Ilepatril (BioDeep_00000413190)

   


代谢物信息卡片


Ilepatril

化学式: C22H28N2O5S (432.17188380000005)
中文名称: 伊里帕特里尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NC1CC2=CC=CC=C2C3CCCC(N3C1=O)C(=O)O)SC(=O)C
InChI: InChI=1S/C22H28N2O5S/c1-12(2)19(30-13(3)25)20(26)23-16-11-14-7-4-5-8-15(14)17-9-6-10-18(22(28)29)24(17)21(16)27/h4-5,7-8,12,16-19H,6,9-11H2,1-3H3,(H,23,26)(H,28,29)/t16-,17+,18-,19-/m0/s1

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4207; ORIGINAL_PRECURSOR_SCAN_NO 4205
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4238; ORIGINAL_PRECURSOR_SCAN_NO 4236
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4229; ORIGINAL_PRECURSOR_SCAN_NO 4226
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4224; ORIGINAL_PRECURSOR_SCAN_NO 4221
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4237; ORIGINAL_PRECURSOR_SCAN_NO 4235
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8771; ORIGINAL_PRECURSOR_SCAN_NO 8768
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8784; ORIGINAL_PRECURSOR_SCAN_NO 8782
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8787; ORIGINAL_PRECURSOR_SCAN_NO 8785
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8812; ORIGINAL_PRECURSOR_SCAN_NO 8809
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8809; ORIGINAL_PRECURSOR_SCAN_NO 8804
CONFIDENCE standard compound; INTERNAL_ID 1338; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8820; ORIGINAL_PRECURSOR_SCAN_NO 8818

同义名列表

1 个代谢物同义名

Ilepatril



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Manuel Portero-Otín, Reinald Pamplona, Jordi Boada, Mariona Jové, Hugo Gonzalo, Marie Buleon, Wolfgang Linz, Stefan Schäfer, Ivan Tack, Jean-Pierre Girolami. Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats. Biochemical and biophysical research communications. 2008 Apr; 368(3):528-35. doi: 10.1016/j.bbrc.2008.01.101. [PMID: 18243127]
  • C Krebs, I Hamming, S Sadaghiani, O M Steinmetz, C Meyer-Schwesinger, S Fehr, R A K Stahl, I M Garrelds, A H J Danser, H van Goor, A Contrepas, G Nguyen, U Wenzel. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney international. 2007 Sep; 72(6):725-30. doi: 10.1038/sj.ki.5002408. [PMID: 17597696]
  • O M Steinmetz, S Sadaghiani, U Panzer, C Krebs, C Meyer-Schwesinger, T Streichert, S Fehr, I Hamming, H van Goor, R A K Stahl, U Wenzel. Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. American journal of physiology. Renal physiology. 2007 Feb; 292(2):F876-87. doi: 10.1152/ajprenal.00174.2006. [PMID: 17062848]
  • Alexander Riad, Jia Long Zhuo, Heinz Peter Schultheiss, Carsten Tschöpe. The role of the renal kallikrein-kinin system in diabetic nephropathy. Current opinion in nephrology and hypertension. 2007 Jan; 16(1):22-6. doi: 10.1097/mnh.0b013e328011a20c. [PMID: 17143067]
  • Willemijn A K M Windt, Wouter B A Eijkelkamp, Robert H Henning, Alex C A Kluppel, Pieter A de Graeff, Hans L Hillege, Stefan Schäfer, Dick de Zeeuw, Richard P E van Dokkum. Renal damage after myocardial infarction is prevented by renin-angiotensin-aldosterone-system intervention. Journal of the American Society of Nephrology : JASN. 2006 Nov; 17(11):3059-66. doi: 10.1681/asn.2006030209. [PMID: 17005935]
  • Wolfgang Linz, Stefan Schäfer, Freni Afkham, Martin Gerl, Hans-Ludwig Schmidts, Hartmut Rütten. Vasopeptidase inhibition prevents target organ damage and improves survival in spontaneously hypertensive rats. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2006 Sep; 7(3):155-61. doi: 10.3317/jraas.2006.025. [PMID: 17094052]
  • Michel Azizi, Alvine Bissery, Séverine Peyrard, Than Tam Guyene, Marie-Laure Ozoux, Anne Floch, Joël Ménard. Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans. Clinical pharmacology and therapeutics. 2006 Jan; 79(1):49-61. doi: 10.1016/j.clpt.2005.09.011. [PMID: 16413241]
  • Thomas Quaschning, Berthold Hocher, Sabine Ruhl, Annette Kraemer-Guth, Johannes Tilgner, Christoph Wanner, Jan Galle. Vasopeptidase inhibition normalizes blood pressure and restores endothelial function in renovascular hypertension. Kidney & blood pressure research. 2006; 29(6):351-9. doi: 10.1159/000097625. [PMID: 17139187]
  • Oliver Gross, Marie-Louise Koepke, Bogdan Beirowski, Eckhard Schulze-Lohoff, Stephan Segerer, Manfred Weber. Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688. Kidney international. 2005 Aug; 68(2):456-63. doi: 10.1111/j.1523-1755.2005.00423.x. [PMID: 16014022]
  • C Wihler, S Schäfer, K Schmid, E K Deemer, G Münch, M Bleich, A E Busch, T Dingermann, V Somoza, J W Baynes, J Huber. Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition. Diabetologia. 2005 Aug; 48(8):1645-53. doi: 10.1007/s00125-005-1837-9. [PMID: 16010524]
  • Ariela Benigni, Carla Zoja, Cristina Zatelli, Daniela Corna, Lorena Longaretti, Daniela Rottoli, Paola Maggioni, Marta Todeschini, Marina Noris, Giuseppe Remuzzi. Vasopeptidase inhibitor restores the balance of vasoactive hormones in progressive nephropathy. Kidney international. 2004 Nov; 66(5):1959-65. doi: 10.1111/j.1523-1755.2004.00982.x. [PMID: 15496167]
  • Stefan Schäfer, Hans-Ludwig Schmidts, Markus Bleich, Andreas E Busch, Wolfgang Linz. Nephroprotection in Zucker diabetic fatty rats by vasopeptidase inhibition is partly bradykinin B2 receptor dependent. British journal of pharmacology. 2004 Sep; 143(1):27-32. doi: 10.1038/sj.bjp.0705884. [PMID: 15289289]
  • James C Russell, Sandra E Kelly, Stefan Schäfer. Vasopeptidase inhibition improves insulin sensitivity and endothelial function in the JCR:LA-cp rat. Journal of cardiovascular pharmacology. 2004 Aug; 44(2):258-65. doi: 10.1097/00005344-200408000-00016. [PMID: 15243308]
  • Stefan Schäfer, Wolfgang Linz, Axel Bube, Martin Gerl, Jochen Huber, Gert Ulrich Kürzel, Markus Bleich, Hans-Ludwig Schmidts, Andreas E Busch, Hartmut Rütten. Vasopeptidase inhibition prevents nephropathy in Zucker diabetic fatty rats. Cardiovascular research. 2003 Nov; 60(2):447-54. doi: 10.1016/s0008-6363(03)00544-3. [PMID: 14613875]
  • Nadine Weckler, Daniela Leitzbach, Leszek Kalinowski, Tadeusz Malinski, Andreas E Busch, Wolfgang Linz, Ludmila Kalinowski. Effect of chronic treatment with the vasopeptidase inhibitor AVE 7688 and ramipril on endothelial function in atherogenic diet rabbits. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2003 Sep; 4(3):191-6. doi: 10.3317/jraas.2003.031. [PMID: 14608526]