Aminohippuric acid (BioDeep_00000418804)
Main id: BioDeep_00000014435
natural product PANOMIX_OTCML-2023
代谢物信息卡片
Aminohippuric acid (USP)
化学式: C9H10N2O3 (194.069139)
中文名称: 4-氨基马尿酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C(=O)NCC(=O)O)N
InChI: InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)
描述信息
An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.
V - Various > V04 - Diagnostic agents > V04C - Other diagnostic agents > V04CH - Tests for renal function and ureteral injuries
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
ATC code: V04CH30
4-Aminohippuric acid is a diagnostic agent used in renal testing and is used in the determination of renal plasma flow.
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:104011
- KEGGdrug: D06890
- KEGGdrug: D88242
- PubChem: 2148
- Metlin: METLIN3927
- DrugBank: DB00345
- ChEMBL: CHEMBL463
- MeSH: p-Aminohippuric Acid
- CAS: 94-16-6
- CAS: 61-78-9
- MoNA: PS103201
- MoNA: PS103202
- MoNA: PS103203
- MoNA: PS103204
- MetaboLights: MTBLC104011
- RefMet: Aminohippuric acid
- medchemexpress: HY-B1306
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 3708 Brassica napus: 10.3389/FNUT.2022.822033
- 35525 Daphnia magna: 10.1016/J.ENVINT.2009.12.006
- 3708 Brassica napus: 10.3389/FNUT.2022.822033
- 35525 Daphnia magna: 10.1016/J.ENVINT.2009.12.006
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Journal of exposure science & environmental epidemiology.
2022 01; 32(1):82-93. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Carissa Vinovskis, Lu-Ping Li, Pottumarthi Prasad, Kalie Tommerdahl, Laura Pyle, Robert G Nelson, Meda E Pavkov, Daniel van Raalte, Marian Rewers, Marlon Pragnell, Farid H Mahmud, David Z Cherney, Richard J Johnson, Kristen J Nadeau, Petter Bjornstad. Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes.
Diabetes.
2020 12; 69(12):2700-2708. doi:
10.2337/db20-0457. [PMID: 32737116] - Weize Huang, Nina Isoherranen. Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption.
CPT: pharmacometrics & systems pharmacology.
2020 10; 9(10):571-583. doi:
10.1002/psp4.12553. [PMID: 32977369] - Kelly E Mercer, Gabriella A M Ten Have, Lindsay Pack, Renny Lan, Nicolaas E P Deutz, Sean H Adams, Brian D Piccolo. Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs.
American journal of physiology. Gastrointestinal and liver physiology.
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Journal of biochemical and molecular toxicology.
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Molecular pharmacology.
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2018 Feb; 537(1-2):172-182. doi:
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Pharmacology.
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Nephrology (Carlton, Vic.).
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Analytical biochemistry.
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Nephron.
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Toxicology and applied pharmacology.
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Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
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Drug metabolism and disposition: the biological fate of chemicals.
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Circulation. Heart failure.
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Journal of separation science.
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American journal of physiology. Renal physiology.
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
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Diabetes research and clinical practice.
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British journal of clinical pharmacology.
2013 Apr; 75(4):990-6. doi:
10.1111/j.1365-2125.2012.04440.x. [PMID: 22905856] - Atcharaporn Ontawong, Naruwan Saowakon, Pornpun Vivithanaporn, Anchalee Pongchaidecha, Narissara Lailerd, Doungporn Amornlerdpison, Anusorn Lungkaphin, Chutima Srimaroeng. Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats.
BioMed research international.
2013; 2013(?):820786. doi:
10.1155/2013/820786. [PMID: 23862157] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - David Z I Cherney, James W Scholey, Shan Jiang, Ronnie Har, Vesta Lai, Etienne B Sochett, Heather N Reich. The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes.
Diabetes care.
2012 Nov; 35(11):2324-30. doi:
10.2337/dc12-0773. [PMID: 22837362] - Tao Liu, Qiang Meng, Changyuan Wang, Qi Liu, Xinjin Guo, Huijun Sun, Jinyong Peng, Xiaochi Ma, Taiichi Kaku, Kexin Liu. Changes in expression of renal Oat1, Oat3 and Mrp2 in cisplatin-induced acute renal failure after treatment of JBP485 in rats.
Toxicology and applied pharmacology.
2012 Nov; 264(3):423-30. doi:
10.1016/j.taap.2012.08.019. [PMID: 22992436] - Rais A Ansari, Syed A A Rizvi, Kazim Husain, Anastasios Lymperopoulos, William O Berndt. Effect of sulfhydryl modification on rat kidney basolateral plasma membrane transport function.
Bulletin of environmental contamination and toxicology.
2012 Oct; 89(4):699-703. doi:
10.1007/s00128-012-0756-y. [PMID: 22936015] - Chunja Lee, David S Riddick. Aryl hydrocarbon receptor-dependence of dioxin's effects on constitutive mouse hepatic cytochromes P450 and growth hormone signaling components.
Canadian journal of physiology and pharmacology.
2012 Oct; 90(10):1354-63. doi:
10.1139/y2012-099. [PMID: 22978700] - Yohannes Hagos, Gunnar Schley, Johannes Schödel, Wolfgang Krick, Gerhard Burckhardt, Carsten Willam, Birgitta C Burckhardt. α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).
Pflugers Archiv : European journal of physiology.
2012 Oct; 464(4):367-74. doi:
10.1007/s00424-012-1140-9. [PMID: 22875277] - Jianghao Ye, Qi Liu, Changyuan Wang, Qiang Meng, Jinyong Peng, Huijun Sun, Taiichi Kaku, Kexin Liu. Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Sep; 47(2):341-6. doi:
10.1016/j.ejps.2012.06.004. [PMID: 22728397] - Xia Lu, Na Li, Nelli Shushakova, Roland Schmitt, Jan Menne, Nathan Susnik, Matthias Meier, Michael Leitges, Hermann Haller, Faikah Gueler, Song Rong. C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion.
Journal of nephrology.
2012 Sep; 25(5):738-43. doi:
10.5301/jn.5000053. [PMID: 22180224] - Kathryn K Surdyk, Dawn L Sloan, Scott A Brown. Renal effects of carprofen and etodolac in euvolemic and volume-depleted dogs.
American journal of veterinary research.
2012 Sep; 73(9):1485-90. doi:
10.2460/ajvr.73.9.1485. [PMID: 22924732] - Alberto Montanari, Almerina Biggi, Aderville Cabassi, Irene Pelloni, Filippo Pigazzani, Silvana Pinelli, Giovanna Pelà, Luisa Musiari, David Z Cherney. Renal hemodynamic response to L-arginine in uncomplicated, type 1 diabetes mellitus: the role of buffering anions and tubuloglomerular feedback.
American journal of physiology. Renal physiology.
2012 Sep; 303(5):F648-58. doi:
10.1152/ajprenal.00149.2012. [PMID: 22739534] - Jing Wang, Yan Zhong, Steven G Carmella, J Bradley Hochalter, Diane Rauch, Andrew Oliver, Joni Jensen, Dorothy K Hatsukami, Pramod Upadhyaya, Stephen S Hecht, Cheryl L Zimmerman. Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation.
The Journal of pharmacology and experimental therapeutics.
2012 Sep; 342(3):750-60. doi:
10.1124/jpet.112.194118. [PMID: 22674470] - Malgorzata Lipowska, Jeffrey Klenc, Luigi G Marzilli, Andrew T Taylor. Preclinical evaluation of 99mTc(CO)3-aspartic-N-monoacetic acid, a renal radiotracer with pharmacokinetic properties comparable to 131I-o-iodohippurate.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 Aug; 53(8):1277-83. doi:
10.2967/jnumed.111.102236. [PMID: 22717977] - Idit F Schwartz, Ayelet Grupper, Hila Soetendorp, Oren Hillel, Ido Laron, Tamara Chernichovski, Merav Ingbir, Allexander Shtabski, Talia Weinstein, Gil Chernin, Moshe Shashar, Rami Hershkoviz, Doron Schwartz. Attenuated glomerular arginine transport prevents hyperfiltration and induces HIF-1α in the pregnant uremic rat.
American journal of physiology. Renal physiology.
2012 Aug; 303(3):F396-404. doi:
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Human & experimental toxicology.
2012 Aug; 31(8):759-70. doi:
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Acta biomaterialia.
2012 Jul; 8(6):2279-87. doi:
10.1016/j.actbio.2012.03.008. [PMID: 22406909] - M M Al-Bataineh, D Van Der Merwe, B D Schultz, R Gehring. Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV).
Journal of veterinary pharmacology and therapeutics.
2012 Jun; 35(3):209-15. doi:
10.1111/j.1365-2885.2011.01309.x. [PMID: 21623837] - Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M Aleksunes, Ryan M Pelis. Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):617-24. doi:
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BMC clinical pharmacology.
2012 Feb; 12(?):3. doi:
10.1186/1472-6904-12-3. [PMID: 22305183] - Antoine G Schneider, Lucie Hofmann, Grégoire Wuerzner, Nicolas Glatz, Marc Maillard, Jean-Yves Meuwly, Philippe Eggimann, Michel Burnier, Bruno Vogt. Renal perfusion evaluation with contrast-enhanced ultrasonography.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Feb; 27(2):674-81. doi:
10.1093/ndt/gfr345. [PMID: 21690200] - Yuichi Uwai, Hiroaki Honjo, Kikuo Iwamoto. Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.
Pharmacological research.
2012 Feb; 65(2):254-60. doi:
10.1016/j.phrs.2011.11.003. [PMID: 22108572] - Yanna Zhu, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Taiichi Kaku, Kexin Liu. Organic anion transporters involved in the excretion of bestatin in the kidney.
Peptides.
2012 Feb; 33(2):265-71. doi:
10.1016/j.peptides.2012.01.007. [PMID: 22273603] - Daochuan Li, Qing Wang, Caixia Liu, Huawei Duan, Xiaowen Zeng, Bo Zhang, Xiaodong Li, Jian Zhao, Shifu Tang, Zhifang Li, Xiumei Xing, Ping Yang, Liping Chen, Junling Zeng, Xiaonian Zhu, Shixin Zhang, Zhengbao Zhang, Lu Ma, Zhini He, Erman Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen. Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Feb; 125(2):382-91. doi:
10.1093/toxsci/kfr299. [PMID: 22048643] - Waja Wegner, Birgitta Christina Burckhardt, Gerhard Burckhardt, Maja Henjakovic. Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6.
PloS one.
2012; 7(4):e35556. doi:
10.1371/journal.pone.0035556. [PMID: 22530049] - Julia J Spaan, Timo Ekhart, Marc E A Spaanderman, Louis L H Peeters. Renal function after preeclampsia: a longitudinal pilot study.
Nephron. Clinical practice.
2012; 120(3):c156-61. doi:
10.1159/000338690. [PMID: 22687919] - Syed Quadri, Debra W Jackson, Priyanka Prathipati, Courtney Dean, Keith E Jackson. Heme induction with delta-aminolevulinic Acid stimulates an increase in water and electrolyte excretion.
International journal of hypertension.
2012; 2012(?):690973. doi:
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Clinical science (London, England : 1979).
2012 Jan; 122(2):63-73. doi:
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PloS one.
2012; 7(4):e36311. doi:
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PPAR research.
2012; 2012(?):219319. doi:
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Pharmacology.
2012; 90(1-2):66-77. doi:
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Journal of toxicology and environmental health. Part A.
2012; 75(18):1163-73. doi:
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Journal of cardiac failure.
2011 Dec; 17(12):982-9. doi:
10.1016/j.cardfail.2011.08.012. [PMID: 22123359] - Jinhwa Chang, Sujin Kim, Joohyun Jung, Heechun Lee, Hojung Choi, Dongwoo Chang, Youngwon Lee, Junghee Yoon, Mincheol Choi. Assessment of glomerular filtration rate with dynamic computed tomography in normal Beagle dogs.
Journal of veterinary science.
2011 Dec; 12(4):393-9. doi:
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Journal of animal science.
2011 Nov; 89(11):3501-13. doi:
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Journal of dairy science.
2011 Nov; 94(11):5558-68. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2011 Nov; 124(1):99-108. doi:
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Journal of cardiac failure.
2011 Oct; 17(10):797-803. doi:
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Diabetes care.
2011 Aug; 34(8):1821-6. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Aug; 26(8):2498-502. doi:
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Kidney international.
2011 Aug; 80(3):295-301. doi:
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