Cinchophen (BioDeep_00000413118)

   


代谢物信息卡片


Cinchophen

化学式: C16H11NO2 (249.079)
中文名称: 2-苯基喹啉-4-羧酸
谱图信息: 最多检出来源 Homo sapiens(general) 100%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)O
InChI: InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19)

描述信息

M - Musculo-skeletal system > M04 - Antigout preparations > M04A - Antigout preparations > M04AC - Preparations with no effect on uric acid metabolism
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4523; ORIGINAL_PRECURSOR_SCAN_NO 4519
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4546; ORIGINAL_PRECURSOR_SCAN_NO 4543
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4500; ORIGINAL_PRECURSOR_SCAN_NO 4498
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4520; ORIGINAL_PRECURSOR_SCAN_NO 4516
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4555; ORIGINAL_PRECURSOR_SCAN_NO 4552
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4546; ORIGINAL_PRECURSOR_SCAN_NO 4545
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8905; ORIGINAL_PRECURSOR_SCAN_NO 8900
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8921; ORIGINAL_PRECURSOR_SCAN_NO 8919
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8942; ORIGINAL_PRECURSOR_SCAN_NO 8939
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8878; ORIGINAL_PRECURSOR_SCAN_NO 8876
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8996; ORIGINAL_PRECURSOR_SCAN_NO 8993
CONFIDENCE standard compound; INTERNAL_ID 1051; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8968; ORIGINAL_PRECURSOR_SCAN_NO 8966

同义名列表

1 个代谢物同义名

Cinchophen



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • A A M Stolker, P Rutgers, E Oosterink, J J P Lasaroms, R J B Peters, J A van Rhijn, M W F Nielen. Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. Analytical and bioanalytical chemistry. 2008 Jul; 391(6):2309-22. doi: 10.1007/s00216-008-2168-8. [PMID: 18491081]
  • S G Krylova, E P Zueva, T G Razina, V F Turetskova, E N Amosova. [A dried aspen bark extract in the experimental therapy of gastric peptic ulcer]. Eksperimental'naia i klinicheskaia farmakologiia. 2000 Mar; 63(2):44-7. doi: ". [PMID: 10834093]
  • S A DALIMOV, M S ABDULLAKHODZHAEVA, L A ELKIND. [DISTRIBUTION AND CONTENT OF RIBONUCLEOPROTEINS IN THE SMALL INTESTINE MUCOUS MEMBRANE IN CHRONIC EXPERIMENTAL STOMACH ULCER IN DOGS]. Meditsinskii zhurnal Uzbekistana. 1963 Aug; 39(?):50-3. doi: NULL. [PMID: 14090897]
  • J A SANTOME, C TANTURI. [Proteolytic and necrosing activity of the euglobulinic fraction of the serum of dogs treated with atophan]. Revista de la Asociacion Medica Argentina. 1960 Nov; 74(?):609-13. doi: NULL. [PMID: 13746366]
  • C CRONE, U V LASSEN. Action of cinchophen on urate excretion and plasma uric acid level in the normal human subject; with special reference to increased uric acid production during administration. Acta pharmacologica et toxicologica. 1956; 12(4):342-5. doi: 10.1111/j.1600-0773.1956.tb01394.x. [PMID: 13372322]
  • C CRONE, U V LASSEN. The action of cinchophen on the renal excretion of urate in normal man. Acta pharmacologica et toxicologica. 1956; 12(4):338-41. doi: 10.1111/j.1600-0773.1956.tb01393.x. [PMID: 13372321]
  • F NOVASZEL, I FAREDIN, E KENDE, K SZEITZ. [Data on the relationship of experimental atophan ulcer to adrenal cortical function]. Magyar belorvosi archivum (1955). 1955 Apr; 8(2):36-41. doi: NULL. [PMID: 13252987]
  • S GJORUP, H POULSEN. Effects of probenecid, cinchophen and colchicine on the plasma concentration and renal excretion of oxypurine in patients with gout. Acta pharmacologica et toxicologica. 1955; 11(4):343-52. doi: 10.1111/j.1600-0773.1955.tb03268.x. [PMID: 13301783]
  • K KURIAKI, I HARAGUCHI. Mechanism of the antirheumatic effect of salicylates and cinchophen. Japanese journal of pharmacology. 1954 Mar; 3(2):82-6. doi: 10.1254/jjp.3.82. [PMID: 13191850]
  • V FABER, M IVERSEN. Variation in serum hyaluronidase-inhibitor during treatment with 3-hydroxy-2-phenyl-cinchoninic acid. Acta medica Scandinavica. 1952 Sep; 143(6):436-41. doi: 10.1111/j.0954-6820.1952.tb19156.x. [PMID: 12976035]
  • C BIANCHI, G BERNINI. [Observations on the action of 2-phenylquinoline-4-carboxylic acid (atophan) on renal function]. Archivio di scienze biologiche. 1952 Jul; 36(4):440-6. doi: NULL. [PMID: 12997336]
  • C G ZUBROD, E H DEARBORN, E K MARSHALL. Effect of 3-hydroxy-2-phenylcinchoninic acid on renal secretion of phenyl red and penicillin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1950 Aug; 74(4):671-4. doi: 10.3181/00379727-74-18011. [PMID: 14781145]
  • A QUEVAUVILLER. [Can the modifications of calcemia provoked by cincophen explain its action and that of other antirheumatic drugs on the permeability of the kidneys to uric acid?]. Annales pharmaceutiques francaises. 1950 Feb; 8(2):111-4. doi: NULL. [PMID: 15413842]
  • G STABILINI, F SILVESTRINI, E POLLI, G RATTI. [Very acute hepato-nephropathy and acute hemolytic syndrome from atophan, in a subject sensitive to the drug]. Archivio di patologia e clinica medica. 1950; 28(5):366-83. doi: NULL. [PMID: 24539538]