3-nitro-L-tyrosine (BioDeep_00000412623)
Secondary id: BioDeep_00000605609
natural product PANOMIX_OTCML-2023
代谢物信息卡片
3-nitro-L-tyrosine
化学式: C9H10N2O5 (226.058969)
中文名称: 3-硝基-L-酪氨酸
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 2.49%
分子结构信息
SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)[N+](=O)[O-])O
InChI: InChI=1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)
描述信息
A 3-nitrotyrosine comprising L-tyrosine having a nitro group at the 3-position on the phenyl ring.
3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.
同义名列表
1 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:44454
- PubChem: 65124
- DrugBank: DB03867
- ChEMBL: CHEMBL1234745
- CAS: 621-44-3
- MoNA: CCMSLIB00000578228
- MoNA: CCMSLIB00005464409
- MoNA: CCMSLIB00005464418
- MoNA: MoNA024110
- MoNA: MoNA024101
- MoNA: EMBL-MCF_spec49689
- MoNA: EMBL-MCF_spec49681
- MoNA: MoNA016635
- MetaboLights: MTBLC44454
- medchemexpress: HY-113248
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nayomi Camilus, Stephanie Gao, Musonda Mitti, Jun-Ray Macairan, Rafik Naccache, Sanela Martic. Selective detection of nitrotyrosine using dual-fluorescent carbon dots.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
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10.1016/j.saa.2022.121444. [PMID: 35660143] - Lidia A Pérez-Márquez, Marcelle D Perretti, Raúl García-Rodríguez, Fernando Lahoz, Romen Carrillo. A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.
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2022 Jul; 61(28):e202205403. doi:
10.1002/anie.202205403. [PMID: 35511212] - Manjeet Gupta, Vimal Kumar Paliwal, G Nagesh Babu. Serum fractalkine and 3-nitrotyrosine levels correlate with disease severity in Parkinson's disease: a pilot study.
Metabolic brain disease.
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10.1007/s11011-021-00801-9. [PMID: 34342811] - Marcelo Queiroz, Adriana Leandro, Lara Azul, Artur Figueirinha, Raquel Seiça, Cristina M Sena. Luteolin Improves Perivascular Adipose Tissue Profile and Vascular Dysfunction in Goto-Kakizaki Rats.
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Biosensors & bioelectronics.
2021 Sep; 187(?):113284. doi:
10.1016/j.bios.2021.113284. [PMID: 34022499] - Muhammad Nadeem, Adam Kindelin, Laura Mahady, Kanchan Bhatia, Md Nasrul Hoda, Andrew F Ducruet, Saif Ahmad. Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy.
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Anticancer research.
2019 Mar; 39(3):1383-1389. doi:
10.21873/anticanres.13252. [PMID: 30842172] - B E Orimadegun, O A Awolude, E O Agbedana. Markers of lipid and protein peroxidation among Nigerian university students with dysmenorrhea.
Nigerian journal of clinical practice.
2019 Feb; 22(2):174-180. doi:
10.4103/njcp.njcp_279_18. [PMID: 30729939] - W Zurawinski, T Kokot, E Swietochowska, K Sosada, M Muc-Wierzgon. The influence of the low-energy defibrillating impulse on the endothelin-1 concentration in the left heart ventricle and blood serum of the healthy rabbits.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2019 02; 70(1):. doi:
10.26402/jpp.2019.1.04. [PMID: 31019122] - Iina Saimanen, Dina Rahkola, Viivi Kuosmanen, Jari Kärkkäinen, Tuomas Selander, Anu Holopainen, Samuli Aspinen, Matti Eskelinen. Nitrotyrosine (NT), a Nitrosative Stress Biomarker, Plasma Concentrations in Gallstone Disease and Cancer Patients.
Anticancer research.
2019 Feb; 39(2):809-814. doi:
10.21873/anticanres.13179. [PMID: 30711961] - Ahmed Nadeem, Sheikh F Ahmad, Sabry M Attia, Laila Y Al-Ayadhi, Naif O Al-Harbi, Saleh A Bakheet. Dysregulated enzymatic antioxidant network in peripheral neutrophils and monocytes in children with autism.
Progress in neuro-psychopharmacology & biological psychiatry.
2019 01; 88(?):352-359. doi:
10.1016/j.pnpbp.2018.08.020. [PMID: 30145184] - Hironori Uekita, Toshiyuki Ishibashi, Masashi Shiomi, Hidenori Koyama, Shukuko Ohtsuka, Hiroshi Yamamoto, Shoichi Yamagishi, Hiroyoshi Inoue, Hiroyuki Itabe, Koichi Sugimoto, Masashi Kamioka, Hiroshi Ohkawara, Ikuo Wada, Takeishi Yasuchika. Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis.
Fukushima journal of medical science.
2019; 65(3):109-121. doi:
10.5387/fms.2019-12. [PMID: 31915324] - Jinit Masania, Gernot Faustmann, Attia Anwar, Hildegard Hafner-Giessauf, Nasir Rajpoot, Johanna Grabher, Kashif Rajpoot, Beate Tiran, Barbara Obermayer-Pietsch, Brigitte M Winklhofer-Roob, Johannes M Roob, Naila Rabbani, Paul J Thornalley. Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health.
Oxidative medicine and cellular longevity.
2019; 2019(?):4851323. doi:
10.1155/2019/4851323. [PMID: 31827677] - Midori Awazu, Tokiya Abe, Akinori Hashiguchi, Mariko Hida. Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring.
PloS one.
2019; 14(9):e0221686. doi:
10.1371/journal.pone.0221686. [PMID: 31479481] - Jinghan Feng, Xingmiao Chen, Shengwen Lu, Wenting Li, Dan Yang, Weiwei Su, Xijun Wang, Jiangang Shen. Naringin Attenuates Cerebral Ischemia-Reperfusion Injury Through Inhibiting Peroxynitrite-Mediated Mitophagy Activation.
Molecular neurobiology.
2018 Dec; 55(12):9029-9042. doi:
10.1007/s12035-018-1027-7. [PMID: 29627876] - Yi Zhou, Huanyuan Wang, Fuli Man, Zhiying Guo, Jiahui Xu, Wenjing Yan, Jiaying Li, Qi Pan, Wen Wang. Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats.
Cardiovascular drugs and therapy.
2018 12; 32(6):541-552. doi:
10.1007/s10557-018-6831-9. [PMID: 30328028] - Qing Liu, Zhengfen Li, Yuexin Liu, Qiuxia Xiao, Xuan Peng, Qi Chen, Rui Deng, Zhiwei Gao, Fengxu Yu, Ying Zhang. Hydromorphine postconditioning protects isolated rat heart against ischemia-reperfusion injury via activating P13K/Akt/eNOS signaling.
Cardiovascular therapeutics.
2018 Dec; 36(6):e12481. doi:
10.1111/1755-5922.12481. [PMID: 30597772] - Bridget Peters, Christopher Ballmann, Tiffany Quindry, Emily G Zehner, Justin McCroskey, Matthew Ferguson, Tony Ward, Charles Dumke, John C Quindry. Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress.
Journal of occupational and environmental medicine.
2018 12; 60(12):1073-1081. doi:
10.1097/jom.0000000000001437. [PMID: 30188494] - Marika Cordaro, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Alessio Filippo Peritore, Ramona D'Amico, Enrico Gugliandolo, Rosanna Di Paola, Salvatore Cuzzocrea. 2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Molecular neurobiology.
2018 Dec; 55(12):9251-9266. doi:
10.1007/s12035-018-1064-2. [PMID: 29656363] - Maysa Isernhagen Schaedler, Rhanany Alan Calloi Palozi, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Valdinei de Oliveira Araújo, Emerson Luiz Botelho Lourenço, Lauro Mera de Souza, Francislaine Aparecida Dos Reis Lívero, Arquimedes Gasparotto Junior. Redox regulation and NO/cGMP plus K+ channel activation contributes to cardiorenal protection induced by Cuphea carthagenensis (Jacq.) J.F. Macbr. in ovariectomized hypertensive rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Dec; 51(?):7-19. doi:
10.1016/j.phymed.2018.05.011. [PMID: 30466630] - Matheus A Pasquali, Bernard L Harlow, Claudio N Soares, Michael W Otto, Lee S Cohen, Luciano Minuzzi, Daniel P Gelain, Jose Claudio F Moreira, Benicio N Frey. A longitudinal study of neurotrophic, oxidative, and inflammatory markers in first-onset depression in midlife women.
European archives of psychiatry and clinical neuroscience.
2018 Dec; 268(8):771-781. doi:
10.1007/s00406-017-0812-z. [PMID: 28550365] - Ayman G Mustafa, Othman Al-Shboul, Mahmoud A Alfaqih, Mohammad A Al-Qudah, Ahmed N Al-Dwairi. Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins.
Archives of physiology and biochemistry.
2018 Dec; 124(5):418-423. doi:
10.1080/13813455.2017.1415939. [PMID: 29256275] - Elisabetta Bigagli, Cristina Luceri, Maria De Angioletti, Konstantin Chegaev, Mario D'Ambrosio, Chiara Riganti, Elena Gazzano, Simona Saponara, Mariangela Longini, Francesca Luceri, Lorenzo Cinci. New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations.
Investigational new drugs.
2018 12; 36(6):985-998. doi:
10.1007/s10637-018-0590-0. [PMID: 29607467] - Tatsuki Matsuzaki, Ayame Kano, Tetsuro Kamiya, Hirokazu Hara, Tetsuo Adachi. Enhanced ability of plasma-activated lactated Ringer's solution to induce A549 cell injury.
Archives of biochemistry and biophysics.
2018 10; 656(?):19-30. doi:
10.1016/j.abb.2018.08.011. [PMID: 30170003] - Sofia Fortalezas, Dorinda Marques-da-Silva, Carlos Gutierrez-Merino. Creatine Protects Against Cytosolic Calcium Dysregulation, Mitochondrial Depolarization and Increase of Reactive Oxygen Species Production in Rotenone-Induced Cell Death of Cerebellar Granule Neurons.
Neurotoxicity research.
2018 Oct; 34(3):717-732. doi:
10.1007/s12640-018-9940-0. [PMID: 30094708] - Il Young Kim, Sang Soo Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H Lovett, Sang Heon Song. The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus.
BMC nephrology.
2018 09; 19(1):248. doi:
10.1186/s12882-018-1029-8. [PMID: 30253743] - Shenpeng R Zhang, Marius Piepke, Hannah X Chu, Brad Rs Broughton, Raymond Shim, Connie Hy Wong, Seyoung Lee, Megan A Evans, Antony Vinh, Samy Sakkal, Thiruma V Arumugam, Tim Magnus, Samuel Huber, Mathias Gelderblom, Grant R Drummond, Christopher G Sobey, Hyun Ah Kim. IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.
JCI insight.
2018 09; 3(18):. doi:
10.1172/jci.insight.121560. [PMID: 30232272] - Ning Ma, Hong-Mei Liu, Ting Xia, Jian-Dong Liu, Xiao-Ze Wang. Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide.
Canadian journal of physiology and pharmacology.
2018 Sep; 96(9):902-908. doi:
10.1139/cjpp-2018-0153. [PMID: 29862831] - Takaaki Kimura, Kazuhiro Shiizaki, Tetsu Akimoto, Takahiro Shinzato, Toshihiro Shimizu, Akira Kurosawa, Taro Kubo, Koji Nanmoku, Makoto Kuro-O, Takashi Yagisawa. The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney.
American journal of physiology. Renal physiology.
2018 08; 315(2):F345-F352. doi:
10.1152/ajprenal.00486.2017. [PMID: 29693450] - Jinghan Feng, Xingmiao Chen, Binghe Guan, Caiming Li, Jinhua Qiu, Jiangang Shen. Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury.
Molecular neurobiology.
2018 Aug; 55(8):6369-6386. doi:
10.1007/s12035-017-0859-x. [PMID: 29307080] - Andjelika Kalezic, Biljana Macanovic, Eliana Garalejic, Aleksandra Korac, Vesna Otasevic, Bato Korac. Level of NO/nitrite and 3-nitrotyrosine in seminal plasma of infertile men: Correlation with sperm number, motility and morphology.
Chemico-biological interactions.
2018 Aug; 291(?):264-270. doi:
10.1016/j.cbi.2018.07.002. [PMID: 29983398] - Hsiao-Jou Cortina Chen, Jereme G Spiers, Conrad Sernia, Nickolas A Lavidis. Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress.
The international journal of neuropsychopharmacology.
2018 08; 21(8):786-795. doi:
10.1093/ijnp/pyy033. [PMID: 29579222] - Guntur Divya, N S Jayaprakash, Krishnan Venkataraman. Development and Characterization of Monoclonal Antibodies Against Nitro-166Tyrosine of High-Density Lipoprotein: Apolipoprotein A1.
Monoclonal antibodies in immunodiagnosis and immunotherapy.
2018 Aug; 37(4):167-174. doi:
10.1089/mab.2018.0018. [PMID: 30132720] - Zivanit Ergaz, Liza Weinstein-Fudim, Asher Ornoy. High sucrose low copper diet in pregnant diabetic rats induces transient oxidative stress, hypoxia, and apoptosis in the offspring's liver.
Birth defects research.
2018 07; 110(12):1001-1015. doi:
10.1002/bdr2.1341. [PMID: 29851303] - Akihiro Saito, Mariko Hamano, Hiroyuki Kataoka. Simultaneous analysis of multiple urinary biomarkers for the evaluation of oxidative stress by automated online in-tube solid-phase microextraction coupled with negative/positive ion-switching mode liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2018 Jul; 41(13):2743-2749. doi:
10.1002/jssc.201800175. [PMID: 29679453] - Gabriel T do Vale, Janaina A Simplicio, Natália A Gonzaga, Rodrigo Yokota, Amanda A Ribeiro, Dulce E Casarini, Bruno S de Martinis, Carlos R Tirapelli. Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol.
Atherosclerosis.
2018 07; 274(?):67-76. doi:
10.1016/j.atherosclerosis.2018.04.041. [PMID: 29753230] - Hanaa H Gaballah, Rasha A Gaber, Ragia S Sharshar, Samah A Elshweikh. NOD2 expression, DNA damage and oxido-inflammatory status in atopic bronchial asthma: Exploring their nexus to disease severity.
Gene.
2018 Jun; 660(?):128-135. doi:
10.1016/j.gene.2018.03.061. [PMID: 29572197] - Annie R Knight, Emma L Taylor, Roman Lukaszewski, Karina Tveen Jensen, Helen E Jones, Jane E Carré, Michail N Isupov, Jennifer A Littlechild, Stephen J Bailey, Emily Brewer, Timothy J McDonald, Andrew R Pitt, Corinne M Spickett, Paul G Winyard. A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells.
Free radical biology & medicine.
2018 05; 120(?):246-254. doi:
10.1016/j.freeradbiomed.2018.03.026. [PMID: 29555590] - Lixia Zeng, Anna V Mathew, Jaeman Byun, Kevin B Atkins, Frank C Brosius, Subramaniam Pennathur. Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis.
The Journal of biological chemistry.
2018 05; 293(19):7238-7249. doi:
10.1074/jbc.ra117.000559. [PMID: 29581235] - Ademola A Oyagbemi, Temidayo O Omobowale, Grace O Ochigbo, Ebunoluwa R Asenuga, Olufunke Eunice Ola-Davies, Temitayo O Ajibade, Adebowale B Saba, Adeolu A Adedapo. Polyphenol-Rich Fraction of Parquetina nigrescens Mitigates Dichlorvos-Induced Cardiorenal Dysfunction Through Reduction in Cardiac Nitrotyrosine and Renal p38 Expressions in Wistar Rats.
Journal of dietary supplements.
2018 May; 15(3):269-284. doi:
10.1080/19390211.2017.1336148. [PMID: 28800275] - Daniela V Bavaresco, Mágada T Schwalm, Beatriz M de Farias, Luciane B Ceretta, Maria Inês da Rosa, Samira S Valvassori. INCREASED OXIDATIVE STRESS IN THE BLOOD OF OSTOMY PATIENTS.
Arquivos de gastroenterologia.
2018 Apr; 55(2):164-169. doi:
10.1590/s0004-2803.201800000-29. [PMID: 30043867] - Silvina Bartesaghi, Rafael Radi. Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration.
Redox biology.
2018 04; 14(?):618-625. doi:
10.1016/j.redox.2017.09.009. [PMID: 29154193] - Zhengjie Yan, Youjin Dai, Heling Fu, Yuan Zheng, Dan Bao, Yuan Yin, Qin Chen, Xiaowei Nie, Qingting Hao, Daorong Hou, Yugui Cui. Curcumin exerts a protective effect against premature ovarian failure in mice.
Journal of molecular endocrinology.
2018 04; 60(3):261-271. doi:
10.1530/jme-17-0214. [PMID: 29437881] - Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan. Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice.
Vascular pharmacology.
2018 03; 102(?):11-20. doi:
10.1016/j.vph.2017.05.003. [PMID: 28552746] - Jong-Min Lim, Young Joon Lee, Hyung-Rae Cho, Dong-Chan Park, Go-Woon Jung, Sae Kwang Ku, Jae-Suk Choi. Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice.
International journal of molecular medicine.
2018 Mar; 41(3):1245-1264. doi:
10.3892/ijmm.2017.3251. [PMID: 29138805] - Xing-Guang Zhang, Yan-Qi Zhang, Qian-Peng Cheng, Yi Cao, Jian-Min Sun, Xiao-Feng Lv. The impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy.
European journal of medical research.
2018 Feb; 23(1):7. doi:
10.1186/s40001-018-0304-2. [PMID: 29433562] - Derya Öztürk Okatan, Haydar Kaya, Yüksel Aliyazıcıoğlu, Selim Demir, Serdar Çolakoğlu, Ersan Odacı. Continuous 900-megahertz electromagnetic field applied in middle and late-adolescence causes qualitative and quantitative changes in the ovarian morphology, tissue and blood biochemistry of the rat.
International journal of radiation biology.
2018 02; 94(2):186-198. doi:
10.1080/09553002.2018.1420924. [PMID: 29268055] - Edina Bodnár, Edina Bakondi, Katalin Kovács, Csaba Hegedűs, Petra Lakatos, Agnieszka Robaszkiewicz, Zsolt Regdon, László Virág, Éva Szabó. Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds.
Oxidative medicine and cellular longevity.
2018; 2018(?):5286785. doi:
10.1155/2018/5286785. [PMID: 30581533] - Prachi Jain, Satish C Bhatla. Tyrosine nitration of cytosolic peroxidase is probably triggered as a long distance signaling response in sunflower seedling cotyledons subjected to salt stress.
PloS one.
2018; 13(5):e0197132. doi:
10.1371/journal.pone.0197132. [PMID: 29768452] - Anna Malgorzata Papinska, Kathleen Elizabeth Rodgers. Long-Term Administration of Angiotensin (1-7) to db/db Mice Reduces Oxidative Stress Damage in the Kidneys and Prevents Renal Dysfunction.
Oxidative medicine and cellular longevity.
2018; 2018(?):1841046. doi:
10.1155/2018/1841046. [PMID: 30425780]