Indole-2-carboxylic acid (BioDeep_00000416073)

Main id: BioDeep_00000017887

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Indole-2-carboxylic acid

化学式: C9H7NO2 (161.0477)
中文名称: 吲哚-2-羧酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=C(N2)C(=O)O
InChI: InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12)

描述信息

COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current[1][2].
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current[1][2].

同义名列表

2 个代谢物同义名

Indole-2-carboxylic acid; Indole-2-carboxylic acid



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Amy M Sheflin, Erica C Borresen, Melissa J Wdowik, Sangeeta Rao, Regina J Brown, Adam L Heuberger, Corey D Broeckling, Tiffany L Weir, Elizabeth P Ryan. Pilot dietary intervention with heat-stabilized rice bran modulates stool microbiota and metabolites in healthy adults. Nutrients. 2015 Feb; 7(2):1282-300. doi: 10.3390/nu7021282. [PMID: 25690418]
  • Tim Sparey, Pravien Abeywickrema, Sarah Almond, Nick Brandon, Noel Byrne, Alister Campbell, Pete H Hutson, Marlene Jacobson, Brian Jones, Sanjeev Munshi, Danette Pascarella, Andrew Pike, G Sridhar Prasad, Nancy Sachs, Melanie Sakatis, Vinod Sardana, Shankar Venkatraman, Mary Beth Young. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorganic & medicinal chemistry letters. 2008 Jun; 18(11):3386-91. doi: 10.1016/j.bmcl.2008.04.020. [PMID: 18455394]
  • Grazyna Faure, Veerabasappa T Gowda, Rachid C Maroun. Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics. BMC structural biology. 2007 Dec; 7(?):82. doi: 10.1186/1472-6807-7-82. [PMID: 18062812]
  • J Scott Daniels, Robert Espina, Kevin Cao, Haodan Yuan, Jianrong Lin, Sharon Diamond, Barry Johnson, James Rodgers, Shimoga Prakash, Steve Unger, David Christ, Gerald Miwa, Liang-Shang Gan, Abdul Mutlib. Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey. Chemical research in toxicology. 2007 Nov; 20(11):1709-17. doi: 10.1021/tx700170q. [PMID: 17939741]
  • Fang Zhang, Brian E Lavan, Francine M Gregoire. Selective Modulators of PPAR-gamma Activity: Molecular Aspects Related to Obesity and Side-Effects. PPAR research. 2007; 2007(?):32696. doi: 10.1155/2007/32696. [PMID: 17389769]
  • James F Dropinski, Taro Akiyama, Monica Einstein, Bahanu Habulihaz, Tom Doebber, Joel P Berger, Peter T Meinke, Guo Q Shi. Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists. Bioorganic & medicinal chemistry letters. 2005 Nov; 15(22):5035-8. doi: 10.1016/j.bmcl.2005.08.002. [PMID: 16153845]
  • Baihua Hu, James W Jetter, Jay E Wrobel, Thomas M Antrilli, Jean S Bauer, Li Di, Sergiusz Polakowski, Uday Jain, David L Crandall. Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1. Bioorganic & medicinal chemistry letters. 2005 Aug; 15(15):3514-8. doi: 10.1016/j.bmcl.2005.05.095. [PMID: 15982877]
  • Guillaume A Schoch, Roger Attias, Monique Le Ret, Danièle Werck-Reichhart. Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1. Homology guided site-directed mutagenesis. European journal of biochemistry. 2003 Sep; 270(18):3684-95. doi: 10.1046/j.1432-1033.2003.03739.x. [PMID: 12950252]
  • V Stetinová, L Smetanová, V Grossmann, P Anzenbacher. In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives. General physiology and biophysics. 2002 Jun; 21(2):153-62. doi: . [PMID: 12236544]
  • C Kuehm-Caubere, P Caubere, B Jamart-Gregoire, A Negre-Salvayre, D Bonnefont-Rousselot, J G Bizot-Espiard, B Pfeiffer, D H Caignard, B Guardiola-Lemaitre, P Renard. Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation. Journal of medicinal chemistry. 1997 Apr; 40(8):1201-10. doi: 10.1021/jm960542k. [PMID: 9111294]