Benzohydroxamic acid (BioDeep_00000413080)

   


代谢物信息卡片


Benzohydroxamic acid

化学式: C7H7NO2 (137.0476762)
中文名称: 苯甲羟肟酸, N-羟基苯甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)NO
InChI: InChI=1S/C7H7NO2/c9-7(8-10)6-4-2-1-3-5-6/h1-5,10H,(H,8,9)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 908; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3041; ORIGINAL_PRECURSOR_SCAN_NO 3038
CONFIDENCE standard compound; INTERNAL_ID 908; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3046; ORIGINAL_PRECURSOR_SCAN_NO 3045
CONFIDENCE standard compound; INTERNAL_ID 908; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3021; ORIGINAL_PRECURSOR_SCAN_NO 3019
CONFIDENCE standard compound; INTERNAL_ID 908; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3034; ORIGINAL_PRECURSOR_SCAN_NO 3032
CONFIDENCE standard compound; INTERNAL_ID 908; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3039; ORIGINAL_PRECURSOR_SCAN_NO 3037
CONFIDENCE standard compound; INTERNAL_ID 908; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3047; ORIGINAL_PRECURSOR_SCAN_NO 3045

同义名列表

3 个代谢物同义名

Benzohydroxamic acid; N-Hydroxybenzamide; N-Hydroxybenzamide



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shaktikumar C Shivhare, Arjun O Patidar, K G Malviya, K K Shivhare-Malviya. Antioxidant and anticancer evaluation of Scindapsus officinalis (Roxb.) Schott fruits. Ayu. 2011 Jul; 32(3):388-94. doi: 10.4103/0974-8520.93921. [PMID: 22529657]
  • Jong H Kim, Kathleen L Chan, Noreen Mahoney, Bruce C Campbell. Antifungal activity of redox-active benzaldehydes that target cellular antioxidation. Annals of clinical microbiology and antimicrobials. 2011 May; 10(?):23. doi: 10.1186/1476-0711-10-23. [PMID: 21627838]
  • Kei Kimura, Hidekazu Kuwayama, Aiko Amagai, Yasuo Maeda. Developmental significance of cyanide-resistant respiration under stressed conditions: experiments in Dictyostelium cells. Development, growth & differentiation. 2010 Sep; 52(7):645-56. doi: 10.1111/j.1440-169x.2010.01200.x. [PMID: 20887565]
  • Marion Flipo, Julie Charton, Akila Hocine, Sandrine Dassonneville, Benoit Deprez, Rebecca Deprez-Poulain. Hydroxamates: relationships between structure and plasma stability. Journal of medicinal chemistry. 2009 Nov; 52(21):6790-802. doi: 10.1021/jm900648x. [PMID: 19821586]
  • Juan M García-Martínez, Jennifer Moran, Rosemary G Clarke, Alex Gray, Sabina C Cosulich, Christine M Chresta, Dario R Alessi. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). The Biochemical journal. 2009 Jun; 421(1):29-42. doi: 10.1042/bj20090489. [PMID: 19402821]
  • Krisztián Szigeti, László Smeller, Szabolcs Osváth, Zsuzsanna Majer, Judit Fidy. The structure of horseradish peroxidase C characterized as a molten globule state after Ca(2+) depletion. Biochimica et biophysica acta. 2008 Dec; 1784(12):1965-74. doi: 10.1016/j.bbapap.2008.08.015. [PMID: 18805513]
  • E V Dzyubinskaya, D B Kiselevsky, N V Lobysheva, A A Shestak, V D Samuilov. Death of stoma guard cells in leaf epidermis under disturbance of energy provision. Biochemistry. Biokhimiia. 2006 Oct; 71(10):1120-7. doi: 10.1134/s0006297906100105. [PMID: 17125461]
  • Fernando Ruy, Anibal E Vercesi, Alicia J Kowaltowski. Inhibition of specific electron transport pathways leads to oxidative stress and decreased Candida albicans proliferation. Journal of bioenergetics and biomembranes. 2006 Apr; 38(2):129-35. doi: 10.1007/s10863-006-9012-7. [PMID: 17053999]
  • Henrik R Hallingbäck, Razif R Gabdoulline, Rebecca C Wade. Comparison of the binding and reactivity of plant and mammalian peroxidases to indole derivatives by computational docking. Biochemistry. 2006 Mar; 45(9):2940-50. doi: 10.1021/bi051510e. [PMID: 16503648]
  • Malgorzata Czarna, Wieslawa Jarmuszkiewicz. Activation of alternative oxidase and uncoupling protein lowers hydrogen peroxide formation in amoeba Acanthamoeba castellanii mitochondria. FEBS letters. 2005 Jun; 579(14):3136-40. doi: 10.1016/j.febslet.2005.04.081. [PMID: 15919080]
  • Aleksandr G Medentsev, Anna Yu Arinbasarova, Vasilii K Akimenko. Reactivation of the alternative oxidase of Yarrowia lipolytica by nucleoside monophosphates. FEMS yeast research. 2004 Dec; 5(3):231-6. doi: 10.1016/j.femsyr.2004.08.003. [PMID: 15556084]
  • Valéria G Tudella, Carlos Curti, Frederico M Soriani, Antonio C Santos, Sergio A Uyemura. In situ evidence of an alternative oxidase and an uncoupling protein in the respiratory chain of Aspergillus fumigatus. The international journal of biochemistry & cell biology. 2004 Jan; 36(1):162-72. doi: 10.1016/s1357-2725(03)00194-8. [PMID: 14592541]
  • Aleksandr G Medentsev, Anna Yu Arinbasarova, Nikolai P Golovchenko, Vassily K Akimenko. Involvement of the alternative oxidase in respiration of Yarrowia lipolytica mitochondria is controlled by the activity of the cytochrome pathway. FEMS yeast research. 2002 Dec; 2(4):519-24. doi: 10.1111/j.1567-1364.2002.tb00118.x. [PMID: 12702267]
  • N P Matveeva, O O Voĭtsekh, D S Andreiuk, I P Ermakov. [The role of H+/- ATPase and alternative oxidase in the regulation of intracellular pH at the different stages of development of the tobacco male gametophyte]. Ontogenez. 2002 Nov; 33(6):436-43. doi: NULL. [PMID: 12500552]
  • Kåre Meno, Simon Jennings, Andrew T Smith, Anette Henriksen, Michael Gajhede. Structural analysis of the two horseradish peroxidase catalytic residue variants H42E and R38S/H42E: implications for the catalytic cycle. Acta crystallographica. Section D, Biological crystallography. 2002 Oct; 58(Pt 10 Pt 2):1803-12. doi: 10.1107/s090744490201329x. [PMID: 12351824]
  • G Milani, W Jarmuszkiewicz, C M Sluse-Goffart, A Z Schreiber, A E Vercesi, F E Sluse. Respiratory chain network in mitochondria of Candida parapsilosis: ADP/O appraisal of the multiple electron pathways. FEBS letters. 2001 Nov; 508(2):231-5. doi: 10.1016/s0014-5793(01)03060-5. [PMID: 11718721]
  • H A Heering, M A Jansen, R N Thorneley, G Smulevich. Cationic ascorbate peroxidase isoenzyme II from tea: structural insights into the heme pocket of a unique hybrid peroxidase. Biochemistry. 2001 Aug; 40(34):10360-70. doi: 10.1021/bi0106033. [PMID: 11513615]
  • M J Lee, D W Shoeman, D J Goon, H T Nagasawa. N-hydroxybenzenecarboximidic acid derivatives: a new class of nitroxyl-generating prodrugs. Nitric oxide : biology and chemistry. 2001 Jun; 5(3):278-87. doi: 10.1006/niox.2001.0349. [PMID: 11384201]
  • M Gajhede. Plant peroxidases: substrate complexes with mechanistic implications. Biochemical Society transactions. 2001 May; 29(Pt 2):91-98. doi: 10.1042/0300-5127:0290091. [PMID: 11356134]
  • W Jarmuszkiewicz, O Fraczyk, L Hryniewiecka. Effect of growth at low temperature on the alternative pathway respiration in Acanthamoeba castellanii mitochondria. Acta biochimica Polonica. 2001; 48(3):729-37. doi: 10.18388/abp.2001_3907. [PMID: 11833781]
  • A G Medentsev, A Iu Arinbasarova, V K Akimenko. [Level of cyclic AMP during induction of alternative oxidase in Yarrowia lipolytica yeast cells]. Mikrobiologiia. 2001 Jan; 70(1):29-33. doi: ". [PMID: 11338832]
  • W Jarmuszkiewicz, A M Almeida, A E Vercesi, F E Sluse, C M Sluse-Goffart. Proton re-uptake partitioning between uncoupling protein and ATP synthase during benzohydroxamic acid-resistant state 3 respiration in tomato fruit mitochondria. The Journal of biological chemistry. 2000 May; 275(18):13315-20. doi: 10.1074/jbc.275.18.13315. [PMID: 10788438]
  • A G Medentsev, V K Akimenko. Development and activation of cyanide-resistant respiration in the yeast Yarrowia lipolytica. Biochemistry. Biokhimiia. 1999 Aug; 64(8):945-51. doi: ". [PMID: 10498813]
  • W Jarmuszkiewicz, A M Almeida, C M Sluse-Goffart, F E Sluse, A E Vercesi. Linoleic acid-induced activity of plant uncoupling mitochondrial protein in purified tomato fruit mitochondria during resting, phosphorylating, and progressively uncoupled respiration. The Journal of biological chemistry. 1998 Dec; 273(52):34882-6. doi: 10.1074/jbc.273.52.34882. [PMID: 9857016]
  • M Tanaka, S Nagano, K Ishimori, I Morishima. Hydrogen bond network in the distal site of peroxidases: spectroscopic properties of Asn70 --> Asp horseradish peroxidase mutant. Biochemistry. 1997 Aug; 36(32):9791-8. doi: 10.1021/bi9706172. [PMID: 9245411]
  • A V Sitozhevsky, I V Havalkin, V V Ivanov, I V Kondakova. Kinetics of tert-butyl hydroperoxide decomposition in erythrocyte suspension. Membrane & cell biology. 1997; 11(4):487-95. doi: NULL. [PMID: 9553936]
  • N C Veitch, R J Williams, R C Bray, J F Burke, S A Sanders, R N Thorneley, A T Smith. Structural studies by proton-NMR spectroscopy of plant horseradish peroxidase C, the wild-type recombinant protein from Escherichia coli and two protein variants, Phe41----Val and Arg38----Lys. European journal of biochemistry. 1992 Jul; 207(2):521-31. doi: 10.1111/j.1432-1033.1992.tb17078.x. [PMID: 1633807]
  • H Schuel, R Schuel. Sea urchin sperm peroxidase is competitively inhibited by benzohydroxamic acid and phenylhydrazine. Biochemistry and cell biology = Biochimie et biologie cellulaire. 1986 Dec; 64(12):1333-8. doi: 10.1139/o86-175. [PMID: 3566961]