YGGFL (BioDeep_00000412690)

   


代谢物信息卡片


YGGFL

化学式: C28H37N5O7 (555.2692852)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)

描述信息

D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins

同义名列表

1 个代谢物同义名

YGGFL



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Luying Cui, Hele Cai, Fazhuang Sun, Yali Wang, Yang Qu, Junsheng Dong, Heng Wang, Jun Li, Chen Qian, Jianji Li. Beta-endorphin inhibits the inflammatory response of bovine endometrial cells through δ opioid receptor in vitro. Developmental and comparative immunology. 2021 08; 121(?):104074. doi: 10.1016/j.dci.2021.104074. [PMID: 33775662]
  • Yue Du, Jinxue Wei, Xiao Yang, Yikai Dou, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Qiang Wang, Wei Deng, Minli Li, Dongtao Lin, Tao Li, Xiaohong Ma. Plasma metabolites were associated with spatial working memory in major depressive disorder. Medicine. 2021 Feb; 100(8):e24581. doi: 10.1097/md.0000000000024581. [PMID: 33663067]
  • Keisuke Mizomichi, Takayuki Yamagishi, Tomoko Kawashima, Michael Dürr, Satoka Aoyagi. Investigating matrix effects of different combinations of lipids and peptides on TOF-SIMS data. Biointerphases. 2020 04; 15(2):021008. doi: 10.1116/6.0000036. [PMID: 32241114]
  • Robert J Cassell, Krishna K Sharma, Hongyu Su, Benjamin R Cummins, Haoyue Cui, Kendall L Mores, Arryn T Blaine, Ryan A Altman, Richard M van Rijn. The Meta-Position of Phe4 in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244542. [PMID: 31842282]
  • O G Pinaeva, O A Lebed'ko, S K Pinaev, E N Sazonova. Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia. Bulletin of experimental biology and medicine. 2019 Aug; 167(4):428-431. doi: 10.1007/s10517-019-04542-9. [PMID: 31502135]
  • Hejun Chen, Junlian Xue, Xinjiang Wu. Traditional versus Percutaneous Transforaminal Endoforaminal Discectomy Effect on the Nervous System Function and Serum LEK, GFAP and PGE-2 in Patients with Senile Lumbar Spinal Stenosis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2019 Apr; 29(4):341-344. doi: 10.29271/jcpsp.2019.04.341. [PMID: 30925957]
  • Jean-Louis Beaudeau, Véronique Blais, Brian J Holleran, Alexandre Bergeron, Graciela Piñeyro, Brigitte Guérin, Louis Gendron, Yves L Dory. N-Guanidyl and C-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties. ACS chemical neuroscience. 2019 03; 10(3):1615-1626. doi: 10.1021/acschemneuro.8b00550. [PMID: 30614675]
  • Robert J Cassell, Kendall L Mores, Breanna L Zerfas, Amr H Mahmoud, Markus A Lill, Darci J Trader, Richard M van Rijn. Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2019 03; 29(3):450-456. doi: 10.1016/j.euroneuro.2018.12.013. [PMID: 30591345]
  • Beata Wilenska, Dagmara Tymecka, Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Maria Wiśniewska-Jarosińska, Jolanta Dyniewicz, Árpád Somogyi, Jakub Fichna, Aleksandra Misicka. Enkephalin degradation in serum of patients with inflammatory bowel diseases. Pharmacological reports : PR. 2019 Feb; 71(1):42-47. doi: 10.1016/j.pharep.2018.08.001. [PMID: 30391790]
  • Jiao Feng, Sinda Lepetre-Mouelhi, Anne Gautier, Simona Mura, Catherine Cailleau, François Coudore, Michel Hamon, Patrick Couvreur. A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine. Science advances. 2019 02; 5(2):eaau5148. doi: 10.1126/sciadv.aau5148. [PMID: 30788432]
  • Aliye Ozalp, Begona Barroso, John Meijer, Cas van den Beld. Determination of methionine-enkephalin and leucine-enkephalin by LC-MS in human plasma: Study of pre-analytical stability. Analytical biochemistry. 2018 10; 559(?):24-29. doi: 10.1016/j.ab.2018.07.001. [PMID: 29981318]
  • Ryan A Altman, Krishna K Sharma, Lian G Rajewski, Paul C Toren, Michael J Baltezor, Mohan Pal, Somnath N Karad. Tyr1-ψ[( Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin. ACS chemical neuroscience. 2018 07; 9(7):1735-1742. doi: 10.1021/acschemneuro.8b00085. [PMID: 29648788]
  • Shusuke Nakano, Takayuki Yamagishi, Satoka Aoyagi, André Portz, Michael Dürr, Hideo Iwai, Tomoko Kawashima. Evaluation of matrix effects on TOF-SIMS data of leu-enkephalin and 1,2-dioleoyl-sn-glycero-3-phosphocholine mixed samples. Biointerphases. 2018 01; 13(3):03B403. doi: 10.1116/1.5013219. [PMID: 29351722]
  • Lenka A Vodstrcil, Thusitha W T Rupasinghe, Fabian Y S Kong, Dedreia Tull, Karen Worthington, Marcus Y Chen, Wilhelmina M Huston, Peter Timms, Malcolm J McConville, Christopher K Fairley, Catriona S Bradshaw, Sepehr N Tabrizi, Jane S Hocking. Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS). PloS one. 2017; 12(5):e0177615. doi: 10.1371/journal.pone.0177615. [PMID: 28498845]
  • A V Solin, A Yu Lyashev, Yu D Lyashev. Effects of Opioid Peptides on Changes in Lipid Metabolism in Rats Subjected to Swimming Stress. Bulletin of experimental biology and medicine. 2017 Jan; 162(3):313-315. doi: 10.1007/s10517-017-3603-7. [PMID: 28091903]
  • Da-Chao Wen, Xiao-Yu Hu, Yan-Yan Wang, Jian-Xing Luo, Wu Lin, Ling-Yan Jia, Xin-Yue Gong. Effects of aqueous extracts from Panax ginseng and Hippophae rhamnoides on acute alcohol intoxication: An experimental study using mouse model. Journal of ethnopharmacology. 2016 Nov; 192(?):67-73. doi: 10.1016/j.jep.2016.06.063. [PMID: 27374757]
  • A V Solin, Yu D Lyashev. [THE INFLUENCE OF OPIOID PEPTIDES DSLET AND DAGO ON LIPID PEROXIDATION AND THE ACTIVITY OF ANTIOXIDANT ENZYMES IN THE LIVER TISSUE OF RATS IN THE STRESS OF DIFFERENT DURATION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2016 Sep; 102(9):1066-73. doi: ". [PMID: 30193423]
  • Subhendu Sekhar Bag, Subhashis Jana, Manoj Kumar Pradhan. Synthesis, photophysical properties of triazolyl-donor/acceptor chromophores decorated unnatural amino acids: Incorporation of a pair into Leu-enkephalin peptide and application of triazolylperylene amino acid in sensing BSA. Bioorganic & medicinal chemistry. 2016 08; 24(16):3579-95. doi: 10.1016/j.bmc.2016.05.069. [PMID: 27372839]
  • A V Solin, Yu D Lyashev. [THE INFLUENCE OF OPIOID PEPTIDES ON LIPID PEROXIDATION AND ANTIOXIDANT ENZYME ACTIVITY IN RATS AFTER SWIMMING STRESS]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2015 Aug; 101(8):929-35. doi: NULL. [PMID: 26591588]
  • Oskar González, Michael van Vliet, Carola W N Damen, Frans M van der Kloet, Rob J Vreeken, Thomas Hankemeier. Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion. Analytical chemistry. 2015 Jun; 87(12):5921-9. doi: 10.1021/ac504268y. [PMID: 25965142]
  • A Lalatsa, A G Schätzlein, N L Garrett, J Moger, Michael Briggs, Lisa Godfrey, Antonio Iannitelli, Jay Freeman, I F Uchegbu. Chitosan amphiphile coating of peptide nanofibres reduces liver uptake and delivers the peptide to the brain on intravenous administration. Journal of controlled release : official journal of the Controlled Release Society. 2015 Jan; 197(?):87-96. doi: 10.1016/j.jconrel.2014.10.028. [PMID: 25449808]
  • Z K Vymjatnina, E Y Prosekina, T A Tomova. [THE INFLUENCE OF LEU-ENKEPHALIN AND MEDICAL PLANTS ON MOTOR ACTIVITY OF STOMACH IN DOGS]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology. 2015; ?(9):64-9. doi: ". [PMID: 26931013]
  • L Colaianni, S C Kung, D K Taggart, R A Picca, J Greaves, R M Penner, N Cioffi. Reduction of spectral interferences using ultraclean gold nanowire arrays in the LDI-MS analysis of a model peptide. Analytical and bioanalytical chemistry. 2014 Jul; 406(19):4571-83. doi: 10.1007/s00216-014-7876-7. [PMID: 24980599]
  • Zhi-Yang Chen, Huaqing Wang, Weiping Xu, Hui Xu, Xinchun Fu. Effect of intravenous general anaesthesia with epidural block on the expression of pre-endogenous opioid peptide genes. The Journal of international medical research. 2014 Jun; 42(3):765-72. doi: 10.1177/0300060513515642. [PMID: 24743873]
  • Kristina Rochon, Arnaud Proteau-Gagné, Philippe Bourassa, Jean-François Nadon, Jérome Côté, Véronique Bournival, Fernand Gobeil, Brigitte Guérin, Yves L Dory, Louis Gendron. Preparation and evaluation at the delta opioid receptor of a series of linear leu-enkephalin analogues obtained by systematic replacement of the amides. ACS chemical neuroscience. 2013 Aug; 4(8):1204-16. doi: 10.1021/cn4000583. [PMID: 23650868]
  • Richard M van Rijn, Jessica H Harvey, Daniela I Brissett, Julia N DeFriel, Jennifer L Whistler. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. The Journal of pharmacology and experimental therapeutics. 2013 Jan; 344(1):179-88. doi: 10.1124/jpet.112.198655. [PMID: 23097213]
  • A V Solin, Yu D Lyashev. Effect of opioid peptides on the content of LPO products and antioxidant enzyme activity in the liver of rats after restraint stress. Bulletin of experimental biology and medicine. 2012 Oct; 153(6):827-9. doi: 10.1007/s10517-012-1836-z. [PMID: 23113295]
  • Mathew W Jones, Giuseppe Mantovani, Claudia A Blindauer, Sinead M Ryan, Xuexuan Wang, David J Brayden, David M Haddleton. Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts. Journal of the American Chemical Society. 2012 May; 134(17):7406-13. doi: 10.1021/ja211855q. [PMID: 22494012]
  • Marte Balchen, Hanne Lund, Léon Reubsaet, Stig Pedersen-Bjergaard. Fast, selective, and sensitive analysis of low-abundance peptides in human plasma by electromembrane extraction. Analytica chimica acta. 2012 Feb; 716(?):16-23. doi: 10.1016/j.aca.2011.02.058. [PMID: 22284872]
  • Cécile D Cros, Istvan Toth, Joanne T Blanchfield. Lipophilic derivatives of leu-enkephalinamide: in vitro permeability, stability and in vivo nasal delivery. Bioorganic & medicinal chemistry. 2011 Feb; 19(4):1528-34. doi: 10.1016/j.bmc.2010.12.042. [PMID: 21273080]
  • Yoram Shechter, Eli Heldman, Keren Sasson, Tzach Bachar, Mary Popov, Matityahu Fridkin. Delivery of neuropeptides from the periphery to the brain: studies with enkephalin. ACS chemical neuroscience. 2010 May; 1(5):399-406. doi: 10.1021/cn100001j. [PMID: 22778833]
  • Terry A McNearney, K A Sluka, C Ahn, J D Reveille, Michael Fischbach, Maureen D Mayes. Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory associations. Clinical and experimental rheumatology. 2010 Mar; 28(2 Suppl 58):S7-11. doi: NULL. [PMID: 20576209]
  • Soohwan Sul, Yuan Feng, Uyen Le, Douglas J Tobias, Nien-Hui Ge. Interactions of tyrosine in Leu-enkephalin at a membrane-water interface: an ultrafast two-dimensional infrared study combined with density functional calculations and molecular dynamics simulations. The journal of physical chemistry. B. 2010 Jan; 114(2):1180-90. doi: 10.1021/jp9105844. [PMID: 20017523]
  • Bogdan Marek, Dariusz Kajdaniuk, Beata Kos-Kudła, Janusz Kapustecki, Elzbieta Swietochowska, Zofia Ostrowska, Lucyna Siemińska, Mariusz Nowak, Joanna Głogowska-Szelag, Halina Borgiel-Marek, Nelly Ciesielska-Kopacz, Wanda Foltyn, Krystyna Pierzchała, Robert Krysiak, Radosław Bienek. Mean daily plasma concentrations of beta-endorphin, leu-enkephalin, ACTH, cortisol, and DHEAS in epileptic patients with complex partial seizures evolving to generalized tonic-clonic seizures. Endokrynologia Polska. 2010 Jan; 61(1):103-10. doi: NULL. [PMID: 20205112]
  • Craig Bolte, Gilbert Newman, Jo El J Schultz. Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation. American journal of physiology. Heart and circulatory physiology. 2009 Apr; 296(4):H967-75. doi: 10.1152/ajpheart.00909.2008. [PMID: 19181965]
  • Pai-Huei Peng, Ho-Shiang Huang, Yih-Jing Lee, Yih-Sharng Chen, Ming-Chieh Ma. Novel role for the delta-opioid receptor in hypoxic preconditioning in rat retinas. Journal of neurochemistry. 2009 Feb; 108(3):741-54. doi: 10.1111/j.1471-4159.2008.05807.x. [PMID: 19054276]
  • Manuel A Méndez, Michel Prudent, Bin Su, Hubert H Girault. Peptide-phospholipid complex formation at liquid-liquid interfaces. Analytical chemistry. 2008 Dec; 80(24):9499-507. doi: 10.1021/ac801651f. [PMID: 19072264]
  • R Frithiof, S Eriksson, M Rundgren. Central inhibition of opioid receptor subtypes and its effect on haemorrhagic hypotension in conscious sheep. Acta physiologica (Oxford, England). 2007 Sep; 191(1):25-34. doi: 10.1111/j.1748-1716.2007.01720.x. [PMID: 17550406]
  • Nick C Polfer, Jos Oomens. Reaction products in mass spectrometry elucidated with infrared spectroscopy. Physical chemistry chemical physics : PCCP. 2007 Aug; 9(29):3804-17. doi: 10.1039/b702993b. [PMID: 17637973]
  • Nick C Polfer, Jos Oomens, Sandor Suhai, Béla Paizs. Infrared spectroscopy and theoretical studies on gas-phase protonated leu-enkephalin and its fragments: direct experimental evidence for the mobile proton. Journal of the American Chemical Society. 2007 May; 129(18):5887-97. doi: 10.1021/ja068014d. [PMID: 17428052]
  • Chiara Falciani, Luisa Lozzi, Alessandro Pini, Federico Corti, Monica Fabbrini, Andrea Bernini, Barbara Lelli, Neri Niccolai, Luisa Bracci. Molecular basis of branched peptides resistance to enzyme proteolysis. Chemical biology & drug design. 2007 Mar; 69(3):216-21. doi: 10.1111/j.1747-0285.2007.00487.x. [PMID: 17441908]
  • L Kamel, A Saleh, A Morsy, A Ghali, H El Khayat. Plasma met-enkephalin, beta-endorphin and leu-enkephalin levels in human hepatic encephalopathy. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. 2007 Mar; 13(2):257-65. doi: NULL. [PMID: 17684846]
  • Jia-Xu Chen, Xin Zhao, Guang-Xin Yue, Zhu-Feng Wang. Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A1-13. Cellular and molecular neurobiology. 2007 Feb; 27(1):1-10. doi: 10.1007/s10571-006-9110-4. [PMID: 16858636]
  • Olivier Mozziconacci, Krzysztof Bobrowski, Carla Ferreri, Chryssostomos Chatgilialoglu. Reactions of hydrogen atoms with met-enkephalin and related peptides. Chemistry (Weinheim an der Bergstrasse, Germany). 2007; 13(7):2029-33. doi: 10.1002/chem.200600828. [PMID: 17124712]
  • Ulkü Bayar, Mustafa Basaran, Sibel Kiran, Ayhan Coskun, Sener Gezer. Use of an aromatase inhibitor in patients with polycystic ovary syndrome: a prospective randomized trial. Fertility and sterility. 2006 Nov; 86(5):1447-51. doi: 10.1016/j.fertnstert.2006.04.026. [PMID: 17070196]
  • Maja Roscić, Stefica Horvat. Transformations of bioactive peptides in the presence of sugars--characterization and stability studies of the adducts generated via the Maillard reaction. Bioorganic & medicinal chemistry. 2006 Jul; 14(14):4933-43. doi: 10.1016/j.bmc.2006.03.006. [PMID: 16563774]
  • Ana Reis, Pedro Domingues, António J V Ferrer-Correia, M Rosário M Domingues. Peptide-phospholipid cross-linking reactions: identification of leucine enkephalin-alka(e)nal-glycerophosphatidylcholine adducts by tandem mass spectrometry. Journal of the American Society for Mass Spectrometry. 2006 May; 17(5):657-60. doi: 10.1016/j.jasms.2006.01.006. [PMID: 16517179]
  • Jeffrey Wang, Derk J Hogenkamp, Minhtam Tran, Wen-Yen Li, Ryan F Yoshimura, Timothy B C Johnstone, Wei-Chiang Shen, Kelvin W Gee. Reversible lipidization for the oral delivery of leu-enkephalin. Journal of drug targeting. 2006 Apr; 14(3):127-36. doi: 10.1080/10611860600648221. [PMID: 16753826]
  • Shaoqian Liu, Akira Shibata, Satoru Ueno, Feng Xu, Yoshinobu Baba, Dejian Jiang, Yuanjian Li. Investigation of interaction of Leu-enkephalin with lipid membranes. Colloids and surfaces. B, Biointerfaces. 2006 Mar; 48(2):148-58. doi: 10.1016/j.colsurfb.2006.02.005. [PMID: 16542826]
  • Iu A Zolotarev, A K Dadaian, O V Dolotov, V S Kozik, N V Kost, O Iu Sokolov, E M Dorokhova, V K Meshavkin, L S Inozemtseva, M V Gabaeva, L A Andreeva, L Iu Alfeeva, T S Pavlov, K E Badmaeva, S E Badmaeva, Z V Bakaeva, G N Kopylova, G E Samonina, B V Vas'kovskiĭ, I A Grivennikov, A A Zozulia, N F Miasoedov. [Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation]. Bioorganicheskaia khimiia. 2006 Mar; 32(2):183-91. doi: NULL. [PMID: 16637290]
  • Arndt Psurek, Frank-Michael Matysik, Gerhard K E Scriba. Determination of enkephalin peptides by nonaqueous capillary electrophoresis with electrochemical detection. Electrophoresis. 2006 Mar; 27(5-6):1199-208. doi: 10.1002/elps.200500499. [PMID: 16523458]
  • Sherry Wu, Christopher Campbell, Yasuko Koda, Joanne T Blanchfield, Istvan Toth. Investigation of the route of absorption of lipid and sugar modified leu-enkephalin analogues and their enzymatic stability using the caco-2 cell monolayer system. Medicinal chemistry (Shariqah (United Arab Emirates)). 2006 Mar; 2(2):203-11. doi: 10.2174/157340606776056205. [PMID: 16787368]
  • Indira Chandrasekhar, Wilfred F van Gunsteren, Giorgia Zandomeneghi, Philip T F Williamson, Beat H Meier. Orientation and conformational preference of leucine-enkephalin at the surface of a hydrated dimyristoylphosphatidylcholine bilayer: NMR and MD simulation. Journal of the American Chemical Society. 2006 Jan; 128(1):159-70. doi: 10.1021/ja054785q. [PMID: 16390143]
  • Jun Yang, Wen-Yan Liu, Cao-You Song, Bao-Cheng Lin. Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing acupuncture analgesia in the rat. Neuroscience research. 2006 Jan; 54(1):49-56. doi: 10.1016/j.neures.2005.10.006. [PMID: 16310878]
  • Eric Bonneil, Sylvain Tessier, Alain Carrier, Pierre Thibault. Multiplex multidimensional nanoLC-MS system for targeted proteomic analyses. Electrophoresis. 2005 Dec; 26(24):4575-89. doi: 10.1002/elps.200500603. [PMID: 16358250]
  • Saadet Inan, Alan Cowan. Reduced kappa-opioid activity in a rat model of cholestasis. European journal of pharmacology. 2005 Aug; 518(2-3):182-6. doi: 10.1016/j.ejphar.2005.06.025. [PMID: 16054619]
  • Yuzuru Kato. [Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)]. Nihon rinsho. Japanese journal of clinical medicine. 2005 Aug; 63 Suppl 8(?):211-2. doi: NULL. [PMID: 16149492]
  • Andreja Jakas, Stefica Horvat. The effect of glycation on the chemical and enzymatic stability of the endogenous opioid peptide, leucine-enkephalin, and related fragments. Bioorganic chemistry. 2004 Dec; 32(6):516-26. doi: 10.1016/j.bioorg.2004.05.011. [PMID: 15530992]
  • Aron D Mosnaim, Javier Puente, Vasant Ranade, Catherine Hoang, Marion E Wolf. Inhibition of human plasma leucine5-enkephalin aminopeptidase hydrolysis by various endogenous peptides and a select number of clinically used drugs. American journal of therapeutics. 2004 Nov; 11(6):459-65. doi: 10.1097/01.mjt.0000134785.42464.17. [PMID: 15543085]
  • Adam C Myers, Jennifer A Kowalski, Mark A Lipton. Facile incorporation of urea pseudopeptides into protease substrate analogue inhibitors. Bioorganic & medicinal chemistry letters. 2004 Oct; 14(20):5219-22. doi: 10.1016/j.bmcl.2004.07.092. [PMID: 15380231]
  • Iu A Zolotarev, O Iu Sokolov, N V Kost, B V Vas'kovskiĭ, N F Miasoedov, A A Zozulia. [Leu-enkephalin homogeneously labeled with tritium in studying the Selank inhibiting effect on the enkephalin-degrading enzymes of human plasma]. Bioorganicheskaia khimiia. 2004 May; 30(3):234-40. doi: 10.1023/b:rubi.0000030126.09208.c3. [PMID: 15344652]
  • O Yu Sokolov, O B Kurasova, N V Kost, M V Gabaeva, E V Korneeva, I G Mikheeva, A A Zozulya. Half-life of leu-enkephalin in the serum of infants of the first year of life on different types of feeding: relationship with temperament. Bulletin of experimental biology and medicine. 2004 Apr; 137(4):342-4. doi: 10.1023/b:bebm.0000035124.19324.19. [PMID: 15452596]
  • B S Dezfuli, L Giari, E Simoni, A P Shinn, G Bosi. Immunohistochemistry, histopathology and ultrastructure of Gasterosteus aculeatus tissues infected with Glugea anomala. Diseases of aquatic organisms. 2004 Mar; 58(2-3):193-202. doi: 10.3354/dao058193. [PMID: 15109142]
  • Zheng-Zheng Shan, Sheng-Ming Dai, Feng Fang, Ding-Feng Su. Changes of central norepinephrine, beta-endorphin, LEU-enkephalin, peripheral arginine-vasopressin, and angiotensin II levels in acute and chronic phases of sino-aortic denervation in rats. Journal of cardiovascular pharmacology. 2004 Feb; 43(2):234-41. doi: 10.1097/00005344-200402000-00011. [PMID: 14716211]
  • Aira Naito, Katsuyuki Nishimura. Conformational analysis of opioid peptides in the solid states and the membrane environments by NMR spectroscopy. Current topics in medicinal chemistry. 2004; 4(1):135-45. doi: 10.2174/1568026043451645. [PMID: 14754381]
  • Stanislava Stanojević, Mirjana Dimitrijević, Vesna Kovacević-Jovanović, Tatjana Miletić, Vesna Vujić, Jelena Radulović. Stress applied during primary immunization affects the secondary humoral immune response in the rat: involvement of opioid peptides. Stress (Amsterdam, Netherlands). 2003 Dec; 6(4):247-58. doi: 10.1080/1025389032000114515. [PMID: 14660057]
  • T A Ivandini, B V Sarada, C Terashima, T N Rao, D A Tryk, H Ishiguro, Y Kubota, A Fujishima. Gradient liquid chromatography of leucine-enkephalin peptide and its metabolites with electrochemical detection using highly boron-doped diamond electrode. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 791(1-2):63-72. doi: 10.1016/s1570-0232(03)00204-6. [PMID: 12798166]
  • N V Kost, O Iu Sokolov, M V Gabaeva, Iu A Zolotarev, V V Malinin, V Kh Khavinson. [Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum]. Izvestiia Akademii nauk. Seriia biologicheskaia. 2003 Jul; ?(4):427-9. doi: NULL. [PMID: 12942748]
  • Aron D Mosnaim, Javier Puente, Rolando Saavedra, Seymour Diamond, Marion E Wolf. In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure. Pharmacology. 2003 Jan; 67(1):6-13. doi: 10.1159/000066781. [PMID: 12444298]
  • Dian Hu, Hang Gu, Liping Cao, Xinru Hong, Yan Liu, Zhijun Jin, Ping Li. [Study on the relationship between endogenous opioid peptides and fetal distress]. Zhonghua fu chan ke za zhi. 2002 Dec; 37(12):718-20. doi: NULL. [PMID: 12622912]
  • Eric Bonneil, Jianjun Li, T-L Tremblay, John J Bergeron, Pierre Thibault. Integration of solid-phase extraction membranes for sample multiplexing: application to rapid protein identification from gel-isolated protein extracts. Electrophoresis. 2002 Oct; 23(20):3589-98. doi: 10.1002/1522-2683(200210)23:20<3589::aid-elps3589>3.0.co;2-o. [PMID: 12412129]
  • O Yu Sokolov, V K Meshavkin, N V Kost, A A Zozulya. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bulletin of experimental biology and medicine. 2002 Feb; 133(2):133-5. doi: 10.1023/a:1015582302311. [PMID: 12432865]
  • H Kenneth Kramer, Irma Onoprishvili, Matthew L Andria, Kayane Hanna, Karina Sheinkman, Lisa B Haddad, Eric J Simon. Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases. BMC pharmacology. 2002; 2(?):5. doi: 10.1186/1471-2210-2-5. [PMID: 11897012]
  • R D Egleton, S A Mitchell, J D Huber, M M Palian, R Polt, T P Davis. Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation. The Journal of pharmacology and experimental therapeutics. 2001 Dec; 299(3):967-72. doi: NULL. [PMID: 11714884]
  • G Piñeyro, M Azzi, A De Léan, P Schiller, M Bouvier. Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity. Molecular pharmacology. 2001 Oct; 60(4):816-27. doi: . [PMID: 11562445]
  • J X Li, C J Xiang, X Q Liu. [Clinical study on analgesic mechanism of bitongxiao in treating neck pain due to cervical spondylitis]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2001 Jul; 21(7):516-8. doi: NULL. [PMID: 12575397]
  • P Li, S Tjen-A-Looi, J C Longhurst. Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats. Autonomic neuroscience : basic & clinical. 2001 Jun; 89(1-2):38-47. doi: 10.1016/s1566-0702(01)00247-8. [PMID: 11474645]
  • T Iu Rebrova, L N Maslov, Iu B Lishmanov, S V Tam. [The role of mu- and delta-opiate receptors in resistance of the myocardium to free radical damage]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2001 May; 87(5):628-41. doi: ". [PMID: 11452797]
  • A J Gawron, S M Lunte. Detection of neuropeptides using on-capillary copper complexation and capillary electrophoresis with electrochemical detection. Electrophoresis. 2000 Sep; 21(15):3205-11. doi: 10.1002/1522-2683(20000901)21:15<3205::aid-elps3205>3.0.co;2-7. [PMID: 11001219]
  • A D Mosnaim, M E Wolf, T D Nguyen, J Puente, F Freitag, S Diamond. Degradation kinetics of leucine5-enkephalin by plasma samples from healthy controls and various patient populations: in vitro drug effects. American journal of therapeutics. 2000 May; 7(3):185-94. doi: 10.1097/00045391-200007030-00006. [PMID: 11317167]
  • S D Mikhailova, N V Glushchenko, T M Semushkina, G I Storozhakov. Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists. Bulletin of experimental biology and medicine. 2000 May; 129(5):423-4. doi: 10.1007/bf02439790. [PMID: 10977939]
  • E Dermitzaki, E Chatzaki, A Gravanis, A N Margioris. Opioids transiently prevent activation of apoptotic mechanisms following short periods of serum withdrawal. Journal of neurochemistry. 2000 Mar; 74(3):960-9. doi: 10.1046/j.1471-4159.2000.0740960.x. [PMID: 10693926]
  • K Fredholt, C Adrian, L Just, D Hoj Larsen, S Weng, B Moss, G Juel Friis. Chemical and enzymatic stability as well as transport properties of a Leu-enkephalin analogue and ester prodrugs thereof. Journal of controlled release : official journal of the Controlled Release Society. 2000 Feb; 63(3):261-73. doi: 10.1016/s0168-3659(99)00196-0. [PMID: 10601722]
  • N I Nechipurenko, T V Dudina, A I Elkina, Iu B Elkin. [Pathogenetic basis for the use of GABA-ergic preparations in combination with atropine during chronic pain syndrome in patients with neurologic manifestations of lumbar osteochondrosis]. Voprosy meditsinskoi khimii. 2000 Jan; 46(1):36-42. doi: . [PMID: 10802884]
  • R S Prosser, H Bryant, R G Bryant, R R Vold. Lanthanide chelates as bilayer alignment tools in NMR studies of membrane-associated peptides. Journal of magnetic resonance (San Diego, Calif. : 1997). 1999 Dec; 141(2):256-60. doi: 10.1006/jmre.1999.1855. [PMID: 10579948]
  • A R Volpe, G Fontecchio, M Carmignani. Regulatory role of bradykinin in the coronary and cerebral circulations and in systemic hemodynamics. Immunopharmacology. 1999 Oct; 44(1-2):87-92. doi: 10.1016/s0162-3109(99)00140-x. [PMID: 10604529]
  • K Shreder, L Zhang, J P Gleeson, J A Ericsson, V V Yalamoori, M Goodman. Solid phase organic synthesis of piperazinone containing enkephalin mimetics: a readily derivatized, traceless scaffold. Journal of combinatorial chemistry. 1999 Sep; 1(5):383-7. doi: 10.1021/cc9900100. [PMID: 10748734]
  • A Galli, L D Jayanthi, I S Ramsey, J W Miller, R T Fremeau, L J DeFelice. L-proline and L-pipecolate induce enkephalin-sensitive currents in human embryonic kidney 293 cells transfected with the high-affinity mammalian brain L-proline transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Aug; 19(15):6290-7. doi: . [PMID: 10414958]
  • L Fuso, M Marini, M Marzano, B Nardecchia, L G Roda, P Rossi, A Urbani. Hydrolysis of peripheral leucine enkephalin in allergic asthma. Clinical immunology (Orlando, Fla.). 1999 Mar; 90(3):411-9. doi: 10.1006/clim.1998.4667. [PMID: 10075871]
  • A Bak, M Fich, B D Larsen, S Frokjaer, G J Friis. N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin: synthesis, chemical and enzymatic stability studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 1999 Mar; 7(4):317-23. doi: 10.1016/s0928-0987(98)00044-x. [PMID: 9971915]
  • Iu B Lishmanov, L A Maĭmeskulova, E V Uskina, L N Maslov. [Opiatergic mechanisms of cardioprotective and anti-arrhythmic effects of adaptation]. Biulleten' eksperimental'noi biologii i meditsiny. 1999 Feb; 127(2):167-70. doi: ". [PMID: 10095946]
  • H K Kramer, E J Simon. Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. Journal of neurochemistry. 1999 Feb; 72(2):585-93. doi: 10.1046/j.1471-4159.1999.0720585.x. [PMID: 9930730]
  • H K Kramer, E J Simon. Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC. Journal of neurochemistry. 1999 Feb; 72(2):594-604. doi: 10.1046/j.1471-4159.1999.0720594.x. [PMID: 9930731]
  • R Babst, L Bongiorno, M Marini, L G Roda, G Spagnoli, A Urbani. Trauma decreases leucine enkephalin hydrolysis in human plasma. The Journal of pharmacology and experimental therapeutics. 1999 Feb; 288(2):766-73. doi: NULL. [PMID: 9918587]
  • L Bongiorno, M Marzano, M Marini, L G Roda, A Urbani, G Spagnoli. Age increases leucine enkephalin hydrolysis in human plasma. Gerontology. 1999 Jan; 45(1):10-6. doi: 10.1159/000022049. [PMID: 9852375]
  • O S Gudmundsson, K Nimkar, S Gangwar, T Siahaan, R T Borchardt. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation. Pharmaceutical research. 1999 Jan; 16(1):16-23. doi: 10.1023/a:1018802324759. [PMID: 9950273]
  • T W Spradau, J A Katzenellenbogen. Protein and peptide labeling with (cyclopentadienyl)tricarbonyl rhenium and technetium. Bioconjugate chemistry. 1998 Nov; 9(6):765-72. doi: 10.1021/bc980043t. [PMID: 9815171]
  • C Yurdaydin, D Karavelioglu, O Onaran, T Celik, M H Yaşa, O Uzunalimoglu. Opioid receptor ligands in human hepatic encephalopathy. Journal of hepatology. 1998 Nov; 29(5):796-801. doi: 10.1016/s0168-8278(98)80261-4. [PMID: 9833918]
  • M Klin, M Waluga, R Rudka, A Madej, M Janiszewska, E Grzebieniak, A Wesolowky. Plasma catecholamines, neuropeptide Y and leucine-enkephalin in uremic patients before and after dialysis during rest and handgrip. Bollettino chimico farmaceutico. 1998 Sep; 137(8):306-13. doi: NULL. [PMID: 9835145]