Dobesilic acid (BioDeep_00000413194)

   


代谢物信息卡片


2,5-Dihydroxybenzenesulfonate

化学式: C6H6O5S (189.9935946)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1O)S(=O)(=O)O)O
InChI: InChI=1S/C6H6O5S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3,7-8H,(H,9,10,11)

描述信息

D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
CONFIDENCE standard compound; INTERNAL_ID 1355; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 898; ORIGINAL_PRECURSOR_SCAN_NO 897
CONFIDENCE standard compound; INTERNAL_ID 1355; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 907; ORIGINAL_PRECURSOR_SCAN_NO 905
CONFIDENCE standard compound; INTERNAL_ID 1355; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 894; ORIGINAL_PRECURSOR_SCAN_NO 893
CONFIDENCE standard compound; INTERNAL_ID 1355; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 903; ORIGINAL_PRECURSOR_SCAN_NO 902
CONFIDENCE standard compound; INTERNAL_ID 1355; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 895; ORIGINAL_PRECURSOR_SCAN_NO 894
CONFIDENCE standard compound; INTERNAL_ID 1355; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 917; ORIGINAL_PRECURSOR_SCAN_NO 916

同义名列表

2 个代谢物同义名

Dobesilic acid; 2,5-Dihydroxybenzenesulfonate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alemiddin Ozdemir, Mustafa Ogden, Bahar Kartal, Asli Fahriye Ceylan, Ulas Yuksel, Bulent Bakar. Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats. Neurological research. 2023 May; 45(5):472-487. doi: 10.1080/01616412.2022.2159109. [PMID: 36548871]
  • Elham Hakimizadeh, Mohammad Yassin Zamanian, Morteza Damankhorshid, Lydia Giménez-Llort, Clara Sciorati, Marjan Nikbakhtzadeh, Khadijeh Moradbeygi, Małgorzata Kujawska, Ayat Kaeidi, Zahra Taghipour, Iman Fatemi. Calcium dobesilate protects against d-galactose-induced hepatic and renal dysfunction, oxidative stress, and pathological damage. Fundamental & clinical pharmacology. 2022 Aug; 36(4):721-730. doi: 10.1111/fcp.12766. [PMID: 35112398]
  • Zhijuan Xie, Lanji Wei, Jianying Chen, Zhong Chen. Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury. Bioengineered. 2022 02; 13(2):2816-2826. doi: 10.1080/21655979.2021.2024394. [PMID: 35038964]
  • Yuehong Zhang, Xuedong An, Liyun Duan, De Jin, Yingying Duan, Rongrong Zhou, Yuqing Zhang, Xiaomin Kang, Fengmei Lian. Effect of Chinese Patent Medicines on Ocular Fundus Signs and Vision in Calcium Dobesilate-Treated Persons With Non-Proliferative Diabetic Retinopathy: A Systematic Review and Meta-Analysis. Frontiers in endocrinology. 2022; 13(?):799337. doi: 10.3389/fendo.2022.799337. [PMID: 35370950]
  • Wenjuan Zhu, Pingning Jin, Meng Cheng, Hongrui Yang, Mengmeng Du, Tiemei Li, Guifen Zhu, Jing Fan. Novel recyclable acidic hydrophobic deep eutectic solvents for highly efficient extraction of calcium dobesilate in water and urine samples. Talanta. 2021 Oct; 233(?):122523. doi: 10.1016/j.talanta.2021.122523. [PMID: 34215026]
  • Hailan Shen, Kena Chen, Ju Cao. A new method for anti-negative interference of calcium dobesilate in serum creatinine enzymatic analysis. Journal of clinical laboratory analysis. 2021 Sep; 35(9):e23928. doi: 10.1002/jcla.23928. [PMID: 34329518]
  • Gholamreza Bazmandegan, Iman Fatemi, Ayat Kaeidi, Morteza Khademalhosseini, Ali Fathinejad, Morteza Amirteimoury. Calcium dobesilate prevents cisplatin-induced nephrotoxicity by modulating oxidative and histopathological changes in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2021 03; 394(3):515-521. doi: 10.1007/s00210-020-01990-3. [PMID: 33057778]
  • Hao Zhang, Shao-Hua Guo, Zheng-Kai Xue, Ya-Ru Zhang, Jia-Rui Wang, Jing-Jin Che, Tong Liu, Hua-Yue Tao, Guang-Ping Li, Seung-Woon Rha, Swapnil-Zaman Ashraful-Haque, Kang-Yin Chen. Effect of Calcium Dobesilate in Preventing Contrast-Induced Nephropathy in Patients with Diabetes and Chronic Kidney Disease. Clinics (Sao Paulo, Brazil). 2021; 76(?):e2942. doi: 10.6061/clinics/2021/e2942. [PMID: 34669873]
  • Nazma Akhter, Hong Sun, Jerrmia Ong'achwa Machuki, Hong-Qi Ren. Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice. Nephron. 2021; 145(5):553-567. doi: 10.1159/000515420. [PMID: 34126619]
  • Yanping Wang, Bangjie Zuo, Nannan Wang, Shulin Li, Caixia Liu, Dong Sun. Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Dec; 132(?):110798. doi: 10.1016/j.biopha.2020.110798. [PMID: 33011612]
  • Maria José Martinez-Zapata, Robin Wm Vernooij, Daniel Simancas-Racines, Sonia Maria Uriona Tuma, Airton T Stein, Rosa Maria M Moreno Carriles, Emilio Vargas, Xavier Bonfill Cosp. Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews. 2020 11; 11(?):CD003229. doi: 10.1002/14651858.cd003229.pub4. [PMID: 33141449]
  • Tianjiao Zhang, Xiuzhi Guo, Li'an Hou, Haijian Zhao, Rong Ma, Liangyu Xia, Honglei Li, Tingting You, Ling Qiu, Chuanbao Zhang. Effects of calcium dobesilate (CaD) interference on serum creatinine measurements: a national External Quality Assessment (EQA)-based educational survey of drug-laboratory test interactions. Clinical chemistry and laboratory medicine. 2020 07; 59(1):139-145. doi: 10.1515/cclm-2020-0424. [PMID: 32653871]
  • Florence Njau, Nelli Shushakova, Heiko Schenk, Vera Christine Wulfmeyer, Robin Bollin, Jan Menne, Hermann Haller. Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice. PloS one. 2020; 15(1):e0218494. doi: 10.1371/journal.pone.0218494. [PMID: 31935212]
  • Xi'an Li, Xin Bu, Fei Yan, Fuli Wang, Di Wei, Jiarui Yuan, Wanxiang Zheng, Jin Su, Jianlin Yuan. Deletion of discoidin domain receptor 2 attenuates renal interstitial fibrosis in a murine unilateral ureteral obstruction model. Renal failure. 2019 Nov; 41(1):481-488. doi: 10.1080/0886022x.2019.1621759. [PMID: 31169440]
  • Jie Liu, Shulin Li, Dong Sun. Calcium Dobesilate and Micro-vascular diseases. Life sciences. 2019 Mar; 221(?):348-353. doi: 10.1016/j.lfs.2019.02.023. [PMID: 30769115]
  • Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Zhaohui Ni. Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose. Mediators of inflammation. 2019; 2019(?):9893682. doi: 10.1155/2019/9893682. [PMID: 31780874]
  • Xiuzhi Guo, Fang Zhao, Yicong Yin, Danchen Wang, Li'an Hou, Jie Wu, Dandan Li, Xinqi Cheng, Liangyu Xia, Ermu Xu, Ling Qiu. Calcium dobesilate: A drug treatment for diabetic retinopathy can negatively interfere with the measurement of glycated albumin using the enzymatic method. Clinica chimica acta; international journal of clinical chemistry. 2018 Aug; 483(?):1-5. doi: 10.1016/j.cca.2018.04.014. [PMID: 29653084]
  • Xiuzhi Guo, Li'an Hou, Yicong Yin, Jie Wu, Fang Zhao, Liangyu Xia, Xinqi Cheng, Qian Liu, Li Liu, Ermu Xu, Ling Qiu. Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays. PloS one. 2018; 13(2):e0192440. doi: 10.1371/journal.pone.0192440. [PMID: 29432460]
  • Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Shan Mou, Zhaohui Ni. Diabetic Nephropathy Can Be Treated with Calcium Dobesilate by Alleviating the Chronic Inflammatory State and Improving Endothelial Cell Function. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 51(3):1119-1133. doi: 10.1159/000495491. [PMID: 30476916]
  • Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni. Calcium dobesilate may alleviate diabetes‑induced endothelial dysfunction and inflammation. Molecular medicine reports. 2017 Dec; 16(6):8635-8642. doi: 10.3892/mmr.2017.7740. [PMID: 29039485]
  • Tian Cai, Xiao-Yun Wu, Xiao-Qian Zhang, Hong-Xia Shang, Zhong-Wen Zhang, Lin Liao, Jian-Jun Dong. Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells. DNA and cell biology. 2017 Apr; 36(4):249-255. doi: 10.1089/dna.2016.3276. [PMID: 28151018]
  • Hermann Haller, Linong Ji, Klaus Stahl, Anna Bertram, Jan Menne. Molecular Mechanisms and Treatment Strategies in Diabetic Nephropathy: New Avenues for Calcium Dobesilate-Free Radical Scavenger and Growth Factor Inhibition. BioMed research international. 2017; 2017(?):1909258. doi: 10.1155/2017/1909258. [PMID: 29082239]
  • Eberhard Rabe, Stefania Ballarini, Lorenz Lehr. A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. Phlebology. 2016 May; 31(4):264-74. doi: 10.1177/0268355515586097. [PMID: 25991692]
  • A Seker, O Bardakci, S Eryilmaz, S Kocarslan, A Incebiyik, Y Yucel, A Taskin, M Soyalp, O Gokalp, A Uzunkoy. Does calcium dobesilate protect against intestinal ischemia-reperfusion injury induced in rats?. European review for medical and pharmacological sciences. 2016 05; 20(10):2168-73. doi: NULL. [PMID: 27249620]
  • Maria José Martinez-Zapata, Robin W M Vernooij, Sonia Maria Uriona Tuma, Airton T Stein, Rosa M Moreno, Emilio Vargas, Dolors Capellà, Xavier Bonfill Cosp. Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews. 2016 Apr; 4(?):CD003229. doi: 10.1002/14651858.cd003229.pub3. [PMID: 27048768]
  • Xiuzhi Guo, Li'an Hou, Xinqi Cheng, Tianjiao Zhang, Songlin Yu, Huiling Fang, Liangyu Xia, Zhihong Qi, Xuzhen Qin, Lin Zhang, Qian Liu, Li Liu, Shuling Chi, Yingying Hao, Ling Qiu. Strong Negative Interference by Calcium Dobesilate in Sarcosine Oxidase Assays for Serum Creatinine Involving the Trinder Reaction. Medicine. 2015 Jun; 94(23):e905. doi: 10.1097/md.0000000000000905. [PMID: 26061311]
  • XinYuan Zhang, Wei Liu, ShanShan Wu, JingLong Jin, WeiHong Li, NingLi Wang. Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis. Science China. Life sciences. 2015 Jan; 58(1):101-7. doi: 10.1007/s11427-014-4792-1. [PMID: 25528255]
  • Hamid Nasri. Antioxidants for prevention of gentamicin-induced nephrotoxicity. Iranian journal of kidney diseases. 2014 Jan; 8(1):1-2. doi: NULL. [PMID: 24413712]
  • Mostafa Jafarey, Saeed Changizi Ashtiyani, Houshang Najafi. Calcium dobesilate for prevention of gentamicin-induced nephrotoxicity in rats. Iranian journal of kidney diseases. 2014 Jan; 8(1):46-52. doi: NULL. [PMID: 24413721]
  • Alireza Javadzadeh, Amir Ghorbanihaghjo, Farzad Hami Adl, Dima Andalib, Hassan Khojasteh-Jafari, Kamyar Ghabili. Calcium dobesilate reduces endothelin-1 and high-sensitivity C-reactive protein serum levels in patients with diabetic retinopathy. Molecular vision. 2013; 19(?):62-8. doi: NULL. [PMID: 23335852]
  • Nirmal Perera, Danae Liolitsa, Satheesh Iype, Anna Croxford, Muhammed Yassin, Peter Lang, Obioha Ukaegbu, Christopher van Issum. Phlebotonics for haemorrhoids. The Cochrane database of systematic reviews. 2012 Aug; ?(8):CD004322. doi: 10.1002/14651858.cd004322.pub3. [PMID: 22895941]
  • Javier Angulo, Concepción Peiró, Tania Romacho, Argentina Fernández, Begoña Cuevas, Rocío González-Corrochano, Guillermo Giménez-Gallego, Iñigo Sáenz de Tejada, Carlos F Sánchez-Ferrer, Pedro Cuevas. Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial proliferation, arterial relaxation, vascular permeability and angiogenesis by dobesilate. European journal of pharmacology. 2011 Sep; 667(1-3):153-9. doi: 10.1016/j.ejphar.2011.06.015. [PMID: 21703259]
  • M CERRAHOGLU, A TANER KURDAL, I ISKESEN, E ONUR, H SIRIN. Calcium dobesilate reduces oxidative stress in cardiac surgery. The Journal of cardiovascular surgery. 2009 Oct; 50(5):695-701. doi: NULL. [PMID: 19339957]
  • I Cihan Ozbek, C Arslan, E Cantürk, O Süzer. The effects of calcium dobesilate on the mechanical function of rat hearts. The Journal of cardiovascular surgery. 2009 Jun; 50(3):395-401. doi: NULL. [PMID: 19543197]
  • Mei-Juan Gao, Ming Liu, Bo Li, Ming-Long Li, Li-Xiang Bian, Gui-Na Yu. [Protective effect of calcium dobesilate against early diabetic nephropathy of rat kidney]. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Feb; 44(2):126-33. doi: NULL. [PMID: 19408680]
  • Maria L Ribeiro, Andras I Seres, Angela M Carneiro, Michael Stur, Alain Zourdani, Patricia Caillon, José G Cunha-Vaz. Effect of calcium dobesilate on progression of early diabetic retinopathy: a randomised double-blind study. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2006 Dec; 244(12):1591-600. doi: 10.1007/s00417-006-0318-2. [PMID: 16763797]
  • C Koksal, A K Bozkurt, N Ustundag, D Konukoglu, B Musellim, G Sirin, T Cortelekoglu, A G Sayin. Attenuation of acute lung injury following lower limb ischemia/reperfusion: the pharmacological approach. The Journal of cardiovascular surgery. 2006 Aug; 47(4):445-9. doi: NULL. [PMID: 16953164]
  • Ihsan Iskesen, Osman Saribulbul, Mustafa Cerrahoglu, Ece Onur, Cetin Tekin, Hayrettin Sirin. Cardioprotective effect of calcium dobesilate during open-heart surgery. Acta cardiologica. 2006 Feb; 61(1):69-74. doi: 10.2143/ac.61.1.2005142. [PMID: 16485735]
  • Junwu Dong, Xiaochen Liu, Shenwei Liu, Mingbo Li, Yanmei Xu, Bing Cui. Effects of calcium dobesilate on glomerulus TIMP1 and collagen IV of diabetic rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2005; 25(4):416-8, 426. doi: 10.1007/bf02828211. [PMID: 16196291]
  • Xiaocheng Liu, Xinming Liu. Effect of calcium dobesilate on nephropathy in type 2 diabetic rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2005; 25(1):36-8. doi: 10.1007/bf02831381. [PMID: 15934303]
  • Xiao-cheng Liu, Yong-man Lu, Xiao-bing Jin, Hong-bing Zeng, Hong-yu Gao. [Dobesilate Calcium in the treatment of chronic kidney failure]. Zhonghua yi xue za zhi. 2004 Nov; 84(22):1892-3. doi: NULL. [PMID: 15631801]
  • Zhenghua Song, Qiaoli Yue, Changna Wang. Flow injection chemiluninescence for detecting picogram amounts of dobesilate in human urine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2004 Aug; 60(10):2377-82. doi: 10.1016/j.saa.2003.12.011. [PMID: 15249028]
  • Hervé Allain, Albert A Ramelet, Elisabeth Polard, Danièle Bentué-Ferrer. Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids. Drug safety. 2004; 27(9):649-60. doi: 10.2165/00002018-200427090-00003. [PMID: 15230646]
  • Charandeep Kaur, Rashmi Sarkar, Amrinder J Kanwar, Ashok K Attri, Ajay K Dabra, Suman Kochhar. An open trial of calcium dobesilate in patients with venous ulcers and stasis dermatitis. International journal of dermatology. 2003 Feb; 42(2):147-52. doi: 10.1046/j.1365-4362.2003.01709.x. [PMID: 12709007]
  • A K Bozkurt, D Konukoğlu, N Ustündağ, L Yüceyar, A S Mayda. Calcium dobesilate ameliorates lung injury following lower limb ischemia/reperfusion. Drugs under experimental and clinical research. 2002; 28(4):127-32. doi: NULL. [PMID: 12512230]
  • K Róna, K Ary. Determination of calcium dobesilate in human plasma using ion-pairing extraction and high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2001 May; 755(1-2):245-51. doi: 10.1016/s0378-4347(01)00114-1. [PMID: 11393710]
  • P Tamás, T Csermely, T Ertl, M Vizer, I Szabó, F T Prievara. Calcium dobesilate lowers the blood pressure in mild to moderate midtrimester hypertension: a pilot study. Gynecologic and obstetric investigation. 1999; 47(3):210-3. doi: 10.1159/000010080. [PMID: 10087420]
  • J Brunet, J C Farine, R P Garay, P Hannaert. In vitro antioxidant properties of calcium dobesilate. Fundamental & clinical pharmacology. 1998; 12(2):205-12. doi: 10.1111/j.1472-8206.1998.tb00943.x. [PMID: 9565776]
  • C Suschek, H Kolb, V Kolb-Bachofen. Dobesilate enhances endothelial nitric oxide synthase-activity in macro- and microvascular endothelial cells. British journal of pharmacology. 1997 Dec; 122(7):1502-8. doi: 10.1038/sj.bjp.0701512. [PMID: 9421302]
  • H Zhong, L Guo. [The plasma levels of endothelin in diabetic retinopathy and their changes after treatment with doxium]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. 1997; 22(1):56-8. doi: NULL. [PMID: 9868029]
  • A Haas, G Trummer, M Eckhardt, O Schmut, I Uyguner, K P Pfeiffer. [Effect of calcium dobesilate on progression of diabetic retinopathy]. Klinische Monatsblatter fur Augenheilkunde. 1995 Jul; 207(1):17-21. doi: 10.1055/s-2008-1035343. [PMID: 7564132]
  • M Muros, T López, C León, M Merino, M Calvo. Analytical interferences from calcium dobesilate in five serum assays. Clinical chemistry. 1993 Feb; 39(2):371. doi: 10.1093/clinchem/39.2.371. [PMID: 8432036]
  • L Szlavy, I Repa, H J Hachen. The influence of CLS 2210 on the course of myocardial infarction: a pilot study in man. Angiology. 1991 Aug; 42(8):639-47. doi: 10.1177/000331979104200806. [PMID: 1892239]
  • B Vojnikovic. Doxium (calcium dobesilate) reduces blood hyperviscosity and lowers elevated intraocular pressure in patients with diabetic retinopathy and glaucoma. Ophthalmic research. 1991; 23(1):12-20. doi: 10.1159/000267080. [PMID: 1870835]
  • I Repa, J D Garnic, N K Hollenberg. Myocardial infarction treated with two lymphagogues, calcium dobesilate (CLS 2210) and hyaluronidase: a coded, placebo-controlled animal study. Journal of cardiovascular pharmacology. 1990 Aug; 16(2):286-91. doi: 10.1097/00005344-199008000-00015. [PMID: 1697385]
  • L Szlavy, I Repa, I Lengyel, L Lamboy. Calcium dobesilate (CLS 2210) protects the myocardium in early acute myocardial infarction: a preliminary randomized, double-blind, placebo-controlled study of its effects on biochemical markers. Journal of cardiovascular pharmacology. 1990 Jan; 15(1):89-95. doi: 10.1097/00005344-199001000-00014. [PMID: 1688988]
  • G Androulakis, P A Panoysis. Plethysmographic confirmation of the beneficial effect of calcium dobesilate in primary varicose veins. Angiology. 1989 Jan; 40(1):1-4. doi: 10.1177/000331978904000101. [PMID: 2642669]
  • C T Plessas, S Souras, P E Karayannacos, S T Plessas, I Dontas, D Kotsarelis, G Asimakopoulos, J Gogas. Pharmacokinetic interaction in beagle dogs of antiplatelet drugs: acetylsalicylic acid, dipyridamole and calcium dobesilate. European journal of drug metabolism and pharmacokinetics. 1989 Jan; 14(1):79-83. doi: 10.1007/bf03190845. [PMID: 2759138]
  • P Költringer, O Eber, W Rothlauer, G Klima, P Lind, W Langsteger, P Wakonig. Calcium dobesilate and its effects on hemorheology and microcirculation. International journal of clinical pharmacology, therapy, and toxicology. 1988 Oct; 26(10):500-2. doi: NULL. [PMID: 3235217]
  • P Költringer, O Eber, G Klima, W Langsteger, P Wakonig, P Lind, W Rothlauer. [The acute hemorheologic effect of calcium dobesilate]. Acta medica Austriaca. 1988; 15(3):78-80. doi: NULL. [PMID: 3223220]
  • H Sinzinger, H Vinazzer. [Modification of eicosanoid synthesis by calcium dobesilate]. Wiener klinische Wochenschrift. 1987 Sep; 99(17):600-2. doi: NULL. [PMID: 3118578]
  • H Sinzinger, F Rauscha, H Vinazzer. Platelet function and prostaglandins in patients with peripheral vascular disease treated with calcium dobesilate. Prostaglandins, leukotrienes, and medicine. 1987 Sep; 29(1):1-9. doi: 10.1016/0262-1746(87)90091-6. [PMID: 2959967]
  • C T Plessas, P Karayannakos, S T Plessas, A Costakis, I Donta, G Skalkeas. Pharmacokinetics of calcium dobesilate in beagle dogs after a single administration. European journal of drug metabolism and pharmacokinetics. 1986 Oct; 11(4):303-8. doi: 10.1007/bf03189115. [PMID: 3582425]
  • C T Plessas, P Karayannakos, S T Plessas, A Costakis, I Donta, G Skalkeas. Pharmacokinetics of calcium dobesilate in beagle dogs after repeated administration. European journal of drug metabolism and pharmacokinetics. 1986 Oct; 11(4):309-12. doi: 10.1007/bf03189116. [PMID: 3582426]
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