Lorazepam glucuronide (BioDeep_00000425311)
代谢物信息卡片
化学式: C21H18Cl2N2O8 (496.04401679999995)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)OC4C(C(C(C(O4)C(=O)O)O)O)O)Cl
InChI: InChI=1S/C21H18Cl2N2O8/c22-8-5-6-12-10(7-8)13(9-3-1-2-4-11(9)23)25-19(18(29)24-12)33-21-16(28)14(26)15(27)17(32-21)20(30)31/h1-7,14-17,19,21,26-28H,(H,24,29)(H,30,31)/t14-,15-,16+,17-,19?,21-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Brittany Malik-Wolf, Shawn Vorce, Justin Holler, Thomas Bosy. Evaluation of abalone β-glucuronidase substitution in current urine hydrolysis procedures.
Journal of analytical toxicology.
2014 Apr; 38(3):171-6. doi:
10.1093/jat/bku003. [PMID: 24488113] - Olga Papini, Carlo Bertucci, Sergio Pereira da Cunha, Neife Aparecida Guinaim Dos Santos, Vera Lucia Lanchote. Quantitative assay of lorazepam and its metabolite glucuronide by reverse-phase liquid chromatography-tandem mass spectrometry in human plasma and urine samples.
Journal of pharmaceutical and biomedical analysis.
2006 Feb; 40(2):389-96. doi:
10.1016/j.jpba.2005.07.033. [PMID: 16243469] - Olga Papini, Sergio Pereira da Cunha, Angelo do Carmo da Silva Mathes, Carlo Bertucci, Elaine Christine Dantas Moisés, Luciana de Barros Duarte, Ricardo de Carvalho Cavalli, Vera Lucia Lanchote. Kinetic disposition of lorazepam with focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples.
Journal of pharmaceutical and biomedical analysis.
2006 Feb; 40(2):397-403. doi:
10.1016/j.jpba.2005.07.021. [PMID: 16143486] - Andrea Baldacci, Wolfgang Thormann. Analysis of lorazepam and its 30-glucuronide in human urine by capillary electrophoresis: evidence for the formation of two distinct diastereoisomeric glucuronides.
Journal of separation science.
2006 Jan; 29(1):153-63. doi:
10.1002/jssc.200500268. [PMID: 16485721] - Eleonora L Swart, Joost de Jongh, Klaas P Zuideveld, Meindert Danhof, Lambertus G Thijs, Robert J M Strack van Schijndel. Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2005 Feb; 45(2):360-71. doi:
10.1053/j.ajkd.2004.09.004. [PMID: 15685515] - W Weinmann, N Lehmann, C Müller, A Wiedemann, M Svoboda. Identification of lorazepam and sildenafil as examples for the application of LC/ionspray-MS and MS-MS with mass spectra library searching in forensic toxicology.
Forensic science international.
2000 Sep; 113(1-3):339-44. doi:
10.1016/s0379-0738(00)00256-5. [PMID: 10978646] - G Morrison, S T Chiang, H H Koepke, B R Walker. Effect of renal impairment and hemodialysis on lorazepam kinetics.
Clinical pharmacology and therapeutics.
1984 May; 35(5):646-52. doi:
10.1038/clpt.1984.89. [PMID: 6713774] - A J Cummings, A G Whitelaw. A study of conjugation and drug elimination in the human neonate.
British journal of clinical pharmacology.
1981 Oct; 12(4):511-5. doi:
10.1111/j.1365-2125.1981.tb01259.x. [PMID: 6117307] - R Verbeeck, T B Tjandramaga, R Verberckmoes, P J De Schepper. Biotransformation and excretion of lorazepam in patients with chronic renal failure.
British journal of clinical pharmacology.
1976 Dec; 3(6):1033-9. doi:
10.1111/j.1365-2125.1976.tb00354.x. [PMID: 22216526]