Sterol (BioDeep_00000004419)
human metabolite Endogenous
代谢物信息卡片
tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-ol
化学式: C17H28O (248.2140038)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 21.94%
分子结构信息
SMILES: C1CC2CCC3C4CCC(CC4CCC3C2C1)O
InChI: InChI=1S/C17H28O/c18-13-6-9-15-12(10-13)5-8-16-14-3-1-2-11(14)4-7-17(15)16/h11-18H,1-10H2
描述信息
Sterols, also known as steroid alcohols, are a subgroup of the steroids and an important class of organic molecules. They occur naturally in plants, animals, and fungi, with the most familiar type of animal sterol being cholesterol. Cholesterol is vital to animal cell membrane structure and function and a precursor to fat-soluble vitamins and steroid hormones. (Wikipedia)
Sterols are a subgroup of the steroids and an important class of organic molecules. They occur naturally in plants, animals, and fungi, with the most familiar type of animal sterol being cholesterol. Cholesterol is vital to cellular function, and a precursor to fat-soluble vitamins and steroid hormones. Sterols is found in burdock, soft-necked garlic, and sesame.
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- KEGG: C00370
- PubChem: 1107
- HMDB: HMDB0060512
- Metlin: METLIN63345
- Wikipedia: Sterol
- MeSH: Sterols
- foodb: FDB003714
- chemspider: 1076
- PMhub: MS000016859
- ChEBI: CHEBI:15889
- PubChem: 3660
- NIKKAJI: J2.729.444H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(1)
- sphingolipid biosynthesis (plants):
NADP+ + sphinganine ⟶ 3-dehydrosphinganine + H+ + NADPH
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yingjie Song, Xuewei Yang, Shuangfei Li, Yanqing Luo, Jo-Shu Chang, Zhangli Hu. Thraustochytrids as a promising source of fatty acids, carotenoids, and sterols: bioactive compound biosynthesis, and modern biotechnology.
Critical reviews in biotechnology.
2024 Jun; 44(4):618-640. doi:
10.1080/07388551.2023.2196373. [PMID: 37158096] - Christophe Der, Pierre-Emmanuel Courty, Ghislaine Recorbet, Daniel Wipf, Françoise Simon-Plas, Patricia Gerbeau-Pissot. Sterols, pleiotropic players in plant-microbe interactions.
Trends in plant science.
2024 May; 29(5):524-534. doi:
10.1016/j.tplants.2024.03.002. [PMID: 38565452] - Gabriela Haist, Boriana Sidjimova, Elina Yankova-Tsvetkova, Milena Nikolova, Rumen Denev, Ivanka Semerdjieva, Jaume Bastida, Strahil Berkov. Metabolite profiling and histochemical localization of alkaloids in Hippeastrum papilio (Ravena) van Scheepen.
Journal of plant physiology.
2024 May; 296(?):154223. doi:
10.1016/j.jplph.2024.154223. [PMID: 38507926] - Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure. Resolving phytosterols in microalgae using offline two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Analytical methods : advancing methods and applications.
2024 Apr; 16(15):2278-2285. doi:
10.1039/d3ay02261g. [PMID: 38525815] - Lingling Wei, Haiping Shi, Bin Chen, Xiujuan Li, Wenchan Chen, Chengdong Wu, Yunpeng Gai, Changjun Chen. Functional Plasticity, Redundancy, and Specificity of Lanosterol 14α-Demethylase in Regulating the Sensitivity to DMIs in Calonectria ilicicola.
Journal of agricultural and food chemistry.
2024 Apr; 72(15):8444-8459. doi:
10.1021/acs.jafc.4c01948. [PMID: 38574108] - Reiichi Ohno, Malwina Mainka, Rebecca Kirchhoff, Nicole M Hartung, Nils Helge Schebb. Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX.
Molecules (Basel, Switzerland).
2024 Apr; 29(8):. doi:
10.3390/molecules29081745. [PMID: 38675565] - Vanessa Hermann-Ene, Walter Vetter. Stable Carbon Isotope Ratios (δ13C Values [‰]) of Individual Sterols in the Oils of C3, C4, and CAM Plants.
Journal of agricultural and food chemistry.
2024 Apr; 72(14):8247-8256. doi:
10.1021/acs.jafc.3c08324. [PMID: 38551065] - Shaojie Cui, Jin Ye. 7-Dehydrocholesterol: A sterol shield against an iron sword.
Molecular cell.
2024 Apr; 84(7):1183-1185. doi:
10.1016/j.molcel.2024.03.003. [PMID: 38579675] - Jamila Gagour, Otmane Hallouch, Abderrahim Asbbane, Laila Bijla, Abdellatif Laknifli, Learn-Han Lee, Gokhan Zengin, Abdelhakim Bouyahya, El Hassan Sakar, Said Gharby. A Review of Recent Progresses on Olive Oil Chemical Profiling, Extraction Technology, Shelf-life, and Quality Control.
Chemistry & biodiversity.
2024 Apr; 21(4):e202301697. doi:
10.1002/cbdv.202301697. [PMID: 38345352] - Zhijie Qin, Yunliang Zhang, Song Liu, Weizhu Zeng, Jingwen Zhou, Sha Xu. Combining Metabolic Engineering and Lipid Droplet Assembly to Achieve Campesterol Overproduction in Saccharomyces cerevisiae.
Journal of agricultural and food chemistry.
2024 Mar; 72(9):4814-4824. doi:
10.1021/acs.jafc.3c09764. [PMID: 38389392] - Nicolas Fuggetta, Nicola Rigolli, Maud Magdeleine, Amazigh Hamaï, Agnese Seminara, Guillaume Drin. Reconstitution of ORP-mediated lipid exchange coupled to PI4P metabolism.
Proceedings of the National Academy of Sciences of the United States of America.
2024 Mar; 121(10):e2315493121. doi:
10.1073/pnas.2315493121. [PMID: 38408242] - Sally E Khaled, Fatma A-M Hashem, Manal H Shabana, Abdel-Mohsen M Hammam, Abdel Nasser A Madboli, Mohamed A Farag, Dalia A Al-Mahdy. A metabolomics approach for the evaluation of Ficus benghalensis female in vivo reproductive effects relative to its metabolite fingerprint as determined via UPLC-MS and GC-MS.
Journal of ethnopharmacology.
2024 Mar; 321(?):117519. doi:
10.1016/j.jep.2023.117519. [PMID: 38043752] - Bhawana Mishra, Shilpi Bansal, Sandhya Tripathi, Smrati Mishra, Ritesh K Yadav, Neelam S Sangwan. Differential regulation of key triterpene synthase gene under abiotic stress in Withania somnifera L. Dunal and its co-relation to sterols and withanolides.
Plant physiology and biochemistry : PPB.
2024 Mar; 208(?):108419. doi:
10.1016/j.plaphy.2024.108419. [PMID: 38377888] - Ayumi Okayama, Tatsuya Hoshino, Kohei Wada, Hiroshi Takahashi. Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers.
Chemistry and physics of lipids.
2024 03; 259(?):105376. doi:
10.1016/j.chemphyslip.2024.105376. [PMID: 38325710] - Tolga Akcan. Investigating the Quality and Purity Profiles of Olive Oils from Diverse Regions in Selçuk, İzmir.
Molecules (Basel, Switzerland).
2024 Feb; 29(5):. doi:
10.3390/molecules29051104. [PMID: 38474614] - Jiangcheng Ye, Mingxiu Gong, Yifan Zhang, Qianqian Xu, Jin Zhao. Effects of Fermented Extracts of Wuniuzao Dark Loose Tea on Hepatic Sterol Regulatory Element-Binding Protein Pathway and Gut Microbiota Disorder in Obese Mice.
The Journal of nutrition.
2024 02; 154(2):626-637. doi:
10.1016/j.tjnut.2023.12.019. [PMID: 38110182] - Haiqiang Zhang, Zichen Liu, Yunxiao Wang, Siyu Mu, Hongzhong Yue, Yanjie Luo, Zhengao Zhang, Yuhong Li, Peng Chen. A mutation in CsDWF7 gene encoding a delta7 sterol C-5(6) desaturase leads to the phenotype of super compact in cucumber (Cucumis sativus L.).
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.
2024 Jan; 137(1):20. doi:
10.1007/s00122-023-04518-4. [PMID: 38221593] - Leticia Caballero-Moreno, Aurelio Luna, Isabel Legaz. Lipidomes in Cadaveric Decomposition and Determination of the Postmortem Interval: A Systematic Review.
International journal of molecular sciences.
2024 Jan; 25(2):. doi:
10.3390/ijms25020984. [PMID: 38256058] - Marco Pozzi, Chiara Vantaggiato, Francesca Brivio, Genny Orso, Maria Teresa Bassi. Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients.
Translational psychiatry.
2024 Jan; 14(1):13. doi:
10.1038/s41398-023-02686-x. [PMID: 38191558] - Astrid Radkohl, Veronika Schusterbauer, Lukas Bernauer, Gerald N Rechberger, Heimo Wolinski, Matthias Schittmayer, Ruth Birner-Gruenberger, Gerhard G Thallinger, Erich Leitner, Melanie Baeck, Harald Pichler, Anita Emmerstorfer-Augustin. Human Sterols Are Overproduced, Stored and Excreted in Yeasts.
International journal of molecular sciences.
2024 Jan; 25(2):. doi:
10.3390/ijms25020781. [PMID: 38255855] - Theodore L Steck, S M Ali Tabei, Yvonne Lange. Estimating the Cholesterol Affinity of Integral Membrane Proteins from Experimental Data.
Biochemistry.
2024 Jan; 63(1):19-26. doi:
10.1021/acs.biochem.3c00567. [PMID: 38099740] - V Blanco-Morales, D Mercatante, M T Rodriguez-Estrada, G Garcia-Llatas. Current and New Insights on Delivery Systems for Plant Sterols in Food.
Advances in experimental medicine and biology.
2024; 1440(?):403-435. doi:
10.1007/978-3-031-43883-7_20. [PMID: 38036891] - Shubhrima Ghosh, Imen Ghzaiel, Anne Vejux, Steve Meaney, Sagnik Nag, Gérard Lizard, Garima Tripathi, Falal Naez, Srijita Paul. Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects.
Advances in experimental medicine and biology.
2024; 1440(?):163-191. doi:
10.1007/978-3-031-43883-7_9. [PMID: 38036880] - Rita Gutorov, Ben Katz, Maximilian Peters, Baruch Minke. Membrane lipid modulations by methyl-β-cyclodextrin uncouple the Drosophila light-activated phospholipase C from TRP and TRPL channel gating.
The Journal of biological chemistry.
2024 Jan; 300(1):105484. doi:
10.1016/j.jbc.2023.105484. [PMID: 37992804] - Yan Lin, Qiuyan Hu, Qiang Ye, Haohua Zhang, Ziyu Bao, Yongping Li, Luo Jian Mo. Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L.
PeerJ.
2024; 12(?):e16702. doi:
10.7717/peerj.16702. [PMID: 38282859] - Laetitia Fouillen, Lilly Maneta-Peyret, Patrick Moreau. ER Membrane Lipid Composition and Metabolism: Lipidomic Analysis.
Methods in molecular biology (Clifton, N.J.).
2024; 2772(?):137-148. doi:
10.1007/978-1-0716-3710-4_10. [PMID: 38411811] - Quanxin Wang, Ruiqi Zhang, Yijun He, Guangmin Mao, Zhaolu Kong. Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway.
International journal of radiation biology.
2024; 100(5):791-801. doi:
10.1080/09553002.2024.2324475. [PMID: 38442139] - Solenne Vigne, Caroline Pot. Implication of Oxysterols and Phytosterols in Aging and Human Diseases.
Advances in experimental medicine and biology.
2024; 1440(?):231-260. doi:
10.1007/978-3-031-43883-7_12. [PMID: 38036883] - Yao Guo, Bing Liu, Yaping Geng, Ke Chen, Junyan Li, Xiangju Yin, Shenshen Zhang. Fisetin, a dietary flavonoid, promotes transintestinal cholesterol excretion through the activation of PPARδ.
Food research international (Ottawa, Ont.).
2024 Jan; 175(?):113783. doi:
10.1016/j.foodres.2023.113783. [PMID: 38129008] - Ahmet Yalcinkaya, Yeşim Er Öztaş, Suna Sabuncuoğlu. Sterols in Inflammatory Diseases: Implications and Clinical Utility.
Advances in experimental medicine and biology.
2024; 1440(?):261-275. doi:
10.1007/978-3-031-43883-7_13. [PMID: 38036884] - Amy-Doan P Vo, Soo-Kyung Kim, Moon Young Yang, Alison E Ondrus, William A Goddard. Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex.
Proceedings of the National Academy of Sciences of the United States of America.
2023 Dec; 120(49):e2300919120. doi:
10.1073/pnas.2300919120. [PMID: 38015850] - T Brunoir, C Mulligan, A Sistiaga, K M Vuu, P M Shih, S S O'Reilly, R E Summons, D A Gold. Common origin of sterol biosynthesis points to a feeding strategy shift in Neoproterozoic animals.
Nature communications.
2023 Dec; 14(1):7941. doi:
10.1038/s41467-023-43545-z. [PMID: 38040676] - Lukas Bernauer, Paula Berzak, Leonie Lehmayer, Julia Messenlehner, Gustav Oberdorfer, Günther Zellnig, Heimo Wolinski, Christoph Augustin, Melanie Baeck, Anita Emmerstorfer-Augustin. Sterol interactions influence the function of Wsc sensors.
Journal of lipid research.
2023 12; 64(12):100466. doi:
10.1016/j.jlr.2023.100466. [PMID: 37918524] - Dongmei Liu, Wentong Diao, Xueyan Sun, Junqin Zong, Xiwu Qi, Chengyuan Liang. Application of Miscanthus substrates in the cultivation of Ganoderma lingzhi.
Archives of microbiology.
2023 Nov; 205(12):384. doi:
10.1007/s00203-023-03720-8. [PMID: 37975884] - Arun Maji, Corinne P Soutar, Jiabao Zhang, Agnieszka Lewandowska, Brice E Uno, Su Yan, Yogesh Shelke, Ganesh Murhade, Evgeny Nimerovsky, Collin G Borcik, Andres S Arango, Justin D Lange, Jonnathan P Marin-Toledo, Yinghuan Lyu, Keith L Bailey, Patrick J Roady, Jordan T Holler, Anuj Khandelwal, Anna M SantaMaria, Hiram Sanchez, Praveen R Juvvadi, Gina Johns, Michael J Hageman, Joanna Krise, Teclegiorgis Gebremariam, Eman G Youssef, Ken Bartizal, Kieren A Marr, William J Steinbach, Ashraf S Ibrahim, Thomas F Patterson, Nathan P Wiederhold, David R Andes, Taras V Pogorelov, Charles D Schwieters, Timothy M Fan, Chad M Rienstra, Martin D Burke. Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
Nature.
2023 Nov; ?(?):. doi:
10.1038/s41586-023-06710-4. [PMID: 37938782] - Jing-Jing Zhang, Yan Gao, Xiao Xu, Mei-Ling Zhao, Bo-Nan Xi, Yu Shu, Cong Li, Yehua Shen. In Situ Rapid Analysis of Squalene, Tocopherols, and Sterols in Walnut Oils Based on Supercritical Fluid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry.
Journal of agricultural and food chemistry.
2023 Nov; 71(43):16371-16380. doi:
10.1021/acs.jafc.3c05857. [PMID: 37867462] - Farhana Tasleem, Syed Sabir Hassan, Safia Abidi, Saima Zahid, Zafar Alam Mahmood. Anxiolytic interventions of extracts and pure compounds from Adenanthera pavonina and Peltophorum pterocarpum leaves to treat acute anxiety and depression symptoms in mice.
Pakistan journal of pharmaceutical sciences.
2023 Nov; 36(6):1823-1829. doi:
. [PMID: 38124423] - He Huang, Baijun Chu, Qiaona Yuan, Pan Gao, Wu Zhong, Jiaojiao Yin, Chuanrong Hu, Dongping He, Xiaoming Jiang, Xingguo Wang. Effect of enzymatic Maillard reaction conditions on the physicochemical properties, nutrition, fatty acids composition, and key aroma compounds of fragrant rapeseed oil.
Journal of the science of food and agriculture.
2023 Oct; ?(?):. doi:
10.1002/jsfa.13082. [PMID: 37897493] - Yohei Ishibashi, Shohei Sadamitsu, Yoshitomo Fukahori, Yuki Yamamoto, Rin Tanogashira, Takashi Watanabe, Masahiro Hayashi, Makoto Ito, Nozomu Okino. Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186.
Applied and environmental microbiology.
2023 Oct; ?(?):e0100123. doi:
10.1128/aem.01001-23. [PMID: 37874286] - Samuel Furse, Carlos Martel, Abdikarim Yusuf, Gemma C Shearman, Hauke Koch, Philip C Stevenson. Sterol composition in plants is specific to pollen, leaf, pollination and pollinator.
Phytochemistry.
2023 Oct; 214(?):113800. doi:
10.1016/j.phytochem.2023.113800. [PMID: 37532086] - Robert S Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D Dale, Tegan A Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S Hopes, Martin Heier, Irene A Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T Handley. Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
The Journal of biological chemistry.
2023 Sep; ?(?):105295. doi:
10.1016/j.jbc.2023.105295. [PMID: 37774976] - Qiannan Ren, Qiming Sun, Junfen Fu. Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease.
Autophagy.
2023 Sep; ?(?):1-21. doi:
10.1080/15548627.2023.2254191. [PMID: 37700498] - Xia Ke, Zi-Hao Pan, Hong-Fei Du, Yi Shen, Ji-Dong Shen, Zhi-Qiang Liu, Yu-Guo Zheng. Secretory Production of 7-dehydrocholesterol by Engineered Saccharomyces cerevisiae.
Biotechnology journal.
2023 Sep; ?(?):e2300056. doi:
10.1002/biot.202300056. [PMID: 37688450] - Runjie Yu, Fuyin Xie, Qiguo Tang. Insight into adaption to hypoxia in Tibetan chicken embryonic brains using lipidomics.
Biochemical and biophysical research communications.
2023 09; 671(?):183-191. doi:
10.1016/j.bbrc.2023.05.084. [PMID: 37302293] - Natalia Ozolina, Irina Kapustina, Veronika Gurina, Ekaterina Spiridonova, Vadim Nurminsky. The microdomains (rafts) of plasmalemma in the protection of the plant cell under oxidative stress.
Protoplasma.
2023 Sep; 260(5):1365-1374. doi:
10.1007/s00709-023-01852-8. [PMID: 36959427] - Sarah Schlag, Yvonne Bräckle, Marina Jelečević, Walter Vetter. Gas chromatography with mass spectrometry analysis of 4,4-dimethylsterols and 4-methylsterols in edible oils after their enrichment by means of solid phase extraction.
Journal of chromatography. A.
2023 Aug; 1705(?):464166. doi:
10.1016/j.chroma.2023.464166. [PMID: 37356364] - Samuel Furse, Hauke Koch, Geraldine A Wright, Philip C Stevenson. Sterol and lipid metabolism in bees.
Metabolomics : Official journal of the Metabolomic Society.
2023 08; 19(9):78. doi:
10.1007/s11306-023-02039-1. [PMID: 37644282] - M Martini, I Altomonte, I Sodi, Y Vasylieva, F Salari. Sterols, tocopherols, and bioactive fatty acids differences between conventional, high quality, and organic cow milk.
Journal of dairy science.
2023 Aug; ?(?):. doi:
10.3168/jds.2023-23378. [PMID: 37641300] - Xin Zhao, Zhangjiang He, Yifei Gao, Yanze Kan, Yufei Jiao, Yunxia Liu, Shuaishuai Huang, Zhibing Luo, Yongjun Zhang. Sterol Regulatory Element-Binding Protein, BbSre1, Controls Oxidative Stress Response, Peroxisome Division, and Lipid Homeostasis in an Insect Fungal Pathogen.
Journal of agricultural and food chemistry.
2023 Aug; 71(32):12250-12263. doi:
10.1021/acs.jafc.3c02568. [PMID: 37493643] - Sara Ovejero, Sylvain Kumanski, Caroline Soulet, Julie Azarli, Benjamin Pardo, Olivier Santt, Angelos Constantinou, Philippe Pasero, María Moriel-Carretero. A sterol-PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response.
The EMBO journal.
2023 08; 42(15):e112684. doi:
10.15252/embj.2022112684. [PMID: 37303233] - Lauren E Davey, Per N Malkus, Max Villa, Lee Dolat, Zachary C Holmes, Jeff Letourneau, Eduard Ansaldo, Lawrence A David, Gregory M Barton, Raphael H Valdivia. A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression.
Nature microbiology.
2023 08; 8(8):1450-1467. doi:
10.1038/s41564-023-01407-w. [PMID: 37337046] - Xue-Ming Zhu, Lin Li, Jian-Dong Bao, Jiao-Yu Wang, Shuang Liang, Li-Li Zhao, Chang-Li Huang, Jiong-Yi Yan, Ying-Ying Cai, Xi-Yu Wu, Bo Dong, Xiao-Hong Liu, Daniel J Klionsky, Fu-Cheng Lin. MoVast2 combined with MoVast1 regulates lipid homeostasis and autophagy in Magnaporthe oryzae.
Autophagy.
2023 08; 19(8):2353-2371. doi:
10.1080/15548627.2023.2181739. [PMID: 36803211] - Takeshi Sakaki, Tomoko Koizumi, Yosuke Ikeido, Kouichi Soga, Kazuyuki Wakabayashi, Takayuki Hoson. Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions.
Life sciences in space research.
2023 Aug; 38(?):53-58. doi:
10.1016/j.lssr.2023.05.005. [PMID: 37481308] - Erin Hirtzel, Madison Edwards, Dallas Freitas, Ziying Liu, Fen Wang, Xin Yan. Aziridination-Assisted Mass Spectrometry of Nonpolar Sterol Lipids with Isomeric Resolution.
Journal of the American Society for Mass Spectrometry.
2023 Jul; ?(?):. doi:
10.1021/jasms.3c00161. [PMID: 37523498] - Carl Recsei, Robert A Russell, Marina Cagnes, Tamim Darwish. Deuterated squalene and sterols from modified Saccharomyces cerevisiae.
Organic & biomolecular chemistry.
2023 Jul; ?(?):. doi:
10.1039/d3ob00754e. [PMID: 37523212] - Ana Guadalupe Fracchia-Durán, Emilia Ramos-Zambrano, Facundo Joaquín Márquez-Rocha, Alma Leticia Martínez-Ayala. Bioprocess conditions and regulation factors to optimize squalene production in thraustochytrids.
World journal of microbiology & biotechnology.
2023 Jul; 39(9):251. doi:
10.1007/s11274-023-03689-y. [PMID: 37442840] - Ross D Etherington, Mark Bailey, Jean-Baptiste Boyer, Laura Armbruster, Xulyu Cao, Juliet C Coates, Thierry Meinnel, Markus Wirtz, Carmela Giglione, Daniel J Gibbs. Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases.
Plant physiology.
2023 Jul; ?(?):. doi:
10.1093/plphys/kiad406. [PMID: 37427787] - Emily Carroll, Baradwaj Ravi Gopal, Indu Raghavan, Minakshi Mukherjee, Zhen Q Wang. A cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis.
Nature communications.
2023 Jul; 14(1):4042. doi:
10.1038/s41467-023-39719-4. [PMID: 37422531] - Anatoly Zhukov, Valery Popov. Eukaryotic Cell Membranes: Structure, Composition, Research Methods and Computational Modelling.
International journal of molecular sciences.
2023 Jul; 24(13):. doi:
10.3390/ijms241311226. [PMID: 37446404] - Hau Lam Choy, Elizabeth A Gaylord, Tamara L Doering. Ergosterol distribution controls surface structure formation and fungal pathogenicity.
mBio.
2023 Jul; ?(?):e0135323. doi:
10.1128/mbio.01353-23. [PMID: 37409809] - A Castellaneta, I Losito, B Leoni, M Renna, C Mininni, P Santamaria, C D Calvano, T R I Cataldi, G Liebisch, S Matysik. A targeted GC-MS/MS approach for the determination of eight sterols in microgreen and mature plant material.
The Journal of steroid biochemistry and molecular biology.
2023 Jul; ?(?):106361. doi:
10.1016/j.jsbmb.2023.106361. [PMID: 37419395] - Min He, Si-Yuan Guo, Yan Yin, Chi Zhang, Xia-Nan Zhang. [Gene clone and functional identification of sterol glycosyltransferases from Paris polyphylla var. yunnanensis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jul; 48(14):3774-3785. doi:
10.19540/j.cnki.cjcmm.20230413.101. [PMID: 37475069] - Liang-Liang Zhai, Ting-Ting Jiang, Rong Zhang, Jian-Nan Li, Yi-Jie Zhai, Qiang Zhang, Ding Li, Wen-Bo Han. Ergostane-type sterols and sesquiterpenes with anti-neuroinflammatory activity from a Nigrograna species associated with Clematis shensiensis.
Phytochemistry.
2023 Jul; 211(?):113690. doi:
10.1016/j.phytochem.2023.113690. [PMID: 37150432] - Di Wen, Zhi Chen, Jiamin Wen, Qiangqiang Jia. Sterol Regulation of Development and 20-Hydroxyecdysone Biosynthetic and Signaling Genes in Drosophila melanogaster.
Cells.
2023 Jun; 12(13):. doi:
10.3390/cells12131739. [PMID: 37443773] - Martin Geiger, Sara Oppi, Stefanie Nusser-Stein, Sarah Costantino, Shafeeq Ahmed Mohammed, Era Gorica, Joanne A Hoogerland, Christian M Matter, Ana T Guillaumon, Frank Ruschitzka, Francesco Paneni, Maaike H Oosterveer, Sokrates Stein. Genetic deletion of hepatic NCOR1 protects from atherosclerosis by promoting alternative bile acid-metabolism and sterol excretion.
Cardiovascular diabetology.
2023 Jun; 22(1):144. doi:
10.1186/s12933-023-01865-w. [PMID: 37349757] - Chenchen Zhang, Wanlu Ma, Minyan Xu, Tao Li, Guomin Han, Longjiang Gu, Meng Chen, Mengting Zhang, Beijiu Cheng, Xin Zhang. Identification and Functional Characterization of ZmSCYL2 Involved in Phytosterol Accumulation in Plants.
International journal of molecular sciences.
2023 Jun; 24(12):. doi:
10.3390/ijms241210411. [PMID: 37373558] - Tristan Wegner, Anna L L Matos, Karine Porte, Kira Mehring, Marco Pierau, Hendrik Horstmeier, Volker Gerke, Frank Glorius. A bifunctional imidazolium-based cholesterol analog for the tracking of cellular cholesterol distributions and cholesterol-protein interactions.
Organic & biomolecular chemistry.
2023 06; 21(23):4817-4822. doi:
10.1039/d3ob00494e. [PMID: 37248844] - J B S K Jayantha, Farshid Mashayekhy Rad, J K Vidanarachchi, Jonas Bergquist, S J Kumari A Ubhayasekera. A fast ultra performance supercritical fluid chromatography-tandem mass spectrometric method for profiling of targeted phytosterols.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2023 Jun; 1225(?):123737. doi:
10.1016/j.jchromb.2023.123737. [PMID: 37210885] - Ena Cegledi, Maja Repajić, Sandra Balbino, Matea Peričić, Verica Dragović-Uzelac. Sterols and pentacyclic triterpenoids from nettle root: content and composition as affected by pressurized liquid extraction.
Journal of the science of food and agriculture.
2023 Jun; 103(8):4058-4067. doi:
10.1002/jsfa.12373. [PMID: 36478201] - XueMei Li, Xin Zeng, DoYeon Kim, Jian Jiang, Fen Wei, JingYu Zhang, Bao Chai, Li Fu, Young Lee, ChangDeok Kim, HongXiang Chen. Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1.
Biochemical and biophysical research communications.
2023 May; 667(?):146-152. doi:
10.1016/j.bbrc.2023.05.043. [PMID: 37229823] - Miki Hatada, Ryota Akiyama, Moeko Yamagishi, Kimitsune Ishizaki, Masaharu Mizutani. MpDWF5A-encoded sterol Δ7-reductase is essential for the normal growth and development of Marchantia polymorpha.
Plant & cell physiology.
2023 May; ?(?):. doi:
10.1093/pcp/pcad043. [PMID: 37178336] - Jun-Ichi Sakamaki, Noboru Mizushima. Cell biology of protein-lipid conjugation.
Cell structure and function.
2023 May; 48(1):99-112. doi:
10.1247/csf.23016. [PMID: 37019684] - Theodore L Steck, Yvonne Lange. Is reverse cholesterol transport regulated by active cholesterol?.
Journal of lipid research.
2023 May; ?(?):100385. doi:
10.1016/j.jlr.2023.100385. [PMID: 37169287] - Anna Grygier, Suryakant Chakradhari, Katarzyna Ratusz, Magdalena Rudzińska, Khageshwar Singh Patel, Danija Lazdiņa, Dalija Segliņa, Paweł Górnaś. Evaluation of Selected Medicinal, Timber and Ornamental Legume Species' Seed Oils as Sources of Bioactive Lipophilic Compounds.
Molecules (Basel, Switzerland).
2023 May; 28(10):. doi:
10.3390/molecules28103994. [PMID: 37241735] - Gabriel Hernández-Fernández, Miguel G Acedos, José L García, Beatriz Galán. Identification of the aldolase responsible for the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from natural sterols in Mycolicibacterium smegmatis.
Microbial biotechnology.
2023 May; ?(?):. doi:
10.1111/1751-7915.14270. [PMID: 37154793] - Kristelle Hughes, Thanh Binh Le, Patrick Van Der Smissen, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, Joëlle Quetin-Leclercq. The Antileishmanial Activity of Eugenol Associated with Lipid Storage Reduction Rather Than Membrane Properties Alterations.
Molecules (Basel, Switzerland).
2023 May; 28(9):. doi:
10.3390/molecules28093871. [PMID: 37175277] - Chaitanya S Haram, Samrat Moitra, Rilee Keane, F Matthew Kuhlmann, Cheryl Frankfater, Fong-Fu Hsu, Stephen M Beverley, Kai Zhang, Peter A Keyel. The sphingolipids ceramide and inositol phosphorylceramide protect the Leishmania major membrane from sterol-specific toxins.
The Journal of biological chemistry.
2023 Apr; ?(?):104745. doi:
10.1016/j.jbc.2023.104745. [PMID: 37094699] - Carmen A Nebauer, Marielle C Schleifer, Fabian A Ruedenauer, Sara D Leonhardt, Johannes Spaethe. Perception, regulation, and fitness effects of pollen phytosterols in the bumble bee, Bombus terrestris.
American journal of botany.
2023 Apr; ?(?):e16165. doi:
10.1002/ajb2.16165. [PMID: 37071779] - Ashlee M Plummer-Medeiros, Alan T Culbertson, Claudio L Morales-Perez, Maofu Liao. Activity and Structural Dynamics of Human ABCA1 in a Lipid Membrane.
Journal of molecular biology.
2023 Apr; 435(8):168038. doi:
10.1016/j.jmb.2023.168038. [PMID: 36889459] - Yi-Tse Liu, Jennifer Senkler, Cornelia Herrfurth, Hans-Peter Braun, Ivo Feussner. Defining the lipidome of Arabidopsis leaf mitochondria: Specific lipid complement and biosynthesis capacity.
Plant physiology.
2023 04; 191(4):2185-2203. doi:
10.1093/plphys/kiad035. [PMID: 36691154] - Ilijana Begcevic Brkovic, Madlen Reinicke, Soroth Chey, Ingo Bechmann, Uta Ceglarek. Characterization of Non-Cholesterol Sterols in Microglia Cell Membranes Using Targeted Mass Spectrometry.
Cells.
2023 03; 12(7):. doi:
10.3390/cells12070974. [PMID: 37048046] - Lydia Qian, Nicola A Scott, Isabelle M Capell-Hattam, Eliza A Draper, Nicole M Fenton, Winnie Luu, Laura J Sharpe, Andrew J Brown. Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6.
Journal of lipid research.
2023 Mar; ?(?):100362. doi:
10.1016/j.jlr.2023.100362. [PMID: 36958722] - Yunxiao Zhang, Philip A Beachy. Cellular and molecular mechanisms of Hedgehog signalling.
Nature reviews. Molecular cell biology.
2023 Mar; ?(?):. doi:
10.1038/s41580-023-00591-1. [PMID: 36932157] - Janathan Altuzar, Judith Notbohm, Frank Stein, Per Haberkant, Pia Hempelmann, Saskia Heybrock, Jutta Worsch, Paul Saftig, Doris Höglinger. Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor.
Proceedings of the National Academy of Sciences of the United States of America.
2023 03; 120(11):e2213886120. doi:
10.1073/pnas.2213886120. [PMID: 36893262] - Khondker R Hossain, Daniel R Turkewitz, Stephen A Holt, Anton P Le Brun, Stella M Valenzuela. Sterol Structural Features' Impact on the Spontaneous Membrane Insertion of CLIC1 into Artificial Lipid Membranes.
Langmuir : the ACS journal of surfaces and colloids.
2023 03; 39(9):3286-3300. doi:
10.1021/acs.langmuir.2c03129. [PMID: 36821411] - Chenchen Yang, Yinglian Zhao, Zhipan Luo, Ying Hu, Shuxian Wang, Shuang Hu, Yan Yao, Linxin Pan, Chuanpu Shen, Tao Xu. Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38α in Alcoholic Liver Disease.
Planta medica.
2023 Mar; 89(3):273-285. doi:
10.1055/a-1878-3991. [PMID: 35714651] - Weizhen Wang, Zhaolin Xue, Linfang Xie, Xin Zhou, Fan Zhang, Sicong Zhang, Francine Govers, Xili Liu. Sterol-Sensing Domain (SSD)-Containing Proteins in Sterol Auxotrophic Phytophthora capsici Mediate Sterol Signaling and Play a Role in Asexual Reproduction and Pathogenicity.
Microbiology spectrum.
2023 02; 11(1):e0379722. doi:
10.1128/spectrum.03797-22. [PMID: 36629430] - Nina Kubatova, Thomas Schmidt, Charles D Schwieters, G Marius Clore. Quantitative analysis of sterol-modulated monomer-dimer equilibrium of the β1-adrenergic receptor by DEER spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America.
2023 Feb; 120(7):e2221036120. doi:
10.1073/pnas.2221036120. [PMID: 36745787] - Yvonne Lange, S M Ali Tabei, Theodore L Steck. A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding.
Journal of lipid research.
2023 Feb; ?(?):100344. doi:
10.1016/j.jlr.2023.100344. [PMID: 36791915] - Yutaka Ishibashi, Hiroshi Yoshida, Kazuhiko Kotani, Yusuke Akiyama, Hisako Fujii, Mariko Harada-Shiba, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Kota Matsuki, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Shozo Yano, Hisako Yoshida, Shoji Tetsuo. Serum Values of Cholesterol Absorption and Synthesis Biomarkers in Japanese Healthy Subjects: The CACHE Study HEALTHY Analysis.
Journal of atherosclerosis and thrombosis.
2023 Feb; ?(?):. doi:
10.5551/jat.63943. [PMID: 36740276] - Estelle Morvan, Nada Taib-Maamar, Axelle Grélard, Antoine Loquet, Erick J Dufourc. Bio-membranes: Picosecond to second dynamics and plasticity as deciphered by solid state NMR.
Biochimica et biophysica acta. Biomembranes.
2023 02; 1865(2):184097. doi:
10.1016/j.bbamem.2022.184097. [PMID: 36442647] - Yunling Wang, Jinyue Yang, Yuming Wang, Yaoguang Chang, Changhu Xue, Tiantian Zhang. Preparation and properties of fucoxanthin-loaded liposomes stabilized by sea cucumber derived cholesterol sulfate instead of cholesterol.
Journal of bioscience and bioengineering.
2023 Feb; 135(2):160-166. doi:
10.1016/j.jbiosc.2022.11.004. [PMID: 36494249] - Suzanne A E van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J A Hendriks, Jeroen F J Bogie, Jan B van Klinken, Frederic M Vaz, Aldo Jongejan, Menno P J de Winther, Noam Zelcer. Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
Journal of lipid research.
2023 Feb; 64(2):100325. doi:
10.1016/j.jlr.2022.100325. [PMID: 36592658] - Wei Luo, Julia Z Adamska, Chunfeng Li, Rohit Verma, Qing Liu, Thomas Hagan, Florian Wimmers, Shakti Gupta, Yupeng Feng, Wenxia Jiang, Jiehao Zhou, Erika Valore, Yanli Wang, Meera Trisal, Shankar Subramaniam, Timothy F Osborne, Bali Pulendran. SREBP signaling is essential for effective B cell responses.
Nature immunology.
2023 02; 24(2):337-348. doi:
10.1038/s41590-022-01376-y. [PMID: 36577930] - Julia Borzyszkowska-Bukowska, Jacek Czub, Paweł Szczeblewski, Tomasz Laskowski. Antibiotic-sterol interactions provide insight into the selectivity of natural aromatic analogues of amphotericin B and their photoisomers.
Scientific reports.
2023 Jan; 13(1):762. doi:
10.1038/s41598-023-28036-x. [PMID: 36641464] - Lin Zhu, Jie-Jie Xu, Hai-Di Li, Juan-Juan Li, Miao Cheng, Xue-Ni Niu, Peng-Cheng Jia, Jing-Yu Liu, Cheng Huang, Xiong-Wen Lv, Jun Li. Berberine Ameliorates Abnormal Lipid Metabolism via the Adenosine Monophosphate-Activated Protein Kinase/Sirtuin 1 Pathway in Alcohol-Related Liver Disease.
Laboratory investigation; a journal of technical methods and pathology.
2023 Jan; 103(4):100041. doi:
10.1016/j.labinv.2022.100041. [PMID: 36870291] - Na Zhan, Boyang Wang, Nikita Martens, Yankai Liu, Shangge Zhao, Gardi Voortman, Jeroen van Rooij, Frank Leijten, Tim Vanmierlo, Folkert Kuipers, Johan W Jonker, Vincent W Bloks, Dieter Lütjohann, Marcella Palumbo, Francesca Zimetti, Maria Pia Adorni, Hongbing Liu, Monique T Mulder. Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases.
International journal of molecular sciences.
2023 Jan; 24(2):. doi:
10.3390/ijms24021290. [PMID: 36674804] - Yong-Nan Liu, Feng-Yuan Wu, Ren-Yuan Tian, Yi-Xin Shi, Zi-Qi Xu, Ji-Ye Liu, Jia Huang, Fei-Fei Xue, Bi-Yang Liu, Gao-Qiang Liu. The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi.
Communications biology.
2023 01; 6(1):1. doi:
10.1038/s42003-022-04154-6. [PMID: 36596887] - Caitlin E O'Brien, Susan H Younger, Lily Yeh Jan, Yuh Nung Jan. The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling.
The Journal of cell biology.
2023 01; 222(1):. doi:
10.1083/jcb.202112108. [PMID: 36239632]