boydağ Güvenç, Ayse Irem Sofuoğlu, Esra Şevketoğlu. MIS-C and Identical Twins: A Case Series. The Pediatric infectious disease journal. 2022 01; 41(1):e32-e34. doi: 10.1097/inf.0000000000003392. [PMID: 34862348]
Noreen Nasir, Salma Tajuddin, Sarah Khaskheli, Naveera Khan, Hammad Niamatullah, Nosheen Nasir. Clinical outcomes of immunomodulatory therapies in the management of COVID-19: A tertiary-care experience from Pakistan. PloS one. 2022; 17(1):e0262608. doi: 10.1371/journal.pone.0262608. [PMID: 35085312]
Przemysław Kłosowski, Renata Świątkowska-Stodulska, Dominik Stodulski, Mariusz Kaszubowski, Bartosz Karaszewski, Krzysztof Sworczak. Effect of Glucocorticoid Administration in Intravenous Pulses on Selected Parameters of the Coagulation System. International journal of clinical practice. 2022; 2022(?):3144685. doi: 10.1155/2022/3144685. [PMID: 35685509]
Bhadran Bose, Sunil V Badve, David W Johnson, Carmel Hawley, Vivekanand Jha, Donna Reidlinger, Chen Au Peh. Treatment preferences for primary membranous nephropathy: Results of a multinational survey among nephrologists in the South Asia Pacific region. Nephrology (Carlton, Vic.). 2022 Jan; 27(1):35-43. doi: 10.1111/nep.13953. [PMID: 34392579]
Lorenzo Porta, Sih-Shiang Huang, Chen Wei, Chin-Hua Su, Wan-Ting Hsu, Wang-Huei Sheng, Chien-Chang Lee. Effect of methylprednisolone treatment on COVID-19: An inverse probability of treatment weighting analysis. PloS one. 2022; 17(6):e0266901. doi: 10.1371/journal.pone.0266901. [PMID: 35714141]
Qinghong Fan, Kai Deng, Huang Huang, Ruiying He, Xizi Deng, Yun Lan, Yizhou Tan, Weilie Chen, Yaping Wang, Xilong Deng, Fengyu Hu, Feng Li. Kinetics of Severity Biomarkers and Immunological Features of Methylprednisolone Therapy for Severe COVID-19 Patients. Frontiers in immunology. 2022; 13(?):758946. doi: 10.3389/fimmu.2022.758946. [PMID: 35350784]
Yaning Ding, Bai Lv, Jinpeng Zheng, Caihong Lu, Jingzhou Liu, Yaran Lei, Meiyan Yang, Yuli Wang, Zhiping Li, Yang Yang, Wei Gong, Jing Han, Chunsheng Gao. RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery. Journal of controlled release : official journal of the Controlled Release Society. 2022 01; 341(?):702-715. doi: 10.1016/j.jconrel.2021.12.018. [PMID: 34933051]
Gagan Kumar, Dhaval Patel, Martin Hererra, David Jefferies, Ankit Sakhuja, Mark Meersman, Drew Dalton, Rahul Nanchal, Achuta Kumar Guddati. Do high-dose corticosteroids improve outcomes in hospitalized COVID-19 patients?. Journal of medical virology. 2022 01; 94(1):372-379. doi: 10.1002/jmv.27357. [PMID: 34559436]
Masataro Toda, Kentaro Fujii, Ayumi Yoshifuji, Yasushi Kondo, Kazuto Itoh, Kazuhiko Sekine, Takahide Kikuchi, Munekazu Ryuzaki. Clinical efficacy and safety of combination therapy of tocilizumab and steroid pulse therapy for critical COVID-19 in HD patients. Clinical and experimental nephrology. 2022 Jan; 26(1):75-85. doi: 10.1007/s10157-021-02126-4. [PMID: 34436742]
Hamid Yaqoob, Daniel Greenberg, Frank Hwang, Curtis Lee, David Vernik, Ravi Manglani, Zhen Wang, M Hassan Murad, Dipak Chandy, Oleg Epelbaum. Comparison of pulse-dose and high-dose corticosteroids with no corticosteroid treatment for COVID-19 pneumonia in the intensive care unit. Journal of medical virology. 2022 01; 94(1):349-356. doi: 10.1002/jmv.27351. [PMID: 34542192]
Elif Sargin Altunok, Celal Satici, Veysel Dinc, Sadettin Kamat, Mustafa Alkan, Mustafa Asim Demirkol, Ilkim Deniz Toprak, Muhammed Emin Kostek, Semih Yazla, Sinem Nihal Esatoglu. Comparison of demographic and clinical characteristics of hospitalized COVID-19 patients with severe/critical illness in the first wave versus the second wave. Journal of medical virology. 2022 01; 94(1):291-297. doi: 10.1002/jmv.27319. [PMID: 34491575]
Rashmi Ranjan Mohanty, Smita Das, Biswa Mohan Padhy, Bikash Ranjan Meher. Comparison of Clinical Outcome between Dexamethasone and Methyl Prednisolone in Treatment of Moderate to Severe COVID-19: A Systematic Review and Meta-Analysis. The Journal of the Association of Physicians of India. 2022 Jan; 70(1):11-12. doi: NULL. [PMID: 35062806]
Ravindra K Garg, Hardeep S Malhotra, Neeraj Kumar, Shweta Pandey, Manish R Patil, Ravi Uniyal, Imran Rizvi. Tumefactive Demyelinating Brain Lesion Developing after Administration of Adenovector-Based COVID-19 Vaccine: A Case Report. Neurology India. 2022 Jan; 70(1):409-411. doi: 10.4103/0028-3886.338642. [PMID: 35263930]
Satoshi Hirose, Makoto Hara, Kento Koda, Naotoshi Natori, Yuki Yokota, Satoko Ninomiya, Hideto Nakajima. Acute autoimmune transverse myelitis following COVID-19 vaccination: A case report. Medicine. 2021 Dec; 100(51):e28423. doi: 10.1097/md.0000000000028423. [PMID: 34941191]
Manana Dewage Sankani Vishvara Kularathna, Senanayake Abeysinghe Mudiyanselage Kularatne, Manoji Pathirage, Pala Thanthirige Madhushi Anuradha Nanayakkara. Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report. Journal of medical case reports. 2021 Dec; 15(1):584. doi: 10.1186/s13256-021-03135-3. [PMID: 34903283]
Wei Shi, Ying Chen, Meng-Qiu Zhang, Guo-Wei Che, Hai Yu. Effects of methylprednisolone on early postoperative pain and recovery in patients undergoing thoracoscopic lung surgery: A randomized controlled trial. Journal of clinical anesthesia. 2021 12; 75(?):110526. doi: 10.1016/j.jclinane.2021.110526. [PMID: 34610541]
Fangzhou Ye, Jing Liu, Liangkai Chen, Bin Zhu, Li Yu, Boyun Liang, Ling Xu, Sumeng Li, Sihong Lu, Lei Fan, Dongliang Yang, Xin Zheng. Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study. Annals of medicine. 2021 12; 53(1):181-188. doi: 10.1080/07853890.2020.1851394. [PMID: 33183091]
Radu Crisan Dabija, Ileana Antohe, Antigona Trofor, Sabina A Antoniu. Corticosteroids in SARS-COV2 infection: certainties and uncertainties in clinical practice. Expert review of anti-infective therapy. 2021 12; 19(12):1553-1562. doi: 10.1080/14787210.2021.1933437. [PMID: 34015985]
Kimitaka Suetsugu, Shota Muraki, Junshiro Fukumoto, Ryosuke Matsukane, Yasuo Mori, Takeshi Hirota, Toshihiro Miyamoto, Nobuaki Egashira, Koichi Akashi, Ichiro Ieiri. Effects of Letermovir and/or Methylprednisolone Coadministration on Voriconazole Pharmacokinetics in Hematopoietic Stem Cell Transplantation: A Population Pharmacokinetic Study. Drugs in R&D. 2021 Dec; 21(4):419-429. doi: 10.1007/s40268-021-00365-0. [PMID: 34655050]
Albert Bui, Emily Brooke Butts, Nabeel Aslam. 47-Year-Old Woman With Bilateral Flank Pain. Mayo Clinic proceedings. 2021 12; 96(12):3147-3152. doi: 10.1016/j.mayocp.2021.03.042. [PMID: 34863400]
Zi-Wei Ye, Shuofeng Yuan, Jasper Fuk-Woo Chan, Anna Jinxia Zhang, Ching-Yun Yu, Chon Phin Ong, Dong Yang, Chris Chun-Yiu Chan, Kaiming Tang, Jianli Cao, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Jian-Piao Cai, Hin Chu, Kwok-Yung Yuen, Dong-Yan Jin. Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection. Emerging microbes & infections. 2021 Dec; 10(1):291-304. doi: 10.1080/22221751.2021.1885998. [PMID: 33538646]
Sasitorn Siritho, Tanawin Nopsopon, Krit Pongpirul. Therapeutic plasma exchange vs conventional treatment with intravenous high dose steroid for neuromyelitis optica spectrum disorders (NMOSD): a systematic review and meta-analysis. Journal of neurology. 2021 Dec; 268(12):4549-4562. doi: 10.1007/s00415-020-10257-z. [PMID: 33037886]
Emilie P Buddingh, Ann C T M Vossen, Hildo J Lamb, Roel L F van der Palen, Danielle M C Brinkman. Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2 Without Recurrence of Multisystem Inflammatory Syndrome in Children. The Pediatric infectious disease journal. 2021 12; 40(12):e491-e492. doi: 10.1097/inf.0000000000003280. [PMID: 34382616]
Tianyu Wang, Tao Qiu, Yan Yuan, Zhongbao Chen, Xiaoxiong Ma, Long Zhang, Zeya Jin, Jilin Zou, Yalong Zhang, Jiangqiao Zhou. Summary report of seven cases of COVID-19 infection in renal transplant recipients. Transplant immunology. 2021 12; 69(?):101445. doi: 10.1016/j.trim.2021.101445. [PMID: 34384886]
Andrea Dean, Amira Said, Kavitha Marri, Daniel Chelius. Stridor Due to Cranial Nerve X Palsy Progressing to Polyneuropathy in a Teenager With COVID-19. Pediatrics. 2021 12; 148(6):. doi: 10.1542/peds.2021-051534. [PMID: 34851417]