CI-1044 (BioDeep_00000413183)

   


代谢物信息卡片


CI-1044

化学式: C23H19N5O2 (397.1539)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN2C(=O)C(N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=CN=CC=C5
InChI: InChI=1S/C23H19N5O2/c24-17-11-15-8-10-28-20(15)18(12-17)19(14-5-2-1-3-6-14)26-21(23(28)30)27-22(29)16-7-4-9-25-13-16/h1-7,9,11-13,21H,8,10,24H2,(H,27,29)/t21-/m0/s1

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1305; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6780; ORIGINAL_PRECURSOR_SCAN_NO 6778
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058988 - Phosphodiesterase 4 Inhibitors
CONFIDENCE standard compound; INTERNAL_ID 1305; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6785; ORIGINAL_PRECURSOR_SCAN_NO 6781
CONFIDENCE standard compound; INTERNAL_ID 1305; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6803; ORIGINAL_PRECURSOR_SCAN_NO 6801
CONFIDENCE standard compound; INTERNAL_ID 1305; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6797; ORIGINAL_PRECURSOR_SCAN_NO 6796
CONFIDENCE standard compound; INTERNAL_ID 1305; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6814; ORIGINAL_PRECURSOR_SCAN_NO 6812
CONFIDENCE standard compound; INTERNAL_ID 1305; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6816; ORIGINAL_PRECURSOR_SCAN_NO 6813

同义名列表

1 个代谢物同义名

CI-1044



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Lucie Clarysse, Maxime Guéguinou, Marie Potier-Cartereau, Grégoire Vandecasteele, Philippe Bougnoux, Stephan Chevalier, Aurélie Chantôme, Christophe Vandier. cAMP-PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3-Orai1 complex. Pflugers Archiv : European journal of physiology. 2014 Oct; 466(10):1921-32. doi: 10.1007/s00424-013-1435-5. [PMID: 24458591]
  • Grainne A McMahon Tobin, Jun Zhang, David Goodwin, Sharron Stewart, Lin Xu, Alan Knapton, Carlos González, Simona Bancos, Leshuai Zhang, Michael P Lawton, Bradley E Enerson, James L Weaver. The role of eNOS phosphorylation in causing drug-induced vascular injury. Toxicologic pathology. 2014 Jun; 42(4):709-24. doi: 10.1177/0192623314522885. [PMID: 24705881]
  • Christopher M Sheth, Bradley E Enerson, David Peters, Michael P Lawton, James L Weaver. Effects of modulating in vivo nitric oxide production on the incidence and severity of PDE4 inhibitor-induced vascular injury in Sprague-Dawley rats. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Jul; 122(1):7-15. doi: 10.1093/toxsci/kfr082. [PMID: 21498876]
  • Marie-Pierre Pruniaux, Vincent Lagente, Malika Ouaged, Bernadette Bertin, François Moreau, Christine Julien-Larose, Marie-Noelle Rocher, Christelle Leportier, Brigitte Martin, Anita Bouget, Jean-Pierre Dubuit, Catherine Burnouf, Annette M Doherty, Claude P Bertrand. Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways. Fundamental & clinical pharmacology. 2010 Feb; 24(1):73-82. doi: 10.1111/j.1472-8206.2009.00725.x. [PMID: 19650853]
  • Gilles Hanton, Cécile Sobry, Nicolas Daguès, Jean-Pierre Provost, Jean-Loic Le Net, Pierre Comby, Stephan Chevalier. Characterisation of the vascular and inflammatory lesions induced by the PDE4 inhibitor CI-1044 in the dog. Toxicology letters. 2008 Jun; 179(1):15-22. doi: 10.1016/j.toxlet.2008.03.009. [PMID: 18485625]
  • Nicolas Daguès, Valérie Pawlowski, Ghislaine Guigon, David Ledieu, Cécile Sobry, Gilles Hanton, Jean-Louis Freslon, Stephan Chevalier. Altered gene expression in rat mesenteric tissue following in vivo exposure to a phosphodiesterase 4 inhibitor. Toxicology and applied pharmacology. 2007 Jan; 218(1):52-63. doi: 10.1016/j.taap.2006.10.018. [PMID: 17157341]