Pepcid (BioDeep_00000413137)

   


代谢物信息卡片


famotidine

化学式: C8H15N7O2S3 (337.044933)
中文名称: 法莫替丁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
InChI: InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2002; ORIGINAL_PRECURSOR_SCAN_NO 2000
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BA - H2-receptor antagonists
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1942; ORIGINAL_PRECURSOR_SCAN_NO 1939
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1950; ORIGINAL_PRECURSOR_SCAN_NO 1949
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1959; ORIGINAL_PRECURSOR_SCAN_NO 1957
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1977; ORIGINAL_PRECURSOR_SCAN_NO 1975
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2003; ORIGINAL_PRECURSOR_SCAN_NO 2000
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4186; ORIGINAL_PRECURSOR_SCAN_NO 4184
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4210; ORIGINAL_PRECURSOR_SCAN_NO 4209
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4236; ORIGINAL_PRECURSOR_SCAN_NO 4235
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4229; ORIGINAL_PRECURSOR_SCAN_NO 4227
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4226; ORIGINAL_PRECURSOR_SCAN_NO 4225
CONFIDENCE standard compound; INTERNAL_ID 1121; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4191; ORIGINAL_PRECURSOR_SCAN_NO 4189
Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

同义名列表

3 个代谢物同义名

famotidine; Pepcid; MK-208



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rajalakshmi Munusamy, Sangeetha Shanmugasundharam. Improved gastric residence time of famotidine by raft-forming drug delivery system using DOE. International journal of immunopathology and pharmacology. 2024 Jan; 38(?):3946320241249429. doi: 10.1177/03946320241249429. [PMID: 38721971]
  • Juan C Durán-Álvarez, Blanca Prado, Rodolfo Zanella, Mario Rodríguez, Suhaila Díaz. Wastewater surveillance of pharmaceuticals during the COVID-19 pandemic in Mexico City and the Mezquital Valley: A comprehensive environmental risk assessment. The Science of the total environment. 2023 Nov; 900(?):165886. doi: 10.1016/j.scitotenv.2023.165886. [PMID: 37524191]
  • Mona F Mahmoud, Walied Abdo, Mohamed Nabil, Badreddine Drissi, Assem M El-Shazly, Mohamed A O Abdelfattah, Mansour Sobeh. Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Feb; 160(?):114331. doi: 10.1016/j.biopha.2023.114331. [PMID: 36736281]
  • Ahmed A Ishola, Tanuja Joshi, Suliat I Abdulai, Habibu Tijjani, Hemlata Pundir, Subhash Chandra. Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19. Journal of biomolecular structure & dynamics. 2022 08; 40(13):5785-5802. doi: 10.1080/07391102.2021.1873191. [PMID: 33491579]
  • Huan Yang, Sam J George, Dane A Thompson, Harold A Silverman, Téa Tsaava, Aisling Tynan, Valentin A Pavlov, Eric H Chang, Ulf Andersson, Michael Brines, Sangeeta S Chavan, Kevin J Tracey. Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm. Molecular medicine (Cambridge, Mass.). 2022 05; 28(1):57. doi: 10.1186/s10020-022-00483-8. [PMID: 35578169]
  • Christina M Brennan, Sandeep Nadella, Xiang Zhao, Richard J Dima, Nicole Jordan-Martin, Breanna R Demestichas, Sam O Kleeman, Miriam Ferrer, Eva Carlotta von Gablenz, Nicholas Mourikis, Michael E Rubin, Harsha Adnani, Hassal Lee, Taehoon Ha, Soma Prum, Cheryl B Schleicher, Sharon S Fox, Michael G Ryan, Christina Pili, Gary Goldberg, James M Crawford, Sara Goodwin, Xiaoyue Zhang, Jonathan B Preall, Ana S H Costa, Joseph Conigliaro, Joseph R Masci, Jie Yang, David A Tuveson, Kevin J Tracey, Tobias Janowitz. Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial. Gut. 2022 05; 71(5):879-888. doi: 10.1136/gutjnl-2022-326952. [PMID: 35144974]
  • Toshiki Kuno, Matsuo So, Mai Takahashi, Natalia N Egorova. The association between famotidine and in-hospital mortality of patients with COVID-19. Journal of medical virology. 2022 03; 94(3):1186-1189. doi: 10.1002/jmv.27375. [PMID: 34609001]
  • Foad Rommasi, Mohammad Javad Nasiri, Mehdi Mirsaeidi. Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features. Molecular and cellular biochemistry. 2022 Mar; 477(3):711-726. doi: 10.1007/s11010-021-04325-9. [PMID: 35013850]
  • Song Ren, Karthick Vishwanathan, Mireille Cantarini, Paul Frewer, Indira Hara, Graeme Scarfe, Wendy Burke, Stein Schalkwijk, Yan Li, David Han, Ronald Goldwater. Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam. British journal of clinical pharmacology. 2022 02; 88(2):655-668. doi: 10.1111/bcp.14994. [PMID: 34322894]
  • Martine Gehin, Jolanta Wierdak, Giancarlo Sabattini, Patricia N Sidharta, Jasper Dingemanse. Effect of gastric pH and of a moderate CYP3A4 inducer on the pharmacokinetics of daridorexant, a dual orexin receptor antagonist. British journal of clinical pharmacology. 2022 02; 88(2):810-819. doi: 10.1111/bcp.15029. [PMID: 34371524]
  • Moein Mohseni, Vahid Raissi, Yasamin Sharifan, Kimia Barikro, Sasan Amiri, Maedeh Sadat Mohseni, Farid Raeisi, Kimia Masoumi, Sina Khodakarami, Omid Raiesi. Therapeutic Status of Famotidine in COVID-19 Patients: A Review. Infectious disorders drug targets. 2022; 22(3):e070122200096. doi: 10.2174/1871526522666220107125511. [PMID: 34994318]
  • Weizheng Li, Yongxue Dong, Xianmei Lei. No Evidence Indicates Famotidine Reduces the Risk of Serious Disease in COVID-19 Patients After Propensity Score Matching: Meta-Analysis and Systematic Reviews. Digestive diseases and sciences. 2022 01; 67(1):351-353. doi: 10.1007/s10620-021-07214-9. [PMID: 34471967]
  • Kin Wah Fung, Seo H Baik, Fitsum Baye, Zhaonian Zheng, Vojtech Huser, Clement J McDonald. Effect of common maintenance drugs on the risk and severity of COVID-19 in elderly patients. PloS one. 2022; 17(4):e0266922. doi: 10.1371/journal.pone.0266922. [PMID: 35436293]
  • Marcus A Banks. Core Concept: In the wake of COVID-19, decentralized clinical trials move to center stage. Proceedings of the National Academy of Sciences of the United States of America. 2021 11; 118(47):. doi: 10.1073/pnas.2119097118. [PMID: 34789570]
  • Chenyu Sun, Yue Chen, Lei Hu, Yile Wu, Mingming Liang, Mubashir Ayaz Ahmed, Chandur Bhan, Zhichun Guo, Hongru Yang, Yijing Zuo, Yue Yan, Qin Zhou. Does Famotidine Reduce the Risk of Progression to Severe Disease, Death, and Intubation for COVID-19 Patients? A Systemic Review and Meta-Analysis. Digestive diseases and sciences. 2021 11; 66(11):3929-3937. doi: 10.1007/s10620-021-06872-z. [PMID: 33625613]
  • Robert W Malone. More Than Just Heartburn: Does Famotidine Effectively Treat Patients with COVID-19?. Digestive diseases and sciences. 2021 11; 66(11):3672-3673. doi: 10.1007/s10620-021-06875-w. [PMID: 33625612]
  • Jiandong Zhou, Xiansong Wang, Sharen Lee, William Ka Kei Wu, Bernard Man Yung Cheung, Qingpeng Zhang, Gary Tse. Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study. Gut. 2021 10; 70(10):2012-2013. doi: 10.1136/gutjnl-2020-323668. [PMID: 33277346]
  • Parth Sarthi Sen Gupta, Satyaranjan Biswal, Dipankar Singha, Malay Kumar Rana. Binding insight of clinically oriented drug famotidine with the identified potential target of SARS-CoV-2. Journal of biomolecular structure & dynamics. 2021 Sep; 39(14):5327-5333. doi: 10.1080/07391102.2020.1784795. [PMID: 32579065]
  • Rukmini Mukherjee, Anshu Bhattacharya, Denisa Bojkova, Ahmad Reza Mehdipour, Donghyuk Shin, Khadija Shahed Khan, Hayley Hei-Yin Cheung, Kam-Bo Wong, Wai-Lung Ng, Jindrich Cinatl, Paul P Geurink, Gerbrand J van der Heden van Noort, Krishnaraj Rajalingam, Sandra Ciesek, Gerhard Hummer, Ivan Dikic. Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection. The Journal of biological chemistry. 2021 08; 297(2):100925. doi: 10.1016/j.jbc.2021.100925. [PMID: 34214498]
  • Rahul Sethia, Manya Prasad, Pramod Kumar Garg. Famotidine and Mortality in Coronavirus Disease 2019. Gastroenterology. 2021 07; 161(1):361-362. doi: 10.1053/j.gastro.2020.12.045. [PMID: 33388317]
  • Santenna Chenchula, Avik Ray, Balakrishnan Sadasivam. Famotidine Repurposing for Novel Corona Virus Disease of 2019: A Systematic Review. Drug research. 2021 Jul; 71(6):295-301. doi: 10.1055/a-1397-6763. [PMID: 33757133]
  • Waseem Amjad, Adnan Malik. Famotidine and Hospitalized COVID-19 Patients: Are the Benefits True?. The American journal of gastroenterology. 2021 07; 116(7):1561. doi: 10.14309/ajg.0000000000001217. [PMID: 34183586]
  • Daniel E Freedberg, Timothy C Wang, Julian A Abrams. Famotidine and Coronavirus Disease 2019. Gastroenterology. 2021 07; 161(1):360-361. doi: 10.1053/j.gastro.2020.12.044. [PMID: 33387529]
  • Faisal Kamal, Muhammad Ali Khan, Sachit Sharma, Zaid Imam, Colin W Howden. Lack of Consistent Associations Between Pharmacologic Gastric Acid Suppression and Adverse Outcomes in Patients With Coronavirus Disease 2019: Meta-Analysis of Observational Studies. Gastroenterology. 2021 06; 160(7):2588-2590.e7. doi: 10.1053/j.gastro.2021.02.028. [PMID: 33609504]
  • Chia Siang Kow, Ismail Abdul Sattar Burud, Syed Shahzad Hasan. Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19: A Meta-analysis. Mayo Clinic proceedings. 2021 05; 96(5):1365-1367. doi: 10.1016/j.mayocp.2021.03.001. [PMID: 33958065]
  • Carl J Lavie. In Reply-Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19: A Meta-analysis. Mayo Clinic proceedings. 2021 05; 96(5):1367-1368. doi: 10.1016/j.mayocp.2021.03.002. [PMID: 33958066]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ka Shing Cheung, Ivan F N Hung, Wai K Leung. Association Between Famotidine Use and COVID-19 Severity in Hong Kong: A Territory-wide Study. Gastroenterology. 2021 04; 160(5):1898-1899. doi: 10.1053/j.gastro.2020.05.098. [PMID: 32682763]
  • Vijay P Singh, Bara El-Kurdi, Christopher Rood. What Underlies the Benefit of Famotidine Formulations Used During COVID-19?. Gastroenterology. 2021 04; 160(5):1899-1900. doi: 10.1053/j.gastro.2020.07.051. [PMID: 32777281]
  • Jeffrey Mather. Response to Ma and Wu. The American journal of gastroenterology. 2021 04; 116(4):849-850. doi: 10.14309/ajg.0000000000001068. [PMID: 33982974]
  • Azza Shoaibi, Stephen Patrick Fortin, Rachel Weinstein, Jesse A Berlin, Patrick Ryan. Comparative Effectiveness of Famotidine in Hospitalized COVID-19 Patients. The American journal of gastroenterology. 2021 04; 116(4):692-699. doi: 10.14309/ajg.0000000000001153. [PMID: 33982938]
  • Tianyi Ma, Meng Wu. Association Between Famotidine Use and Clinical Outcomes in Patients With COVID-19: Assessment of Available Evidence. The American journal of gastroenterology. 2021 04; 116(4):848-849. doi: 10.14309/ajg.0000000000001008. [PMID: 33982973]
  • Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O'Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D Weeks, Florian Douam, Mohsan Saeed, Ali H Munawar. The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication. Scientific reports. 2021 03; 11(1):5433. doi: 10.1038/s41598-021-84782-w. [PMID: 33686143]
  • Theoharis C Theoharides. Potential association of mast cells with coronavirus disease 2019. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2021 03; 126(3):217-218. doi: 10.1016/j.anai.2020.11.003. [PMID: 33161155]
  • Samrat Yeramaneni, Pratik Doshi, Kenneth Sands, Mandelin Cooper, Dax Kurbegov, Gregg Fromell. Famotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized Patients With Coronavirus Disease 2019 From a Large Healthcare System. Gastroenterology. 2021 02; 160(3):919-921.e3. doi: 10.1053/j.gastro.2020.10.011. [PMID: 33058865]
  • Leonard Chiu, Max Shen, Chun-Han Lo, Nicholas Chiu, Austin Chen, Hyun Joon Shin, Elizabeth Horn Prsic, Chin Hur, Ronald Chow, Benjamin Lebwohl. Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysis. PloS one. 2021; 16(11):e0259514. doi: 10.1371/journal.pone.0259514. [PMID: 34735523]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Hiroyuki Takita, Daniel Scotcher, Rajkumar Chinnadurai, Philip A Kalra, Aleksandra Galetin. Physiologically-Based Pharmacokinetic Modelling of Creatinine-Drug Interactions in the Chronic Kidney Disease Population. CPT: pharmacometrics & systems pharmacology. 2020 12; 9(12):695-706. doi: 10.1002/psp4.12566. [PMID: 33049120]
  • Hamid Reza Samimagham, Mehdi Hassani Azad, Maryam Haddad, Mohsen Arabi, Dariush Hooshyar, Mitra KazemiJahromi. The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Oct; 21(1):848. doi: 10.1186/s13063-020-04773-6. [PMID: 33050945]
  • Hinata Ueda, Katsuya Narumi, Yu Sato, Ayako Furugen, Masaki Kobayashi, Ken Iseki. Evaluation of possible pharmacokinetic interaction between methotrexate and proton pump inhibitors in rats. Pharmacological reports : PR. 2020 Oct; 72(5):1426-1432. doi: 10.1007/s43440-020-00130-1. [PMID: 32671657]
  • Jeffrey F Mather, Richard L Seip, Raymond G McKay. Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19. The American journal of gastroenterology. 2020 10; 115(10):1617-1623. doi: 10.14309/ajg.0000000000000832. [PMID: 32852338]
  • Ekjot Grewal, Bayu Sutarjono, Ibbad Mohammed. Angioedema, ACE inhibitor and COVID-19. BMJ case reports. 2020 Sep; 13(9):. doi: 10.1136/bcr-2020-237888. [PMID: 32912894]
  • Daniel E Freedberg, Joseph Conigliaro, Timothy C Wang, Kevin J Tracey, Michael V Callahan, Julian A Abrams. Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study. Gastroenterology. 2020 09; 159(3):1129-1131.e3. doi: 10.1053/j.gastro.2020.05.053. [PMID: 32446698]
  • Tobias Janowitz, Eva Gablenz, David Pattinson, Timothy C Wang, Joseph Conigliaro, Kevin Tracey, David Tuveson. Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series. Gut. 2020 09; 69(9):1592-1597. doi: 10.1136/gutjnl-2020-321852. [PMID: 32499303]
  • Reed B Hogan Ii, Reed B Hogan Iii, Tim Cannon, Maria Rappai, John Studdard, Doug Paul, Thomas P Dooley. Dual-histamine receptor blockade with cetirizine - famotidine reduces pulmonary symptoms in COVID-19 patients. Pulmonary pharmacology & therapeutics. 2020 08; 63(?):101942. doi: 10.1016/j.pupt.2020.101942. [PMID: 32871242]
  • Ritwik Ghosh, Subhankar Chatterjee, Souvik Dubey, Carl J Lavie. Famotidine Against SARS-CoV2: A Hope or Hype?. Mayo Clinic proceedings. 2020 08; 95(8):1797-1799. doi: 10.1016/j.mayocp.2020.05.027. [PMID: 32753153]
  • Rania El-Shaheny, Mohamed O Radwan, Fathalla Belal, Koji Yamada. Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability. Journal of pharmaceutical and biomedical analysis. 2020 Jul; 186(?):113305. doi: 10.1016/j.jpba.2020.113305. [PMID: 32353682]
  • Joseph T Ortega, Maria Luisa Serrano, Beata Jastrzebska. Class A G Protein-Coupled Receptor Antagonist Famotidine as a Therapeutic Alternative Against SARS-CoV2: An In Silico Analysis. Biomolecules. 2020 Jun; 10(6):. doi: 10.3390/biom10060954. [PMID: 32599963]
  • Gergő Dargó, Dávid Bajusz, Kristóf Simon, Judit Müller, György T Balogh. Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. Journal of medicinal chemistry. 2020 02; 63(4):1763-1774. doi: 10.1021/acs.jmedchem.0c00046. [PMID: 31995375]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Kacey Anderson, Hao Zheng, Mona Kotecha, Jennifer Cuvin, Bob Scott, Shringi Sharma, Ann Ran-Ran Qin, Florence Namour, Yan Xin. The Relative Bioavailability and Effects of Food and Acid-Reducing Agents on Filgotinib Tablets in Healthy Subjects. Clinical pharmacology in drug development. 2019 07; 8(5):585-594. doi: 10.1002/cpdd.659. [PMID: 30768860]
  • Sundar Kumar Kondru, Ajay Godwin Potnuri, Lingesh Allakonda, Prasad Konduri. Histamine 2 receptor antagonism elicits protection against doxorubicin-induced cardiotoxicity in rodent model. Molecular and cellular biochemistry. 2018 Apr; 441(1-2):77-88. doi: 10.1007/s11010-017-3175-x. [PMID: 28887671]
  • Katsuya Narumi, Yu Sato, Masaki Kobayashi, Ayako Furugen, Kumiko Kasashi, Takehiro Yamada, Takanori Teshima, Ken Iseki. Effects of proton pump inhibitors and famotidine on elimination of plasma methotrexate: Evaluation of drug-drug interactions mediated by organic anion transporter 3. Biopharmaceutics & drug disposition. 2017 Dec; 38(9):501-508. doi: 10.1002/bdd.2091. [PMID: 28801980]
  • Wan Sun, Karen J Klamerus, Lisa M Yuhas, Sylvester Pawlak, Anna Plotka, Melissa O'Gorman, Leonid Kirkovsky, Maha Kosa, Diane Wang. Impact of Acid-Reducing Agents on the Pharmacokinetics of Palbociclib, a Weak Base With pH-Dependent Solubility, With Different Food Intake Conditions. Clinical pharmacology in drug development. 2017 Nov; 6(6):614-626. doi: 10.1002/cpdd.356. [PMID: 28430398]
  • M K Tolbert, A Graham, A Odunayo, J Price, J M Steiner, K Newkirk, S Hecht. Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs. Journal of veterinary internal medicine. 2017 Jan; 31(1):117-123. doi: 10.1111/jvim.14615. [PMID: 27906465]
  • Gary C W Chan, K M Lee, Lorraine P Y Kwan, Maggie M Y Mok, Maggie K M Ma, Desmond Y H Yap, Sydney C W Tang. A Rare Case of Famotidine-Induced Delirium in a Peritoneal Dialysis Patient. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2017 1-2; 37(1):118-120. doi: 10.3747/pdi.2016.00145. [PMID: 28153970]
  • Sneh Verma, Vijay L Kumar. Attenuation of gastric mucosal damage by artesunate in rat: Modulation of oxidative stress and NFκB mediated signaling. Chemico-biological interactions. 2016 Sep; 257(?):46-53. doi: 10.1016/j.cbi.2016.07.027. [PMID: 27474069]
  • Lesley Pahs, Chris Droege, Hilary Kneale, Arthur Pancioli. A Novel Approach to the Treatment of Orolingual Angioedema After Tissue Plasminogen Activator Administration. Annals of emergency medicine. 2016 09; 68(3):345-8. doi: 10.1016/j.annemergmed.2016.02.019. [PMID: 27174372]
  • Jennifer E Hibma, Arik A Zur, Richard A Castro, Matthias B Wittwer, Ron J Keizer, Sook Wah Yee, Srijib Goswami, Sophie L Stocker, Xuexiang Zhang, Yong Huang, Claire M Brett, Radojka M Savic, Kathleen M Giacomini. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clinical pharmacokinetics. 2016 06; 55(6):711-21. doi: 10.1007/s40262-015-0346-3. [PMID: 26597253]
  • Salwa R Elshaboury, Niveen A Mohamed, Sameh Ahmed, Shereen Farrag. An Efficient Ion-Pair Liquid Chromatographic Method for the Determination of Some H2 Receptor Antagonists. Journal of chromatographic science. 2016 Mar; 54(3):419-28. doi: 10.1093/chromsci/bmv159. [PMID: 26538490]
  • David J Good, Ruiling Hartley, Neil Mathias, John Crison, Giridhar Tirucherai, Peter Timmins, Munir Hussain, Raja Haddadin, Otilia Koo, Faranak Nikfar, Nga Kit Eliza Fung. Mitigation of Adverse Clinical Events of a Narrow Target Therapeutic Index Compound through Modified Release Formulation Design: An in Vitro, in Vivo, in Silico, and Clinical Pharmacokinetic Analysis. Molecular pharmaceutics. 2015 Dec; 12(12):4434-44. doi: 10.1021/acs.molpharmaceut.5b00624. [PMID: 26536519]
  • Lyndsi K Meyenburg, Andrew J Crannage, Julie A Murphy, Matthew J Korobey. Evaluation of a Pharmacy-Managed Pharmacokinetic Dosing Program. Journal of pharmacy practice. 2015 Dec; 28(6):529-34. doi: 10.1177/0897190014544825. [PMID: 25107423]
  • Sangho Kim, Kenji Hosoya, Satoshi Takagi, Masahiro Okumura. Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog. Journal of the American Animal Hospital Association. 2015 Nov; 51(6):407-12. doi: 10.5326/jaaha-ms-6270. [PMID: 26535461]
  • S G Krylova, Z K Vymyatnina, E P Zueva, E N Amosova, T G Razina, V I Litvinenko. Effects of Cichorium Intybus L. Root Extract on Secretory Activity of the Stomach in Health and Ulcer Disease. Bulletin of experimental biology and medicine. 2015 Sep; 159(5):638-41. doi: 10.1007/s10517-015-3035-1. [PMID: 26468023]
  • Natsuko Wakabayashi, Shin-ichi Takeda, Toshimi Imai, Tetsu Akimoto, Daisuke Nagata. Unexpected observation of glomerular crescents in a patient with diabetes who developed drug-induced acute tubulointerstitial nephritis: A possible feature of diabetic nephropathy?. Nephrology (Carlton, Vic.). 2015 Jun; 20(6):438-9. doi: 10.1111/nep.12409. [PMID: 25900387]
  • Mark A Dickson, Michael S Gordon, Gerald Edelman, Johanna C Bendell, Ragini R Kudchadkar, Patricia M LoRusso, Stuart H Johnston, Douglas O Clary, Gary K Schwartz. Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Investigational new drugs. 2015 Apr; 33(2):349-56. doi: 10.1007/s10637-014-0191-5. [PMID: 25476894]
  • Malik Alamgir, Muhammad Yar Khuhawar, Saima Q Memon, Amir Hayat, Rizwan Ali Zounr. Spectrofluorimetric analysis of famotidine in pharmaceutical preparations and biological fluids by derivatization with benzoin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Jan; 134(?):449-52. doi: 10.1016/j.saa.2014.06.118. [PMID: 25033237]
  • Mohammed A S Abourehab, Khaled A Khaled, Hatem A A Sarhan, Osama A A Ahmed. Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study. Drug design, development and therapy. 2015; 9(?):2159-69. doi: 10.2147/dddt.s81109. [PMID: 25926722]
  • S Parkinson, K Tolbert, K Messenger, A Odunayo, M Brand, G Davidson, E Peters, A Reed, M G Papich. Evaluation of the effect of orally administered acid suppressants on intragastric pH in cats. Journal of veterinary internal medicine. 2015 Jan; 29(1):104-12. doi: 10.1111/jvim.12493. [PMID: 25537303]
  • Aly Ahmed Abdelbary, Ibrahim Elsayed, Ahmed Hassen Elshafeey. Design and development of novel lipid based gastroretentive delivery system: response surface analysis, in-vivo imaging and pharmacokinetic study. Drug delivery. 2015 Jan; 22(1):37-49. doi: 10.3109/10717544.2013.868960. [PMID: 24350634]
  • Mahboubeh Razavi, Shaik Nyamathulla, Hamed Karimian, Soheil Zorofchian Moghadamtousi, Mohamed Ibrahim Noordin. Hydrogel polysaccharides of tamarind and xanthan to formulate hydrodynamically balanced matrix tablets of famotidine. Molecules (Basel, Switzerland). 2014 Sep; 19(9):13909-31. doi: 10.3390/molecules190913909. [PMID: 25197930]
  • Xuehua Zhu, Xiaole Qi, Zhenghong Wu, Ziwei Zhang, Jiayu Xing, Xiangbo Li. Preparation of multiple-unit floating-bioadhesive cooperative minitablets for improving the oral bioavailability of famotidine in rats. Drug delivery. 2014 Sep; 21(6):459-66. doi: 10.3109/10717544.2013.879626. [PMID: 24456044]
  • N L Parente, N Bari Olivier, K R Refsal, C A Johnson. Serum concentrations of gastrin after famotidine and omeprazole administration to dogs. Journal of veterinary internal medicine. 2014 Sep; 28(5):1465-70. doi: 10.1111/jvim.12408. [PMID: 25056694]
  • K Asokkumar, Saikat Sen, M Umamaheswari, A T Sivashanmugam, V Subhadradevi. Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa. Pharmacological reports : PR. 2014 Aug; 66(4):594-9. doi: 10.1016/j.pharep.2014.01.006. [PMID: 24948059]
  • Mariusz J Świąder, Stanisław J Czuczwar. Interaction of famotidine, an H2 histamine receptor antagonist, with conventional antiepileptic drugs in mice. Pharmacological reports : PR. 2014 Jun; 66(3):485-91. doi: 10.1016/j.pharep.2013.11.006. [PMID: 24905528]
  • Walter D Y Quan, Francine Marie Quan. Activity of outpatient intravenous interleukin-2 and famotidine in metastatic clear cell kidney cancer. Cancer biotherapy & radiopharmaceuticals. 2014 Mar; 29(2):58-61. doi: 10.1089/cbr.2013.1555. [PMID: 24251758]
  • Angela A Huertas-Ceballos, Stuart Logan, Cathy Bennett, Colin Macarthur, Alice E Martin. WITHDRAWN: Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. The Cochrane database of systematic reviews. 2014 Feb; ?(2):CD003017. doi: 10.1002/14651858.cd003017.pub3. [PMID: 24532249]
  • Vaibhav Agarwal, Mayank Bansal. Statistical optimization and fabrication of a press coated pulsatile dosage form to treat nocturnal acid breakthrough. Current drug delivery. 2013 Aug; 10(4):444-52. doi: 10.2174/1567201811310040009. [PMID: 23253145]
  • Xiaoming Wang, Erik Rytting, Doaa R Abdelrahman, Tatiana N Nanovskaya, Gary D V Hankins, Mahmoud S Ahmed. Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography-mass spectrometry. Biomedical chromatography : BMC. 2013 Jul; 27(7):866-73. doi: 10.1002/bmc.2873. [PMID: 23401067]
  • Christie E Ferrecchia, Theodore R Hobbs. Efficacy of oral fecal bacteriotherapy in rhesus macaques (Macaca mulatta) with chronic diarrhea. Comparative medicine. 2013 Feb; 63(1):71-5. doi: NULL. [PMID: 23561941]
  • Vaibhav Agarwal, Mayank Bansal. Design and optimization of a chronotherapeutic dosage form for treatment of nocturnal acid breakthrough. Current drug delivery. 2012 Nov; 9(6):608-16. doi: 10.2174/156720112803529756. [PMID: 22935056]
  • Akihito Matsuoka, Naoto Takahashi, Masatomo Miura, Takenori Niioka, Kimihiro Kawakami, Takuya Matsunaga, Kenichi Sawada. H2-receptor antagonist influences dasatinib pharmacokinetics in a patient with Philadelphia-positive acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology. 2012 Aug; 70(2):351-2. doi: 10.1007/s00280-012-1900-4. [PMID: 22678358]
  • Elise S Demitrack, Eitaro Aihara, Susan Kenny, Andrea Varro, Marshall H Montrose. Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage. Gut. 2012 Jun; 61(6):804-11. doi: 10.1136/gutjnl-2011-300420. [PMID: 21997560]
  • Naoto Takahashi, Masatomo Miura, Takenori Niioka, Kenichi Sawada. Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients. Cancer chemotherapy and pharmacology. 2012 Apr; 69(4):999-1004. doi: 10.1007/s00280-011-1797-3. [PMID: 22147077]
  • Ana P Ortega-Galisteo, María Rodríguez-Serrano, Diana M Pazmiño, Dharmendra K Gupta, Luisa M Sandalio, María C Romero-Puertas. S-Nitrosylated proteins in pea (Pisum sativum L.) leaf peroxisomes: changes under abiotic stress. Journal of experimental botany. 2012 Mar; 63(5):2089-103. doi: 10.1093/jxb/err414. [PMID: 22213812]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Ishtiaq Rehman, Caroline A Evans, Adam Glen, Simon S Cross, Colby L Eaton, Jenny Down, Giancarlo Pesce, Joshua T Phillips, Ow Saw Yen, George N Thalmann, Phillip C Wright, Freddie C Hamdy. iTRAQ identification of candidate serum biomarkers associated with metastatic progression of human prostate cancer. PloS one. 2012; 7(2):e30885. doi: 10.1371/journal.pone.0030885. [PMID: 22355332]
  • Ahmed S Alrashdi, Suzy M Salama, Salim S Alkiyumi, Mahmood A Abdulla, A Hamid A Hadi, Siddig I Abdelwahab, Manal M Taha, Jamal Hussiani, Nur Asykin. Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):786426. doi: 10.1155/2012/786426. [PMID: 22550543]
  • Souryvanh Nirasay, Yves Mouget, Isabelle Marcotte, Jerome P Claverie. Supported bilayer on a nanopatterned membrane as model PAMPA membranes. International journal of pharmaceutics. 2011 Dec; 421(1):170-5. doi: 10.1016/j.ijpharm.2011.09.013. [PMID: 21959106]
  • Travis T Wager, Betty A Pettersen, Anne W Schmidt, Douglas K Spracklin, Scot Mente, Todd W Butler, Harry Howard, Daniel J Lettiere, David M Rubitski, Diane F Wong, Frank M Nedza, Frederick R Nelson, Hans Rollema, Jeffrey W Raggon, Jiri Aubrecht, Jody K Freeman, John M Marcek, Julie Cianfrogna, Karen W Cook, Larry C James, Linda A Chatman, Philip A Iredale, Michael J Banker, Michael L Homiski, Jennifer B Munzner, Rama Y Chandrasekaran. Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764). Journal of medicinal chemistry. 2011 Nov; 54(21):7602-20. doi: 10.1021/jm200939b. [PMID: 21928839]
  • A Mordecai, R K Sellon, K L Mealey. Normal dogs treated with famotidine for 14 days have only transient increases in serum gastrin concentrations. Journal of veterinary internal medicine. 2011 Nov; 25(6):1248-52. doi: 10.1111/j.1939-1676.2011.00826.x. [PMID: 22092612]
  • Xiaodong Wang, Marta Boffito, Jenny Zhang, Ellen Chung, Li Zhu, Yaoshi Wu, Kristine Patterson, Angela Kashuba, Pablo Tebas, Michael Child, Lisa Mahnke, Richard Bertz. Effects of the H2-receptor antagonist famotidine on the pharmacokinetics of atazanavir-ritonavir with or without tenofovir in HIV-infected patients. AIDS patient care and STDs. 2011 Sep; 25(9):509-15. doi: 10.1089/apc.2011.0113. [PMID: 21770762]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • H Matsuo, H Sakamoto, K Arizono, R Shinohara. Behavior of pharmaceuticals in waste water treatment plant in Japan. Bulletin of environmental contamination and toxicology. 2011 Jul; 87(1):31-5. doi: 10.1007/s00128-011-0299-7. [PMID: 21562834]
  • Kazuyoshi Hirota, Mihoko Kudo, Hiroshi Hashimoto, Tetsuya Kushikata. A marked increase in gastric fluid volume during cardiopulmonary bypass. Journal of clinical biochemistry and nutrition. 2011 Jul; 49(1):16-9. doi: 10.3164/jcbn.10-101. [PMID: 21765601]
  • Desmond J Stackpole, René E Vaillancourt, Ana Alves, José Rodrigues, Brad M Potts. Genetic Variation in the Chemical Components of Eucalyptus globulus Wood. G3 (Bethesda, Md.). 2011 Jul; 1(2):151-9. doi: 10.1534/g3.111.000372. [PMID: 22384327]
  • Analava Mitra, Baishakhi Dey. Chitosan microspheres in novel drug delivery systems. Indian journal of pharmaceutical sciences. 2011 Jul; 73(4):355-66. doi: 10.4103/0250-474x.95607. [PMID: 22707817]
  • Kentaro Shimizu, Hiroshi Ogura, Toshimitsu Hamasaki, Miki Goto, Osamu Tasaki, Takashi Asahara, Koji Nomoto, Masami Morotomi, Asako Matsushima, Yasuyuki Kuwagata, Hisashi Sugimoto. Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome. Digestive diseases and sciences. 2011 Apr; 56(4):1171-7. doi: 10.1007/s10620-010-1418-8. [PMID: 20931284]
  • Amirhossein Ahmadi, Mohammad Ali Ebrahimzadeh, Saeb Ahmad-Ashrafi, Mohammad Karami, Mohammad Reza Mahdavi, Seyed Soheil Saeedi Saravi. Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists. Fundamental & clinical pharmacology. 2011 Feb; 25(1):72-9. doi: 10.1111/j.1472-8206.2009.00810.x. [PMID: 20070855]