Roxarsone (BioDeep_00000412966)

   


代谢物信息卡片


4-Hydroxy-3-nitrophenylarsonic acid

化学式: C6H6AsNO6 (262.9411076)
中文名称: 4-羟基-3-硝基苯胂酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1[As](=O)(O)O)[N+](=O)[O-])O
InChI: InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
CONFIDENCE standard compound; INTERNAL_ID 422; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1752; ORIGINAL_PRECURSOR_SCAN_NO 1751
CONFIDENCE standard compound; INTERNAL_ID 422; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1742; ORIGINAL_PRECURSOR_SCAN_NO 1741
CONFIDENCE standard compound; INTERNAL_ID 422; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1756; ORIGINAL_PRECURSOR_SCAN_NO 1755
CONFIDENCE standard compound; INTERNAL_ID 422; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1743; ORIGINAL_PRECURSOR_SCAN_NO 1742
CONFIDENCE standard compound; INTERNAL_ID 422; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1784; ORIGINAL_PRECURSOR_SCAN_NO 1783

同义名列表

2 个代谢物同义名

Roxarsone; 4-Hydroxy-3-nitrophenylarsonic acid



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu. Roxarsone inhibits hepatic stellate cell activation and ameliorates liver fibrosis by blocking TGF-β1/Smad signaling pathway. International immunopharmacology. 2023 Jan; 114(?):109527. doi: 10.1016/j.intimp.2022.109527. [PMID: 36700762]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tao Yang, Sisi Wu, Chunping Liu, Yulei Liu, Haochen Zhang, Haijun Cheng, Lu Wang, Lin Guo, Yuying Li, Minchao Liu, Jun Ma. Efficient Degradation of Organoarsenic by UV/Chlorine Treatment: Kinetics, Mechanism, Enhanced Arsenic Removal, and Cytotoxicity. Environmental science & technology. 2021 02; 55(3):2037-2047. doi: 10.1021/acs.est.0c05084. [PMID: 33435681]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ke Huang, Hanyong Peng, Fan Gao, QingQing Liu, Xiufen Lu, Qirong Shen, X Chris Le, Fang-Jie Zhao. Biotransformation of arsenic-containing roxarsone by an aerobic soil bacterium Enterobacter sp. CZ-1. Environmental pollution (Barking, Essex : 1987). 2019 Apr; 247(?):482-487. doi: 10.1016/j.envpol.2019.01.076. [PMID: 30703681]
  • Guowei Chen, Huan Liu, Wei Zhang, Baoguo Li, Li Liu, Gang Wang. Roxarsone exposure jeopardizes nitrogen removal and regulates bacterial community in biological sequential batch reactors. Ecotoxicology and environmental safety. 2018 Sep; 159(?):232-239. doi: 10.1016/j.ecoenv.2018.05.012. [PMID: 29753825]
  • Qing-Long Fu, Lee Blaney, Dong-Mei Zhou. Identifying Plant Stress Responses to Roxarsone in Soybean Root Exudates: New Insights from Two-Dimensional Correlation Spectroscopy. Journal of agricultural and food chemistry. 2018 Jan; 66(1):53-62. doi: 10.1021/acs.jafc.7b04706. [PMID: 29240415]
  • Arjun Sekar, James Simon, Jonathan Taliercio. Adult-Onset Proximal Tubule Dysfunction. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2018 01; 71(1):A12-A14. doi: 10.1053/j.ajkd.2017.08.025. [PMID: 29273156]
  • Qing-Long Fu, Lee Blaney, Dong-Mei Zhou. Phytotoxicity and uptake of roxarsone by wheat (Triticum aestivum L.) seedlings. Environmental pollution (Barking, Essex : 1987). 2016 Dec; 219(?):210-218. doi: 10.1016/j.envpol.2016.10.041. [PMID: 27814537]
  • Lixian Yao, Lianxi Huang, Zhaohuan He, Changmin Zhou, Weisheng Lu, Cuihua Bai. Delivery of roxarsone via chicken diet→chicken→chicken manure→soil→rice plant. The Science of the total environment. 2016 Oct; 566-567(?):1152-1158. doi: 10.1016/j.scitotenv.2016.05.157. [PMID: 27265740]
  • Junhao Qin, Huashou Li, Chuxia Lin. Fenton process-affected transformation of roxarsone in paddy rice soils: Effects on plant growth and arsenic accumulation in rice grain. Ecotoxicology and environmental safety. 2016 Aug; 130(?):4-10. doi: 10.1016/j.ecoenv.2016.03.047. [PMID: 27060198]
  • Zonglin Yang, Hanyong Peng, Xiufen Lu, Qingqing Liu, Rongfu Huang, Bin Hu, Gary Kachanoski, Martin J Zuidhof, X Chris Le. Arsenic Metabolites, Including N-Acetyl-4-hydroxy-m-arsanilic Acid, in Chicken Litter from a Roxarsone-Feeding Study Involving 1600 Chickens. Environmental science & technology. 2016 07; 50(13):6737-43. doi: 10.1021/acs.est.5b05619. [PMID: 26876684]
  • Bing Li, Xiangyang Zhu, Kaili Hu, Yongsheng Li, Jianfang Feng, Jianlin Shi, Jinlou Gu. Defect creation in metal-organic frameworks for rapid and controllable decontamination of roxarsone from aqueous solution. Journal of hazardous materials. 2016 Jan; 302(?):57-64. doi: 10.1016/j.jhazmat.2015.09.040. [PMID: 26444487]
  • Ting Shao, Chun-xia Yao, Yuan-yuan Shen, Yu-jie Zhang, Nan-nan Su, Shou-biao Zhou. [Residue and Degradation of Roxarsone in the System of Soil-Vegetable]. Huan jing ke xue= Huanjing kexue. 2015 Aug; 36(8):3068-73. doi: ". [PMID: 26592042]
  • Wenzhong Zhang, Fang Xu, Jingjing Han, Qun Sun, Kai Yang. Comparative cytotoxicity and accumulation of Roxarsone and its photodegradates in freshwater Protozoan Tetrahymenathermophila. Journal of hazardous materials. 2015 Apr; 286(?):171-8. doi: 10.1016/j.jhazmat.2015.01.001. [PMID: 25577319]
  • Lianxi Huang, Lixian Yao, Zhaohuan He, Changmin Zhou, Guoliang Li, Baomei Yang, Xiancai Deng. Roxarsone and its metabolites in chicken manure significantly enhance the uptake of As species by vegetables. Chemosphere. 2014 Apr; 100(?):57-62. doi: 10.1016/j.chemosphere.2013.12.074. [PMID: 24461427]
  • Lixian Yao, Lianxi Huang, Zhaohuan He, Changmin Zhou, Guoliang Li, Baomei Yang, Xiancai Deng. External inorganic N source enhances the uptake of As species in garland chrysanthemum (C. coronarium) amended with chicken manure bearing roxarsone and its metabolites. Journal of hazardous materials. 2013 Jun; 254-255(?):270-276. doi: 10.1016/j.jhazmat.2013.03.048. [PMID: 23632040]
  • Li-Xian Yao, Lian-Xi Huang, Zong-Yong Jiang, Zhao-Huan He, Chang-Min Zhou, Guo-Liang Li. [Investigation of As, Cu and Zn species and concentrations in animal feeds]. Huan jing ke xue= Huanjing kexue. 2013 Feb; 34(2):732-9. doi: ". [PMID: 23668148]
  • Lixian Yao, Lianxi Huang, Zhaohuan He, Changmin Zhou, Guoliang Li. Occurrence of arsenic impurities in organoarsenics and animal feeds. Journal of agricultural and food chemistry. 2013 Jan; 61(2):320-4. doi: 10.1021/jf3045022. [PMID: 23259671]
  • Lian Xi Huang, Li Xian Yao, Zhao Huan He, Chang Min Zhou, Guo Liang Li, Bao Mei Yang, Ying Fen Li. Uptake of arsenic species by turnip (Brassica rapa L.) and lettuce (Lactuca sativa L.) treated with roxarsone and its metabolites in chicken manure. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2013; 30(9):1546-55. doi: 10.1080/19440049.2013.812809. [PMID: 23859781]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sean D Conklin, Nohora Shockey, Kevin Kubachka, Karyn D Howard, Mary C Carson. Development of an ion chromatography-inductively coupled plasma-mass spectrometry method to determine inorganic arsenic in liver from chickens treated with roxarsone. Journal of agricultural and food chemistry. 2012 Sep; 60(37):9394-404. doi: 10.1021/jf302366a. [PMID: 22897610]
  • Ross C Beier, Phelue N Anderson, Michael E Hume, Toni L Poole, Sara E Duke, Tawni L Crippen, Cynthia L Sheffield, David J Caldwell, James A Byrd, Robin C Anderson, David J Nisbet. Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter. Foodborne pathogens and disease. 2011 May; 8(5):593-600. doi: 10.1089/fpd.2010.0702. [PMID: 21235389]
  • Syam S Andra, Konstantinos C Makris, Shahida Quazi, Dibyendu Sarkar, Rupali Datta, Stephan B H Bach. Organocopper complexes during roxarsone degradation in wastewater lagoons. Environmental science and pollution research international. 2010 Jun; 17(5):1167-73. doi: 10.1007/s11356-009-0281-7. [PMID: 20099042]
  • Lixian Yao, Guoliang Li, Zhi Dang, Baomei Yang, Zhaohuan He, Changmin Zhou. Uptake and transport of roxarsone and its metabolites in water spinach as affected by phosphate supply. Environmental toxicology and chemistry. 2010 Apr; 29(4):947-51. doi: 10.1002/etc.114. [PMID: 20821525]
  • Konstantinos C Makris, Jason Salazar, Shahida Quazi, Syam S Andra, Dibyendu Sarkar, Stephan B H Bach, Rupali Datta. Controlling the fate of roxarsone and inorganic arsenic in poultry litter. Journal of environmental quality. 2008 May; 37(3):963-71. doi: 10.2134/jeq2007.0416. [PMID: 18453419]
  • Charlita G Rosal, Georges-Marie Momplaisir, Edward M Heithmar. Roxarsone and transformation products in chicken manure: determination by capillary electrophoresis-inductively coupled plasma-mass spectrometry. Electrophoresis. 2005 Apr; 26(7-8):1606-14. doi: 10.1002/elps.200406198. [PMID: 15761918]
  • K L Chen, P W Chiout. Oral treatment of mule ducks with arsenicals for inducing fatty liver. Poultry science. 2001 Mar; 80(3):295-301. doi: 10.1093/ps/80.3.295. [PMID: 11261559]
  • K L Chen, C P Wu, P W Chiou. Effect of roxarsone inclusion in the diet on the performance and hepatic lipid metabolism of laying Tsaiya duck. British poultry science. 2000 Jul; 41(3):363-9. doi: 10.1080/713654924. [PMID: 11081432]
  • B R Blakley, E G Clark, R Fairley. Roxarsone (3-nitro-4-hydroxyphenylarsonic acid) poisoning in pigs. The Canadian veterinary journal = La revue veterinaire canadienne. 1990 May; 31(5):385-7. doi: NULL. [PMID: 17423588]
  • NULL. NTP Toxicology and Carcinogenesis Studies of Roxarsone (CAS No. 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). National Toxicology Program technical report series. 1989 Mar; 345(?):1-198. doi: NULL. [PMID: 12724787]
  • K M Abdo, M R Elwell, C A Montgomery, M B Thompson, R B Thompson, J D Prejean. Toxic responses in F344 rats and B6C3F1 mice given roxarsone in their diets for up to 13 weeks. Toxicology letters. 1989 Jan; 45(1):55-66. doi: 10.1016/0378-4274(89)90159-8. [PMID: 2916249]
  • D A Rice, S Kennedy, C H McMurray, W J Blanchflower. Experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs. Research in veterinary science. 1985 Jul; 39(1):47-51. doi: 10.1016/s0034-5288(18)31769-7. [PMID: 4035090]
  • G L Czarnecki, D H Baker. Reduction of liver copper concentration by the organic arsenical, 3-nitro-4-hydroxyphenylarsonic acid. Journal of animal science. 1985 Feb; 60(2):440-50. doi: 10.2527/jas1985.602440x. [PMID: 3988630]
  • G L Czarnecki, D H Baker. Feed additive interactions in the chicken: reduction of tissue copper deposition by dietary roxarsone in healthy and in Eimeria acervulina-infected or Eimeria tenella-infected chicks. Poultry science. 1984 Jul; 63(7):1412-8. doi: 10.3382/ps.0631412. [PMID: 6473253]
  • G L Czarnecki, D H Baker. Roxarsone toxicity in the chick as influenced by dietary cysteine and copper and by experimental infection with Eimeria acervulina. Poultry science. 1982 Mar; 61(3):516-23. doi: 10.3382/ps.0610516. [PMID: 7088802]
  • C C Calvert, L W Smith. Arsenic in tissues of sheep and milk of dairy cows fed arsanilic acid and 3-nitro-4-hydroxyphenylarsonic acid. Journal of animal science. 1980 Aug; 51(2):414-21. doi: 10.2527/jas1980.512414x. [PMID: 7440438]
  • M Mitrovic, E Schildknecht, C Trainor. Effects of lasalocid and monensin in combination with roxarsone on lesion reduction and oocyst suppression in chicks infected with Eimeria tenella field isolates. Poultry science. 1977 May; 56(3):979-84. doi: 10.3382/ps.0560979. [PMID: 605069]
  • W M Reid. Relative value of oocyst counts in evaluating anticoccidial activity. Avian diseases. 1975 Oct; 19(4):802-11. doi: 10.2307/1589193. [PMID: 1200950]
  • L M Kowalski, W M Reid. Effects of roxarsone on pigmentation and coccidiosis in broilers. Poultry science. 1975 Sep; 54(5):1544-9. doi: 10.3382/ps.0541544. [PMID: 1187515]