Lodoxamide (BioDeep_00000423868)

   


代谢物信息卡片


Lodoxamide

化学式: C11H6ClN3O6 (310.9945126)
中文名称: 罗多沙胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C=C(C(=C1NC(=O)C(=O)O)Cl)NC(=O)C(=O)O)C#N
InChI: InChI=1S/C11H6ClN3O6/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21)

描述信息

C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C29714 - Mast Cell Stabilizer
S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics
D018926 - Anti-Allergic Agents
Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

同义名列表

2 个代谢物同义名

Lodoxamide; U-42585E (free acid)



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • So-Yeon Nam, Soo-Jin Park, Dong-Soon Im. Protective effect of lodoxamide on hepatic steatosis through GPR35. Cellular signalling. 2019 01; 53(?):190-200. doi: 10.1016/j.cellsig.2018.10.001. [PMID: 30304698]
  • Samia Yazid, Egle Solito, Helen Christian, Simon McArthur, Nicolas Goulding, Roderick Flower. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochemical pharmacology. 2009 Jun; 77(12):1814-26. doi: 10.1016/j.bcp.2009.03.010. [PMID: 19428336]
  • N Acar, E Toker, H Kazokoğlu. Tear and serum eosinophil cationic protein levels in seasonal allergic conjunctivitis. European journal of ophthalmology. 2003 Oct; 13(8):671-5. doi: 10.1177/112067210301300801. [PMID: 14620169]
  • C Blondin, B Cholley, N Haeffner-Cavaillon, P Goldschmidt. [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter]. Journal francais d'ophtalmologie. 2003 Apr; 26(4):328-36. doi: . [PMID: 12843888]
  • S Komatsu, M B Grisham, J M Russell, D N Granger. Enhanced mucosal permeability and nitric oxide synthase activity in jejunum of mast cell deficient mice. Gut. 1997 Nov; 41(5):636-41. doi: 10.1136/gut.41.5.636. [PMID: 9414970]
  • L Liao, D N Granger. Role of mast cells in oxidized low-density lipoprotein-induced microvascular dysfunction. The American journal of physiology. 1996 Nov; 271(5 Pt 2):H1795-800. doi: 10.1152/ajpheart.1996.271.5.h1795. [PMID: 8945893]
  • B R Ito, R L Engler, U del Balzo. Role of cardiac mast cells in complement C5a-induced myocardial ischemia. The American journal of physiology. 1993 May; 264(5 Pt 2):H1346-54. doi: 10.1152/ajpheart.1993.264.5.h1346. [PMID: 7684573]
  • J C Fitzpatrick, H Fisher, L Flancbaum. Mobilization of renal carnosine and histidine to histamine during compound-48/80-induced shock. Nephron. 1991; 59(2):299-303. doi: 10.1159/000186568. [PMID: 1956492]
  • M J Lynch, C M Grum, K P Gallagher, S F Bolling, G M Deeb, M L Morganroth. Xanthine oxidase inhibition attenuates ischemic-reperfusion lung injury. The Journal of surgical research. 1988 May; 44(5):538-44. doi: 10.1016/0022-4804(88)90159-x. [PMID: 3374117]
  • R S Desowitz, N E Palumbo, S F Perri, M S Sylvester. Inhibition of the adverse reaction to diethylcarbamazine in Dirofilaria immitis-infected dogs by lodoxamide ethyl. The American journal of tropical medicine and hygiene. 1982 Mar; 31(2):309-12. doi: 10.4269/ajtmh.1982.31.309. [PMID: 7072895]