Laurocapram (BioDeep_00000413157)

   


代谢物信息卡片


Laurocapram

化学式: C18H35NO (281.27185000000003)
中文名称: 月桂氮酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCN1CCCCCC1=O
InChI: InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)20/h2-17H2,1H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1212; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 11050; ORIGINAL_PRECURSOR_SCAN_NO 11048
C2140 - Adjuvant
CONFIDENCE standard compound; INTERNAL_ID 1212; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 11056; ORIGINAL_PRECURSOR_SCAN_NO 11055
CONFIDENCE standard compound; INTERNAL_ID 1212; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 11073; ORIGINAL_PRECURSOR_SCAN_NO 11072
CONFIDENCE standard compound; INTERNAL_ID 1212; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 11096; ORIGINAL_PRECURSOR_SCAN_NO 11095
CONFIDENCE standard compound; INTERNAL_ID 1212; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 11099; ORIGINAL_PRECURSOR_SCAN_NO 11098
CONFIDENCE standard compound; INTERNAL_ID 1212; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 11105; ORIGINAL_PRECURSOR_SCAN_NO 11104

同义名列表

1 个代谢物同义名

Laurocapram



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shupeng Liu, Xiang Bao, Songpo Zhang, Heng Zhang, Xiaofeng Lu, Taihao Li, Zhenyi Chen, Na Chen. The study of ultrasound and iontophoresis on oxaprozin transdermal penetration using surface-enhanced Raman spectroscopy. Drug delivery and translational research. 2020 02; 10(1):83-92. doi: 10.1007/s13346-019-00664-9. [PMID: 31407271]
  • Barbora Amélie Čuříková, Kamila Procházková, Barbora Filková, Petra Diblíková, Jan Svoboda, Andrej Kováčik, Kateřina Vávrová, Jarmila Zbytovská. Simplified stratum corneum model membranes for studying the effects of permeation enhancers. International journal of pharmaceutics. 2017 Dec; 534(1-2):287-296. doi: 10.1016/j.ijpharm.2017.10.038. [PMID: 29061325]
  • Xiaochang Liu, Peng Quan, Shanshan Li, Chao Liu, Yuan Zhao, Yongshan Zhao, Liang Fang. Time dependence of the enhancement effect of chemical enhancers: Molecular mechanisms of enhancing kinetics. Journal of controlled release : official journal of the Controlled Release Society. 2017 02; 248(?):33-44. doi: 10.1016/j.jconrel.2017.01.017. [PMID: 28088574]
  • Quoc Dat Pham, Sebastian Björklund, Johan Engblom, Daniel Topgaard, Emma Sparr. Chemical penetration enhancers in stratum corneum - Relation between molecular effects and barrier function. Journal of controlled release : official journal of the Controlled Release Society. 2016 06; 232(?):175-87. doi: 10.1016/j.jconrel.2016.04.030. [PMID: 27108613]
  • Jia Song, Xiucong Fan, Qi Shen. Daidzein-loaded nanostructured lipid carriers-PLGA nanofibers for transdermal delivery. International journal of pharmaceutics. 2016 Mar; 501(1-2):245-52. doi: 10.1016/j.ijpharm.2016.02.003. [PMID: 26851353]
  • Carolina Gonçalves Pupe, Flávia Almada Do Carmo, Valéria Pereira De Sousa, Marlene Lopes, Bárbara Abrahim-Vieira, António José Ribeiro, Francisco Veiga, Carlos Rangel Rodrigues, Cristina Padula, Patrizia Santi, Lucio Mendes Cabral. Development of a doxazosin and finasteride transdermal system for combination therapy of benign prostatic hyperplasia. Journal of pharmaceutical sciences. 2013 Nov; 102(11):4057-64. doi: 10.1002/jps.23715. [PMID: 23983168]
  • Lars B Heemstra, Barrie C Finnin, Joseph A Nicolazzo. The buccal mucosa as an alternative route for the systemic delivery of risperidone. Journal of pharmaceutical sciences. 2010 Nov; 99(11):4584-92. doi: 10.1002/jps.22175. [PMID: 20845457]
  • Diksha Kaushik, Bozena Michniak-Kohn. Percutaneous penetration modifiers and formulation effects: thermal and spectral analyses. AAPS PharmSciTech. 2010 Sep; 11(3):1068-83. doi: 10.1208/s12249-010-9469-x. [PMID: 20582492]
  • Zhao-Hua Shi, Fu-Liang Xiong, Zhi-Jun Huang, Deng-Ke Xiong, Qing-Hui Zeng. [Effects of penetration enhancers on percutaneous permeability of geniposide in Xiao'er Ninhuang tuire cataplasms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Sep; 33(18):2061-3. doi: ". [PMID: 19160783]
  • Wen-gang Wang, Liu-hong Yun, Rui Wang, Gui-ying Fu, Ze-yuan Liu. [Preparation of transdermal drug delivery system of felodipine-metoprolol and its bioavailability in rabbits]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Nov; 42(11):1206-14. doi: NULL. [PMID: 18300480]
  • Takashi Katsu, Tomonori Imamura, Keiko Komagoe, Kazufumi Masuda, Tohru Mizushima. Simultaneous measurements of K+ and calcein release from liposomes and the determination of pore size formed in a membrane. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2007 May; 23(5):517-22. doi: 10.2116/analsci.23.517. [PMID: 17495394]
  • Ying-zi Wang, Tian-chi Ren, Yong-qing Xiao. [Effects of different penetration enhancers on percutaneous absorption of lappaconitine gel in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 May; 30(9):665-8. doi: . [PMID: 16075728]
  • Xueqin Zhou, Jing Xu, Kangde Yao, Dongzhi Liu, Lei Wang, Xueyan Wang, Xinjian Yang, Yun Liu, Yaqin Fang. Interaction of 1-dodecyl-azacycloheptan-2-one with mouse stratum corneum. Journal of biomaterials science. Polymer edition. 2005; 16(5):563-74. doi: 10.1163/1568562053783740. [PMID: 16001716]
  • K Vávrová, J Zbytovská, A Hrabálek. Amphiphilic transdermal permeation enhancers: structure-activity relationships. Current medicinal chemistry. 2005; 12(19):2273-91. doi: 10.2174/0929867054864822. [PMID: 16178785]
  • Adrian C Williams, Brian W Barry. Penetration enhancers. Advanced drug delivery reviews. 2004 Mar; 56(5):603-18. doi: 10.1016/j.addr.2003.10.025. [PMID: 15019749]
  • Zhi-Ping L, Qiang Liu, Xin-Wei Lu. [Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA. 2002 Nov; 22(11):1003-4. doi: ". [PMID: 12433630]
  • C Puglia, F Bonina, G Trapani, M Franco, M Ricci. Evaluation of in vitro percutaneous absorption of lorazepam and clonazepam from hydro-alcoholic gel formulations. International journal of pharmaceutics. 2001 Oct; 228(1-2):79-87. doi: 10.1016/s0378-5173(01)00806-7. [PMID: 11576770]
  • D Evrard, E Touitou, S Kolusheva, Y Fishov, R Jelinek. A new colorimetric assay for studying and rapid screening of membrane penetration enhancers. Pharmaceutical research. 2001 Jul; 18(7):943-9. doi: 10.1023/a:1010980009823. [PMID: 11496953]
  • G S Pilgram, J van der Meulen, G S Gooris, H K Koerten, J A Bouwstra. The influence of two azones and sebaceous lipids on the lateral organization of lipids isolated from human stratum corneum. Biochimica et biophysica acta. 2001 Apr; 1511(2):244-54. doi: 10.1016/s0005-2736(01)00271-1. [PMID: 11286967]
  • A López-Castellano, C Cortell-Ivars, G López-Carballo, M Herráez-Domínguez. The influence of Span20 on stratum corneum lipids in langmuir monolayers: comparison with Azone. International journal of pharmaceutics. 2000 Aug; 203(1-2):245-53. doi: 10.1016/s0378-5173(00)00463-4. [PMID: 10967446]
  • G S Pilgram, A M Engelsma-van Pelt, H K Koerten, J A Bouwstra. The effect of two azones on the lateral lipid organization of human stratum corneum and its permeability. Pharmaceutical research. 2000 Jul; 17(7):796-802. doi: 10.1023/a:1007547906856. [PMID: 10990197]
  • L Norlén, J Engblom. Structure-related aspects on water diffusivity in fatty acid-soap and skin lipid model systems. Journal of controlled release : official journal of the Controlled Release Society. 2000 Jan; 63(1-2):213-26. doi: 10.1016/s0168-3659(99)00201-1. [PMID: 10640594]
  • S Engström, K Ekelund, J Engblom, L Eriksson, E Sparr, H Wennerström. The skin barrier from a lipid perspective. Acta dermato-venereologica. Supplementum. 2000; 208(?):31-5. doi: 10.1080/000155500750042835. [PMID: 10884937]
  • L Norlén, J Engblom, M Andersson, B Forslind. A new computer-based evaporimeter system for rapid and precise measurements of water diffusion through stratum corneum in vitro. The Journal of investigative dermatology. 1999 Oct; 113(4):533-40. doi: 10.1046/j.1523-1747.1999.00727.x. [PMID: 10504437]
  • J Engblom, S Engström, B Jönsson. Phase coexistence in cholesterol-fatty acid mixtures and the effect of the penetration enhancer Azone. Journal of controlled release : official journal of the Controlled Release Society. 1998 Mar; 52(3):271-80. doi: 10.1016/s0168-3659(97)00219-8. [PMID: 9743447]
  • J Wang, L Guo, L Li. [Screening of enhancers for permeation of berberine in ruyi patcher in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1998 Feb; 23(2):90-1, 128. doi: ". [PMID: 11596267]
  • T Ogiso, T Paku, M Iwaki, T Tanino. Percutaneous penetration of fluorescein isothiocyanate-dextrans and the mechanism for enhancement effect of enhancers on the intercellular penetration. Biological & pharmaceutical bulletin. 1995 Nov; 18(11):1566-71. doi: 10.1248/bpb.18.1566. [PMID: 8593481]
  • W H Craane-van Hinsberg, J C Verhoef, L J Bax, H E Junginger, H E Boddé. Role of appendages in skin resistance and iontophoretic peptide flux: human versus snake skin. Pharmaceutical research. 1995 Oct; 12(10):1506-12. doi: 10.1023/a:1016243706415. [PMID: 8584490]
  • J Yu, Y Cheng, Q Feng, K Jin. [Percutaneous absorption of venenum bufonis in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1995 Sep; 20(9):539-41, 575. doi: ". [PMID: 8679090]
  • I Saitoh, K Ikeda, Y Takagishi. Effect of benzyl alcohol on rat skin as a solvent of liquid droplet dispersion ointment. Biological & pharmaceutical bulletin. 1995 Feb; 18(2):321-5. doi: 10.1248/bpb.18.321. [PMID: 7742806]
  • E Mukherji, N J Millenbaugh, J L Au. Percutaneous absorption of 2',3'-dideoxyinosine in rats. Pharmaceutical research. 1994 Jun; 11(6):809-15. doi: 10.1023/a:1018965305234. [PMID: 7937518]
  • T M Turunen, A Urtti, P Paronen, K L Audus, J H Rytting. Effect of some penetration enhancers on epithelial membrane lipid domains: evidence from fluorescence spectroscopy studies. Pharmaceutical research. 1994 Feb; 11(2):288-94. doi: 10.1023/a:1018919811227. [PMID: 8165190]
  • R C Wester, J Melendres, L Sedik, H I Maibach. Percutaneous absorption of azone following single and multiple doses to human volunteers. Journal of pharmaceutical sciences. 1994 Feb; 83(2):124-5. doi: 10.1002/jps.2600830203. [PMID: 8169776]
  • Z R Guo. [Comparison of therapeutic value of various topical agents in Pseudomonas aeruginosa infection. An experimental study]. Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns. 1993 May; 9(3):181-3, 238. doi: NULL. [PMID: 8402350]
  • T Yano, N Higo, K Furukawa, M Tsuji, K Noda, M Otagiri. Evaluation of a new penetration enhancer 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101). Journal of pharmacobio-dynamics. 1992 Sep; 15(9):527-33. doi: 10.1248/bpb1978.15.527. [PMID: 1287186]
  • J Priborský, K Takayama, Y Obata, Z Príborská, T Nagai. Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs. Arzneimittel-Forschung. 1992 Feb; 42(2):116-9. doi: NULL. [PMID: 1610418]
  • K Sugibayashi, S Nakayama, T Seki, K Hosoya, Y Morimoto. Mechanism of skin penetration-enhancing effect by laurocapram. Journal of pharmaceutical sciences. 1992 Jan; 81(1):58-64. doi: 10.1002/jps.2600810112. [PMID: 1619571]
  • M Okumura, Y Nakamori, K Sugibayashi, Y Morimoto. Enhanced skin permeation of papaverine by a medium chain glyceride. Drug design and delivery. 1991 Apr; 7(2):147-57. doi: ". [PMID: 1910439]
  • L P Ruan, J M Zheng. [Research on nifedipine patch]. Yao xue xue bao = Acta pharmaceutica Sinica. 1991; 26(4):286-92. doi: NULL. [PMID: 1957675]
  • Y Obata, K Takayama, H Okabe, T Nagai. Effect of cyclic monoterpenes on percutaneous absorption in the case of a water-soluble drug (diclofenac sodium). Drug design and delivery. 1990 Oct; 6(4):319-28. doi: NULL. [PMID: 2083031]
  • T Itoh, J Xia, R Magavi, T Nishihata, J H Rytting. Use of shed snake skin as a model membrane for in vitro percutaneous penetration studies: comparison with human skin. Pharmaceutical research. 1990 Oct; 7(10):1042-7. doi: 10.1023/a:1015943200982. [PMID: 2281034]
  • H Okabe, Y Obata, K Takayama, T Nagai. Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes. Drug design and delivery. 1990 Sep; 6(3):229-38. doi: . [PMID: 2076182]
  • J W Wiechers, B F Drenth, F A Adolfsen, L Prins, R A de Zeeuw. Disposition and metabolic profiling of the penetration enhancer Azone. I. In vitro studies: urinary profiles of hamster, rat, monkey, and man. Pharmaceutical research. 1990 May; 7(5):496-9. doi: 10.1023/a:1015864632474. [PMID: 2367317]
  • J W Wiechers, B F Drenth, J H Jonkman, R A de Zeeuw. Percutaneous absorption, metabolic profiling, and excretion of the penetration enhancer azone after multiple dosing of an azone-containing triamcinolone acetonide cream in humans. Journal of pharmaceutical sciences. 1990 Feb; 79(2):111-5. doi: 10.1002/jps.2600790207. [PMID: 2324957]
  • W Y Xuan, Y Zhao, A Y Li, P S Xie, X Liu. [Effect of artesunate transdermal preparation on Plasmodium cynomolgi]. Yao xue xue bao = Acta pharmaceutica Sinica. 1990; 25(3):220-2. doi: ". [PMID: 2239338]
  • W J Lambert, W I Higuchi, K Knutson, S L Krill. Dose-dependent enhancement effects of azone on skin permeability. Pharmaceutical research. 1989 Sep; 6(9):798-803. doi: 10.1023/a:1015931715829. [PMID: 2813277]
  • H Okabe, K Takayama, A Ogura, T Nagai. Effect of limonene and related compounds on the percutaneous absorption of indomethacin. Drug design and delivery. 1989 Jun; 4(4):313-21. doi: NULL. [PMID: 2775451]
  • T Ogiso, Y Ito, M Iwaki, H Atago. A pharmacokinetic model for the percutaneous absorption of indomethacin and the prediction of drug disposition kinetics. Journal of pharmaceutical sciences. 1989 Apr; 78(4):319-23. doi: 10.1002/jps.2600780412. [PMID: 2724095]
  • T Seki, K Sugibayashi, K Juni, Y Morimoto. Percutaneous absorption enhancer applied to membrane permeation-controlled transdermal delivery of nicardipine hydrochloride. Drug design and delivery. 1989 Jan; 4(1):69-75. doi: NULL. [PMID: 2775447]
  • S Kondo, T Mizuno, I Sugimoto. Effects of penetration enhancers on percutaneous absorption of nifedipine. Comparison between Deet and Azone. Journal of pharmacobio-dynamics. 1988 Feb; 11(2):88-94. doi: 10.1248/bpb1978.11.88. [PMID: 3379568]
  • B W Barry, S L Bennett. Effect of penetration enhancers on the permeation of mannitol, hydrocortisone and progesterone through human skin. The Journal of pharmacy and pharmacology. 1987 Jul; 39(7):535-46. doi: 10.1111/j.2042-7158.1987.tb03173.x. [PMID: 2886623]
  • T Sekine, Y Machida, T Nagai. Gel ointment of verapamil for percutaneous absorption. Drug design and delivery. 1987 Feb; 1(3):245-52. doi: NULL. [PMID: 3509338]
  • T Ohshima, H Yoshikawa, K Takada, S Muranishi. Enhancing effect of absorption promoters on percutaneous absorption of a model dye (6-carboxyfluorescein) as poorly absorbable drugs. II. Study on the absorption promoting effect of azone. Journal of pharmacobio-dynamics. 1985 Nov; 8(11):900-5. doi: 10.1248/bpb1978.8.900. [PMID: 4093845]
  • J Hadgraft, K A Walters, P K Wotton. Facilitated transport of sodium salicylate across an artificial lipid membrane by Azone. The Journal of pharmacy and pharmacology. 1985 Oct; 37(10):725-7. doi: 10.1111/j.2042-7158.1985.tb04951.x. [PMID: 2867142]