11-deoxy-PGE1 (BioDeep_00000410617)

   


代谢物信息卡片


(13E,15S)-15-Hydroxy-9-oxoprost-13-en-1-oic acid

化学式: C20H34O4 (338.24569640000004)
中文名称: 11-脱氧前列腺素E1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCC(C=CC1CCC(=O)C1CCCCCCC(=O)O)O
InChI: InChI=1S/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1

描述信息

D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Origin: Plant; SubCategory_DNP: Lipids, Prostaglandins

同义名列表

5 个代谢物同义名

(13E,15S)-15-Hydroxy-9-oxoprost-13-en-1-oic acid; 11-deoxy-PGE1; 9-oxo-15S-hydroxy-13E-prostaenoic acid; 11-deoxy-Prostaglandin E1; 11-Deoxy-PGE1.



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Emi Yamamoto, Takeshi Izawa, Vetnizah Juniantito, Mitsuru Kuwamura, Kikuya Sugiura, Tadayoshi Takeuchi, Jyoji Yamate. Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions. Histology and histopathology. 2010 08; 25(8):995-1007. doi: 10.14670/hh-25.995. [PMID: 20552550]
  • Philip Bidwell, Kiwon Joh, H Anne Leaver, Maria Teresa Rizzo. Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK. Prostaglandins & other lipid mediators. 2010 Feb; 91(1-2):18-29. doi: 10.1016/j.prostaglandins.2009.12.002. [PMID: 20015475]
  • A I Hubich, T A Zheldakova, T V Chernikhova, E V Koroleva, F A Lakhvich, M V Sholukh. Synthetic heteroprostanoids of A- and E-types as novel non-comprehensive inhibitors of adenylyl cyclase in rat hepatocytes. Biochemical and biophysical research communications. 2006 Mar; 341(2):357-62. doi: 10.1016/j.bbrc.2005.12.196. [PMID: 16427025]
  • Rung-chi Li, Tereza Cindrova-Davies, Jeremy N Skepper, Lynda A Sellers. Prostacyclin induces apoptosis of vascular smooth muscle cells by a cAMP-mediated inhibition of extracellular signal-regulated kinase activity and can counteract the mitogenic activity of endothelin-1 or basic fibroblast growth factor. Circulation research. 2004 Apr; 94(6):759-67. doi: 10.1161/01.res.0000121568.40692.97. [PMID: 14963006]
  • T L Davis, N A Sharif. Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. British journal of pharmacology. 2000 Aug; 130(8):1919-26. doi: 10.1038/sj.bjp.0703525. [PMID: 10952683]
  • L Tang, K Loutzenhiser, R Loutzenhiser. Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors. Circulation research. 2000 Mar; 86(6):663-70. doi: 10.1161/01.res.86.6.663. [PMID: 10747002]
  • R Ishibashi, I Tanaka, M Kotani, S Muro, M Goto, A Sugawara, M Mukoyama, Y Sugimoto, A Ichikawa, S Narumiya, K Nakao. Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions. Kidney international. 1999 Aug; 56(2):589-600. doi: 10.1046/j.1523-1755.1999.00566.x. [PMID: 10432398]
  • Y Boie, R Stocco, N Sawyer, D M Slipetz, M D Ungrin, F Neuschäfer-Rube, G P Püschel, K M Metters, M Abramovitz. Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. European journal of pharmacology. 1997 Dec; 340(2-3):227-41. doi: 10.1016/s0014-2999(97)01383-6. [PMID: 9537820]
  • B Z Simkhovich, D V Meĭrena, Kh B Khagi, Ia F Freĭmanis. [Effect of doprostone on fatty acid metabolism disturbances in the rat heart caused by adrenergic influences]. Farmakologiia i toksikologiia. 1989 Jul; 52(4):24-7. doi: NULL. [PMID: 2806522]
  • A S Bergman, A Zh Ozolinia, Ia F Freĭmanis, M M Veveris, A A Kimenis. [Experimental study on the effect of 11-deoxyprostaglandin E1 on hormonal balance in animals]. Problemy endokrinologii. 1984 Jan; 30(1):77-81. doi: NULL. [PMID: 6709608]