zinc ion (BioDeep_00000004371)
Secondary id: BioDeep_00001868764
代谢物信息卡片
Zinc cation
化学式: Zn+2 (63.929145)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [Zn+2]
InChI: InChI=1S/Zn/q+2
描述信息
A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AB - Enzymes
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059004 - Topoisomerase I Inhibitors
C307 - Biological Agent > C29726 - Enzyme Replacement or Supplement Agent
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:29105
- ChEBI: CHEBI:63056
- KEGG: C00038
- PubChem: 32051
- DrugBank: DB14532
- ChEMBL: CHEMBL1236970
- CAS: 1492823-75-2
- CAS: 126603-04-1
- CAS: 23713-49-7
- CAS: 9025-42-7
- PMhub: MS000016782
- ChEBI: CHEBI:27363
- PubChem: 3340
- PDB-CCD: ZN
- NIKKAJI: J3.735D
分类词条
相关代谢途径
Reactome(112)
- Metabolism
- Biological oxidations
- Aflatoxin activation and detoxification
- Phase I - Functionalization of compounds
- Metabolism of vitamins and cofactors
- Metabolism of proteins
- Post-translational protein modification
- Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
- Disease
- Phase II - Conjugation of compounds
- Amino acid and derivative metabolism
- Diseases of signal transduction by growth factor receptors and second messengers
- Drug ADME
- Asparagine N-linked glycosylation
- Metabolism of lipids
- Metabolism of cofactors
- Diseases of metabolism
- Transport of small molecules
- SLC-mediated transmembrane transport
- Transport of bile salts and organic acids, metal ions and amine compounds
- Choline catabolism
- Methylation
- DNA Repair
- DNA Damage Reversal
- Signaling Pathways
- Mycobacterium tuberculosis biological processes
- Mycothiol metabolism
- Mycothiol-dependent detoxification
- Immune System
- Innate Immune System
- Antimicrobial peptides
- Nucleotide metabolism
- Nucleotide catabolism
- Purine catabolism
- Disorders of transmembrane transporters
- SLC transporter disorders
- Biosynthesis of specialized proresolving mediators (SPMs)
- Biosynthesis of EPA-derived SPMs
- Biosynthesis of E-series 18(R)-resolvins
- Fatty acid metabolism
- Amino acid synthesis and interconversion (transamination)
- Sulfur compound metabolism
- Cysteine synthesis from O-phosphoserine
- Metabolism of water-soluble vitamins and cofactors
- Vitamin B6 activation to pyridoxal phosphate
- Metabolism of nitric oxide: NOS3 activation and regulation
- eNOS activation and regulation
- eNOS activation
- Signaling by Receptor Tyrosine Kinases
- Signaling by VEGF
- VEGFA-VEGFR2 Pathway
- Cellular responses to stimuli
- Cellular responses to stress
- Detoxification of Reactive Oxygen Species
- Infectious disease
- Latent infection of Homo sapiens with Mycobacterium tuberculosis
- Latent infection - Other responses of Mtb to phagocytosis
- Adaptive Immune System
- Infection with Mycobacterium tuberculosis
- Leishmania infection
- Cellular response to chemical stress
- Bacterial Infection Pathways
- Parasitic Infection Pathways
- Arachidonic acid metabolism
- Carbohydrate metabolism
- The citric acid (TCA) cycle and respiratory electron transport
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Integration of energy metabolism
- Heme synthesis
- Phospholipid metabolism
- Glycerophospholipid biosynthesis
- Sulfur amino acid metabolism
- Degradation of cysteine and homocysteine
- Surfactant metabolism
- Tolerance by Mtb to nitric oxide produced by macrophages
- Aspartate and asparagine metabolism
- Viral Infection Pathways
- Porphyrin metabolism
- Heme biosynthesis
- Signaling by GPCR
- GPCR ligand binding
- Class A/1 (Rhodopsin-like receptors)
- Peptide ligand-binding receptors
- GPCR downstream signalling
- G alpha (i) signalling events
- Metal ion SLC transporters
- Hemostasis
- Sphingolipid metabolism
- Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
- Opioid Signalling
- DARPP-32 events
- Transport to the Golgi and subsequent modification
- N-glycan antennae elongation in the medial/trans-Golgi
- Defects in vitamin and cofactor metabolism
- Metal sequestration by antimicrobial proteins
- APAP ADME
- Mycothiol biosynthesis
- Metabolic disorders of biological oxidation enzymes
- Nicotinate metabolism
- Response to metal ions
- Metallothioneins bind metals
- Sphingolipid catabolism
- Digestion and absorption
- Digestion
- VEGFR2 mediated vascular permeability
- Signaling by Nuclear Receptors
- Muscle contraction
- Death Receptor Signaling
- p75 NTR receptor-mediated signalling
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by Retinoic Acid
- RA biosynthesis pathway
BioCyc(301)
- salvage pathways of pyrimidine ribonucleotides
- pyrimidine ribonucleosides degradation
- superpathway of pyrimidine deoxyribonucleoside salvage
- superpathway of pyrimidine ribonucleosides salvage
- pyrimidine ribonucleosides salvage I
- pyrimidine ribonucleosides salvage II
- pyrimidine deoxyribonucleosides salvage
- superpathway of pyrimidine ribonucleosides degradation
- pyrimidine ribonucleosides degradation II
- myricetin gentiobioside biosynthesis
- kaempferol gentiobioside biosynthesis
- allantoin degradation to ureidoglycolate II (ammonia producing)
- allantoin degradation to glyoxylate III
- superpathway of L-phenylalanine biosynthesis
- superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation
- superpathway of N-acetylneuraminate degradation
- superpathway of L-methionine biosynthesis (transsulfuration)
- superpathway of L-homoserine and L-methionine biosynthesis
- L-methionine biosynthesis I
- superpathway of hexitol degradation (bacteria)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I
- superpathway of aromatic amino acid biosynthesis
- chorismate biosynthesis I
- chorismate biosynthesis from 3-dehydroquinate
- CMP-3-deoxy-D-manno-octulosonate biosynthesis
- sucrose degradation II (sucrose synthase)
- superpathway of L-tyrosine biosynthesis
- superpathway of hyoscyamine and scopolamine biosynthesis
- superpathway of chorismate metabolism
- aspartate superpathway
- superpathway of betalain biosynthesis
- superpathway of S-adenosyl-L-methionine biosynthesis
- salvianin biosynthesis
- superpathway of L-tryptophan biosynthesis
- pelargonidin conjugates biosynthesis
- superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)
- shisonin biosynthesis
- superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)
- superpathway of anaerobic sucrose degradation
- methanogenesis from acetate
- quercetin gentiotetraside biosynthesis
- chlorzoxazone degradation
- superpathway of tryptophan utilization
- superpathway of glycol metabolism and degradation
- coumarin metabolism (to melilotic acid)
- glycogen degradation I
- glycolate and glyoxylate degradation I
- glycolate and glyoxylate degradation II
- protocatechuate degradation I (meta-cleavage pathway)
- trans-4-hydroxy-L-proline degradation II
- gossypol biosynthesis
- starch biosynthesis
- L-lysine biosynthesis I
- superpathway of fucose and rhamnose degradation
- fucose degradation
- urea cycle
- superpathway of polyamine biosynthesis I
- superpathway of arginine and polyamine biosynthesis
- uracil degradation II (oxidative)
- superpathway of L-citrulline metabolism
- L-citrulline biosynthesis
- L-arginine degradation VIII (arginine oxidase pathway)
- L-arginine degradation VI (arginase 2 pathway)
- L-arginine degradation X (arginine monooxygenase pathway)
- creatinine degradation I
- superpathway of purines degradation in plants
- arginine degradation VI (arginase 2 pathway)
- citrulline biosynthesis
- superpathway of aromatic compound degradation
- methanol oxidation to carbon dioxide
- morphine biosynthesis
- methanol oxidation to formaldehyde III
- methanol oxidation to formaldehyde II
- glycine betaine degradation I
- caffeine degradation III (bacteria, via demethylation)
- formaldehyde oxidation II (glutathione-dependent)
- aurone biosynthesis
- polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)
- isoflavonoid biosynthesis II
- aflatoxins B1 and G1 biosynthesis
- kaempferide triglycoside biosynthesis
- superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)
- L-arabinose degradation I
- D-arabinose degradation I
- superpathway of pentose and pentitol degradation
- ginsenosides biosynthesis
- anhydromuropeptides recycling I
- volatile esters biosynthesis (during fruit ripening)
- hydroxycinnamic acid tyramine amides biosynthesis
- (1,3)-β-D-xylan degradation
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
- superpathay of heme b biosynthesis from glutamate
- TCA cycle I (prokaryotic)
- L-tryptophan degradation I (via anthranilate)
- stachyose biosynthesis
- γ-butyrobetaine degradation
- aromatic biogenic amine degradation (bacteria)
- superpathway of microbial D-galacturonate and D-glucuronate degradation
- L-carnitine degradation II
- mixed acid fermentation
- N-methyl-Δ1-pyrrolinium cation biosynthesis
- nicotine degradation II (pyrrolidine pathway)
- 1,3-propanediol biosynthesis (engineered)
- streptomycin biosynthesis
- superpathway of CMP-sialic acids biosynthesis
- superpathway of glycerol degradation to 1,3-propanediol
- superpathway of glyoxylate bypass and TCA
- tetrapyrrole biosynthesis I (from glutamate)
- germacrene biosynthesis
- isovitexin glycosides biosynthesis
- superpathway of L-lysine degradation
- purine nucleotides degradation II (aerobic)
- L-lysine fermentation to acetate and butanoate
- superpathway of tetrahydrofolate biosynthesis
- superpathway of tetrahydrofolate biosynthesis and salvage
- N10-formyl-tetrahydrofolate biosynthesis
- L-phenylalanine degradation IV (mammalian, via side chain)
- NADH to cytochrome bo oxidase electron transfer I
- NADH to cytochrome bd oxidase electron transfer I
- acetone degradation II (to acetoacetate)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation
- superpathway of Clostridium acetobutylicum solventogenic fermentation
- propane degradation I
- ammonia oxidation I (aerobic)
- esculetin modification
- superpathway of scopolin and esculin biosynthesis
- galactitol degradation
- superpathway of glycolysis and the Entner-Doudoroff pathway
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
- reactive oxygen species degradation
- NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)
- superpathway NAD/NADP - NADH/NADPH interconversion (yeast)
- spermidine biosynthesis I
- gluconeogenesis I
- L-arginine biosynthesis II (acetyl cycle)
- glycolysis II (from fructose 6-phosphate)
- glycolysis I (from glucose 6-phosphate)
- L-rhamnose degradation I
- myo-inositol biosynthesis
- superpathway NAD/NADP - NADH/NADPH interconversion
- NAD/NADP-NADH/NADPH cytosolic interconversion
- galactose degradation I (Leloir pathway)
- D-galactose degradation I (Leloir pathway)
- L-asparagine degradation I
- ammonia oxidation IV (autotrophic ammonia oxidizers)
- nitrifier denitrification
- reductive acetyl coenzyme A pathway II (autotrophic methanogens)
- gluconeogenesis II (Methanobacterium thermoautotrophicum)
- Methanobacterium thermoautotrophicum biosynthetic metabolism
- superpathway of cholesterol degradation I (cholesterol oxidase)
- volatile benzenoid biosynthesis I (ester formation)
- limonene degradation II (L-limonene)
- terrequinone A biosynthesis
- volatile cinnamoic ester biosynthesis
- poly(3-O-β-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis
- L-lysine degradation IV
- L-lysine degradation III
- stephacidin A biosynthesis
- melibiose degradation
- guanosine nucleotides degradation
- purine nucleotides degradation
- fumigaclavine biosynthesis
- trans, trans-farnesyl diphosphate biosynthesis
- homogalacturonan biosynthesis
- allantoin degradation IV (anaerobic)
- 2-nitrobenzoate degradation I
- podophyllotoxin glucosides metabolism
- rosmarinic acid biosynthesis II
- colanic acid building blocks biosynthesis
- conversion of succinate to propanoate
- pyruvate fermentation to acetate and lactate II
- CMP-N-acetylneuraminate biosynthesis I (eukaryotes)
- CDP-archaeol biosynthesis
- archaetidylinositol biosynthesis
- 3-phosphoinositide biosynthesis
- archaetidylserine and archaetidylethanolamine biosynthesis
- methyl indole-3-acetate interconversion
- suberin monomers biosynthesis
- pyrimidine deoxyribonucleotides de novo biosynthesis I
- vitamin B6 degradation
- crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)
- superpathway of pyrimidine deoxyribonucleosides degradation
- TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)
- geraniol and geranial biosynthesis
- sakuranetin biosynthesis
- propanoyl CoA degradation I
- superpathway of rosmarinic acid biosynthesis
- pyruvate fermentation to (R)-acetoin II
- L-lysine degradation V
- 3-amino-5-hydroxybenzoate biosynthesis
- gliotoxin biosynthesis
- phosphatidylinositol biosynthesis II (eukaryotes)
- 2-oxobutanoate degradation I
- superpathway of purine deoxyribonucleosides degradation
- D-galactose detoxification
- superpathway of adenosine nucleotides de novo biosynthesis I
- trehalose degradation IV
- superpathway of purine nucleotides de novo biosynthesis I
- methylgallate degradation
- 4-amino-3-hydroxybenzoate degradation
- orcinol degradation
- 4-hydroxyphenylacetate degradation
- purine nucleobases degradation I (anaerobic)
- purine nucleobases degradation II (anaerobic)
- 2-hydroxypenta-2,4-dienoate degradation
- emetine biosynthesis
- nitrilotriacetate degradation
- norspermidine biosynthesis
- plaunotol biosynthesis
- superpathway of polyamine biosynthesis III
- superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP)
- superpathway of (R,R)-butanediol biosynthesis
- superpathway of 2,3-butanediol biosynthesis
- taxadiene biosynthesis (engineered)
- GDP-mannose biosynthesis
- superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis
- superpathway of rifamycin B biosynthesis
- superpathway of penicillin, cephalosporin and cephamycin biosynthesis
- deacetylcephalosporin C biosynthesis
- CDP-D-arabitol biosynthesis
- L-histidine biosynthesis
- UDP-N-acetyl-D-glucosamine biosynthesis II
- phosphinothricin tripeptide biosynthesis
- isopenicillin N biosynthesis
- puromycin biosynthesis
- L-arginine biosynthesis I (via L-ornithine)
- L-threonine degradation II
- L-threonine degradation III (to methylglyoxal)
- meta cleavage pathway of aromatic compounds
- superpathway of β-D-glucuronosides degradation
- flaviolin dimer and mompain biosynthesis
- glycolysis V (Pyrococcus)
- L-rhamnose degradation II
- catechol degradation II (meta-cleavage pathway)
- catechol degradation I (meta-cleavage pathway)
- catechol degradation III (ortho-cleavage pathway)
- guanosine nucleotides degradation III
- L-ornithine biosynthesis I
- pyruvate fermentation to lactate
- androstenedione degradation
- methylerythritol phosphate pathway I
- ubiquinol-8 biosynthesis (prokaryotic)
- L-ascorbate biosynthesis IV
- glycerol degradation II
- aminopropanol phosphate biosynthesis II
- D-galacturonate degradation I
- D-fructuronate degradation
- D-galactonate degradation
- betalamic acid biosynthesis
- superpathway of hexuronide and hexuronate degradation
- superpathway of ubiquinol-8 biosynthesis (prokaryotic)
- D-myo-inositol (1,4,5)-trisphosphate biosynthesis
- gentiodelphin biosynthesis
- di-myo-inositol phosphate biosynthesis
- superpathway of L-threonine metabolism
- superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)
- L-carnitine biosynthesis
- (S)-reticuline biosynthesis I
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
- 2'-deoxy-α-D-ribose 1-phosphate degradation
- trehalose biosynthesis I
- superpathway of L-methionine salvage and degradation
- erythro-tetrahydrobiopterin biosynthesis I
- 3-dehydroquinate biosynthesis I
- glutathione degradation (DUG pathway - yeast)
- complex N-linked glycan biosynthesis (vertebrates)
- complex N-linked glycan biosynthesis (plants)
- adenosine nucleotides de novo biosynthesis
- superpathway of glutathione metabolism (truncated γ-glutamyl cycle)
- glutathione degradation
- glutathione degradation (DUG pathway)
- trehalose biosynthesis
- epoxypseudoisoeugenol-2-methylbutanoate biosynthesis
- succinate to cytochrome bo oxidase electron transfer
- NADH to cytochrome bo oxidase electron transfer II
- D-lactate to cytochrome bo oxidase electron transfer
- glycerol-3-phosphate to cytochrome bo oxidase electron transfer
- proline to cytochrome bo oxidase electron transfer
- pyruvate to cytochrome bo oxidase electron transfer
- pyrimidine nucleobases salvage II
- t-anethole biosynthesis
- trehalose degradation V
- trehalose biosynthesis V
- trehalose biosynthesis IV
- γ-resorcylate degradation I
- stipitatate biosynthesis
- phytate degradation I
- myo-inositol degradation II
- glycine betaine biosynthesis I (Gram-negative bacteria)
- triacylglycerol degradation
- paxilline and diprenylpaxilline biosynthesis
- tRNA charging
- cichoriin interconversion
- (R,R)-butanediol degradation
- (R,R)-butanediol biosynthesis
- superpathway of acetoin and butanediol biosynthesis
- butanediol biosynthesis
- thiocyanate degradation II
- carbon disulfide oxidation I (anaerobic)
- uracil degradation I (reductive)
PlantCyc(54)
- quercetin gentiotetraside biosynthesis
- kaempferol gentiobioside biosynthesis
- superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)
- superpathway of hyoscyamine and scopolamine biosynthesis
- salvianin biosynthesis
- shisonin biosynthesis
- pelargonidin conjugates biosynthesis
- superpathway of betalain biosynthesis
- flavonol glucosylation I
- myricetin gentiobioside biosynthesis
- superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)
- superpathway of anaerobic sucrose degradation
- sucrose degradation II (sucrose synthase)
- coumarin metabolism (to melilotic acid)
- hydroxycinnamic acid tyramine amides biosynthesis
- gossypol biosynthesis
- luteolin biosynthesis
- superpathway of purines degradation in plants
- morphine biosynthesis
- purine nucleotides degradation I (plants)
- aurone biosynthesis
- polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)
- kaempferide triglycoside biosynthesis
- superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)
- volatile esters biosynthesis (during fruit ripening)
- guanosine nucleotides degradation II
- superpathway of guanosine nucleotides degradation (plants)
- guanosine nucleotides degradation I
- stachyose biosynthesis
- N-methyl-Δ1-pyrrolinium cation biosynthesis
- esculetin modification
- superpathway of scopolin and esculin biosynthesis
- volatile benzenoid biosynthesis I (ester formation)
- volatile cinnamoic ester biosynthesis
- superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)
- methyl indole-3-acetate interconversion
- L-histidine biosynthesis
- plaunotol biosynthesis
- podophyllotoxin glucosides metabolism
- sakuranetin biosynthesis
- (S)-reticuline biosynthesis I
- suberin monomers biosynthesis
- D-galactose detoxification
- rosmarinic acid biosynthesis II
- superpathway of rosmarinic acid biosynthesis
- geraniol and geranial biosynthesis
- homogalacturonan biosynthesis
- UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)
- emetine biosynthesis
- betalamic acid biosynthesis
- gentiodelphin biosynthesis
- chrysin biosynthesis
- phytate degradation I
代谢反应
927 个相关的代谢反应过程信息。
Reactome(927)
- Signaling Pathways:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
Ade-Rib ⟶ ADORA1,3:Ade-Rib - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AMP + p-AMPK heterotrimer ⟶ p-AMPK heterotrimer:AMP - Signaling by GPCR:
H2O + cAMP ⟶ AMP - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Infectious disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
Cbl + H+ + Homologues of MMACHC + TPNH ⟶ MMACHC:cob(II)alamin + TPN - Viral Infection Pathways:
NAD + p-S177-N ⟶ ADPr-p-S177-N + H+ + NAM - Respiratory Syncytial Virus Infection Pathway:
GTP + H2O + S-adenosyl-L-methionine + hRSV A nascent mRNAs:RdRP:p-M2-1 ⟶ PPi + Pi + RSV m7GpppG-mRNAs:RdRP:p-M2-1 + S-adenosyl-L-homocysteine - Respiratory syncytial virus (RSV) genome replication, transcription and translation:
GTP + H2O + S-adenosyl-L-methionine + hRSV A nascent mRNAs:RdRP:p-M2-1 ⟶ PPi + Pi + RSV m7GpppG-mRNAs:RdRP:p-M2-1 + S-adenosyl-L-homocysteine - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Porphyrin metabolism:
H2O + PBG ⟶ HMBL + ammonia - Heme biosynthesis:
H2O + PBG ⟶ HMBL + ammonia - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
GHRL + octanoic acid ⟶ GHRL - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Response to metal ions:
MT3 + Zn2+ ⟶ MT3:7Zn2+ - Metallothioneins bind metals:
MT3 + Zn2+ ⟶ MT3:7Zn2+ - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - GPCR ligand binding:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Response to metal ions:
Homologues of MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Metallothioneins bind metals:
Homologues of MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
AGT + H2O ⟶ AGT - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - GPCR ligand binding:
Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
Ade-Rib ⟶ ADORA1,3:Ade-Rib - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Peptide hormone metabolism:
H2O + agt ⟶ agt - Insulin processing:
Ca2+ + Zn2+ + ins ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Cellular responses to stimuli:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Porphyrin metabolism:
BIL + Homologues of GSTA1 ⟶ BIL:GSTA1, FABP1 - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Metabolism of proteins:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Peptide hormone metabolism:
ghr + octanoic acid ⟶ ghr - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Integration of energy metabolism:
PKA:AKAP79:IQGAP1 Complex + cAMP ⟶ PRKACA,PRKACB,PRKACG + cAMP:PKA:AKAP79:IQGAP1 Complex - Regulation of insulin secretion:
PKA:AKAP79:IQGAP1 Complex + cAMP ⟶ PRKACA,PRKACB,PRKACG + cAMP:PKA:AKAP79:IQGAP1 Complex - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Cellular responses to stimuli:
BIL:ALB + O2.- ⟶ ALB + BV - Response to metal ions:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Metallothioneins bind metals:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Cellular responses to stress:
BIL:ALB + O2.- ⟶ ALB + BV - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
AGT + H2O ⟶ AGT - Insulin processing:
6xHC-INS(25-110) + Ca2+ + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Response to metal ions:
MT1_MOUSE + Zn2+ ⟶ MT1A:7Zn2+ - Metallothioneins bind metals:
MT1_MOUSE + Zn2+ ⟶ MT1A:7Zn2+ - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - GPCR ligand binding:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
Agt + H2O ⟶ Agt - Insulin processing:
6xHC-INS(25-110) + Ca2+ + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Porphyrin metabolism:
H2O + PBG ⟶ HMBL + ammonia - Heme biosynthesis:
H2O + PBG ⟶ HMBL + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Porphyrin metabolism:
BIL + GST ⟶ BIL:GSTA1, FABP1 - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
Agt + H2O ⟶ Agt - Insulin processing:
6xHC-INS(25-110) + Ca2+ + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Response to metal ions:
Homologues of MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Metallothioneins bind metals:
Homologues of MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Cellular responses to stimuli:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Porphyrin metabolism:
BIL + UDP-GlcA ⟶ BMG + UDP - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Porphyrin metabolism:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Cellular responses to stimuli:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Response to metal ions:
MT3 + Zn2+ ⟶ MT3:7Zn2+ - Metallothioneins bind metals:
MT3 + Zn2+ ⟶ MT3:7Zn2+ - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Antimicrobial peptides:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metal sequestration by antimicrobial proteins:
Fe3+ + LCN2:2,5DHBA ⟶ LCN2:2,5DHBA:Fe3+ - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Peptide hormone metabolism:
AGT + H2O ⟶ AGT - Insulin processing:
Ca2+ + INS + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - GPCR ligand binding:
Ade-Rib + H0YT13 ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
Ade-Rib + H0YT13 ⟶ ADORA1,3:Ade-Rib - Metabolism of proteins:
EIF5A2 + NAD + SPM ⟶ 1,3-diaminopropane + H+ + H0ZKZ7 + NADH - Peptide hormone metabolism:
H0ZI58 + H2O ⟶ H0ZI58 - Insulin processing:
Ca2+ + H0ZG98 + Zn2+ ⟶ 6xProinsulin:2xZn2+:1xCa2+ - Porphyrin metabolism:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Heme biosynthesis:
H2O + PBG ⟶ HMBL + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Porphyrin metabolism:
BV + TPNH ⟶ BIL + TPN - Heme biosynthesis:
Oxygen + coproporphyrinogen III ⟶ H2O2 + carbon dioxide + protoporphyrinogen - Cellular responses to stimuli:
BV + TPNH ⟶ BIL + TPN - Cellular responses to stress:
BV + TPNH ⟶ BIL + TPN - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Antimicrobial peptides:
H2O + LYZ:PGN ⟶ MurNAc:Peptide + betaGlcNAc - Metal sequestration by antimicrobial proteins:
CO3(2-) + Fe3+ + tf ⟶ LTF:2xFe3+:2xCO3(2-) - GPCR ligand binding:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Class A/1 (Rhodopsin-like receptors):
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - Response to metal ions:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Metallothioneins bind metals:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Response to metal ions:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Metallothioneins bind metals:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Response to metal ions:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Metallothioneins bind metals:
MT1A + Zn2+ ⟶ MT1A:7Zn2+ - Leishmania infection:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Leishmania parasite growth and survival:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Anti-inflammatory response favouring Leishmania parasite infection:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - CD163 mediating an anti-inflammatory response:
TACE + Zn2+ ⟶ ADAM17(215-827):Zn2+ - Cellular response to chemical stress:
BIL:ALB + O2.- ⟶ ALB + BV - Parasitic Infection Pathways:
Adenylate cyclase (Mg2+ cofactor) + Gs:GTP ⟶ Gs-activated adenylate cyclase - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Maturation of hRSV A proteins:
Nascent M2-1 + Zn2+ ⟶ M2-1:Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Cellular response to mitochondrial stress:
YME1L1:Zn2+ hexamer ⟶ Zn2+ - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Molybdenum cofactor biosynthesis:
ATP + MOCS2 + MOCS3-S-S(1-):Zn2+ ⟶ AMP + MOCS3:Zn2+ (ox.) + O22827 + PPi - Cellular responses to external stimuli:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Downstream signaling events of B Cell Receptor (BCR):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
Ca2+ + Calcineurin (CaN) + Calcium:calmodulin ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of nitric oxide: NOS3 activation and regulation:
ADMA + H2O ⟶ DMA + L-Cit - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
ADMA + H2O ⟶ DMA + L-Cit - NOSIP mediated eNOS trafficking:
NOSIP + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
N-WASP + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
ISCIT + TPN ⟶ 2OG + H+ + TPNH + carbon dioxide - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
GTP + H2O ⟶ DHNTP + HCOOH - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Methylation:
6MMP + H+ + Oxygen + TPNH ⟶ 6MP + CH2O + H2O + TPN - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + Q2M2S2 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + Q2M2S2 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - Signaling by Receptor Tyrosine Kinases:
H2O + cAMP ⟶ AMP - Signaling by NTRKs:
A0A3Q1M614 + ATP ⟶ A0A3Q1M614 + ADP - Signaling by NTRK1 (TRKA):
A0A3Q1M614 + ATP ⟶ A0A3Q1M614 + ADP - Signalling to ERKs:
A0A3Q1M614 + ATP ⟶ A0A3Q1M614 + ADP - Prolonged ERK activation events:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Frs2-mediated activation:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Signaling by VEGF:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFA-VEGFR2 Pathway:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
RHOA:GTP:Mg2+ + ppDVL:DAAM1 ⟶ ppDVL:DAAM1:RHOA:GTP - Ca2+ pathway:
CALM1:4xCa2+ + CAMK2A ⟶ CAMK2:CaM - Immune System:
cAMP + epac-1 ⟶ RAPGEF3:cAMP complex - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Muscle contraction:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Cardiac conduction:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by NTRKs:
ATP ⟶ ADP - Signaling by NTRK1 (TRKA):
ATP ⟶ ADP - Signalling to ERKs:
ATP ⟶ ADP - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
MYC gene: H2B K121ub nucleosome + SAM ⟶ MYC gene:H2B K121ub H3K4me3 nucleosome + SAH - Beta-catenin independent WNT signaling:
RHOA:GTP:Mg2+ + ppDVL:DAAM1 ⟶ ppDVL:DAAM1:RHOA:GTP - Ca2+ pathway:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - Transport of small molecules:
CHOL + NPC2 ⟶ NPC2:CHOL - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + Q9U3I4 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + E2RT06 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + E2RT06 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Metabolism of nitric oxide: NOS3 activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSIP mediated eNOS trafficking:
NOSIP + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
WASL + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - Metabolism of vitamins and cofactors:
6x(PCCA:PCCB) + ATP + Btn ⟶ 6x(Btn-PCCA:PCCB) + AMP + PPi - Metabolism of water-soluble vitamins and cofactors:
6x(PCCA:PCCB) + ATP + Btn ⟶ 6x(Btn-PCCA:PCCB) + AMP + PPi - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
A0A0J9YJ98 + C2orf47:AFG3L2:SPG7:PHB:PHB2 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
A0A0J9YJ98 + C2orf47:AFG3L2:SPG7:PHB:PHB2 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - NOSTRIN mediated eNOS trafficking:
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 + wasla ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Metabolism of proteins:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
H2O + cGMP ⟶ GMP - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Immune System:
cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Immune System:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - Adaptive Immune System:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - B Cell Activation:
STIM1:Calcium ⟶ Ca2+ + STIM1 Dimer - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Calcineurin activates NFAT:
A8JUV3 + CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:p-NFATC1,2,3 - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
Ac-CoA + NFKB1:p-S276-RELA:p300/CBP ⟶ CoA + NFKB1:p-S276,5AcK-RELA:p300/CBP - CLEC7A (Dectin-1) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH + Q9GU68 - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by NTRKs:
ATP + P49071 ⟶ ADP + p-S272,T222,T334-MAPKAPK2 - Signaling by NTRK1 (TRKA):
ATP + P49071 ⟶ ADP + p-S272,T222,T334-MAPKAPK2 - Signalling to ERKs:
ATP + P49071 ⟶ ADP + p-S272,T222,T334-MAPKAPK2 - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Cellular responses to stimuli:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Detoxification of Reactive Oxygen Species:
H+ + O2.- ⟶ H2O2 + Oxygen - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + EMRE ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + EMRE ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - DNA Repair:
NTHL1:DHU-dsDNA ⟶ DHU + NTHL1:AP-dsDNA - DNA Double-Strand Break Repair:
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ + NAD ⟶ Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 + NAM + PAR-PARP1,PAR-PARP2 dimers + POLQ homodimer - DNA Double Strand Break Response:
Ac-CoA + DNA DSBs:MRN:ATM dimer:KAT5 ⟶ CoA + DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
A1Z7P5 + DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ + Q9VR91 ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSIP mediated eNOS trafficking:
NOSIP + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
WASp + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + F1NJF9 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + F1NJF9 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by NTRKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signaling by NTRK1 (TRKA):
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signalling to ERKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Prolonged ERK activation events:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Frs2-mediated activation:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - DNA Double Strand Break Response:
Ac-CoA + DNA DSBs:MRN:ATM dimer:KAT5 ⟶ CoA + DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
A0A1D5PAM1 + DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex ⟶ DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
STIM1:Calcium ⟶ Ca2+ + STIM1 Dimer - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + EMRE_HUMAN ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + EMRE_HUMAN ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSIP mediated eNOS trafficking:
NOSIP + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
NOSTRIN homotrimer + eNOS:Caveolin-1 ⟶ eNOS:Caveolin-1:NOSTRIN complex - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
B12r + NADH ⟶ B12s + H+ + NAD - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Damage Reversal:
2OG + Fe2+ + N6-methyladenosine ⟶ CH2O + SUCCA + adenosine + carbon dioxide - MGMT-mediated DNA damage reversal:
MGMT:Zn2+ ⟶ MGMT:Zn2+:6-OMeG-dsDNA - DNA Double-Strand Break Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by NTRKs:
ADORA2A + Ade-Rib + NTRK1,2 ⟶ Ade-Rib:ADORA2A:NTRK1,2 - Signaling by NTRK1 (TRKA):
ADORA2A + Ade-Rib + NTRK1,2 ⟶ Ade-Rib:ADORA2A:NTRK1,2 - Signalling to ERKs:
ATP + MAP kinase p38 (Mg2+ cofactor) ⟶ ADP + Phospho-MAP kinase p38 (Mg2+ cofactor) - Signalling to p38 via RIT and RIN:
Active Trk receptor complex:RIT/RIN-GTP + B-RAF ⟶ Active Trk receptor complex:RIT/RIN-GTP:B-RAF - Prolonged ERK activation events:
BRAF dimer complex + RAP1:GTP ⟶ RAP1:GTP:B-Raf complex - Frs2-mediated activation:
BRAF dimer complex + RAP1:GTP ⟶ RAP1:GTP:B-Raf complex - ARMS-mediated activation:
BRAF complex + Rap1-GTP complex ⟶ Rap1-GTP complex:BRAF complex - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - DARPP-32 events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
PRKG dimer + cGMP ⟶ PRKG homodimer:cGMP - Ca2+ pathway:
PRKG dimer + cGMP ⟶ PRKG homodimer:cGMP - MAPK family signaling cascades:
ATP + Ki-Ras ⟶ ADP + Ki-Ras - ERK1/ERK2 pathway:
ATP + Ki-Ras ⟶ ADP + Ki-Ras - RAF/MAP kinase cascade:
ATP + Ki-Ras ⟶ ADP + Ki-Ras - MTF1 activates gene expression:
MTF1 dimer:12Zn2+ ⟶ MTF1 dimer:12Zn2+:SNCB gene - Muscle contraction:
Guanylate cyclase, soluble + NO ⟶ Guanylate cyclase:NO - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Amyloid fiber formation:
BACE1_HUMAN + H2O ⟶ BACE1_HUMAN + CH3COO- - Uptake and actions of bacterial toxins:
ATP ⟶ PPi + cAMP - Clostridium neurotoxicity:
BoNT/A:NTNHA:HA ⟶ HA1 + HA2 + HA3 + NTNHA + botA HC:LC dimer - Toxicity of botulinum toxin type A (botA):
BoNT/A:NTNHA:HA ⟶ HA1 + HA2 + HA3 + NTNHA + botA HC:LC dimer - Toxicity of botulinum toxin type B (botB):
BoNT/B:NTNHA:HA ⟶ HA1 + HA2 + HA3 + NTNHA + botB HC:LC dimer - Toxicity of botulinum toxin type E (botE):
BoNT/E:NTNHA ⟶ NTNHA + botE HC:LC dimer - Uptake and function of anthrax toxins:
ATP ⟶ PPi + cAMP - Listeria monocytogenes entry into host cells:
CDH1:CTNNB1:CTNND1 + InlA ⟶ InlA:CDH1:CTNNB1:CTNND1 - InlA-mediated entry of Listeria monocytogenes into host cells:
CDH1:CTNNB1:CTNND1 + InlA ⟶ InlA:CDH1:CTNNB1:CTNND1 - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PRKCB + PS ⟶ Activated PKC beta - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + PPP3R1:PPP3CA,B + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - FCERI mediated Ca+2 mobilization:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - C-type lectin receptors (CLRs):
CLEC7A + zymosan ⟶ CLEC7A:1,3-beta-D-glucan - CLEC7A (Dectin-1) signaling:
CLEC7A + zymosan ⟶ CLEC7A:1,3-beta-D-glucan - CLEC7A (Dectin-1) induces NFAT activation:
I(1,4,5)P3 + IP3 receptor homotetramer ⟶ ITPR:I(1,4,5)P3 tetramer - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PS + Prkcb ⟶ Activated PKC beta - Calcineurin activates NFAT:
Ca2+ + Calcineurin (CaN) + Calmodulin:Calcium + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
Ca2+ + Calcineurin (CaN) + Calmodulin:Calcium ⟶ Calcineurin:Calmodulin (CaN:CaM) - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSIP mediated eNOS trafficking:
Nosip + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
NOSTRIN homotrimer + eNOS:Caveolin-1 ⟶ eNOS:Caveolin-1:NOSTRIN complex - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + Q9DB10 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + Q9DB10 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by NTRKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signaling by NTRK1 (TRKA):
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signalling to ERKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Prolonged ERK activation events:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Frs2-mediated activation:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Cellular responses to external stimuli:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular responses to stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Molybdenum cofactor biosynthesis:
ATP + MOCS3-S-S(1-):Zn2+ + Q6Z2X3 ⟶ AMP + MOCS3:Zn2+ (ox.) + PPi + Q6Z2X3 - Metabolism of vitamins and cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of water-soluble vitamins and cofactors:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Transport of small molecules:
CHOL + phosphatidylcholines ⟶ 1-acyl LPC + CHEST - Signaling Pathways:
H2O + cAMP ⟶ AMP - Signaling by Receptor Tyrosine Kinases:
H2O + cAMP ⟶ AMP - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Beta-catenin independent WNT signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Ca2+ pathway:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Immune System:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Innate Immune System:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSIP mediated eNOS trafficking:
Nosip + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
NOSTRIN homotrimer + eNOS:Caveolin-1 ⟶ eNOS:Caveolin-1:NOSTRIN complex - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by NTRKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signaling by NTRK1 (TRKA):
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signalling to ERKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Prolonged ERK activation events:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Frs2-mediated activation:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + D4A7Y9 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + D4A7Y9 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
Ca2+ + DAG + PS + Prkcb ⟶ Activated PKC beta - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - DNA Repair:
NTHL1:DHU-dsDNA ⟶ DHU + NTHL1:AP-dsDNA - DNA Double-Strand Break Repair:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Detoxification of Reactive Oxygen Species:
GSSG + H+ + TPNH ⟶ GSH + TPN - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by Receptor Tyrosine Kinases:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of water-soluble vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Immune System:
H2O + PC ⟶ Cho + PA - Innate Immune System:
H2O + PC ⟶ Cho + PA - Fc epsilon receptor (FCERI) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - DNA Double Strand Break Response:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAM ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 + SAH - Metabolism of vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Metabolism of water-soluble vitamins and cofactors:
4x(PC:Mn2+) + ATP + Btn ⟶ 4x(Btn-PC:Mn2+) + AMP + PPi - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by Receptor Tyrosine Kinases:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFR2 mediated vascular permeability:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - Signaling by WNT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Cellular responses to stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Metabolism of nitric oxide: NOS3 activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - eNOS activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - NOSIP mediated eNOS trafficking:
NOSIP + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
WASL + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Cobalamin (Cbl, vitamin B12) transport and metabolism:
ATP + B12s ⟶ AdoCbl + PPP - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of cofactors:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
MTAD + Pi ⟶ Ade + MTRIBP - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase II - Conjugation of compounds:
PAPS + beta-estradiol ⟶ E2-SO4 + PAP - Methylation:
6MMP + H+ + Oxygen + TPNH ⟶ 6MP + CH2O + H2O + TPN - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + F1SJP7 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + F1SJP7 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by NTRKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signaling by NTRK1 (TRKA):
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Signalling to ERKs:
ATP + MAPKAP kinase ⟶ ADP + Active MAPKAP kinase - Prolonged ERK activation events:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Frs2-mediated activation:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Signaling by VEGF:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFA-VEGFR2 Pathway:
Oxygen + TPNH ⟶ H+ + O2.- + TPN - VEGFR2 mediated vascular permeability:
PAK1,2,3 dimer + p-VAV family:PIP3:RAC1:GTP ⟶ 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 - Signaling by WNT:
AXIN:TNKS + NAD ⟶ NAM + RibC-AXIN:TNKS - Beta-catenin independent WNT signaling:
H2O + cGMP ⟶ GMP - Ca2+ pathway:
H2O + cGMP ⟶ GMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - B Cell Activation:
PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - Downstream signaling events of B Cell Receptor (BCR):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Fc epsilon receptor (FCERI) signaling:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - FCERI mediated Ca+2 mobilization:
H2O + PI(4,5)P2 ⟶ DAG + I(1,4,5)P3 - C-type lectin receptors (CLRs):
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) signaling:
ATP + CLEC7A:1,3-beta-D-glucan ⟶ 1,3-beta-D-glucan:p-Y15-CLEC7A + ADP - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - DNA Repair:
MUTYH:(8oxoG:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - DNA Double Strand Break Response:
Ac-CoA + DNA DSBs:MRN:ATM dimer:KAT5 ⟶ CoA + DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
A0A287ABB3 + DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ + F1RX57 ⟶ DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 - Transport of small molecules:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Mitochondrial calcium ion transport:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + H0ZHE7 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + H0ZHE7 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Signaling by WNT:
ATP + AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex ⟶ ADP + p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex - Beta-catenin independent WNT signaling:
ATP + CAMK2:CaM ⟶ ADP + p-T286 CAMK2:CaM - Ca2+ pathway:
ATP + CAMK2:CaM ⟶ ADP + p-T286 CAMK2:CaM - Immune System:
ATP + Ag-substrate:E3:E2:Ub ⟶ AMP + E3:Ub:substrate + PPi - Adaptive Immune System:
ATP + Ag-substrate:E3:E2:Ub ⟶ AMP + E3:Ub:substrate + PPi - B Cell Activation:
ATP + H0YZ45 + PI(3,4,5)P3 ⟶ ADP + p-Y139-DAPP1:PIP3 - Downstream signaling events of B Cell Receptor (BCR):
ATP + CARMA1 oligomer ⟶ ADP + p-CARMA1 Oligomer - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + Phosphorylated NFATC1,2,3 ⟶ Calcineurin:Phosphorylated NFATC1,2,3 - Innate Immune System:
ATP + DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer + UBE2N:UBE2V1 ⟶ AMP + DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 + PPi + UBE2N:UBE2V1 - Fc epsilon receptor (FCERI) signaling:
ATP + DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer + UBE2N:UBE2V1 ⟶ AMP + DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 + PPi + UBE2N:UBE2V1 - FCERI mediated Ca+2 mobilization:
ATP + p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 ⟶ ADP + p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases - C-type lectin receptors (CLRs):
ATP + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers ⟶ AMP + PPi + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers - CLEC7A (Dectin-1) signaling:
ATP + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers ⟶ AMP + PPi + UBE2N:UBE2V1 + p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - DNA Repair:
MUTYH:(OGUA:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA - DNA Double-Strand Break Repair:
ATP + DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 ⟶ ADP + DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 + phospho-p-S1981,Ac-K3016-ATM - DNA Double Strand Break Response:
ATP + DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 ⟶ ADP + DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 + phospho-p-S1981,Ac-K3016-ATM - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks:
ATP + DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 ⟶ ADP + DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex + phospho-p-T68-CHEK2 - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP - Methylation:
H2O + SAH ⟶ Ade-Rib + HCYS - eNOS activation and regulation:
H+ + TPNH + sepiapterin ⟶ TPN + dihydrobiopterin - NOSIP mediated eNOS trafficking:
nosip + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
NOSTRIN homotrimer + eNOS:Caveolin-1 ⟶ eNOS:Caveolin-1:NOSTRIN complex - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Molybdenum cofactor biosynthesis:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Detoxification of Reactive Oxygen Species:
GSH + H2O2 ⟶ GSSG + H2O - Transport of small molecules:
ATP + CHOL + H2O ⟶ ADP + CHOL + Pi - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + Q28ED6 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Cardiac conduction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Metabolism of proteins:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Prolonged ERK activation events:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Frs2-mediated activation:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Processing of SMDT1:
C2orf47:AFG3L2:SPG7:PHB:PHB2 + Q9U3I4 ⟶ proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSTRIN mediated eNOS trafficking:
N-WASP + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - FCERI mediated Ca+2 mobilization:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - C-type lectin receptors (CLRs):
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - CLEC7A (Dectin-1) induces NFAT activation:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSTRIN mediated eNOS trafficking:
N-WASP + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - Beta-catenin independent WNT signaling:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Ca2+ pathway:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) ⟶ Calcineurin:Calmodulin (CaN:CaM) - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Prolonged ERK activation events:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - Frs2-mediated activation:
ATP + RAP1:GTP:B-Raf complex ⟶ ADP + RAP1:GTP:activated BRAF dimer - NOSIP mediated eNOS trafficking:
nosip + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
Homologues of N-WASP + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - NOSTRIN mediated eNOS trafficking:
N-WASP + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - O2/CO2 exchange in erythrocytes:
H2O + carbon dioxide ⟶ H+ + HCO3- - Erythrocytes take up carbon dioxide and release oxygen:
H2O + carbon dioxide ⟶ H+ + HCO3- - Metabolism of nitric oxide: NOS3 activation and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - eNOS activation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - NOSIP mediated eNOS trafficking:
NOSIP + palmitoylated, myristoylated eNOS dimer ⟶ eNOS:NOSIP - NOSTRIN mediated eNOS trafficking:
WASL + eNOS:Caveolin-1:NOSTRIN:Dynamin-2 ⟶ eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP - RAS processing:
ATP + Ki-Ras ⟶ ADP + Ki-Ras - Calcineurin activates NFAT:
CALM1:4xCa2+ + Ca2+ + Calcineurin (CaN) + p-NFATC1,2,3 ⟶ Calcineurin:p-NFATC1,2,3 - Cellular response to chemical stress:
BV + TPNH ⟶ BIL + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cellular response to chemical stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular response to chemical stress:
GSSG + H+ + TPNH ⟶ GSH + TPN - Cellular response to chemical stress:
Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Physiological factors:
MME:Zn2+ + sacubitrilat ⟶ MME:Zn2+:sacubitrilat - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Cobalamin (Cbl) metabolism:
H+ + MMACHC:cob(I)alamin + NAD ⟶ MMACHC:cob(II)alamin + NADH - Bacterial Infection Pathways:
H+ + NADH + dlaT(ox.) ⟶ NAD + dlaT - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + ATP5A1 ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + Substrate of AFG3L2 (mitochondrial matrix) ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Mitochondrial protein degradation:
AFG3L2:Zn2+ hexamer + star ⟶ AFG3L2:substrate protein (mitochondrial matrix) - Homology Directed Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA):
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - Processing of DNA double-strand break ends:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - Nonhomologous End-Joining (NHEJ):
dNTP + p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends ⟶ PPi + p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends - Homology Directed Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA):
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - Processing of DNA double-strand break ends:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - Nonhomologous End-Joining (NHEJ):
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 + XRCC5:XRCC6 ⟶ K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome + KAT5_HUMAN + PIASy + PTIP + RIF1_HUMAN + RN168_HUMAN + RNF8:Zn2+ + UBC13:MMS2 + XRCC5:XRCC6:DNA DSBs + p-5T-MDC1 + p-MRN + p-S102-WHSC1 + p-S1981,Ac-K3016-ATM + p-S25,S1778-TP53BP1 + p-T4827,SUMO1-HERC2 - Toxicity of tetanus toxin (tetX):
GD3 ganglioside + GM1a + tetX HC:LC dimer ⟶ tetX:gangliosides - Toxicity of botulinum toxin type C (botC):
GT1b + botC HC:LC dimer ⟶ botC:GT1b - Toxicity of botulinum toxin type D (botD):
SV2A,B,C + beta-GalNAc-(1->4)-{alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3))-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer + botD HC:LC dimer ⟶ botD:SV2:GD2 - Toxicity of botulinum toxin type F (botF):
GT1b + SV2A,B,C + botF HC:LC dimer ⟶ botF:SV2:GT1b - Toxicity of botulinum toxin type G (botG):
GT1b + Synaptotagmin 1 + botG HC:LC dimer ⟶ botG:SYT1:GT1b - Homology Directed Repair:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA):
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - Processing of DNA double-strand break ends:
Ac-K432,K526,K604-RBBP8 homotetramer + NAD ⟶ 2'-O-acetyl-ADP-ribose + NAM + RBBP8 homotetramer - Nonhomologous End-Joining (NHEJ):
dNTP + p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends ⟶ PPi + p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends - Metabolism of cofactors:
ISCIT + TPN ⟶ 2OG + H+ + TPNH + carbon dioxide - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
GTP + H2O ⟶ DHNTP + HCOOH - Metabolism of cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
4 个相关的物种来源信息
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 992 Flexibacter: 10.7164/ANTIBIOTICS.43.158
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 992 Flexibacter: 10.7164/ANTIBIOTICS.43.158
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Heather L Hartman, Katherine E Bowers, Carol A Fierke. Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.
The Journal of biological chemistry.
2004 Jul; 279(29):30546-53. doi:
10.1074/jbc.m403469200. [PMID: 15131129] - D Miyamoto, Y Kusagaya, N Endo, A Sometani, S Takeo, T Suzuki, Y Arima, K Nakajima, Y Suzuki. Thujaplicin-copper chelates inhibit replication of human influenza viruses.
Antiviral research.
1998 Aug; 39(2):89-100. doi:
10.1016/s0166-3542(98)00034-5. [PMID: 9806486]