Carnosol (BioDeep_00000000044)

   

human metabolite PANOMIX_OTCML-2023 Antitumor activity Volatile Flavor Compounds natural product


代谢物信息卡片


2H-9,4A-(EPOXYMETHANO)PHENANTHREN-12-ONE, 1,3,4,9,10,10A-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-(1-METHYLETHYL)-, (4AR-(4A.ALPHA.,9.ALPHA.,10A.BETA.))-

化学式: C20H26O4 (330.18309960000005)
中文名称: 鼠尾草酚, 鼠尾草苦内脂
谱图信息: 最多检出来源 Viridiplantae(otcml) 1.28%

分子结构信息

SMILES: CC(C)C1=C(C(=C2C(=C1)C3CC4C2(CCCC4(C)C)C(=O)O3)O)O
InChI: InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1

描述信息

Carnosol is a naturally occurring phenolic diterpene found in rosemary (Rosemarinus officinalis, Labiatae). It has been known that an extract of rosemary leaves contains high antioxidative activity. Ninety percent of this antioxidative activity can be attributed to carnosol and carnosic acid. Carnosic acid is easily converted to carnosol by oxidation. Carnosol has multiple beneficial medicinal effects including anti-inflammatory, anti-microbial and anti-cancer activities in various disease models. Carnosol may possess important neuroprotective effects against rotenone-induced DA neuronal damage. Naturally occurring antioxidants reduce the risk of neurodegenerative diseases. In addition, carnosol and carnosic acid promoted the synthesis of nerve growth factor in glial cells. Carnosol-mediated neuroprotection in DA neurons is involved in the attenuation of caspase-3 activity, which was induced by rotenone. Furthermore, carnosol-mediated tyrosine hydroxylase (TH) increase, which is dependent on the Raf-mitogen-activated protein kinase (MEK)-extracellular signal-regulated kinase (ERK)1/2 signaling pathway, is responsible for the neuroprotection in SN4741 DA cells. (PMID: 17047462). Carnosol, a phenolic diterpene compound of the labiate herbs rosemary and sage, is an activator of the human peroxisome proliferator-activated receptor gamma (PPARgamma), a ligand activated transcription factor, belonging to the metazoan family of nuclear hormone receptors. Activation of PPARgamma increases the transcription of enzymes involved in primary metabolism, leading to lower blood levels of fatty acids and glucose. Hence, PPARgamma represents the major target for the glitazone type of drugs currently being used clinically for the treatment of type 2 diabetes. (PMID: 16858665).
Bitter principle in Salvia carnosa, Salvia officinalis (sage), Salvia triloba (Greek sage) and Rosmarinus officinalis (rosemary). Nutriceutical with anticancer props.
Carnosol is a diterpenoid.
Carnosol is a natural product found in Podocarpus rumphii, Lepechinia salviae, and other organisms with data available.

同义名列表

18 个代谢物同义名

2H-9,4A-(EPOXYMETHANO)PHENANTHREN-12-ONE, 1,3,4,9,10,10A-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-(1-METHYLETHYL)-, (4AR-(4A.ALPHA.,9.ALPHA.,10A.BETA.))-; 2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR-(4aalpha,9alpha,10abeta))-; 2H-9,4A-(EPOXYMETHANO)PHENANTHREN-12-ONE, 1,3,4,9,10,10A-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-(1-METHYLETHYL)-, (4AR,9S,10AS)-; (1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-(propan-2-yl)-16-oxatetracyclo[6.6.2.0^{1,10}.0^{2,7}]hexadeca-2,4,6-trien-15-one; (4aR,9S,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydro-1H-9,4a-(epoxymethano)phenanthren-12-one; (1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-(propan-2-yl)-16-oxatetracyclo[6.6.2.0¹,¹⁰.0²,⁷]hexadeca-2,4,6-trien-15-one; (1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one; (1R,8S,10S)-3,4-dihydroxy-5-isopropyl-11,11-dimethyl-16-oxatetracyclo[6.6.2.0¹,¹⁰.0²,⁷]hexadeca-2,4,6-trien-15-one; 1,3,4,9,10,10aS-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one; PODOCARPA-8,11,13-TRIEN-17-OIC ACID, 7.BETA.,11,12-TRIHYDROXY-13-ISOPROPYL-, 17,7-LACTONE; CARNOSOL (CONSTITUENT OF ROSEMARY) [DSC]; Carnosol, analytical standard; CARNOSOL [HSDB]; CARNOSOL [MI]; Picrosalvin; Carnosol; MEGxp0_001119; Carnosol



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

77 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xingbing Li, Shuo Wang, Minghao Luo, Ming Wang, Shaoping Wu, Chang Liu, Fengxian Wang, Yong Li. Carnosol alleviates sepsis-induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2-related factor 2/sirtuin-3 signaling pathway to attenuate oxidative damage. Phytotherapy research : PTR. 2024 May; 38(5):2182-2197. doi: 10.1002/ptr.8138. [PMID: 38414287]
  • Hayate Higashino, Asuka Karatsu, Toshiya Masuda. Catalytic Antioxidant Activity of Two Diterpenoid Polyphenols of Rosemary, Carnosol, and Isorosmanol, against Lipid Oxidation in the Presence of Cysteine Thiol. Journal of agricultural and food chemistry. 2024 Jan; 72(4):2193-2201. doi: 10.1021/acs.jafc.3c08248. [PMID: 38254316]
  • Panagiotis Kallimanis, Prokopios Magiatis, Angeliki Panagiotopoulou, Kostas Ioannidis, Ioanna Chinou. Extraction Optimization and Qualitative/Quantitative Determination of Bioactive Abietane-Type Diterpenes from Three Salvia Species (Common Sage, Greek Sage and Rosemary) by 1H-qNMR. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030625. [PMID: 38338370]
  • Xiaojuan Pan, Gang Zhang, Kun Wei, Xiaofan Gu, Jiahuan Dan, Yun Zhao, Xuan Liu, Chunru Cheng, Xiongwen Zhang. Carnosol analogue WK-63 alleviated cancer cachexia by inhibiting NF-κB and activating AKT pathways in muscle while inhibiting NF-κB and AMPK pathways in adipocyte. Toxicology and applied pharmacology. 2023 Nov; 479(?):116729. doi: 10.1016/j.taap.2023.116729. [PMID: 37863360]
  • Agnieszka M Hrebień-Filisińska, Grzegorz Tokarczyk. The Use of Ultrasound-Assisted Maceration for the Extraction of Carnosic Acid and Carnosol from Sage (Salvia officinalis L.) Directly into Fish Oil. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166094. [PMID: 37630345]
  • Antonio Raffo, Irene Baiamonte, Laura De Benedetti, Elisabetta Lupotto, Ilaria Marchioni, Nicoletta Nardo, Claudio Cervelli. Exploring volatile aroma and non-volatile bioactive compounds diversity in wild populations of rosemary (Salvia rosmarinus Schleid.). Food chemistry. 2023 Mar; 404(Pt A):134532. doi: 10.1016/j.foodchem.2022.134532. [PMID: 36242966]
  • Rui Ji, Fangyuan Jia, Xin Chen, Yue Gao, Jing Yang. Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7749. [PMID: 36786429]
  • Nemesio Villa-Ruano, Néstor Hernández-Silva, Jenaro Leocadio Varela-Caselis, Sergio Alberto-Ramirez-Garcia, Clemente Mosso-González. Controlled Production of Carnosic Acid and Carnosol in Cell Suspensions of Lepechinia meyenii Treated with Different Elicitors and Biosynthetic Precursors. Chemistry & biodiversity. 2023 Feb; 20(2):e202200733. doi: 10.1002/cbdv.202200733. [PMID: 36562957]
  • Jun Chen, Nianzhe Sun, Fuhan Li, Haolin Li, Jiale Tian, Songguo Zheng, Li Zhang, Haidong Wang, Yang Luo. Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells. BioMed research international. 2023; 2023(?):1179973. doi: 10.1155/2023/1179973. [PMID: 37415927]
  • Ji-Xia Kuang, Qiang Shen, Rui-Qin Zhang, Qiao-Yu Fang, Xue Deng, Meng Fan, Chun-Ru Cheng, Xiong-Wen Zhang, Xuan Liu. Carnosol attenuated atrophy of C2C12 myotubes induced by tumour-derived exosomal miR-183-5p through inhibiting Smad3 pathway activation and keeping mitochondrial respiration. Basic & clinical pharmacology & toxicology. 2022 Dec; 131(6):500-513. doi: 10.1111/bcpt.13795. [PMID: 36150451]
  • Sylvia L Anderson, Faaria Fasih-Ahmad, Anthony J Evans, Berish Y Rubin. Carnosol, a diterpene present in rosemary, increases ELP1 levels in familial dysautonomia patient-derived cells and healthy adults: a possible therapy for FD. Human molecular genetics. 2022 10; 31(20):3521-3538. doi: 10.1093/hmg/ddac133. [PMID: 35708500]
  • Longfei Yang, Yujie Sui, Lili Zhong, Tonghui Ma, Zhiming Ma, Xin Liu. Carnosol inhibits the growth and biofilm of Candida albicans. Journal de mycologie medicale. 2022 May; 32(2):101234. doi: 10.1016/j.mycmed.2021.101234. [PMID: 34929524]
  • Lianchun Li, Zhenghong Pan, Desheng Ning, Yuxia Fu. Rosmanol and Carnosol Synergistically Alleviate Rheumatoid Arthritis through Inhibiting TLR4/NF-κB/MAPK Pathway. Molecules (Basel, Switzerland). 2021 Dec; 27(1):. doi: 10.3390/molecules27010078. [PMID: 35011304]
  • Hadi Kalantar, Elahe Sadeghi, Farhad Abolnezhadian, Mehdi Goudarzi, Ali Asghar Hemmati, Zahra Basir, Mojtaba Kalantar. Carnosol attenuates bleomycin-induced lung damage via suppressing fibrosis, oxidative stress and inflammation in rats. Life sciences. 2021 Dec; 287(?):120059. doi: 10.1016/j.lfs.2021.120059. [PMID: 34728227]
  • Yunfei Geng, Yue Wang, Ruimin Sun, Xiaohui Kang, Huanyu Zhao, Meiyang Zhu, Yu Sun, Yan Hu, Zhecheng Wang, Xiaofeng Tian, Yan Zhao, Jihong Yao. Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3. Toxicology and applied pharmacology. 2021 12; 432(?):115758. doi: 10.1016/j.taap.2021.115758. [PMID: 34678374]
  • Sylvie Morel, Gérald Hugon, Manon Vitou, Marie Védère, Françoise Fons, Sylvie Rapior, Nathalie Saint, Gilles Carnac. A Bioassay-Guided Fractionation of Rosemary Leaf Extract Identifies Carnosol as a Major Hypertrophy Inducer in Human Skeletal Muscle Cells. Nutrients. 2021 Nov; 13(12):. doi: 10.3390/nu13124190. [PMID: 34959741]
  • Bhaskar Vemu, Restituo Tocmo, Mirielle C Nauman, Stephanie A Flowers, Jacob P Veenstra, Jeremy J Johnson. Pharmacokinetic characterization of carnosol from rosemary (Salvia Rosmarinus) in male C57BL/6 mice and inhibition profile in human cytochrome P450 enzymes. Toxicology and applied pharmacology. 2021 11; 431(?):115729. doi: 10.1016/j.taap.2021.115729. [PMID: 34592323]
  • Shanshan Lu, Yiwei Li, Qiang Shen, Wanli Zhang, Xiaofan Gu, Mingliang Ma, Yiming Li, Liuqiang Zhang, Xuan Liu, Xiongwen Zhang. Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia. Journal of cachexia, sarcopenia and muscle. 2021 06; 12(3):779-795. doi: 10.1002/jcsm.12710. [PMID: 33951335]
  • Shun Hasei, Takeshi Yamamotoya, Yusuke Nakatsu, Yukino Ohata, Shota Itoga, Yuji Nonaka, Yasuka Matsunaga, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Tomoichiro Asano. Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22084040. [PMID: 33919842]
  • Jacob P Veenstra, Bhaskar Vemu, Restituto Tocmo, Mirielle C Nauman, Jeremy J Johnson. Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis. Nutrients. 2021 Feb; 13(3):. doi: 10.3390/nu13030773. [PMID: 33673488]
  • Thibault Lefebvre, Emilie Destandau, Eric Lesellier. Sequential extraction of carnosic acid, rosmarinic acid and pigments (carotenoids and chlorophylls) from Rosemary by online supercritical fluid extraction-supercritical fluid chromatography. Journal of chromatography. A. 2021 Feb; 1639(?):461709. doi: 10.1016/j.chroma.2020.461709. [PMID: 33234291]
  • Zahra Sadeghi, Milena Masullo, Antonietta Cerulli, Filomena Nazzaro, Mahdi Moridi Farimani, Sonia Piacente. Terpenoid Constituents of Perovskia artemisioides Aerial Parts with Inhibitory Effects on Bacterial Biofilm Growth. Journal of natural products. 2021 01; 84(1):26-36. doi: 10.1021/acs.jnatprod.0c00832. [PMID: 33378620]
  • Wei Shi, Guang Xu, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Nan Qin, Xiaorong Hou, Yongqiang Ai, Chunyu Wang, Tingting He, Hongbin Liu, Yuanyuan Chen, Yan Liu, Jiabo Wang, Ming Niu, Yuming Guo, Xiaohe Xiao, Zhaofang Bai. Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases. Cell death & disease. 2020 04; 11(4):252. doi: 10.1038/s41419-020-2460-x. [PMID: 32312957]
  • María D Mira-Sánchez, Julián Castillo-Sánchez, Juana María Morillas-Ruiz. Comparative study of rosemary extracts and several synthetic and natural food antioxidants. Relevance of carnosic acid/carnosol ratio. Food chemistry. 2020 Mar; 309(?):125688. doi: 10.1016/j.foodchem.2019.125688. [PMID: 31732249]
  • Tian-Qi Bao, Yi Li, Cheng Qu, Zu-Guo Zheng, Hua Yang, Ping Li. Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalis L.) and its Phenolic Components. The American journal of Chinese medicine. 2020; 48(6):1353-1368. doi: 10.1142/s0192415x20500664. [PMID: 33016104]
  • Antonios Koutsoulas, Martina Čarnecká, Jiří Slanina, Jaroslav Tóth, Iva Slaninová. Characterization of Phenolic Compounds and Antiproliferative Effects of Salvia pomifera and Salvia fruticosa Extracts. Molecules (Basel, Switzerland). 2019 Aug; 24(16):. doi: 10.3390/molecules24162921. [PMID: 31408993]
  • In Jun Yeo, Ju Ho Park, Jun Sung Jang, Do Yeon Lee, Jung Eun Park, Ye Eun Choi, Jung Hun Joo, Joo Kyung Song, Hyung Ok Jeon, Jin Tae Hong. Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3. Archives of pharmacal research. 2019 Mar; 42(3):274-283. doi: 10.1007/s12272-018-1088-1. [PMID: 30430364]
  • Nicole K Campbell, Hannah K Fitzgerald, Jean M Fletcher, Aisling Dunne. Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1. Frontiers in immunology. 2019; 10(?):345. doi: 10.3389/fimmu.2019.00345. [PMID: 30881359]
  • Yi Zheng, Yong Zhang, Yichun Zheng, Nan Zhang. Carnosol protects against renal ischemia-reperfusion injury in rats. Experimental animals. 2018 Nov; 67(4):545-553. doi: 10.1538/expanim.18-0067. [PMID: 30068825]
  • Xujian Qiu, Charlotte Jacobsen, Ann-Dorit Moltke Sørensen. The effect of rosemary (Rosmarinus officinalis L.) extract on the oxidative stability of lipids in cow and soy milk enriched with fish oil. Food chemistry. 2018 Oct; 263(?):119-126. doi: 10.1016/j.foodchem.2018.04.106. [PMID: 29784296]
  • Nicole K Campbell, Hannah K Fitzgerald, Anna Malara, Roisin Hambly, Cheryl M Sweeney, Brian Kirby, Jean M Fletcher, Aisling Dunne. Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment. Scientific reports. 2018 07; 8(1):10287. doi: 10.1038/s41598-018-28488-6. [PMID: 29980703]
  • Haroon Khan, Kannan R R Rengasamy, Aini Pervaiz, Seyed Mohammad Nabavi, Atanas G Atanasov, Mohammad A Kamal. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation. European journal of medicinal chemistry. 2018 Jun; 153(?):2-28. doi: 10.1016/j.ejmech.2017.12.059. [PMID: 29329790]
  • Filip Vlavcheski, David Baron, Ioannis A Vlachogiannis, Rebecca E K MacPherson, Evangelia Tsiani. Carnosol Increases Skeletal Muscle Cell Glucose Uptake via AMPK-Dependent GLUT4 Glucose Transporter Translocation. International journal of molecular sciences. 2018 Apr; 19(5):. doi: 10.3390/ijms19051321. [PMID: 29710819]
  • Cathy Su, Jeffrey P Gius, Julia Van Steenberg, Alexis H Haskins, Kazuki Heishima, Chisato Omata, Masahiro Iwayama, Mami Murakami, Takashi Mori, Kohji Maruo, Takamitsu A Kato. Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity. Scientific reports. 2017 12; 7(1):16704. doi: 10.1038/s41598-017-16795-3. [PMID: 29196727]
  • Margot Loussouarn, Anja Krieger-Liszkay, Ljubica Svilar, Antoine Bily, Simona Birtić, Michel Havaux. Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms. Plant physiology. 2017 Nov; 175(3):1381-1394. doi: 10.1104/pp.17.01183. [PMID: 28916593]
  • Radhakrishnan Srivedavyasasri, Taylor Hayes, Samir A Ross. Phytochemical and biological evaluation of Salvia apiana. Natural product research. 2017 Sep; 31(17):2058-2061. doi: 10.1080/14786419.2016.1269096. [PMID: 28025900]
  • Jordi Ortuño, Rafael Serrano, Sancho Bañón. Incorporating rosemary diterpenes in lamb diet to improve microbial quality of meat packed in different environments. Animal science journal = Nihon chikusan Gakkaiho. 2017 Sep; 88(9):1436-1445. doi: 10.1111/asj.12768. [PMID: 28139059]
  • Salma Saoudi, Nadia Chammem, Ines Sifaoui, Ignacio A Jiménez, Jacob Lorenzo-Morales, José E Piñero, Maha Bouassida-Beji, Moktar Hamdi, Isabel L Bazzocchi. Combined effect of carnosol, rosmarinic acid and thymol on the oxidative stability of soybean oil using a simplex centroid mixture design. Journal of the science of food and agriculture. 2017 Aug; 97(10):3300-3311. doi: 10.1002/jsfa.8179. [PMID: 27976408]
  • Saeed Samarghandian, Abasalt Borji, Tahere Farkhondeh. Evaluation of Antidiabetic Activity of Carnosol (Phenolic Diterpene in Rosemary) in Streptozotocin-Induced Diabetic Rats. Cardiovascular & hematological disorders drug targets. 2017 07; 17(1):11-17. doi: 10.2174/1871529x16666161229154910. [PMID: 28034282]
  • Chun Ling Seow, Aik Jiang Lau. Differential activation of pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid. Pharmacological research. 2017 Jun; 120(?):23-33. doi: 10.1016/j.phrs.2017.03.007. [PMID: 28288941]
  • Saeed Samarghandian, Mohsen Azimi-Nezhad, Abasalt Borji, Mohammad Samini, Tahereh Farkhondeh. Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats. BMC complementary and alternative medicine. 2017 May; 17(1):249. doi: 10.1186/s12906-017-1753-9. [PMID: 28472953]
  • Mary H Grace, Yin Qiang, Shengmin Sang, Mary Ann Lila. One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography. Journal of separation science. 2017 Mar; 40(5):1057-1062. doi: 10.1002/jssc.201601063. [PMID: 28008719]
  • Andrea Del Pilar Sánchez-Camargo, Virginia García-Cañas, Miguel Herrero, Alejandro Cifuentes, Elena Ibáñez. Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells. International journal of molecular sciences. 2016 Dec; 17(12):. doi: 10.3390/ijms17122046. [PMID: 27941607]
  • Gerlon de A R Oliveira, Anselmo E de Oliveira, Edemílson C da Conceição, Maria I G Leles. Multiresponse optimization of an extraction procedure of carnosol and rosmarinic and carnosic acids from rosemary. Food chemistry. 2016 Nov; 211(?):465-73. doi: 10.1016/j.foodchem.2016.05.042. [PMID: 27283656]
  • Ulschan Scheler, Wolfgang Brandt, Andrea Porzel, Kathleen Rothe, David Manzano, Dragana Božić, Dimitra Papaefthimiou, Gerd Ulrich Balcke, Anja Henning, Swanhild Lohse, Sylvestre Marillonnet, Angelos K Kanellis, Albert Ferrer, Alain Tissier. Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast. Nature communications. 2016 10; 7(?):12942. doi: 10.1038/ncomms12942. [PMID: 27703160]
  • Elodie Bouju, Alain Berthod, Karine Faure. Carnosol purification. Scaling-up centrifugal partition chromatography separations. Journal of chromatography. A. 2016 Sep; 1466(?):59-66. doi: 10.1016/j.chroma.2016.08.015. [PMID: 27590084]
  • Minori Yamahara, Koji Sugimura, Ayako Kumagai, Hiroyuki Fuchino, Azusa Kuroi, Mai Kagawa, Yumi Itoh, Hidehisa Kawahara, Yasuo Nagaoka, Osamu Iida, Nobuo Kawahara, Hiroshi Takemori, Hideto Watanabe. Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells. Journal of natural medicines. 2016 Jan; 70(1):28-35. doi: 10.1007/s11418-015-0933-5. [PMID: 26267810]
  • Zhi-Hui Wang, Yu-Xi Xie, Jun-Wei Zhang, Xiao-Hua Qiu, Ai-Bin Cheng, Li Tian, Bao-Yin Ma, Yu-Bo Hou. Carnosol protects against spinal cord injury through Nrf-2 upregulation. Journal of receptor and signal transduction research. 2016; 36(1):72-8. doi: 10.3109/10799893.2015.1049358. [PMID: 26791582]
  • Jordi Ortuño, Rafael Serrano, Sancho Bañón. Antioxidant and antimicrobial effects of dietary supplementation with rosemary diterpenes (carnosic acid and carnosol) vs vitamin E on lamb meat packed under protective atmosphere. Meat science. 2015 Dec; 110(?):62-9. doi: 10.1016/j.meatsci.2015.07.011. [PMID: 26186399]
  • Sakina M Petiwala, Jeremy J Johnson. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity. Cancer letters. 2015 Oct; 367(2):93-102. doi: 10.1016/j.canlet.2015.07.005. [PMID: 26170168]
  • Margareta Kračun-Kolarević, Slavica Dmitrović, Biljana Filipović, Marija Perić, Danijela Mišić, Ana Simonović, Slađana Todorović. Influence of sodium salicylate on rosmarinic acid, carnosol and carnosic acid accumulation by Salvia officinalis L. shoots grown in vitro. Biotechnology letters. 2015 Aug; 37(8):1693-701. doi: 10.1007/s10529-015-1825-1. [PMID: 25836371]
  • T Kawamura, T Momozane, M Sanosaka, K Sugimura, O Iida, H Fuchino, S Funaki, Y Shintani, M Inoue, M Minami, N Kawahara, H Takemori, M Okumura. Carnosol Is a Potent Lung Protective Agent: Experimental Study on Mice. Transplantation proceedings. 2015 Jul; 47(6):1657-61. doi: 10.1016/j.transproceed.2015.05.004. [PMID: 26293030]
  • Simona Birtić, Pierre Dussort, François-Xavier Pierre, Antoine C Bily, Marc Roller. Carnosic acid. Phytochemistry. 2015 Jul; 115(?):9-19. doi: 10.1016/j.phytochem.2014.12.026. [PMID: 25639596]
  • Ana C Carvalho, Andreia C Gomes, Cristina Pereira-Wilson, Cristovao F Lima. Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence. Free radical biology & medicine. 2015 Jun; 83(?):262-72. doi: 10.1016/j.freeradbiomed.2015.02.022. [PMID: 25744415]
  • Mariano Walter Pertino, Cristina Theoduloz, Estefania Butassi, Susana Zacchino, Guillermo Schmeda-Hirschmann. Synthesis, antiproliferative and antifungal activities of 1,2,3-triazole-substituted carnosic Acid and carnosol derivatives. Molecules (Basel, Switzerland). 2015 May; 20(5):8666-86. doi: 10.3390/molecules20058666. [PMID: 26007173]
  • Vassiliki Exarchou, Loukas Kanetis, Zenovia Charalambous, Sandra Apers, Luc Pieters, Vassilis Gekas, Vlasios Goulas. HPLC-SPE-NMR characterization of major metabolites in Salvia fruticosa Mill. extract with antifungal potential: relevance of carnosic acid, carnosol, and hispidulin. Journal of agricultural and food chemistry. 2015 Jan; 63(2):457-63. doi: 10.1021/jf5050734. [PMID: 25537192]
  • Lucia Cattaneo, Rosella Cicconi, Giuseppina Mignogna, Alessandra Giorgi, Maurizio Mattei, Giulia Graziani, Rosalia Ferracane, Alessandro Grosso, Patrizia Aducci, M Eugenia Schininà, Mauro Marra. Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. PloS one. 2015; 10(7):e0132439. doi: 10.1371/journal.pone.0132439. [PMID: 26176704]
  • Margarita González-Vallinas, Guillermo Reglero, Ana Ramírez de Molina. Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy. Nutrition and cancer. 2015; 67(8):1221-9. doi: 10.1080/01635581.2015.1082110. [PMID: 26452641]
  • Chenxi Zhai, Qing Liu, Yuxin Zhang, Shifeng Wang, Yanling Zhang, Shiyou Li, Yanjiang Qiao. Identification of natural compound carnosol as a novel TRPA1 receptor agonist. Molecules (Basel, Switzerland). 2014 Nov; 19(11):18733-46. doi: 10.3390/molecules191118733. [PMID: 25405290]
  • Isabel Borrás-Linares, Zorica Stojanović, Rosa Quirantes-Piné, David Arráez-Román, Jaroslava Švarc-Gajić, Alberto Fernández-Gutiérrez, Antonio Segura-Carretero. Rosmarinus officinalis leaves as a natural source of bioactive compounds. International journal of molecular sciences. 2014 Nov; 15(11):20585-606. doi: 10.3390/ijms151120585. [PMID: 25391044]
  • M Miroddi, G Calapai, S Isola, P L Minciullo, S Gangemi. Rosmarinus officinalis L. as cause of contact dermatitis. Allergologia et immunopathologia. 2014 Nov; 42(6):616-9. doi: 10.1016/j.aller.2013.04.006. [PMID: 23827646]
  • Alberto Valdés, Virginia García-Cañas, Carolina Simó, Clara Ibáñez, Vicente Micol, Jose A Ferragut, Alejandro Cifuentes. Comprehensive foodomics study on the mechanisms operating at various molecular levels in cancer cells in response to individual rosemary polyphenols. Analytical chemistry. 2014 Oct; 86(19):9807-15. doi: 10.1021/ac502401j. [PMID: 25188358]
  • Cecilia Labbé, Francesca Faini, Daniela Calderón, Juanita Molina, Susana Arredondo. Variations of carnosic acid and carnosol concentrations in ethanol extracts of wild Lepechinia salviae in Spring (2008-2011). Natural product communications. 2014 Oct; 9(10):1413-6. doi: . [PMID: 25522527]
  • Jordi Ortuño, Rafael Serrano, María José Jordán, Sancho Bañón. Shelf life of meat from lambs given essential oil-free rosemary extract containing carnosic acid plus carnosol at 200 or 400 mg kg⁻¹. Meat science. 2014 Apr; 96(4):1452-9. doi: 10.1016/j.meatsci.2013.11.021. [PMID: 24412737]
  • Dengfeng Tang, Guo Ma, Luyan Zhang, Gang Chen. Graphene-epoxy composite electrode fabricated by in situ polycondensation for enhanced amperometric detection in capillary electrophoresis. Journal of chromatography. A. 2013 Nov; 1316(?):127-34. doi: 10.1016/j.chroma.2013.09.077. [PMID: 24119752]
  • Fabrice H F Pierre, Océane C B Martin, Raphaelle L Santarelli, Sylviane Taché, Nathalie Naud, Françoise Guéraud, Marc Audebert, Jacques Dupuy, Nathalie Meunier, Didier Attaix, Jean-Luc Vendeuvre, Sidney S Mirvish, Gunter C G Kuhnle, Noel Cano, Denis E Corpet. Calcium and α-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers. The American journal of clinical nutrition. 2013 Nov; 98(5):1255-62. doi: 10.3945/ajcn.113.061069. [PMID: 24025632]
  • Julia Salvan da Rosa, Bruno Matheus Facchin, Juliana Bastos, Mariana Araújo Siqueira, Gustavo Amadeu Micke, Eduardo Monguilhott Dalmarco, Moacir Geraldo Pizzolatti, Tânia Silvia Fröde. Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy. Planta medica. 2013 Nov; 79(17):1605-14. doi: 10.1055/s-0033-1351018. [PMID: 24288274]
  • María Romo Vaquero, Rocío García Villalba, Mar Larrosa, María J Yáñez-Gascón, Emilie Fromentin, John Flanagan, Marc Roller, Francisco A Tomás-Barberán, Juan C Espín, María-Teresa García-Conesa. Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats. Molecular nutrition & food research. 2013 Oct; 57(10):1834-46. doi: 10.1002/mnfr.201300052. [PMID: 23625681]
  • Justin T Fischedick, Miranda Standiford, Delinda A Johnson, Jeffrey A Johnson. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. Bioorganic & medicinal chemistry. 2013 May; 21(9):2618-22. doi: 10.1016/j.bmc.2013.02.019. [PMID: 23507152]
  • F Emami, H Ali-Beig, S Farahbakhsh, N Mojabi, B Rastegar-Moghadam, S Arbabian, M Kazemi, E Tekieh, L Golmanesh, M Ranjbaran, C Jalili, A Noroozzadeh, H Sahraei. Hydroalcoholic extract of Rosemary (Rosmarinus officinalis L.) and its constituent carnosol inhibit formalin-induced pain and inflammation in mice. Pakistan journal of biological sciences : PJBS. 2013 Apr; 16(7):309-16. doi: 10.3923/pjbs.2013.309.316. [PMID: 24498797]
  • Tsung-Hsien Tsai, Lu-Te Chuang, Tsung-Jung Lien, Yau-Rong Liing, Wei-Yu Chen, Po-Jung Tsai. Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. Journal of medicinal food. 2013 Apr; 16(4):324-33. doi: 10.1089/jmf.2012.2577. [PMID: 23514231]
  • Auxiliadora López-Jiménez, Melissa García-Caballero, Miguel Ángel Medina, Ana R Quesada. Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. European journal of nutrition. 2013 Feb; 52(1):85-95. doi: 10.1007/s00394-011-0289-x. [PMID: 22173778]
  • Daniele G Machado, Mauricio P Cunha, Vivian B Neis, Grasiela O Balen, André Colla, Luis E B Bettio, Agatha Oliveira, Francis Leonardo Pazini, Juliana B Dalmarco, Edésio Luiz Simionatto, Moacir G Pizzolatti, Ana Lúcia S Rodrigues. Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L. Food chemistry. 2013 Jan; 136(2):999-1005. doi: 10.1016/j.foodchem.2012.09.028. [PMID: 23122155]
  • In Gyeong Chae, Mi Hee Yu, Nam-Kyung Im, Young Tae Jung, Jinho Lee, Kyung-Soo Chun, In-Seon Lee. Effect of Rosemarinus officinalis L. on MMP-9, MCP-1 levels, and cell migration in RAW 264.7 and smooth muscle cells. Journal of medicinal food. 2012 Oct; 15(10):879-86. doi: 10.1089/jmf.2012.2162. [PMID: 22985398]
  • Maria J Jordán, Vanesa Lax, Maria C Rota, Susana Lorán, José A Sotomayor. Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts. Journal of agricultural and food chemistry. 2012 Sep; 60(38):9603-8. doi: 10.1021/jf302881t. [PMID: 22957812]
  • Ying Zhang, Jonathan P Smuts, Edra Dodbiba, Rekha Rangarajan, John C Lang, Daniel W Armstrong. Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC. Journal of agricultural and food chemistry. 2012 Sep; 60(36):9305-14. doi: 10.1021/jf302179c. [PMID: 22881034]
  • Julia Bauer, Susanne Kuehnl, Judith M Rollinger, Olga Scherer, Hinnak Northoff, Hermann Stuppner, Oliver Werz, Andreas Koeberle. Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1. The Journal of pharmacology and experimental therapeutics. 2012 Jul; 342(1):169-76. doi: 10.1124/jpet.112.193847. [PMID: 22511203]
  • Arash Mohebati, Joseph B Guttenplan, Amit Kochhar, Zhong-Lin Zhao, Wieslawa Kosinska, Kotha Subbaramaiah, Andrew J Dannenberg. Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis. Cancer prevention research (Philadelphia, Pa.). 2012 Apr; 5(4):593-602. doi: 10.1158/1940-6207.capr-12-0002. [PMID: 22374940]
  • Joseph Tai, Susan Cheung, Matthew Wu, David Hasman. Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Mar; 19(5):436-43. doi: 10.1016/j.phymed.2011.12.012. [PMID: 22325591]
  • Melissa Raboni Alves Rodrigues, Luiz Kae Sales Kanazawa, Thiago Louback Machado das Neves, Carla Francielle da Silva, Heros Horst, Moacir Geraldo Pizzolatti, Adair Roberto Soares Santos, Cristiane Hatsuko Baggio, Maria Fernanda de Paula Werner. Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. Journal of ethnopharmacology. 2012 Jan; 139(2):519-26. doi: 10.1016/j.jep.2011.11.042. [PMID: 22154965]
  • Tomoko Kayashima, Kiminori Matsubara. Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves. Bioscience, biotechnology, and biochemistry. 2012; 76(1):115-9. doi: 10.1271/bbb.110584. [PMID: 22232247]
  • Pi-wen Zhao, David Yue-wei Lee, Zhong-ze Ma, Lian-sha Huang, Li-ping Sun, Ya-dong Li, Jia-xu Chen, Jian-zhao Niu. The antioxidant effect of carnosol in bovine aortic endothelial cells is mainly mediated via estrogen receptor α pathway. Biological & pharmaceutical bulletin. 2012; 35(11):1947-55. doi: 10.1248/bpb.b12-00325. [PMID: 22971524]
  • Chia-Wen Tsai, Chia-Yuan Lin, Yu-Jung Wang. Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway. The Journal of nutrition. 2011 Dec; 141(12):2119-25. doi: 10.3945/jn.111.146779. [PMID: 22031657]
  • N Mulinacci, M Innocenti, M Bellumori, C Giaccherini, V Martini, M Michelozzi. Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: an HPLC/DAD/MS study. Talanta. 2011 Jul; 85(1):167-76. doi: 10.1016/j.talanta.2011.03.050. [PMID: 21645686]
  • Marvin J Núñez, Carolina P Reyes, Ignacio A Jiménez, Hirotaka Hayashi, Harukuni Tokuda, Isabel L Bazzocchi. ent-Rosane and abietane diterpenoids as cancer chemopreventive agents. Phytochemistry. 2011 Apr; 72(4-5):385-90. doi: 10.1016/j.phytochem.2011.01.017. [PMID: 21315389]
  • Andreja Sinkovic, David Suran, Lidija Lokar, Eva Fliser, Mojca Skerget, Zoran Novak, Zeljko Knez. Rosemary extracts improve flow-mediated dilatation of the brachial artery and plasma PAI-1 activity in healthy young volunteers. Phytotherapy research : PTR. 2011 Mar; 25(3):402-7. doi: 10.1002/ptr.3276. [PMID: 20734322]
  • Trude Rakel Balstad, Harald Carlsen, Mari C W Myhrstad, Marit Kolberg, Hanne Reiersen, Lene Gilen, Kanae Ebihara, Ingvild Paur, Rune Blomhoff. Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo - studies in electrophile response element transgenic mice. Molecular nutrition & food research. 2011 Feb; 55(2):185-97. doi: 10.1002/mnfr.201000204. [PMID: 20827676]
  • Chien-chung Chen, Hui-ling Chen, Chia-wen Hsieh, Yi-ling Yang, Being-sun Wung. Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival. Acta pharmacologica Sinica. 2011 Jan; 32(1):62-9. doi: 10.1038/aps.2010.181. [PMID: 21151161]
  • Jeremy J Johnson, Deeba N Syed, Yewseok Suh, Chenelle R Heren, Mohammad Saleem, Imtiaz A Siddiqui, Hasan Mukhtar. Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention. Cancer prevention research (Philadelphia, Pa.). 2010 Sep; 3(9):1112-23. doi: 10.1158/1940-6207.capr-10-0168. [PMID: 20736335]
  • Xiao-Feng Tian, Ji-Hong Yao, Xue-Song Zhang, Shu-Sen Zheng, Xin-Hua Guo, Li-Ming Wang, Zhen-Zhen Wang, Ke-Xin Liu. Protective effect of carnosol on lung injury induced by intestinal ischemia/reperfusion. Surgery today. 2010 Sep; 40(9):858-65. doi: 10.1007/s00595-009-4170-y. [PMID: 20740350]
  • Wagner A Bernardes, Rodrigo Lucarini, Marcos G Tozatti, Maria G M Souza, Márcio L Andrade Silva, Ademar A da Silva Filho, Carlos H Gomes Martins, Antonio E Miller Crotti, Patricia M Pauletti, Milton Groppo, Wilson R Cunha. Antimicrobial activity of Rosmarinus officinalis against oral pathogens: relevance of carnosic acid and carnosol. Chemistry & biodiversity. 2010 Jul; 7(7):1835-40. doi: 10.1002/cbdv.200900301. [PMID: 20658673]
  • Kai-Cheng Lian, Jing-Jing Chuang, Chia-Wen Hsieh, Being-Sun Wung, Guan-Da Huang, Ting-Yan Jian, Yung-Wei Sun. Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells. Toxicology and applied pharmacology. 2010 May; 245(1):21-35. doi: 10.1016/j.taap.2010.01.003. [PMID: 20116392]
  • Yosei Tamaki, Takahito Tabuchi, Toshiyuki Takahashi, Kunio Kosaka, Takumi Satoh. Activated glutathione metabolism participates in protective effects of carnosic acid against oxidative stress in neuronal HT22 cells. Planta medica. 2010 May; 76(7):683-8. doi: 10.1055/s-0029-1240622. [PMID: 19941258]
  • Sang Yong Kim, Euteum Park, Jeong Ae Park, Bong-Suk Choi, Seung Kim, Giuk Jeong, Chun-Sung Kim, Do Kyung Kim, Sung-Jun Kim, Hong Sung Chun. The plant phenolic diterpene carnosol suppresses sodium nitroprusside-induced toxicity in c6 glial cells. Journal of agricultural and food chemistry. 2010 Feb; 58(3):1543-50. doi: 10.1021/jf903294x. [PMID: 20073473]
  • Masahiro Tada, Tomoyuki Ohkanda, Jun Kurabe. Syntheses of carnosic acid and carnosol, anti-oxidants in Rosemary, from pisiferic acid, the major constituent of Sawara. Chemical & pharmaceutical bulletin. 2010 Jan; 58(1):27-9. doi: 10.1248/cpb.58.27. [PMID: 20045961]
  • Carlos Areche, Guillermo Schmeda-Hirschmann, Cristina Theoduloz, Jaime A Rodríguez. Gastroprotective effect and cytotoxicity of abietane diterpenes from the Chilean Lamiaceae Sphacele chamaedryoides (Balbis) Briq. The Journal of pharmacy and pharmacology. 2009 Dec; 61(12):1689-97. doi: 10.1211/jpp/61.12.0015. [PMID: 19958593]
  • Bárbara Mayer, Cristiane Hatsuko Baggio, Cristina Setim Freitas, Ana Cristina dos Santos, André Twardowschy, Heros Horst, Moacir Geraldo Pizzolatti, Gustavo Amadeu Micke, Melina Heller, Elide Pereira dos Santos, Michel Fleith Otuki, Maria Consuelo Andrade Marques. Gastroprotective constituents of Salvia officinalis L. Fitoterapia. 2009 Oct; 80(7):421-6. doi: 10.1016/j.fitote.2009.05.015. [PMID: 19481590]
  • Ji-Hong Yao, Xue-Song Zhang, Shu-Sen Zheng, Ying-Hua Li, Li-Ming Wang, Zhen-Zhen Wang, Liang Chu, Xiao-Wei Hu, Ke-Xin Liu, Xiao-Feng Tian. Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion. World journal of gastroenterology. 2009 Jul; 15(26):3240-5. doi: 10.3748/wjg.15.3240. [PMID: 19598299]
  • Toshiyuki Takahashi, Takahito Tabuchi, Yosei Tamaki, Kunio Kosaka, Yasuhiro Takikawa, Takumi Satoh. Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism. Biochemical and biophysical research communications. 2009 May; 382(3):549-54. doi: 10.1016/j.bbrc.2009.03.059. [PMID: 19289108]