Cyproterone acetate (BioDeep_00000412934)

   


代谢物信息卡片


Cyproterone acetate

化学式: C24H29ClO4 (416.1754)
中文名称: 环丙孕酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C
InChI: InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000726 - Androgen Antagonists
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C146993 - Androgen Receptor Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C242 - Anti-Androgen
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D000970 - Antineoplastic Agents
CONFIDENCE standard compound; INTERNAL_ID 318; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9521; ORIGINAL_PRECURSOR_SCAN_NO 9516
CONFIDENCE standard compound; INTERNAL_ID 318; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9556; ORIGINAL_PRECURSOR_SCAN_NO 9553
CONFIDENCE standard compound; INTERNAL_ID 318; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9587; ORIGINAL_PRECURSOR_SCAN_NO 9585
CONFIDENCE standard compound; INTERNAL_ID 318; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9594; ORIGINAL_PRECURSOR_SCAN_NO 9592
ORIGINAL_PRECURSOR_SCAN_NO 9592; CONFIDENCE standard compound; INTERNAL_ID 318; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9594
CONFIDENCE standard compound; INTERNAL_ID 318; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9566; ORIGINAL_PRECURSOR_SCAN_NO 9564
CONFIDENCE standard compound; INTERNAL_ID 318; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9608; ORIGINAL_PRECURSOR_SCAN_NO 9606

同义名列表

1 个代谢物同义名

Cyproterone acetate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Supanat Burinkul, Krasean Panyakhamlerd, Ammarin Suwan, Punkavee Tuntiviriyapun, Sorawit Wainipitapong. Anti-Androgenic Effects Comparison Between Cyproterone Acetate and Spironolactone in Transgender Women: A Randomized Controlled Trial. The journal of sexual medicine. 2021 07; 18(7):1299-1307. doi: 10.1016/j.jsxm.2021.05.003. [PMID: 34274044]
  • Naomi Even Zohar, Yael Sofer, Iris Yaish, Merav Serebro, Karen Tordjman, Yona Greenman. Low-Dose Cyproterone Acetate Treatment for Transgender Women. The journal of sexual medicine. 2021 07; 18(7):1292-1298. doi: 10.1016/j.jsxm.2021.04.008. [PMID: 34176757]
  • Kunyan Zhou, Jing Zhang, Liangzhi Xu, Chi Eung Danforn Lim. Chinese herbal medicine for subfertile women with polycystic ovarian syndrome. The Cochrane database of systematic reviews. 2021 06; 6(?):CD007535. doi: 10.1002/14651858.cd007535.pub4. [PMID: 34085287]
  • Lachlan M Angus, Brendan J Nolan, Jeffrey D Zajac, Ada S Cheung. A systematic review of antiandrogens and feminization in transgender women. Clinical endocrinology. 2021 05; 94(5):743-752. doi: 10.1111/cen.14329. [PMID: 32926454]
  • Jeahee Ryu, Euiyeon Lee, Chungwon Kang, Minhyeong Lee, Soyoun Kim, Seungil Park, Dae Yeon Lee, Youngeun Kwon. Rapid Screening of Glucocorticoid Receptor (GR) Effectors Using Cortisol-Detecting Sensor Cells. International journal of molecular sciences. 2021 Apr; 22(9):. doi: 10.3390/ijms22094747. [PMID: 33947115]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yan Deng, Yan-Fang Wang, Shi-Yang Zhu, Xiao Ma, Wei Xue, Rui-Lin Ma, Ai-Jun Sun. Is There An Advantage of Using Dingkun Pill () alone or in Combination with Diane-35 for Management of Polycystic Ovary Syndrome? A Randomized Controlled Trial. Chinese journal of integrative medicine. 2020 Dec; 26(12):883-889. doi: 10.1007/s11655-020-3097-4. [PMID: 32915426]
  • Daan M van Velzen, Nienke M Nota, Suat Simsek, Elfi B Conemans, Guy T'Sjoen, Martin den Heijer. Variation in sensitivity and rate of change in body composition: steps toward individualizing transgender care. European journal of endocrinology. 2020 Nov; 183(5):529-536. doi: 10.1530/eje-20-0609. [PMID: 33071222]
  • Guizhen Chen, Hongyuan Liu, Xiaofeng Wu, Xue Wang, Junquan Liang, Yunxiang Xu. Biomarkers of postmenopausal osteoporosis and interventive mechanism of catgut embedding in acupoints. Medicine. 2020 Sep; 99(37):e22178. doi: 10.1097/md.0000000000022178. [PMID: 32925788]
  • Rougin Khalil, Leen Antonio, Michaël R Laurent, Karel David, Na Ri Kim, Pieter Evenepoel, Anton Eisenhauer, Alexander Heuser, Etienne Cavalier, Sundeep Khosla, Frank Claessens, Dirk Vanderschueren, Brigitte Decallonne. Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study. European journal of endocrinology. 2020 Aug; 183(2):181-189. doi: 10.1530/eje-20-0348. [PMID: 32454455]
  • Vanessa Oliveira de Jesus, Valdir Souza Ferreira, Bruno Gabriel Lucca. Electrochemical study and simultaneous voltammetric determination of contraceptives ethinylestradiol and cyproterone acetate using silver nanoparticles solid amalgam electrode and cationic surfactant. Talanta. 2020 Apr; 210(?):120610. doi: 10.1016/j.talanta.2019.120610. [PMID: 31987179]
  • Chaitali Ghosh, Chhanda Mallick. Protective effect of ethanolic extract of Hygrophila auriculata seeds in cyproterone acetate-induced sexual dysfunction in male albino rats. Andrologia. 2020 Mar; 52(2):e13482. doi: 10.1111/and.13482. [PMID: 31815317]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Parisa Ghasemiyeh, Amir Azadi, Saeid Daneshamouz, Reza Heidari, Negar Azarpira, Soliman Mohammadi-Samani. Cyproterone acetate-loaded nanostructured lipid carriers: effect of particle size on skin penetration and follicular targeting. Pharmaceutical development and technology. 2019 Sep; 24(7):812-823. doi: 10.1080/10837450.2019.1596133. [PMID: 30889371]
  • Samira Behboudi-Gandevani, Hayedeh Abtahi, Navid Saadat, Maryam Tohidi, Fahimeh Ramezani Tehrani. Effect of phlebotomy versus oral contraceptives containing cyproterone acetate on the clinical and biochemical parameters in women with polycystic ovary syndrome: a randomized controlled trial. Journal of ovarian research. 2019 Aug; 12(1):78. doi: 10.1186/s13048-019-0554-9. [PMID: 31470879]
  • Chi Eung Danforn Lim, Rachel Wai Chung Ng, Nga Chong Lisa Cheng, George Shengxi Zhang, Hui Chen. Acupuncture for polycystic ovarian syndrome. The Cochrane database of systematic reviews. 2019 07; 7(?):CD007689. doi: 10.1002/14651858.cd007689.pub4. [PMID: 31264709]
  • Shan Liu, Haochang Su, Heng-Xiang Li, Jin-Jun Liu, Lang Lin, Xiang-Rong Xu, Lin-Zi Zuo, Jian-Liang Zhao. Uptake, Elimination, and Biotransformation Potential of a Progestagen (Cyproterone Acetate) in Tilapia Exposed at an Environmental Concentration. Environmental science & technology. 2019 06; 53(12):6804-6813. doi: 10.1021/acs.est.9b02891. [PMID: 31117546]
  • Yu Cao, He Chen, Danyang Zhao, Li Zhang, Xiaogang Yu, Xinmin Zhou, Zhishun Liu. The efficacy of Tung's acupuncture for sex hormones in polycystic ovary syndrome: A randomized controlled trial. Complementary therapies in medicine. 2019 Jun; 44(?):182-188. doi: 10.1016/j.ctim.2019.04.016. [PMID: 31126554]
  • Daan M van Velzen, Alessia Paldino, Maartje Klaver, Nienke M Nota, Justine Defreyne, G Kees Hovingh, Abel Thijs, Suat Simsek, Guy T'Sjoen, Martin den Heijer. Cardiometabolic Effects of Testosterone in Transmen and Estrogen Plus Cyproterone Acetate in Transwomen. The Journal of clinical endocrinology and metabolism. 2019 06; 104(6):1937-1947. doi: 10.1210/jc.2018-02138. [PMID: 30602016]
  • Asutosh Sahu, Priyadarshini Tripathy, Jayashree Mohanty, Attila Nagy. Doppler analysis of ovarian stromal blood flow changes after treatment with metformin versus ethinyl estradiol-cyproterone acetate in women with polycystic ovarian syndrome: A randomized controlled trial. Journal of gynecology obstetrics and human reproduction. 2019 May; 48(5):335-339. doi: 10.1016/j.jogoh.2018.10.006. [PMID: 30316907]
  • Jessica K Hartman, Tyler Beames, Bethany Parks, Daniel Doheny, Gina Song, Alina Efremenko, Miyoung Yoon, Briana Foley, Chad Deisenroth, Patrick D McMullen, Rebecca A Clewell. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis. Toxicology and applied pharmacology. 2018 09; 355(?):112-126. doi: 10.1016/j.taap.2018.05.016. [PMID: 29782964]
  • Xiangyan Ruan, Jinghua Song, Muqing Gu, Lijuan Wang, Husheng Wang, Alfred O Mueck. Effect of Diane-35, alone or in combination with orlistat or metformin in Chinese polycystic ovary syndrome patients. Archives of gynecology and obstetrics. 2018 Jun; 297(6):1557-1563. doi: 10.1007/s00404-018-4762-0. [PMID: 29602978]
  • Jinghua Song, Xiangyan Ruan, Muqing Gu, Lijuan Wang, Husheng Wang, Alfred Otto Mueck. Effect of orlistat or metformin in overweight and obese polycystic ovary syndrome patients with insulin resistance. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2018 May; 34(5):413-417. doi: 10.1080/09513590.2017.1407752. [PMID: 29172796]
  • J Defreyne, B Vantomme, E Van Caenegem, K Wierckx, C J M De Blok, M Klaver, N M Nota, D Van Dijk, C M Wiepjes, M Den Heijer, G T'Sjoen. Prospective evaluation of hematocrit in gender-affirming hormone treatment: results from European Network for the Investigation of Gender Incongruence. Andrology. 2018 05; 6(3):446-454. doi: 10.1111/andr.12485. [PMID: 29602229]
  • Mohammad Mahdi Khataei, Yadollah Yamini, Ali Nazaripour, Meghdad Karimi. Novel generation of deep eutectic solvent as an acceptor phase in three-phase hollow fiber liquid phase microextraction for extraction and preconcentration of steroidal hormones from biological fluids. Talanta. 2018 Feb; 178(?):473-480. doi: 10.1016/j.talanta.2017.09.068. [PMID: 29136850]
  • Flávia Siqueira Cunha, Sorahia Domenice, Maria Helena Palma Sircili, Berenice Bilharinho de Mendonca, Elaine Maria Frade Costa. Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women. Clinics (Sao Paulo, Brazil). 2018; 73(?):e86. doi: 10.6061/clinics/2018/e86. [PMID: 29723345]
  • Justine Defreyne, Nienke Nota, Cecilia Pereira, Thomas Schreiner, Alessandra D Fisher, Martin den Heijer, Guy T'Sjoen. Transient Elevated Serum Prolactin in Trans Women Is Caused by Cyproterone Acetate Treatment. LGBT health. 2017 10; 4(5):328-336. doi: 10.1089/lgbt.2016.0190. [PMID: 28880825]
  • F Schneider, S Kliesch, S Schlatt, N Neuhaus. Andrology of male-to-female transsexuals: influence of cross-sex hormone therapy on testicular function. Andrology. 2017 Sep; 5(5):873-880. doi: 10.1111/andr.12405. [PMID: 28914501]
  • Mina Amiri, Fahimeh Ramezani Tehrani, Fatemeh Nahidi, Ali Kabir, Fereidoun Azizi, Enrico Carmina. Effects of oral contraceptives on metabolic profile in women with polycystic ovary syndrome: A meta-analysis comparing products containing cyproterone acetate with third generation progestins. Metabolism: clinical and experimental. 2017 08; 73(?):22-35. doi: 10.1016/j.metabol.2017.05.001. [PMID: 28732568]
  • Yu Cao, Li Zhang, Danyang Zhao, Zhishun Liu. [DONG's extraordinary acupoints for the ovarian function of polycystic ovary syndrome:a randomized controlled pilot trial]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2017 Jul; 37(7):710-714. doi: 10.13703/j.0255-2930.2017.07.007. [PMID: 29231543]
  • M Zitzmann, J Rohayem, J Raidt, S Kliesch, N Kumar, R Sitruk-Ware, E Nieschlag. Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: a randomized clinical trial. Andrology. 2017 May; 5(3):516-526. doi: 10.1111/andr.12328. [PMID: 28189123]
  • Na Cui, Xiaoye Feng, Zhiming Zhao, Jie Zhang, Yueming Xu, Luning Wang, Guimin Hao. Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin. Clinical therapeutics. 2017 Apr; 39(4):751-758. doi: 10.1016/j.clinthera.2017.02.007. [PMID: 28291580]
  • Linjie Chen, Dennis W Wolff, Yan Xie, Ming-Fong Lin, Yaping Tu. Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5. BMC cancer. 2017 03; 17(1):179. doi: 10.1186/s12885-017-3153-4. [PMID: 28270124]
  • Jing Li, Jing Ren, Wenxia Sun. A comparative systematic review of Yasmin (drospirenone pill) versus standard treatment options for symptoms of polycystic ovary syndrome. European journal of obstetrics, gynecology, and reproductive biology. 2017 Mar; 210(?):13-21. doi: 10.1016/j.ejogrb.2016.11.013. [PMID: 27923166]
  • G Mayrhofer, D Wegner, T Voß. [Urolithiasis in the Long-Term GnRH Agonist Treatment of Patients with Paraphilia: 3 Case Studies]. Aktuelle Urologie. 2016 12; 47(6):487-490. doi: 10.1055/s-0042-112999. [PMID: 27701680]
  • Raymond Fung, Miriam Hellstern-Layefsky, Camille Tastenhoye, Iliana Lega, Leah Steele. Differential Effects of Cyproterone Acetate vs Spironolactone on Serum High-Density Lipoprotein and Prolactin Concentrations in the Hormonal Treatment of Transgender Women. The journal of sexual medicine. 2016 11; 13(11):1765-1772. doi: 10.1016/j.jsxm.2016.09.012. [PMID: 27693265]
  • Kunyan Zhou, Jing Zhang, Liangzhi Xu, Taixiang Wu, Chi Eung Danforn Lim. Chinese herbal medicine for subfertile women with polycystic ovarian syndrome. The Cochrane database of systematic reviews. 2016 Oct; 10(?):CD007535. doi: 10.1002/14651858.cd007535.pub3. [PMID: 27731904]
  • Pauline Plouvier, Maëliss Peigné, Héloïse Gronier, Geoffroy Robin, Sophie Catteau-Jonard, Didier Dewailly. Is the suppressive effect of cyproterone acetate on serum anti-Müllerian-hormone levels in women with polycystic ovary syndrome stronger than under oral contraceptive pill?. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2016 Aug; 32(8):612-616. doi: 10.3109/09513590.2016.1145647. [PMID: 26890873]
  • M Díaz, J M Gallego-Escuredo, F de Zegher, F Villarroya, L Ibáñez. Effects of ethinylestradiol-cyproterone acetate vs. pioglitazone-flutamide-metformin on plasma FGF21 levels in adolescent girls with androgen excess. Diabetes & metabolism. 2016 Jun; 42(3):196-9. doi: 10.1016/j.diabet.2015.10.004. [PMID: 26546387]
  • Qiu-Yi Wang, Yong Song, Wei Huang, Li Xiao, Qiu-Shi Wang, Gui-Mei Feng. Comparison of Drospirenone- with Cyproterone Acetate-Containing Oral Contraceptives, Combined with Metformin and Lifestyle Modifications in Women with Polycystic Ovary Syndrome and Metabolic Disorders: A Prospective Randomized Control Trial. Chinese medical journal. 2016 Apr; 129(8):883-90. doi: 10.4103/0366-6999.179783. [PMID: 27064030]
  • An-Su Tu, Ying Zhong, Xi-Guang Mao. [Changes of serum TOS and TAS levels and their association with apolipoprotein(a) in patients with polycystic ovary syndrome and infertility]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2016 Mar; 36(3):405-9. doi: NULL. [PMID: 27063172]
  • Fernando Bessone, M I Lucena, Marcelo G Roma, Camilla Stephens, Inmaculada Medina-Cáliz, Bernardo Frider, Guillermo Tsariktsian, Nelia Hernández, Miquel Bruguera, Gisela Gualano, Eduardo Fassio, Joaquín Montero, María V Reggiardo, Sebastián Ferretti, Luis Colombato, Federico Tanno, Jaime Ferrer, Lelio Zeno, Hugo Tanno, Raúl J Andrade. Cyproterone acetate induces a wide spectrum of acute liver damage including corticosteroid-responsive hepatitis: report of 22 cases. Liver international : official journal of the International Association for the Study of the Liver. 2016 Feb; 36(2):302-10. doi: 10.1111/liv.12899. [PMID: 26104271]
  • Noorhan S Mhao, Ahmed S A Al-Hilli, Najah R Hadi, Dina A Jamil, Hayder A Al-Aubaidy. A comparative study to illustrate the benefits of using ethinyl estradiol-cyproterone acetate over metformin in patients with polycystic ovarian syndrome. Diabetes & metabolic syndrome. 2016 Jan; 10(1 Suppl 1):S95-8. doi: 10.1016/j.dsx.2015.10.001. [PMID: 26703220]
  • Wei Feng, Yan-Yan Jia, Dong-Ya Zhang, Hui-Rong Shi. Management of polycystic ovarian syndrome with Diane-35 or Diane-35 plus metformin. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2016; 32(2):147-50. doi: 10.3109/09513590.2015.1101441. [PMID: 26507097]
  • Hongqin Wu, Xiangyan Ruan, Jing Jin, Alfred Otto Mueck. Metabolic profile of Diane-35 versus Diane-35 plus metformin in Chinese PCOS women under standardized life-style changes. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2015 Jul; 31(7):548-51. doi: 10.3109/09513590.2015.1029447. [PMID: 26004979]
  • Christopher Green, Jayne Brian, Rakesh Kanda, Martin Scholze, Richard Williams, Susan Jobling. Environmental concentrations of anti-androgenic pharmaceuticals do not impact sexual disruption in fish alone or in combination with steroid oestrogens. Aquatic toxicology (Amsterdam, Netherlands). 2015 Mar; 160(?):117-27. doi: 10.1016/j.aquatox.2014.12.022. [PMID: 25630045]
  • Johannes Fuss, Rainer Hellweg, Eva Van Caenegem, Peer Briken, Günter K Stalla, Guy T'Sjoen, Matthias K Auer. Cross-sex hormone treatment in male-to-female transsexual persons reduces serum brain-derived neurotrophic factor (BDNF). European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2015 Jan; 25(1):95-9. doi: 10.1016/j.euroneuro.2014.11.019. [PMID: 25498415]
  • Chun-Lan Jin, Li-Xin Wei, Ji-Ping Zhao, Zhong-Chao Wu. [Efficacy comparison between electroacupuncture and dyne-35 in treatment of polycystic ovary syndrome]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2014 Dec; 34(12):1174-8. doi: NULL. [PMID: 25876344]
  • Ayse Carlioglu, Ikbal Kaygusuz, Feridun Karakurt, Ilknur Inegol Gumus, Aysel Uysal, Benan Kasapoglu, Ferah Armutcu, Sema Uysal, Esra Aktepe Keskin, Cemile Koca. The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. Archives of gynecology and obstetrics. 2014 Nov; 290(5):929-35. doi: 10.1007/s00404-014-3275-8. [PMID: 24840107]
  • Wei Ding, Michelle E Bishop, Mason G Pearce, Kelly J Davis, Gene A White, Lascelles E Lyn-Cook, Mugimane G Manjanatha. Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats. Mutation research. Genetic toxicology and environmental mutagenesis. 2014 Nov; 774(?):1-7. doi: 10.1016/j.mrgentox.2014.08.005. [PMID: 25440904]
  • Charikleia Christakou, Anastasios Kollias, Christina Piperi, Ilias Katsikis, Dimitrios Panidis, Evanthia Diamanti-Kandarakis. The benefit-to-risk ratio of common treatments in PCOS: effect of oral contraceptives versus metformin on atherogenic markers. Hormones (Athens, Greece). 2014 Oct; 13(4):488-97. doi: 10.14310/horm.2002.1553. [PMID: 25555182]
  • Korhan Kahraman, Yavuz Emre Sükür, Cem Somer Atabekoğlu, Can Ateş, Salih Taşkın, Serife Esra Cetinkaya, Harun Egemen Tolunay, Batuhan Ozmen, Murat Sönmezer, Bülent Berker. Comparison of two oral contraceptive forms containing cyproterone acetate and drospirenone in the treatment of patients with polycystic ovary syndrome: a randomized clinical trial. Archives of gynecology and obstetrics. 2014 Aug; 290(2):321-8. doi: 10.1007/s00404-014-3217-5. [PMID: 24676694]
  • S Ray, K Chatterjee, D De, D Ghosh. Bioefficacy of hydromethanolic extract of tuber of Chlorophytum borivilianum (Safed Musli) for the management of male infertility in cyproterone acetate-treated albino rats. Andrologia. 2014 Aug; 46(6):659-71. doi: 10.1111/and.12133. [PMID: 23957231]
  • Katrien Wierckx, Eva Van Caenegem, Thomas Schreiner, Ira Haraldsen, Alessandra D Fisher, Alessandra Fisher, Kaatje Toye, Jean Marc Kaufman, Guy T'Sjoen. Cross-sex hormone therapy in trans persons is safe and effective at short-time follow-up: results from the European network for the investigation of gender incongruence. The journal of sexual medicine. 2014 Aug; 11(8):1999-2011. doi: 10.1111/jsm.12571. [PMID: 24828032]
  • Feridun Karakurt, Ayse Carlioglu, Ikbal Kaygusuz, Ilknur Inegöl Gumus, Burak Uz, Derya Akdeniz. Effect of ethinyl estradiol-cyproterone acetate treatment on asymmetric dimethyl-arginine levels in women with polycystic ovary syndrome. Archives of gynecology and obstetrics. 2014 Jan; 289(1):135-40. doi: 10.1007/s00404-013-2960-3. [PMID: 23880889]
  • L Tóthová, P Celec, D Ostatníková, M Okuliarová, M Zeman, J Hodosy. Effect of exogenous testosterone on oxidative status of the testes in adult male rats. Andrologia. 2013 Dec; 45(6):417-23. doi: 10.1111/and.12032. [PMID: 23121168]
  • C Erem. Update on idiopathic hirsutism: diagnosis and treatment. Acta clinica Belgica. 2013 Jul; 68(4):268-74. doi: 10.2143/acb.3267. [PMID: 24455796]
  • Christina Teng, Bonnie Goodwin, Keith Shockley, Menghang Xia, Ruili Huang, John Norris, B Alex Merrick, Anton M Jetten, Christopher P Austin, Raymond R Tice. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-biological interactions. 2013 May; 203(3):556-64. doi: 10.1016/j.cbi.2013.03.013. [PMID: 23562765]
  • Lourdes Ibáñez, Marta Díaz, Giorgia Sebastiani, María Victoria Marcos, Abel López-Bermejo, Francis de Zegher. Oral contraception vs insulin sensitization for 18 months in nonobese adolescents with androgen excess: posttreatment differences in C-reactive protein, intima-media thickness, visceral adiposity, insulin sensitivity, and menstrual regularity. The Journal of clinical endocrinology and metabolism. 2013 May; 98(5):E902-7. doi: 10.1210/jc.2013-1041. [PMID: 23547047]
  • J Santiago-Moreno, A Gómez-Brunet, A Toledano-Díaz, R Salas-Vega, F Gómez-Guillamón, A López-Sebastián. Role of testosterone and photoperiod on seasonal changes in horn growth and sperm variables in the Iberian ibex: a model for polygynous wild bovids. The Journal of endocrinology. 2012 Aug; 214(2):155-63. doi: 10.1530/joe-12-0016. [PMID: 22645301]
  • Aysun Karabulut, Semra Demirlenk, Osman Sevket. Effects of ethinyl estradiol-cyproterone acetate treatment on metabolic syndrome, fat distribution and carotid intima media thickness in polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2012 Apr; 28(4):245-8. doi: 10.3109/09513590.2011.613971. [PMID: 21961995]
  • Cahide Gökkuşu, Zeynep Özbek, Gülten Tata. Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women. Archives of gynecology and obstetrics. 2012 Mar; 285(3):733-9. doi: 10.1007/s00404-011-2051-2. [PMID: 21877144]
  • George Markantes, Alexandros D Saltamavros, Vasiliki Vervita, Anastasia K Armeni, Anastasia Karela, George Adonakis, George Decavalas, Neoklis A Georgopoulos. Increased plasma viscosity in young women with polycystic ovary syndrome using an oral contraceptive containing 35 μg ethinyl estradiol and 2 mg cyproterone acetate. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2011 Dec; 27(12):971-7. doi: 10.3109/09513590.2011.569783. [PMID: 21501001]
  • Lourdes Ibáñez, Marta Diaz, Giorgia Sebastiani, David Sánchez-Infantes, Cristina Salvador, Abel Lopez-Bermejo, Francis de Zegher. Treatment of androgen excess in adolescent girls: ethinylestradiol-cyproteroneacetate versus low-dose pioglitazone-flutamide-metformin. The Journal of clinical endocrinology and metabolism. 2011 Nov; 96(11):3361-6. doi: 10.1210/jc.2011-1671. [PMID: 21865363]
  • Vanessa Battisti, Liési D K Maders, Margarete D Bagatini, Luiz Gustavo B Reetz, Juarez Chiesa, Iara E Battisti, Jamile F Gonçalves, Marta M F Duarte, Maria R C Schetinger, Vera M Morsch. Oxidative stress and antioxidant status in prostate cancer patients: relation to Gleason score, treatment and bone metastasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2011 Oct; 65(7):516-24. doi: 10.1016/j.biopha.2011.06.003. [PMID: 21993000]
  • Susuana Kuek, Wen-jun Wang, Sui-qi Gui. Efficacy of Chinese patent medicine Tian Gui Capsule in patients with polycystic ovary syndrome: a randomized controlled trial. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2011 Sep; 9(9):965-72. doi: 10.3736/jcim20110907. [PMID: 21906521]
  • Dimitrios Panidis, Neoklis A Georgopoulos, Athanasia Piouka, Ilias Katsikis, Alexandros D Saltamavros, George Decavalas, Evanthia Diamanti-Kandarakis. The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2011 Aug; 27(8):587-92. doi: 10.3109/09513590.2010.507283. [PMID: 20836726]
  • Levent Kebapcilar, Ayse Gul Kebapcilar, Oktay Bilgir, Cuneyt Eftal Taner, Giray Bozkaya, Yasar Yildiz, Ismail Sari. Metformin plus oral contraceptive may decrease plasma sCD40 ligand in women with PCOS patients. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2011 Feb; 27(2):91-5. doi: 10.3109/09513590.2010.491164. [PMID: 20528207]
  • Barbara J Attardi, Sailaja Koduri, Sheri A Hild. Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Molecular and cellular endocrinology. 2010 Oct; 328(1-2):16-21. doi: 10.1016/j.mce.2010.06.010. [PMID: 20599585]
  • Nadia M S Arafa. Efficacy of echinacea on the action of cyproterone acetate in male rats. Pakistan journal of biological sciences : PJBS. 2010 Oct; 13(20):966-76. doi: 10.3923/pjbs.2010.966.976. [PMID: 21319455]
  • Gerald T Ankley, Kathleen M Jensen, Michael D Kahl, Elizabeth J Durhan, Elizabeth A Makynen, Jenna E Cavallin, Dalma Martinović, Leah C Wehmas, Nathaniel D Mueller, Daniel L Villeneuve. Use of chemical mixtures to differentiate mechanisms of endocrine action in a small fish model. Aquatic toxicology (Amsterdam, Netherlands). 2010 Sep; 99(3):389-96. doi: 10.1016/j.aquatox.2010.05.020. [PMID: 20573408]
  • Timothy W Collette, Quincy Teng, Kathleen M Jensen, Michael D Kahl, Elizabeth A Makynen, Elizabeth J Durhan, Daniel L Villeneuve, Dalma Martinović-Weigelt, Gerald T Ankley, Drew R Ekman. Impacts of an anti-androgen and an androgen/anti-androgen mixture on the metabolite profile of male fathead minnow urine. Environmental science & technology. 2010 Sep; 44(17):6881-6. doi: 10.1021/es1011884. [PMID: 20687545]
  • J J Sidelmann, S O Skouby, F Vitzthum, H Schwarz, J Jespersen. Hormone therapy affects plasma measures of factor VII-activating protease in younger postmenopausal women. Climacteric : the journal of the International Menopause Society. 2010 Aug; 13(4):340-6. doi: 10.3109/13697131003597027. [PMID: 20222844]
  • Anastasios Makedos, Dimitrios G Goulis, Alexis Papanikolaou, Dimitrios Panidis. Serum high-sensitivity C-reactive protein and homocysteine changes during hormonal therapy in women with polycystic ovary syndrome: a prospective, matched study. Angiology. 2010 Aug; 61(6):595-601. doi: 10.1177/0003319709361198. [PMID: 20395229]
  • Levent Kebapcilar, Oktay Bilgir, Cuneyt Eftal Taner, Ayse Gul Kebapcilar, Didem L Kozaci, Ahmet Alacacioglu, Yasar Yildiz, Arif Yuksel, Ismail Sari. Oral contraceptives alone and with spironolactone increase sCD40 ligand in PCOS patients. Archives of gynecology and obstetrics. 2010 Mar; 281(3):539-43. doi: 10.1007/s00404-009-1189-7. [PMID: 19655157]
  • Mei-Jou Chen, Wei-Shiung Yang, Hsin-Fu Chen, Jahn-Jahn Kuo, Hong-Nerng Ho, Yu-Shih Yang, Shee-Uan Chen. Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome. Human reproduction (Oxford, England). 2010 Mar; 25(3):779-85. doi: 10.1093/humrep/dep459. [PMID: 20093255]
  • Cahide Gokkusu, Gulten Tata, Evin Ademoğlu, Sule Tamer. The benefits of hormone replacement therapy on plasma and platelet antioxidant status and fatty acid composition in healthy postmenopausal women. Platelets. 2010; 21(6):439-44. doi: 10.3109/09537104.2010.481475. [PMID: 20459351]
  • Mary J G Zamboni, Carlos A P Cabral, Francisco J B Sampaio, Luiz E M Cardoso. Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women. International urogynecology journal and pelvic floor dysfunction. 2009 Nov; 20(11):1353-9. doi: 10.1007/s00192-009-0948-0. [PMID: 19578802]
  • Mathijs C Bunck, Erik J Giltay, Michaela Diamant, Louis J Gooren, Tom Teerlink. Differential effects of cross-sex hormonal treatment on plasma asymmetric dimethylarginine (ADMA) in healthy male-to-female and female-to-male transsexuals. Atherosclerosis. 2009 Sep; 206(1):245-50. doi: 10.1016/j.atherosclerosis.2009.01.020. [PMID: 19324362]
  • C Palazzi, S D'Angelo, E Pennese, I Olivieri. Persistent normalization of serum levels of uric acid in a gouty patient after administration of cyproterone acetate. Rheumatology international. 2009 Apr; 29(6):711-2. doi: 10.1007/s00296-008-0757-7. [PMID: 19002688]
  • G D Calderón, E Bratoeff, L E Ramírez, B N Osnaya, A R García, M G Barragán, G-E Hernández, O H Juárez. Effects of two new steroids and cyproterone on some biomarkers of oxidative stress and serotonergic system on rat prostate and brain. Andrologia. 2009 Feb; 41(1):29-34. doi: 10.1111/j.1439-0272.2008.00886.x. [PMID: 19143727]
  • E Cecchi, F Lapi, A Vannacci, G Banchelli, T Mazzei, A Mugelli. Increased levels of CA 125 and CA 19.9 serum tumour markers following cyclic combined hormone replacement therapy. Journal of clinical pharmacy and therapeutics. 2009 Feb; 34(1):129-32. doi: 10.1111/j.1365-2710.2008.00995.x. [PMID: 19125912]
  • Ney Carter Borges, Ana Mazuqueli, Ronilson Agnaldo Moreno, Rafael Barrientos Astigarraga, Carlos Eduardo Sverdloff, Paulo Alexandre Rebelo Galvinas, Maurício Rocha de Magalhães Sampaio, Washington Moreira da Silva. Cyproterone acetate quantification in human plasma by high-performance liquid chromatography coupled to atmospheric pressure photoionization tandem mass spectrometry. Application to a comparative pharmacokinetics study. Arzneimittel-Forschung. 2009; 59(7):335-44. doi: 10.1055/s-0031-1296405. [PMID: 19728560]
  • Oktay Bilgir, Levent Kebapcilar, Cuneyt Taner, Ferda Bilgir, Ayse Kebapcilar, Giray Bozkaya, Yasar Yildiz, Arif Yuksel, Ismail Sari. The effect of ethinylestradiol (EE)/cyproterone acetate (CA) and EE/CA plus metformin treatment on adhesion molecules in cases with polycystic ovary syndrome (PCOS). Internal medicine (Tokyo, Japan). 2009; 48(14):1193-9. doi: 10.2169/internalmedicine.48.2177. [PMID: 19602786]
  • E H A Ali. Protective effects of Echinacea on cyproterone acetate induced liver damage in male rats. Pakistan journal of biological sciences : PJBS. 2008 Nov; 11(21):2464-71. doi: 10.3923/pjbs.2008.2464.2471. [PMID: 19205265]
  • Zhang Jing, Xu Liang-Zhi, Wu Tai-Xiang, Tang Ying, Jia Yu-Jian. The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2008 Oct; 24(10):590-600. doi: 10.1080/09513590802288242. [PMID: 19012104]
  • Rosalyn George, Shari Clarke, Diane Thiboutot. Hormonal therapy for acne. Seminars in cutaneous medicine and surgery. 2008 Sep; 27(3):188-96. doi: 10.1016/j.sder.2008.06.002. [PMID: 18786497]
  • Manuel Luque-Ramírez, Francisco Alvarez-Blasco, Miguel Giovanni Uriol Rivera, Héctor F Escobar-Morreale. Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin. Human reproduction (Oxford, England). 2008 Jul; 23(7):1594-601. doi: 10.1093/humrep/den095. [PMID: 18375410]
  • Bulent O Yildiz. Assessment, diagnosis and treatment of a patient with hirsutism. Nature clinical practice. Endocrinology & metabolism. 2008 May; 4(5):294-300. doi: 10.1038/ncpendmet0789. [PMID: 18332896]
  • Dan Zhang, Wan-Ying Luo, Hua Liao, Cheng-Fang Wang, Ying Sun. [The effects of oxidative stress to PCOS]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2008 May; 39(3):421-3. doi: NULL. [PMID: 18575330]
  • Feridun Karakurt, Ibrahim Sahin, Serdar Güler, Berrin Demirbas, Cavit Culha, Rustu Serter, Yalcin Aral, Nuket Bavbek. Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: a randomised controlled study. Advances in therapy. 2008 Apr; 25(4):321-8. doi: 10.1007/s12325-008-0039-5. [PMID: 18389188]
  • Yasir Hasan Siddique, Gulshan Ara, Tanveer Beg, Mohammad Faisal, Mukhtar Ahmad, Mohammad Afzal. Antigenotoxic role of Centella asiatica L. extract against cyproterone acetate induced genotoxic damage in cultured human lymphocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2008 Feb; 22(1):10-7. doi: 10.1016/j.tiv.2007.07.001. [PMID: 17719740]
  • Ozgur Baris Gul, Asli Somunkiran, Oguz Yucel, Fuat Demirci, Ismail Ozdemir. The effect of ethinyl estradiol-cyproterone acetate treatment on homocysteine levels in women with polycystic ovary syndrome. Archives of gynecology and obstetrics. 2008 Jan; 277(1):25-30. doi: 10.1007/s00404-007-0401-x. [PMID: 17618446]
  • Erik J Giltay, Mathijs C Bunck, Louis J Gooren, Frans G Zitman, Michaela Diamant, Tom Teerlink. Effects of sex steroids on the neurotransmitter-specific aromatic amino acids phenylalanine, tyrosine, and tryptophan in transsexual subjects. Neuroendocrinology. 2008; 88(2):103-10. doi: 10.1159/000135710. [PMID: 18511863]
  • Y H Siddique, Gulshan Ara, T Beg, M Afzal. Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells. Acta biologica Hungarica. 2007 Dec; 58(4):397-409. doi: 10.1556/abiol.58.2007.4.7. [PMID: 18277466]
  • Peer Briken, Martin P Kafka. Pharmacological treatments for paraphilic patients and sexual offenders. Current opinion in psychiatry. 2007 Nov; 20(6):609-13. doi: 10.1097/yco.0b013e3282f0eb0b. [PMID: 17921764]
  • E J van Zuuren, H Pijl. [Hirsutism]. Nederlands tijdschrift voor geneeskunde. 2007 Oct; 151(42):2313-8. doi: NULL. [PMID: 18064932]
  • Manuel Luque-Ramírez, Francisco Alvarez-Blasco, José I Botella-Carretero, Raul Sanchón, José L San Millán, Héctor F Escobar-Morreale. Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses. Diabetes care. 2007 Sep; 30(9):2309-13. doi: 10.2337/dc07-0642. [PMID: 17536071]
  • Babette Biruss, Renate Dietl, Claudia Valenta. The influence of selected steroid hormones on the physicochemical behaviour of DPPC liposomes. Chemistry and physics of lipids. 2007 Aug; 148(2):84-90. doi: 10.1016/j.chemphyslip.2007.04.009. [PMID: 17555734]