N-hydroxyl-tryptamine (BioDeep_00000004317)

 

Secondary id: BioDeep_00001869305

human metabolite blood metabolite


代谢物信息卡片


N-[2-(1H-indol-3-yl)ethyl]hydroxylamine

化学式: C10H12N2O (176.09495819999998)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.02%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CN2)CCNO
InChI: InChI=1S/C10H12N2O/c13-12-6-5-8-7-11-10-4-2-1-3-9(8)10/h1-4,7,11-13H,5-6H2

描述信息

N-hydroxyl-tryptamine is a member of the class of compounds known as 3-alkylindoles. 3-alkylindoles are compounds containing an indole moiety that carries an alkyl chain at the 3-position. N-hydroxyl-tryptamine is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). N-hydroxyl-tryptamine can be found in a number of food items such as other cereal product, mammee apple, cloud ear fungus, and spirulina, which makes N-hydroxyl-tryptamine a potential biomarker for the consumption of these food products.

同义名列表

3 个代谢物同义名

N-[2-(1H-indol-3-yl)ethyl]hydroxylamine; N-hydroxyl-tryptamine; Hydroxytryptamine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

8 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(4)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(4)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kamal A Amin, Hamdy H Kamel, Mohamed A Abd Eltawab. The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid. Lipids in health and disease. 2011 May; 10(?):74. doi: 10.1186/1476-511x-10-74. [PMID: 21569551]
  • Kimberly A Phillips, Andrea L Skirpan, Xing Liu, Ashley Christensen, Thomas L Slewinski, Christopher Hudson, Solmaz Barazesh, Jerry D Cohen, Simon Malcomber, Paula McSteen. vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize. The Plant cell. 2011 Feb; 23(2):550-66. doi: 10.1105/tpc.110.075267. [PMID: 21335375]
  • Kamal A Amin, Hamdy H Kamel, Mohamed A Abd Eltawab. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Lipids in health and disease. 2011 Jan; 10(?):6. doi: 10.1186/1476-511x-10-6. [PMID: 21235803]
  • Dean Dessem, Richard M Lovering. Repeated muscle injury as a presumptive trigger for chronic masticatory muscle pain. Pain research and treatment. 2011; 2011(?):647967. doi: 10.1155/2011/647967. [PMID: 22110928]
  • Nathan D Tivendale, Noel W Davies, Peter P Molesworth, Sandra E Davidson, Jason A Smith, Edwin K Lowe, James B Reid, John J Ross. Reassessing the role of N-hydroxytryptamine in auxin biosynthesis. Plant physiology. 2010 Dec; 154(4):1957-65. doi: 10.1104/pp.110.165803. [PMID: 20974893]
  • Sherry LeCLere, Eric A Schmelz, Prem S Chourey. Sugar levels regulate tryptophan-dependent auxin biosynthesis in developing maize kernels. Plant physiology. 2010 May; 153(1):306-18. doi: 10.1104/pp.110.155226. [PMID: 20237017]
  • Keun-Hang Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S Shippenberg, Murat Oz. The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes. The Journal of pharmacology and experimental therapeutics. 2010 May; 333(2):547-54. doi: 10.1124/jpet.109.162594. [PMID: 20160007]
  • Laura J Quittenden, Noel W Davies, Jason A Smith, Peter P Molesworth, Nathan D Tivendale, John J Ross. Auxin biosynthesis in pea: characterization of the tryptamine pathway. Plant physiology. 2009 Nov; 151(3):1130-8. doi: 10.1104/pp.109.141507. [PMID: 19710233]
  • Geetha Govind, Vokkaliga ThammeGowda Harshavardhan, Harshavardhan Vokkaliga ThammeGowda, Jayaker Kalaiarasi Patricia, Patricia Jayaker Kalaiarasi, Ramachandra Dhanalakshmi, Dhanalakshmi Ramchandra Iyer, Muthappa Senthil Kumar, Senthil Kumar Muthappa, Nese Sreenivasulu, Sreenivasulu Nese, Makarla Udayakumar, Udaya Kumar Makarla. Identification and functional validation of a unique set of drought induced genes preferentially expressed in response to gradual water stress in peanut. Molecular genetics and genomics : MGG. 2009 Jun; 281(6):591-605. doi: 10.1007/s00438-009-0432-z. [PMID: 19224247]
  • Goran Laćan, Alain Plenevaux, Daniel J Rubins, Baldwin M Way, Caroline Defraiteur, Christian Lemaire, Joel Aerts, André Luxen, Simon R Cherry, William P Melega. Cyclosporine, a P-glycoprotein modulator, increases [18F]MPPF uptake in rat brain and peripheral tissues: microPET and ex vivo studies. European journal of nuclear medicine and molecular imaging. 2008 Dec; 35(12):2256-66. doi: 10.1007/s00259-008-0832-z. [PMID: 18604533]
  • Mark J S Miller, Brian K Reuter, John L Wallace, Keith A Sharkey. A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. Journal of translational medicine. 2008 Jan; 6(?):3. doi: 10.1186/1479-5876-6-3. [PMID: 18205911]
  • Kuladip Jana, Subarna Jana, Prabhat Kumar Samanta. Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Reproductive biology and endocrinology : RB&E. 2006 Feb; 4(?):9. doi: 10.1186/1477-7827-4-9. [PMID: 16483355]
  • Saima Khaliq, Sadia Haider, Shahida P Ahmed, Tahira Perveen, Darakhshan J Haleem. Relationship of brain tryptophan and serotonin in improving cognitive performance in rats. Pakistan journal of pharmaceutical sciences. 2006 Jan; 19(1):11-5. doi: NULL. [PMID: 16632446]
  • Paola Badino, Rosangela Odore, Maria C Osella, Luciana Bergamasco, Paola Francone, Carlo Girardi, Giovanni Re. Modifications of serotonergic and adrenergic receptor concentrations in the brain of aggressive Canis familiaris. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2004 Nov; 139(3):343-50. doi: 10.1016/j.cbpb.2004.09.019. [PMID: 15556390]
  • Alvin Berger, David M Mutch, J Bruce German, Matthew A Roberts. Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression. Lipids in health and disease. 2002 Oct; 1(?):2. doi: 10.1186/1476-511x-1-2. [PMID: 12617750]