Fadrozole (BioDeep_00000413040)

   


代谢物信息卡片


Fadrozole

化学式: C14H13N3 (223.1109418)
中文名称: 法倔唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N
InChI: InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D047072 - Aromatase Inhibitors
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents
CONFIDENCE standard compound; INTERNAL_ID 759; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5528; ORIGINAL_PRECURSOR_SCAN_NO 5526
CONFIDENCE standard compound; INTERNAL_ID 759; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5562; ORIGINAL_PRECURSOR_SCAN_NO 5560
CONFIDENCE standard compound; INTERNAL_ID 759; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9316; ORIGINAL_PRECURSOR_SCAN_NO 9313
CONFIDENCE standard compound; INTERNAL_ID 759; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9316; ORIGINAL_PRECURSOR_SCAN_NO 9314
CONFIDENCE standard compound; INTERNAL_ID 759; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9337; ORIGINAL_PRECURSOR_SCAN_NO 9336
CONFIDENCE standard compound; INTERNAL_ID 759; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9352; ORIGINAL_PRECURSOR_SCAN_NO 9351

同义名列表

1 个代谢物同义名

Fadrozole



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniel L Villeneuve, Brett R Blackwell, Jenna E Cavallin, Wan-Yun Cheng, David J Feifarek, Kathleen M Jensen, Michael W Kahl, Rebecca Y Milsk, Shane T Poole, Eric C Randolph, Travis W Saari, Gerald T Ankley. Case Study in 21st Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Short-Term In Vivo Responses in Adult Female Fish. Environmental toxicology and chemistry. 2021 04; 40(4):1155-1170. doi: 10.1002/etc.4968. [PMID: 33332681]
  • J W Simkins, A E Joseph, F Bonier, Z M Benowitz-Fredericks. Prenatal aromatase inhibition alters postnatal immunity in domestic chickens (Gallus gallus). General and comparative endocrinology. 2020 08; 294(?):113497. doi: 10.1016/j.ygcen.2020.113497. [PMID: 32360542]
  • Gerald T Ankley, Brett R Blackwell, Jenna E Cavallin, Jon A Doering, David J Feifarek, Kathleen M Jensen, Michael D Kahl, Carlie A LaLone, Shane T Poole, Eric C Randolph, Travis W Saari, Daniel L Villeneuve. Adverse Outcome Pathway Network-Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function. Environmental toxicology and chemistry. 2020 04; 39(4):913-922. doi: 10.1002/etc.4668. [PMID: 31965587]
  • Steve U Ayobahan, Sebastian Eilebrecht, Lisa Baumann, Matthias Teigeler, Henner Hollert, Stefan Kalkhof, Elke Eilebrecht, Christoph Schäfers. Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 2020 Feb; 240(?):124970. doi: 10.1016/j.chemosphere.2019.124970. [PMID: 31726584]
  • Jon A Doering, Daniel L Villeneuve, Shane T Poole, Brett R Blackwell, Kathleen M Jensen, Michael D Kahl, Ashley R Kittelson, David J Feifarek, Charlene B Tilton, Carlie A LaLone, Gerald T Ankley. Quantitative Response-Response Relationships Linking Aromatase Inhibition to Decreased Fecundity are Conserved Across Three Fishes with Asynchronous Oocyte Development. Environmental science & technology. 2019 Sep; 53(17):10470-10478. doi: 10.1021/acs.est.9b02606. [PMID: 31386814]
  • Steve U Ayobahan, Elke Eilebrecht, Matthias Kotthoff, Lisa Baumann, Sebastian Eilebrecht, Matthias Teigeler, Henner Hollert, Stefan Kalkhof, Christoph Schäfers. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific reports. 2019 04; 9(1):6599. doi: 10.1038/s41598-019-43089-7. [PMID: 31036921]
  • Hemagowri Venkatasubramanian, Velanganni Selvaraj, Mohankumar Ramasamy, Kirankumar Santhakumar. Effect of Fadrozole Exposure on Socioreproductive Behaviors and Neurochemical Parameters in Betta splendens. Zebrafish. 2019 04; 16(2):139-151. doi: 10.1089/zeb.2018.1595. [PMID: 30523744]
  • Puja Pal, Sujata Roy Moulik, Shreyasi Gupta, Payel Guha, Suravi Majumder, Sourav Kundu, Buddhadev Mallick, Kousik Pramanick, Dilip Mukherjee. Estrogen-regulated expression of P450arom genes in the brain and ovaries of adult female Indian climbing perch, Anabas testudineus. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2018 01; 329(1):29-42. doi: 10.1002/jez.2158. [PMID: 29667754]
  • Anthony L Schroeder, Gerald T Ankley, Tanwir Habib, Natalia Garcia-Reyero, Barbara L Escalon, Kathleen M Jensen, Michael D Kahl, Elizabeth J Durhan, Elizabeth A Makynen, Jenna E Cavallin, Dalma Martinovic-Weigelt, Edward J Perkins, Daniel L Villeneuve. Rapid effects of the aromatase inhibitor fadrozole on steroid production and gene expression in the ovary of female fathead minnows (Pimephales promelas). General and comparative endocrinology. 2017 Oct; 252(?):79-87. doi: 10.1016/j.ygcen.2017.07.022. [PMID: 28736226]
  • Anja Hofmann, Coy Brunssen, Mirko Peitzsch, Mariya Balyura, Jennifer Mittag, Annika Frenzel, Anett Jannasch, Nicholas F Brown, Steven M Weldon, Kristina K Gueneva-Boucheva, Graeme Eisenhofer, Stefan R Bornstein, Henning Morawietz. The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2017 Jun; 49(6):466-471. doi: 10.1055/s-0043-101821. [PMID: 28427090]
  • Huiying Gu, Zhizhong Ma, Jian Wang, Timothy Zhu, Nicole Du, Adam Shatara, Xin Yi, Mark C Kowala, Yansheng Du. Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice. Scientific reports. 2017 03; 7(1):492. doi: 10.1038/s41598-017-00461-9. [PMID: 28352088]
  • Wan-Yun Cheng, Qiang Zhang, Anthony Schroeder, Daniel L Villeneuve, Gerald T Ankley, Rory Conolly. Editor's Highlight: Computational Modeling of Plasma Vitellogenin Alterations in Response to Aromatase Inhibition in Fathead Minnows. Toxicological sciences : an official journal of the Society of Toxicology. 2016 11; 154(1):78-89. doi: 10.1093/toxsci/kfw142. [PMID: 27503384]
  • Anja Hofmann, Coy Brunssen, Mirko Peitzsch, Melanie Martin, Jennifer Mittag, Anett Jannasch, Felix Engelmann, Nicholas F Brown, Steven M Weldon, Jochen Huber, Rüdiger Streicher, Andreas Deussen, Graeme Eisenhofer, Stefan R Bornstein, Henning Morawietz. Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats. Endocrinology. 2016 Oct; 157(10):3844-3855. doi: 10.1210/en.2016-1358. [PMID: 27526033]
  • Steven M Weldon, Matthew A Cerny, Kristina Gueneva-Boucheva, Derek Cogan, Xin Guo, Neil Moss, Jean-Hugues Parmentier, Jeremy R Richman, Glenn A Reinhart, Nicholas F Brown. Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates. The Journal of pharmacology and experimental therapeutics. 2016 10; 359(1):142-50. doi: 10.1124/jpet.116.236463. [PMID: 27481775]
  • Elke Muth-Köhne, Kathi Westphal-Settele, Jasmin Brückner, Sabine Konradi, Viktoria Schiller, Christoph Schäfers, Matthias Teigeler, Martina Fenske. Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test. Aquatic toxicology (Amsterdam, Netherlands). 2016 Jul; 176(?):116-27. doi: 10.1016/j.aquatox.2016.04.018. [PMID: 27130971]
  • Miyuki Breen, Daniel L Villeneuve, Gerald T Ankley, David Bencic, Michael S Breen, Karen H Watanabe, Alun L Lloyd, Rory B Conolly. Computational model of the fathead minnow hypothalamic-pituitary-gonadal axis: Incorporating protein synthesis in improving predictability of responses to endocrine active chemicals. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2016 May; 183-184(?):36-45. doi: 10.1016/j.cbpc.2016.02.002. [PMID: 26875912]
  • H-W Wang, B S Huang, A Chen, M Ahmad, R A White, F H H Leenen. Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats. Neuroscience. 2016 Feb; 314(?):90-105. doi: 10.1016/j.neuroscience.2015.11.055. [PMID: 26656220]
  • Karen H Watanabe, Michael Mayo, Kathleen M Jensen, Daniel L Villeneuve, Gerald T Ankley, Edward J Perkins. Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB®-Based Model of Oocyte Growth Dynamics. PloS one. 2016; 11(1):e0146594. doi: 10.1371/journal.pone.0146594. [PMID: 26756814]
  • Rainer E Martin, Johannes D Aebi, Benoit Hornsperger, Hans-Jakob Krebs, Bernd Kuhn, Andreas Kuglstatter, André M Alker, Hans Peter Märki, Stephan Müller, Dominique Burger, Giorgio Ottaviani, William Riboulet, Philippe Verry, Xuefei Tan, Kurt Amrein, Alexander V Mayweg. Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. Journal of medicinal chemistry. 2015 Oct; 58(20):8054-65. doi: 10.1021/acs.jmedchem.5b00851. [PMID: 26403853]
  • Natalia Mast, Joseph B Lin, Irina A Pikuleva. Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy. Molecular pharmacology. 2015 Sep; 88(3):428-36. doi: 10.1124/mol.115.099598. [PMID: 26082378]
  • Cornelia M Grombein, Qingzhong Hu, Ralf Heim, Sabrina Rau, Christina Zimmer, Rolf W Hartmann. 1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors. European journal of medicinal chemistry. 2015 Jan; 89(?):597-605. doi: 10.1016/j.ejmech.2014.10.027. [PMID: 25462268]
  • Natàlia Garcia-Reyero, Drew R Ekman, Tanwir Habib, Daniel L Villeneuve, Timothy W Collette, David C Bencic, Gerald T Ankley, Edward J Perkins. Integrated approach to explore the mechanisms of aromatase inhibition and recovery in fathead minnows (Pimephales promelas). General and comparative endocrinology. 2014 Jul; 203(?):193-202. doi: 10.1016/j.ygcen.2014.03.022. [PMID: 24704562]
  • Qingzhong Hu, Lina Yin, Rolf W Hartmann. Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. Journal of medicinal chemistry. 2014 Jun; 57(12):5011-22. doi: 10.1021/jm401430e. [PMID: 24422519]
  • Li-Na Sun, Xiao-Long Jiang, Qing-Ping Xie, Jing Yuan, Bao-Feng Huang, Wen-Jing Tao, Lin-Yan Zhou, Yoshitaka Nagahama, De-Shou Wang. Transdifferentiation of differentiated ovary into functional testis by long-term treatment of aromatase inhibitor in Nile tilapia. Endocrinology. 2014 Apr; 155(4):1476-88. doi: 10.1210/en.2013-1959. [PMID: 24437491]
  • Bing S Huang, Roselyn A White, Monir Ahmad, Frans H H Leenen. Role of brain corticosterone and aldosterone in central angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979). 2013 Sep; 62(3):564-71. doi: 10.1161/hypertensionaha.113.01557. [PMID: 23856493]
  • Nancy J Brown. Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nature reviews. Nephrology. 2013 Aug; 9(8):459-69. doi: 10.1038/nrneph.2013.110. [PMID: 23774812]
  • Miyuki Breen, Daniel L Villeneuve, Gerald T Ankley, David C Bencic, Michael S Breen, Karen H Watanabe, Alun L Lloyd, Rory B Conolly. Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: II. Computational modeling. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Jun; 133(2):234-47. doi: 10.1093/toxsci/kft067. [PMID: 23475784]
  • Daniel L Villeneuve, Miyuki Breen, David C Bencic, Jenna E Cavallin, Kathleen M Jensen, Elizabeth A Makynen, Linnea M Thomas, Leah C Wehmas, Rory B Conolly, Gerald T Ankley. Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: I. Data generation in a small fish model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Jun; 133(2):225-33. doi: 10.1093/toxsci/kft068. [PMID: 23492810]
  • Lin S Huffman, Lauren A O'Connell, Hans A Hofmann. Aromatase regulates aggression in the African cichlid fish Astatotilapia burtoni. Physiology & behavior. 2013 Mar; 112-113(?):77-83. doi: 10.1016/j.physbeh.2013.02.004. [PMID: 23438371]
  • Atul K Singh, Ruchi Singh. In vivo response of melatonin, gonadal activity and biochemical changes during CYP19 inhibited sex reversal in common carp Cyprinus carpio (L). Animal reproduction science. 2013 Jan; 136(4):317-25. doi: 10.1016/j.anireprosci.2012.11.004. [PMID: 23218911]
  • P E Lønning. The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum. Annals of oncology : official journal of the European Society for Medical Oncology. 2011 Mar; 22(3):503-514. doi: 10.1093/annonc/mdq337. [PMID: 20616198]
  • Andrew Chao, Barney A Schlinger, Luke Remage-Healey. Combined liquid and solid-phase extraction improves quantification of brain estrogen content. Frontiers in neuroanatomy. 2011; 5(?):57. doi: 10.3389/fnana.2011.00057. [PMID: 21909323]
  • Aviva Gamliel-Lazarovich, Anna Gantman, Raymond Coleman, Arco Y Jeng, Marielle Kaplan, Shlomo Keidar. FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice. Journal of hypertension. 2010 Sep; 28(9):1900-7. doi: 10.1097/hjh.0b013e32833c2197. [PMID: 20699715]
  • Bing S Huang, Sara Ahmadi, Monir Ahmad, Roselyn A White, Frans H H Leenen. Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-'ouabain' pathway. American journal of physiology. Heart and circulatory physiology. 2010 Aug; 299(2):H422-30. doi: 10.1152/ajpheart.00256.2010. [PMID: 20511409]
  • Dean F Rigel, Fumin Fu, Michael Beil, Chii-Whei Hu, Guiqing Liang, Arco Y Jeng. Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. The Journal of pharmacology and experimental therapeutics. 2010 Jul; 334(1):232-43. doi: 10.1124/jpet.110.167148. [PMID: 20354176]
  • Thierry D Charlier, Kelvin W L Po, Amy E M Newman, Amit H Shah, Colin J Saldanha, Kiran K Soma. 17beta-Estradiol levels in male zebra finch brain: combining Palkovits punch and an ultrasensitive radioimmunoassay. General and comparative endocrinology. 2010 May; 167(1):18-26. doi: 10.1016/j.ygcen.2010.02.002. [PMID: 20144613]
  • M N Vo, M Evans, K Leitzel, S M Ali, M Wilson, L Demers, D B Evans, A Lipton. Elevated plasma endoglin (CD105) predicts decreased response and survival in a metastatic breast cancer trial of hormone therapy. Breast cancer research and treatment. 2010 Feb; 119(3):767-71. doi: 10.1007/s10549-008-0261-5. [PMID: 19115106]
  • Wei-Li Zhang, Lin-Yan Zhou, Balasubramanian Senthilkumaran, Bao-Feng Huang, Cheni Chery Sudhakumari, Tohru Kobayashi, Yoshitaka Nagahama, De-Shou Wang. Molecular cloning of two isoforms of 11beta-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus. General and comparative endocrinology. 2010 Jan; 165(1):34-41. doi: 10.1016/j.ygcen.2009.05.018. [PMID: 19500584]
  • Daniel L Villeneuve, Nathaniel D Mueller, Dalma Martinović, Elizabeth A Makynen, Michael D Kahl, Kathleen M Jensen, Elizabeth J Durhan, Jenna E Cavallin, David Bencic, Gerald T Ankley. Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor. Environmental health perspectives. 2009 Apr; 117(4):624-31. doi: 10.1289/ehp.11891. [PMID: 19440503]
  • Allen W Olmstead, Patricia A Kosian, Joseph J Korte, Gary W Holcombe, Kacie K Woodis, Sigmund J Degitz. Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase inhibitor. Aquatic toxicology (Amsterdam, Netherlands). 2009 Jan; 91(2):143-50. doi: 10.1016/j.aquatox.2008.07.018. [PMID: 18804292]
  • Simon Lucas, Ralf Heim, Christina Ries, Katarzyna E Schewe, Barbara Birk, Rolf W Hartmann. In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. Journal of medicinal chemistry. 2008 Dec; 51(24):8077-87. doi: 10.1021/jm800888q. [PMID: 19049427]
  • Xiaowei Zhang, Markus Hecker, June-Woo Park, Amber R Tompsett, Paul D Jones, John Newsted, Doris W T Au, Richard Kong, Rudolf S S Wu, John P Giesy. Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone. Environmental toxicology and chemistry. 2008 Dec; 27(12):2504-11. doi: 10.1897/08-082.1. [PMID: 18693774]
  • Lo'Rell C Martin, Sean L Veney. The specific estrogen receptor antagonist ICI 182,780 masculinizes development of the zebra finch syrinx. General and comparative endocrinology. 2008 Apr; 156(2):434-9. doi: 10.1016/j.ygcen.2008.01.001. [PMID: 18280473]
  • Bernard G Steinetz, Alma J Williams, George Lust, Christian Schwabe, Erika E Büllesbach, Laura T Goldsmith. Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity. American journal of veterinary research. 2008 Jan; 69(1):59-67. doi: 10.2460/ajvr.69.1.59. [PMID: 18167088]
  • Monica Minnaard-Huiban, Judith M A Emmen, Luc Roumen, Ilona P E Beugels, Géraldine M S Cohuet, Helma van Essen, Eveline Ruijters, Koen Pieterse, Peter A J Hilbers, Harry C J Ottenheijm, Ralf Plate, Marcel E de Gooyer, Jos F M Smits, J J Rob Hermans. Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology. 2008 Jan; 149(1):28-31. doi: 10.1210/en.2007-0584. [PMID: 17884944]
  • Silvia Gobbi, Andrea Cavalli, Matthias Negri, Katarzyna E Schewe, Federica Belluti, Lorna Piazzi, Rolf W Hartmann, Maurizio Recanatini, Alessandra Bisi. Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. Journal of medicinal chemistry. 2007 Jul; 50(15):3420-2. doi: 10.1021/jm0702938. [PMID: 17585752]
  • Zhihao Liu, Fengrui Wu, Baowei Jiao, Xiuyue Zhang, Chongjiang Hu, Baofeng Huang, Linyan Zhou, Xigui Huang, Zhijian Wang, Yaoguang Zhang, Yoshitaka Nagahama, Christopher H K Cheng, Deshou Wang. Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2, and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation. The Journal of endocrinology. 2007 Jul; 194(1):223-41. doi: 10.1677/joe-07-0135. [PMID: 17592036]
  • Allan Lipton, Suhail M Ali, Kim Leitzel, Laurence Demers, Dean B Evans, Peter Hamer, Sheryl Brown-Shimer, Karen Pierce, Walter Carney. Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer. Cancer. 2007 May; 109(10):1933-9. doi: 10.1002/cncr.22637. [PMID: 17407159]
  • David H Miller, Kathleen M Jensen, Daniel L Villeneuve, Michael D Kahl, Elizabeth A Makynen, Elizabeth J Durhan, Gerald T Ankley. Linkage of biochemical responses to population-level effects: a case study with vitellogenin in the fathead minnow (Pimephales promelas). Environmental toxicology and chemistry. 2007 Mar; 26(3):521-7. doi: 10.1897/06-318r.1. [PMID: 17373517]
  • K K Soma. Testosterone and aggression: Berthold, birds and beyond. Journal of neuroendocrinology. 2006 Jul; 18(7):543-51. doi: 10.1111/j.1365-2826.2006.01440.x. [PMID: 16774503]
  • Kathleen M Jensen, Gerald T Ankley. Evaluation of a commercial kit for measuring vitellogenin in the fathead minnow (Pimephales promelas). Ecotoxicology and environmental safety. 2006 Jun; 64(2):101-5. doi: 10.1016/j.ecoenv.2006.02.011. [PMID: 16618508]
  • Joël Ménard, Marie-Françoise Gonzalez, Thanh-Tam Guyene, Alvine Bissery. Investigation of aldosterone-synthase inhibition in rats. Journal of hypertension. 2006 Jun; 24(6):1147-55. doi: 10.1097/01.hjh.0000226205.65442.f2. [PMID: 16685215]
  • Thomas H Hutchinson, Gerald T Ankley, Helmut Segner, Charles R Tyler. Screening and testing for endocrine disruption in fish-biomarkers as 'signposts,' not 'traffic lights,' in risk assessment. Environmental health perspectives. 2006 Apr; 114 Suppl 1(?):106-14. doi: 10.1289/ehp.8062. [PMID: 16818255]
  • Guang-Li Li, Xiao-Chun Liu, Hao-Ran Lin. Effects of aromatizable and nonaromatizable androgens on the sex inversion of red-spotted grouper (Epinephelus akaara). Fish physiology and biochemistry. 2006 Mar; 32(1):25-33. doi: 10.1007/s10695-005-4900-z. [PMID: 20035475]
  • Eva R Trösken, Kathrin Fischer, Wolfgang Völkel, Werner K Lutz. Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation. Toxicology. 2006 Feb; 219(1-3):33-40. doi: 10.1016/j.tox.2005.10.020. [PMID: 16330141]
  • Gloria G Huddleston, Jacquelyn C Paisley, Andrew N Clancy. Effects of estrogen in the male rat medial amygdala: infusion of an aromatase inhibitor lowers mating and bovine serum albumin-conjugated estradiol implants do not promote mating. Neuroendocrinology. 2006; 83(2):106-16. doi: 10.1159/000094400. [PMID: 16825796]
  • Ramji Kumar Bhandari, Mohammad Ashraful Alam, Mikihiko Higa, Kiyoshi Soyano, Masaru Nakamura. Evidence that estrogen regulates the sex change of honeycomb grouper (Epinephelus merra), a protogynous hermaphrodite fish. Journal of experimental zoology. Part A, Comparative experimental biology. 2005 Jun; 303(6):497-503. doi: 10.1002/jez.a.178. [PMID: 15880758]
  • Sarah Ulmschneider, Ursula Müller-Vieira, Markus Mitrenga, Rolf W Hartmann, Sandrine Oberwinkler-Marchais, Christian D Klein, Matthias Bureik, Rita Bernhardt, Iris Antes, Thomas Lengauer. Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. Journal of medicinal chemistry. 2005 Mar; 48(6):1796-805. doi: 10.1021/jm049600p. [PMID: 15771425]
  • Anne Marie Vinggaard, Helene Jacobsen, Stine Broeng Metzdorff, Helle Raun Andersen, Christine Nellemann. Antiandrogenic effects in short-term in vivo studies of the fungicide fenarimol. Toxicology. 2005 Feb; 207(1):21-34. doi: 10.1016/j.tox.2004.08.009. [PMID: 15590119]
  • Syaghalirwa N M Mandiki, Igor Babiak, Johny M Bopopi, Fabien Leprieur, Patrick Kestemont. Effects of sex steroids and their inhibitors on endocrine parameters and gender growth differences in Eurasian perch (Perca fluviatilis) juveniles. Steroids. 2005 Feb; 70(2):85-94. doi: 10.1016/j.steroids.2004.10.009. [PMID: 15631864]
  • Soisungwan Satarug, Muneko Nishijo, Pailin Ujjin, Yuvaree Vanavanitkun, Jason R Baker, Michael R Moore. Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers. Environmental health perspectives. 2004 Nov; 112(15):1512-8. doi: 10.1289/ehp.7192. [PMID: 15531436]
  • G H Panter, T H Hutchinson, K S Hurd, A Sherren, R D Stanley, C R Tyler. Successful detection of (anti-)androgenic and aromatase inhibitors in pre-spawning adult fathead minnows (Pimephales promelas) using easily measured endpoints of sexual development. Aquatic toxicology (Amsterdam, Netherlands). 2004 Oct; 70(1):11-21. doi: 10.1016/j.aquatox.2004.06.007. [PMID: 15451604]
  • Gunther Marx, Aleksandr Jurkevich, Roland Grossmann. Effects of estrogens during embryonal development on crowing in the domestic fowl. Physiology & behavior. 2004 Sep; 82(4):637-45. doi: 10.1016/j.physbeh.2004.05.010. [PMID: 15327911]
  • Ramji Kumar Bhandari, Hiroki Komuro, Mikihiko Higa, Masaru Nakamura. Sex inversion of sexually immature honeycomb grouper (Epinephelus merra) by aromatase inhibitor. Zoological science. 2004 Mar; 21(3):305-10. doi: 10.2108/zsj.21.305. [PMID: 15056925]
  • Ramji Kumar Bhandari, Mikihiko Higa, Shigeo Nakamura, Masaru Nakamura. Aromatase inhibitor induces complete sex change in the protogynous honeycomb grouper (Epinephelus merra). Molecular reproduction and development. 2004 Mar; 67(3):303-7. doi: 10.1002/mrd.20027. [PMID: 14735491]
  • H Tamada, Y Shimizu, T Inaba, N Kawate, T Sawada. The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats. The Journal of endocrinology. 2004 Feb; 180(2):337-45. doi: 10.1677/joe.0.1800337. [PMID: 14765986]
  • Anthony Howell, Mitch Dowsett. Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens. Breast cancer research : BCR. 2004; 6(6):269-74. doi: 10.1186/bcr945. [PMID: 15535858]
  • Valentine A Lance, Alan J Conley, Samantha Mapes, Colin Steven, Allen R Place. Does alligator testis produce estradiol? A comparison of ovarian and testicular aromatase. Biology of reproduction. 2003 Oct; 69(4):1201-7. doi: 10.1095/biolreprod.103.016535. [PMID: 12773408]
  • Louise D McCullough, Kathleen Blizzard, Evan R Simpson, Orhan K Oz, Patricia D Hurn. Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Sep; 23(25):8701-5. doi: 10.1523/jneurosci.23-25-08701.2003. [PMID: 14507969]
  • A Sechman, J Rzasa, H Paczoska-Eliasiewicz. Effect of non-steroidal aromatase inhibitor on blood plasma ovarian steroid and thyroid hormones in laying hen (Gallus domesticus). Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. 2003 Sep; 50(7):333-8. doi: 10.1046/j.1439-0442.2003.00549.x. [PMID: 14633224]
  • S Vaillant, D Guémené, M Dorizzi, C Pieau, N Richard-Mercier, J-P Brillard. Degree of sex reversal as related to plasma steroid levels in genetic female chickens (Gallus domesticus) treated with Fadrozole. Molecular reproduction and development. 2003 Aug; 65(4):420-8. doi: 10.1002/mrd.10318. [PMID: 12840815]
  • Makio Shozu, Kouichi Murakami, Tomoya Segawa, Tadayuki Kasai, Masaki Inoue. Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor. Fertility and sterility. 2003 Mar; 79(3):628-31. doi: 10.1016/s0015-0282(02)04761-1. [PMID: 12620453]
  • Shigeho Ijiri, Yukinori Kazeto, P Mark Lokman, Shinji Adachi, Kohei Yamauchi. Characterization of a cDNA encoding P-450 aromatase (CYP19) from Japanese eel ovary and its expression in ovarian follicles during induced ovarian development. General and comparative endocrinology. 2003 Feb; 130(2):193-203. doi: 10.1016/s0016-6480(02)00589-0. [PMID: 12568797]
  • J Morales-Montor, C Hallal-Calleros, M C Romano, R T Damian. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. International journal for parasitology. 2002 Oct; 32(11):1379-87. doi: 10.1016/s0020-7519(02)00130-3. [PMID: 12350373]
  • Anna Cardone, Raffaella Comitato, Luigi Bellini, Francesco Angelini. Effects of the aromatase inhibitor fadrozole on plasma sex steroid secretion, spermatogenesis and epididymis morphology in the lizard, Podarcis sicula. Molecular reproduction and development. 2002 Sep; 63(1):63-70. doi: 10.1002/mrd.10151. [PMID: 12211062]
  • John C O'Connor, Steven R Frame, Gregory S Ladics. Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators. Toxicological sciences : an official journal of the Society of Toxicology. 2002 Sep; 69(1):79-91. doi: 10.1093/toxsci/69.1.79. [PMID: 12215662]
  • Suhail M Ali, Kim Leitzel, Vernon M Chinchilli, Linda Engle, Laurence Demers, Harold A Harvey, Walter Carney, Jeffrey W Allard, Allan Lipton. Relationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancer. Clinical chemistry. 2002 Aug; 48(8):1314-20. doi: 10.1093/clinchem/48.8.1314. [PMID: 12142389]
  • Yan-Horn Lee, Wen-Shiun Yueh, Jin-Lien Du, Lian-Tien Sun, Ching-Fong Chang. Aromatase inhibitors block natural sex change and induce male function in the protandrous black porgy, Acanthopagrus schlegeli Bleeker: possible mechanism of natural sex change. Biology of reproduction. 2002 Jun; 66(6):1749-54. doi: 10.1095/biolreprod66.6.1749. [PMID: 12021057]
  • Melanie Zerulla, R Länge, T Steger-Hartmann, G Panter, T Hutchinson, D R Dietrich. Morphological sex reversal upon short-term exposure to endocrine modulators in juvenile fathead minnow (Pimephales promelas). Toxicology letters. 2002 May; 131(1-2):51-63. doi: 10.1016/s0378-4274(02)00070-x. [PMID: 11988358]
  • Gerald T Ankley, Michael D Kahl, Kathleen M Jensen, Michael W Hornung, Joseph J Korte, Elizabeth A Makynen, Richard L Leino. Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas). Toxicological sciences : an official journal of the Society of Toxicology. 2002 May; 67(1):121-30. doi: 10.1093/toxsci/67.1.121. [PMID: 11961225]
  • Allan Lipton, S M Ali, K Leitzel, L Demers, V Chinchilli, L Engle, Harold A Harvey, C Brady, C M Nalin, M Dugan, W Carney, J Allard. Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2002 Mar; 20(6):1467-72. doi: 10.1200/jco.2002.20.6.1467. [PMID: 11896093]
  • Y H Lee, J L Du, W S Yueh, B Y Lin, J D Huang, C Y Lee, M F Lee, E L Lau, F Y Lee, C Morrey, Y Nagahama, C F Chang. Sex change in the protandrous black porgy, Acanthopagrus schlegeli: a review in gonadal development, estradiol, estrogen receptor, aromatase activity and gonadotropin. The Journal of experimental zoology. 2001 Dec; 290(7):715-26. doi: 10.1002/jez.1122. [PMID: 11748620]
  • Y Chino, Y Suzuki, N Ubukata, K Yoshihara, T Tani, M Ogata. [Hepatic infusion of docetaxel using PEIT for a patient with stage IV breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy. 2001 Nov; 28(12):1897-9. doi: . [PMID: 11729483]
  • T Ivanova, E Küppers, J Engele, C Beyer. Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism. Journal of neuroscience research. 2001 Oct; 66(2):221-30. doi: 10.1002/jnr.1214. [PMID: 11592117]
  • Y S Weems, P J Bridges, B R LeaMaster, R G Sasser, L Ching, C W Weems. Effect of the aromatase inhibitor CGS-16949A on pregnancy and secretion of progesterone, estradiol-17beta, prostaglandins E and F2alpha (PGE; PGF2alpha) and pregnancy specific protein B (PSPB) in 90-day ovariectomized pregnant ewes. Prostaglandins & other lipid mediators. 2001 Sep; 66(2):77-88. doi: 10.1016/s0090-6980(01)00144-7. [PMID: 11529553]
  • Y H Lee, J L Du, F P Yen, C Y Lee, S Dufour, J D Huang, L T Sun, C F Chang. Regulation of plasma gonadotropin II secretion by sex steroids, aromatase inhibitors, and antiestrogens in the protandrous black porgy, Acanthopagrus schlegeli Bleeker. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2001 Jun; 129(2-3):399-406. doi: 10.1016/s1096-4959(01)00337-2. [PMID: 11399474]
  • K K Soma, K A Sullivan, A D Tramontin, C J Saldanha, B A Schlinger, J C Wingfield. Acute and chronic effects of an aromatase inhibitor on territorial aggression in breeding and nonbreeding male song sparrows. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology. 2000 Jul; 186(7-8):759-69. doi: 10.1007/s003590000129. [PMID: 11016791]
  • K K Soma, A D Tramontin, J C Wingfield. Oestrogen regulates male aggression in the non-breeding season. Proceedings. Biological sciences. 2000 Jun; 267(1448):1089-96. doi: 10.1098/rspb.2000.1113. [PMID: 10885513]
  • M Fukuda, H Watanabe, T Suda, S Shimizu. [Sequential changes in hormone levels in postmenopausal breast cancer patients under long-term treatment with an aromatase inhibitor. Kanagawa AI Study Group]. Gan to kagaku ryoho. Cancer & chemotherapy. 1999 Dec; 26(14):2201-8. doi: . [PMID: 10635305]
  • A Gong, F W Freking, J Wingfield, B A Schlinger, A P Arnold. Effects of embryonic treatment with fadrozole on phenotype of gonads, syrinx, and neural song system in zebra finches. General and comparative endocrinology. 1999 Sep; 115(3):346-53. doi: 10.1006/gcen.1999.7318. [PMID: 10480985]
  • L O Afonso, G K Iwama, J Smith, E M Donaldson. Effects of the aromatase inhibitor Fadrozole on plasma sex steroid secretion and ovulation rate in female coho salmon, Oncorhynchus kisutch, close to final maturation. General and comparative endocrinology. 1999 Feb; 113(2):221-9. doi: 10.1006/gcen.1998.7198. [PMID: 10082624]
  • L A Costa, M S Kopreski, L M Demers, V M Chinchilli, R J Santen, H A Harvey, A Lipton. Effect of the potent aromatase inhibitor fadrozole hydrochloride (CGS 16949A) in postmenopausal women with breast carcinoma. Cancer. 1999 Jan; 85(1):100-3. doi: 10.1002/(sici)1097-0142(19990101)85:1<100::aid-cncr14>3.0.co;2-5. [PMID: 9921980]
  • T P Sharma, D Blache, M A Blackberry, G B Martin. Role of peripheral and central aromatization in the control of gonadotrophin secretion in the male sheep. Reproduction, fertility, and development. 1999; 11(4-5):293-302. doi: 10.1071/rd99084. [PMID: 10898294]
  • G Leboucher, N Béguin, R Mauget, M Kreutzer. Effects of fadrozole on sexual displays and reproductive activity in the female canary. Physiology & behavior. 1998 Nov; 65(2):233-40. doi: 10.1016/s0031-9384(98)00079-1. [PMID: 9855471]
  • G Shetty, H Krishnamurthy, H N Krishnamurthy, S Bhatnagar, R N Moudgal. Effect of estrogen deprivation on the reproductive physiology of male and female primates. The Journal of steroid biochemistry and molecular biology. 1997 Apr; 61(3-6):157-66. doi: 10.1016/s0960-0760(97)80008-8. [PMID: 9365186]
  • J Almadhidi, S Moslemi, M A Drosdowsky, G E Séralini. Equine cytochrome P450 aromatase exhibits an estrogen 2-hydroxylase activity in vitro. The Journal of steroid biochemistry and molecular biology. 1996 Sep; 59(1):55-61. doi: 10.1016/s0960-0760(96)00085-4. [PMID: 9009238]
  • A A Miller, A Lipton, I C Henderson, R Navari, M T Mulagha, J Cooper. Fadrozole hydrochloride in postmenopausal patients with metastatic breast carcinoma. Cancer. 1996 Aug; 78(4):789-93. doi: 10.1002/(sici)1097-0142(19960815)78:4<789::aid-cncr15>3.0.co;2-r. [PMID: 8756373]
  • G H Volas, K Leitzel, Y Teramoto, H Grossberg, L Demers, A Lipton. Serial serum c-erbB-2 levels in patients with breast carcinoma. Cancer. 1996 Jul; 78(2):267-72. doi: 10.1002/(sici)1097-0142(19960715)78:2<267::aid-cncr12>3.0.co;2-u. [PMID: 8674002]
  • M Dukes, P N Edwards, M Large, I K Smith, T Boyle. The preclinical pharmacology of 'Arimidex' (anastrozole; ZD1033)--a potent, selective aromatase inhibitor. The Journal of steroid biochemistry and molecular biology. 1996 Jul; 58(4):439-45. doi: 10.1016/0960-0760(96)00064-7. [PMID: 8903429]