Betamethasone valerate (BioDeep_00000413014)

代谢物信息卡片

Betamethasone 17-valerate

化学式: C27H37FO6 (476.2574)
中文名称: 倍他米松 17-戊酸酯, 倍他米松戊酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO
InChI: InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
CONFIDENCE standard compound; INTERNAL_ID 667; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9654; ORIGINAL_PRECURSOR_SCAN_NO 9651
CONFIDENCE standard compound; INTERNAL_ID 667; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9695; ORIGINAL_PRECURSOR_SCAN_NO 9693
CONFIDENCE standard compound; INTERNAL_ID 667; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9706; ORIGINAL_PRECURSOR_SCAN_NO 9701
CONFIDENCE standard compound; INTERNAL_ID 667; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9748; ORIGINAL_PRECURSOR_SCAN_NO 9744
CONFIDENCE standard compound; INTERNAL_ID 667; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9758; ORIGINAL_PRECURSOR_SCAN_NO 9757
CONFIDENCE standard compound; INTERNAL_ID 667; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9768; ORIGINAL_PRECURSOR_SCAN_NO 9765

同义名列表

3 个代谢物同义名

Betamethasone 17-valerate; Betamethasone valerate; Betamethasone valerate

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:31277
KEGGdrug: D01357
PubChem: 16533
ChEMBL: CHEMBL1497
MeSH: Betamethasone Valerate
CAS: 2152-44-5
MoNA: LU066706
MoNA: LU066705
MoNA: LU066704
MoNA: LU066703
MoNA: LU066702
MoNA: LU066701

分类词条

脂质和类脂分子

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位		关联基因列表

文献列表

Maria Michela Lauriola, Paolo Sena, Antonio De Bitonto, Monica Corazza. Allergic Contact Dermatitis Due to 'Therapeutic Uses' of Tea Tree Oil on the Lips and Toenails. Dermatitis : contact, atopic, occupational, drug. 2021 May; 32(3):e40-e41. doi: 10.1097/der.0000000000000649. [PMID: 33332860]
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Arisha Mahmood, Vamshi Krishna Rapalli, Tejashree Waghule, Srividya Gorantla, Sunil Kumar Dubey, Ranendra Narayan Saha, Gautam Singhvi. UV spectrophotometric method for simultaneous estimation of betamethasone valerate and tazarotene with absorption factor method: Application for in-vitro and ex-vivo characterization of lipidic nanocarriers for topical delivery. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jul; 235(?):118310. doi: 10.1016/j.saa.2020.118310. [PMID: 32251894]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
C J Chen, A Satyanarayan, B J Schlomer. The use of steroid cream for physiologic phimosis in male infants with a history of UTI and normal renal ultrasound is associated with decreased risk of recurrent UTI. Journal of pediatric urology. 2019 Oct; 15(5):472.e1-472.e6. doi: 10.1016/j.jpurol.2019.06.018. [PMID: 31345734]
Beathe Sitter. Urinary detection of corticosteroid in topical treatment of skin disease by 19F MRS. Magma (New York, N.Y.). 2019 Feb; 32(1):157-162. doi: 10.1007/s10334-018-00734-y. [PMID: 30610404]
Upendra Nagaich, Neha Gulati. Preclinical Assessment of Steroidal Nanostructured Lipid Carriers Based Gels for Atopic Dermatitis: Optimization and Product Development. Current drug delivery. 2018; 15(5):641-651. doi: 10.2174/1567201814666170918163615. [PMID: 28925874]
Sharlene Helene H Chua, Giselle Marie S Tioleco, Carmela Augusta F Dayrit, Winlove P Mojica, Belen L Dofitas, Lorna F Frez. Atorvastatin as adjunctive therapy for chronic plaque type psoriasis versus betamethasone valerate alone: A randomized, double-blind, placebo-controlled trial. Indian journal of dermatology, venereology and leprology. 2017 Jul; 83(4):441-447. doi: 10.4103/ijdvl.ijdvl_425_16. [PMID: 28540870]
Ahmed Samir, Nicholas Bodor, Teruko Imai. Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochemical pharmacology. 2017 03; 127(?):82-89. doi: 10.1016/j.bcp.2016.12.010. [PMID: 28017774]
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Juliane Reuter, Constance Huyke, Federica Casetti, Carmen Theek, Uwe Frank, Matthias Augustin, Christoph Schempp. Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 2008 Oct; 6(10):847-51. doi: 10.1111/j.1610-0387.2008.06704.x. [PMID: 18371049]
Katsuhiko Matsuura, Tomofumi Ohmori, Mitsuhiro Nakamura, Yoshinori Itoh, Kazuyuki Hirano. A simple and rapid determination of valproic acid in human plasma using a non-porous silica column and liquid chromatography with tandem mass spectrometric detection. Biomedical chromatography : BMC. 2008 Apr; 22(4):387-93. doi: 10.1002/bmc.944. [PMID: 18004739]
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Finn Schultz Larsen, Lene Simonsen, Anita Melgaard, Katja Wendicke, Anne S Henriksen. An efficient new formulation of fusidic acid and betamethasone 17-valerate (fucicort lipid cream) for treatment of clinically infected atopic dermatitis. Acta dermato-venereologica. 2007; 87(1):62-8. doi: 10.2340/00015555-0174. [PMID: 17225018]
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Iqbal A Bukhari. Solitary mastocytoma successfully treated with a moderate potency topical steroid. Journal of drugs in dermatology : JDD. 2004 May; 3(3):309-10. doi: NULL. [PMID: 15176167]
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T Leivo, P Arjomaa, J Oivula, M Vesterinen, U Kiistala, P Autio, A Oikarinen. Differential modulation of transforming growth factor-beta by betamethasone-17- valerate and isotretinoin: corticosteroid decreases and isotretinoin increases the level of transforming growth factor-beta in suction blister fluid. Skin pharmacology and applied skin physiology. 2000 May; 13(3-4):150-6. doi: 10.1159/000029920. [PMID: 10859533]
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