pyridin-4-ol (BioDeep_00000418816)

Main id: BioDeep_00000231877

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4-HYDROXYPYRIDINE

化学式: C5H5NO (95.03711200000001)
中文名称: 4-羟基吡啶, 吡啶酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CNC=CC1=O
InChI: InChI=1S/C5H5NO/c7-5-1-3-6-4-2-5/h1-4H,(H,6,7)

描述信息

同义名列表

3 个代谢物同义名

4-HYDROXYPYRIDINE; 4(1H)-Pyridinone; pyridin-4-ol



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Di-Zao Li, Zhao-Di Fu, Hong-Yan Liu, Xian-Dao Pan. Facile synthesis and cytotoxicity of substituted uracil-1'(N)-acetic acid and 4-pyridone-1'(N)-acetic acid esters of 20(S)-camptothecins. Journal of Asian natural products research. 2024 Feb; 26(2):259-268. doi: 10.1080/10286020.2023.2300374. [PMID: 38347748]
  • Helena Pelantová, Martina Bugáňová, Martina Holubová, Blanka Šedivá, Jana Zemenová, David Sýkora, Petra Kaválková, Martin Haluzík, Blanka Železná, Lenka Maletínská, Jaroslav Kuneš, Marek Kuzma. Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination. Molecular and cellular endocrinology. 2016 08; 431(?):88-100. doi: 10.1016/j.mce.2016.05.003. [PMID: 27164444]
  • Xiaoqing Cai, Omar M Khdour, Jennifer Jaruvangsanti, Sidney M Hecht. Simplified bicyclic pyridinol analogues protect mitochondrial function. Bioorganic & medicinal chemistry. 2012 Jun; 20(11):3584-95. doi: 10.1016/j.bmc.2012.03.075. [PMID: 22560834]
  • Elena Synesiou, Lynnette D Fairbanks, H Anne Simmonds, Ewa M Slominska, Ryszard T Smolenski, Elizabeth A Carrey. 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside triphosphate (4PyTP), a novel NAD metabolite accumulating in erythrocytes of uremic children: a biomarker for a toxic NAD analogue in other tissues?. Toxins. 2011 06; 3(6):520-37. doi: 10.3390/toxins3060520. [PMID: 22069723]
  • Osama K Abou-Zied, Othman I K Al-Shihi. Characterization of subdomain IIA binding site of human serum albumin in its native, unfolded, and refolded states using small molecular probes. Journal of the American Chemical Society. 2008 Aug; 130(32):10793-801. doi: 10.1021/ja8031289. [PMID: 18642807]
  • Sho Takahata, Maiko Iida, Takuji Yoshida, Ko Kumura, Hideo Kitagawa, Shigeru Hoshiko. Discovery of 4-Pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (FabI) with antibacterial activity against Staphylococcus aureus. The Journal of antibiotics. 2007 Feb; 60(2):123-8. doi: 10.1038/ja.2007.11. [PMID: 17420562]
  • Michael Saeftel, Ramadan Salem Sarite, Tujo Njuguna, Ulrike Holzgrabe, Daniela Ulmer, Achim Hoerauf, Annette Kaiser. Piperidones with activity against Plasmodium falciparum. Parasitology research. 2006 Aug; 99(3):281-6. doi: 10.1007/s00436-006-0173-4. [PMID: 16550432]
  • M M Iba, J Fung, J V Giannone, A B Okey. Comparative induction of CYP1A1 expression by pyridine and its metabolites. Archives of biochemistry and biophysics. 2000 Jun; 378(2):299-310. doi: 10.1006/abbi.2000.1826. [PMID: 10860547]
  • G P Carlson. Comparison of the effects of pyridine and its metabolites on rat liver and kidney. Toxicology letters. 1996 Jun; 85(3):173-8. doi: 10.1016/0378-4274(96)03660-0. [PMID: 8644130]
  • M L W CHANG, B C JOHNSON. N-Methyl-4-pyridone-5-carboxamide, a new major normal metabolite of nicotinic acid in rat urine. The Journal of biological chemistry. 1959 Jul; 234(7):1817-21. doi: 10.1016/s0021-9258(18)69932-6. [PMID: 13672970]