suxibuzone (BioDeep_00000413141)

   


代谢物信息卡片


suxibuzone

化学式: C24H26N2O6 (438.1790776)
中文名称: 琥布宗
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC1(C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)COC(=O)CCC(=O)O
InChI: InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)

描述信息

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4740; ORIGINAL_PRECURSOR_SCAN_NO 4737
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4766; ORIGINAL_PRECURSOR_SCAN_NO 4761
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4755; ORIGINAL_PRECURSOR_SCAN_NO 4750
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4785; ORIGINAL_PRECURSOR_SCAN_NO 4781
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4770; ORIGINAL_PRECURSOR_SCAN_NO 4767
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9123; ORIGINAL_PRECURSOR_SCAN_NO 9121
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9211; ORIGINAL_PRECURSOR_SCAN_NO 9206
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9241; ORIGINAL_PRECURSOR_SCAN_NO 9238
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9265; ORIGINAL_PRECURSOR_SCAN_NO 9264
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9293; ORIGINAL_PRECURSOR_SCAN_NO 9291
CONFIDENCE standard compound; INTERNAL_ID 1135; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9260; ORIGINAL_PRECURSOR_SCAN_NO 9258

同义名列表

1 个代谢物同义名

suxibuzone



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • H H Maurer, F X Tauvel, T Kraemer. Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation. Journal of analytical toxicology. 2001 May; 25(4):237-44. doi: 10.1093/jat/25.4.237. [PMID: 11386636]
  • M V Jaraiz, C Rodriguez, M D San Andres, F Gonzalez, M I San Andres. Disposition and tolerance of suxibuzone in horses. Equine veterinary journal. 1999 Sep; 31(5):411-6. doi: 10.1111/j.2042-3306.1999.tb03841.x. [PMID: 10505957]
  • V Jaraiz, C Rodriguez, M D San Andres, F Gonzalez, M I San Andres. Pharmacokinetics and bioequivalence of two suxibuzone oral dosage forms in horses. Journal of veterinary pharmacology and therapeutics. 1999 Aug; 22(4):247-54. doi: 10.1046/j.1365-2885.1999.00219.x. [PMID: 10499236]
  • F T Delbeke, L Vynckier, M Debackere. The disposition of suxibuzone in the horse. Journal of veterinary pharmacology and therapeutics. 1993 Sep; 16(3):283-90. doi: 10.1111/j.1365-2885.1993.tb00175.x. [PMID: 8230399]
  • M C Caturla, E Cusido. Solid-phase extraction for the high-performance liquid chromatographic determination of indomethacin, suxibuzone, phenylbutazone and oxyphenbutazone in plasma, avoiding degradation of compounds. Journal of chromatography. 1992 Oct; 581(1):101-7. doi: 10.1016/0378-4347(92)80452-v. [PMID: 1429991]
  • F T Delbeke, M Debackere, L Vynckier. Disposition of human drug preparations in the horse. I. Rectally administered indomethacin. Journal of veterinary pharmacology and therapeutics. 1991 Jun; 14(2):145-9. doi: 10.1111/j.1365-2885.1991.tb00816.x. [PMID: 1920602]
  • Y Yasuda, T Shindo, N Mitani, N Ishida, F Oono, T Kageyama. Comparison of the absorption, excretion, and metabolism of suxibuzone and phenylbutazone in humans. Journal of pharmaceutical sciences. 1982 May; 71(5):565-72. doi: 10.1002/jps.2600710521. [PMID: 7097505]
  • T Marunaka, T Shibata, Y Minami, Y Umeno, T Shindo. Simultaneous high-performance liquid chromatographic determination of suxibuzone and its metabolites in plasma and urine. Journal of pharmaceutical sciences. 1980 Nov; 69(11):1258-61. doi: 10.1002/jps.2600691106. [PMID: 7452452]
  • T Shindo, Y Yasuda, K Taira, N Mitani, A Kanda, A Akazawa. [The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione(suxibuzone), antiinflammatory drug. I. Plasma levels and urinary excretion after oral administration of suxibuzone (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1979 Dec; 99(12):1186-200. doi: 10.1248/yakushi1947.99.12_1186. [PMID: 120893]
  • S Erill, J Laporte. Uricosuric activity of suxibuzone, a new phenylbutazone derivative. Archivos de farmacologia y toxicologia. 1975 Mar; 1(1):43-6. doi: NULL. [PMID: 1231648]