Tanshinone II (BioDeep_00000410547)
Main id: BioDeep_00000272646
PANOMIX_OTCML-2023
代谢物信息卡片
Tanshinone IIA
化学式: C19H18O3 (294.1255878)
中文名称: 丹参酮IIA
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
InChI: InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
Origin: Plant; SubCategory_DNP: Diterpenoids, Abietane diterpenoids
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D006401 - Hematologic Agents > D000925 - Anticoagulants
D000893 - Anti-Inflammatory Agents
D000890 - Anti-Infective Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yi-Zhong Zhang, Huan-Ling Lai, Chen Huang, Ze-Bo Jiang, Hao-Xin Yan, Xuan-Run Wang, Chun Xie, Ju-Min Huang, Wen-Kang Ren, Jia-Xin Li, Zhi-Ran Zhai, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leung. Tanshinone IIA induces ER stress and JNK activation to inhibit tumor growth and enhance anti-PD-1 immunotherapy in non-small cell lung cancer.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155431. doi:
10.1016/j.phymed.2024.155431. [PMID: 38537440] - Guilian Zhang, Yuee Sun, Najeeb Ullah, Deepak Kasote, Longyi Zhu, Hui Liu, Ling Xu. Changes in secondary metabolites contents and stress responses in Salvia miltiorrhiza via ScWRKY35 overexpression: Insights from a wild relative Salvia castanea.
Plant physiology and biochemistry : PPB.
2024 Jun; 211(?):108671. doi:
10.1016/j.plaphy.2024.108671. [PMID: 38703500] - Lin Cao, Zhiyan Qin, Ting Yu, Xupeng Bai, Shiqin Jiang, Daifei Wang, Fangqing Ning, Min Huang, Jing Jin. Tanshinone IIA acts as a regulator of lipogenesis to overcome osimertinib acquired resistance in lung cancer.
Biochemical pharmacology.
2024 Jun; 224(?):116207. doi:
10.1016/j.bcp.2024.116207. [PMID: 38621425] - Shao Cheng, Xiaohui Hu, Kanghui Sun, Ziyu Huang, Yongjian Zhao, Yueli Sun, Bo Zeng, Jing Wang, Dongfeng Zhao, Sheng Lu, Qi Shi, Yongjun Wang, Weian Zhang, Xinhua Liu, Bing Shu. Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice.
Journal of orthopaedic surgery and research.
2024 May; 19(1):309. doi:
10.1186/s13018-024-04793-x. [PMID: 38783358] - Jie-Ru Yu, Yu-Yue Liu, Yang-Yang Gao, Li-Hui Qian, Jia-Lin Qiu, Pei-Pei Wang, Guang-Ji Zhang. Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Journal of ethnopharmacology.
2024 Apr; 324(?):117791. doi:
10.1016/j.jep.2024.117791. [PMID: 38301987] - Tianyu Li, Shuangshuang Zhang, Yidan Li, Lipeng Zhang, Wenqin Song, Chengbin Chen. Overexpression of AtMYB2 Promotes Tolerance to Salt Stress and Accumulations of Tanshinones and Phenolic Acid in Salvia miltiorrhiza.
International journal of molecular sciences.
2024 Apr; 25(7):. doi:
10.3390/ijms25074111. [PMID: 38612919] - Weiyang Tang, Meiting Wang, Yelu Wu, Kyung Ho Row, Jian-Liang Zhou. Porous phenolic resin regulated by alcohol-based deep eutectic solvent for selective extraction and separation of tanshinones from Salvia miltiorrhiza.
Talanta.
2024 Apr; 270(?):125558. doi:
10.1016/j.talanta.2023.125558. [PMID: 38183713] - Chunxiang Guo, Wei Zhao, Wei Wang, Zheng Yao, Wenhui Chen, Xiaoyi Feng. Study on the Antitumor Mechanism of Tanshinone IIA In Vivo and In Vitro through the Regulation of PERK-ATF4-HSPA5 Pathway-Mediated Ferroptosis.
Molecules (Basel, Switzerland).
2024 Mar; 29(7):. doi:
10.3390/molecules29071557. [PMID: 38611836] - Xiaoman Lv, Wenyi Zhang, Siyuan Chu, Haihua Zhang, Yongqun Wu, Yun Zhu, Dongfeng Yang, Yonghong Zhu, Dennis R A Mans, Haimin Chen, Zongsuo Liang. Endophytic fungus Penicillium steckii DF33 promoted tanshinones biosynthesis in Salvia miltiorrhiza by regulating the expression of CYP450 genes.
Gene.
2024 Mar; 899(?):148094. doi:
10.1016/j.gene.2023.148094. [PMID: 38142897] - Jiawen Tang, Xueying Zhao. Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge).
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061201. [PMID: 38542838] - Hong-Zhou Li, Dong Han, Rui-Feng Ao, Zhi-Hai Cai, Guo-Zheng Zhu, Di-Zheng Wu, Jia-Wen Gao, Jing-Shen Zhuang, Chen Tu, Kai Zhao, Zhi-Yong Wu, Zhao-Ming Zhong. Tanshinone IIA attenuates osteoarthritis via inhibiting aberrant angiogenesis in subchondral bone.
Archives of biochemistry and biophysics.
2024 Mar; 753(?):109904. doi:
10.1016/j.abb.2024.109904. [PMID: 38253247] - Lei Zhang, Chuncao Xu, Junyuan Huang, Shiqin Jiang, Zhiyan Qin, Lin Cao, Guoyao Tan, Zhongxiang Zhao, Min Huang, Jing Jin. Tanshinone IIA reverses gefitinib resistance in EGFR-mutant lung cancer via inhibition of SREBP1-mediated lipogenesis.
Phytotherapy research : PTR.
2024 Mar; 38(3):1574-1588. doi:
10.1002/ptr.8130. [PMID: 38282115] - Zhi Qin, Min Zhou. [Tanshinone Ⅱ_A inhibits ferroptosis via Nrf2 signaling pathway to protect liver in rats of non-alcoholic fatty liver disease].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Mar; 49(6):1611-1620. doi:
10.19540/j.cnki.cjcmm.20231229.501. [PMID: 38621946] - Qingzhi Wan, Lisha Tang, Kaili Jin, Xuanyi Chen, Yinghuan Li, Xiaofeng Xu. Quercetin and tanshinone prevent mitochondria from oxidation and autophagy to inhibit KGN cell apoptosis through the SIRT1/SIRT3-FOXO3a axis.
Cellular and molecular biology (Noisy-le-Grand, France).
2024 Feb; 70(2):257-263. doi:
10.14715/cmb/2024.70.2.36. [PMID: 38430013] - Monika Bielecka, Marta Stafiniak, Bartosz Pencakowski, Sylwester Ślusarczyk, Jan Paweł Jastrzębski, Łukasz Paukszto, Łukasz Łaczmański, Shima Gharibi, Adam Matkowski. Comparative transcriptomics of two Salvia subg. Perovskia species contribute towards molecular background of abietane-type diterpenoid biosynthesis.
Scientific reports.
2024 02; 14(1):3046. doi:
10.1038/s41598-024-53510-5. [PMID: 38321199] - Ruibai Li, Chengyuan Xue, Yiming Pan, Guangda Li, Ziming Huang, Jing Xu, Jingfang Zhang, Xinyi Chen, Li Hou. Research on different compound combinations of Realgar-Indigo naturalis formula to reverse acute promyelocytic leukemia arsenic resistance by regulating autophagy through mTOR pathway.
Journal of ethnopharmacology.
2024 Feb; ?(?):117778. doi:
10.1016/j.jep.2024.117778. [PMID: 38310990] - Lei Fu, Meijiao Li, Peng Wang, Lang Chen, Jianqiu Huang, Hui Zhang. Tanshinone IIA, a component of the self-made Xiao-Yin decoction, ameliorates psoriasis by inhibiting IL-17/IL-23 and PTGS2/NF-κB/AP-1 pathways.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2024 Feb; 30(2):e13577. doi:
10.1111/srt.13577. [PMID: 38284293] - En-Yu Liang, Meng-He Huang, Ying-Ting Chen, Peng-Wei Zhang, Yan Shen, Xiao-Xin Tu, Wei-Ye Chen, Yi Wang, Jun Yan, Hong-Yu Wang, Pei-Feng Ke, Xian-Zhang Huang. Tanshinone IIA modulates cancer cell morphology and movement via Rho GTPases-mediated actin cytoskeleton remodeling.
Toxicology and applied pharmacology.
2024 Jan; 483(?):116839. doi:
10.1016/j.taap.2024.116839. [PMID: 38290667] - Dengxuan Mao, Hong Wang, Hong Guo, Xiaoyu Che, Miaoying Chen, Xia Li, Yuping Liu, Jiege Huo, Yan Chen. Tanshinone IIA normalized hepatocellular carcinoma vessels and enhanced PD-1 inhibitor efficacy by inhibiting ELTD1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155191. doi:
10.1016/j.phymed.2023.155191. [PMID: 38000104] - Xiao-Qi Liu, Tian Hu, Guang-Liang Wu, Li-Jun Qiao, Ye-Feng Cai, Qi Wang, Shi-Jie Zhang. Tanshinone IIA, the key compound in Salvia miltiorrhiza, improves cognitive impairment by upregulating Aβ-degrading enzymes in APP/PS1 mice.
International journal of biological macromolecules.
2024 Jan; 254(Pt 2):127923. doi:
10.1016/j.ijbiomac.2023.127923. [PMID: 37944734] - Wenbing Su, Meifen Lv, Dayu Wang, Yinghong He, Hui Han, Yu Zhang, Xiuying Zhang, Shaokun Lv, Liqing Yao. Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis.
Mediators of inflammation.
2024; 2024(?):7459054. doi:
10.1155/2024/7459054. [PMID: 38549714] - Jin Xu, XiaoCheng Zhi, YunHui Zhang, Ren Ding. Tanshinone IIA alleviates IL-1β-induced chondrocyte apoptosis and inflammation by regulating FBXO11 expression.
Clinics (Sao Paulo, Brazil).
2024; 79(?):100365. doi:
10.1016/j.clinsp.2024.100365. [PMID: 38677194] - Cong Zhang, Fengjuan Chen, Youshuang Wang, Kefei Zhang, Xu Yang, Xuebing Wang. Tanshinone IIA protects intestinal epithelial cells from deoxynivalenol-induced pyroptosis.
Ecotoxicology and environmental safety.
2024 Jan; 269(?):115743. doi:
10.1016/j.ecoenv.2023.115743. [PMID: 38035519] - Wenbin Liu, Tihui Wang, Wei Wang, Xingzuan Lin, Kailuo Xie. Tanshinone IIA promotes the proliferation and differentiation ability of primary muscle stem cells via MAPK and Akt signaling.
Biochemical and biophysical research communications.
2023 12; 689(?):149235. doi:
10.1016/j.bbrc.2023.149235. [PMID: 37976834] - Li Ren, Linglong Luo, Zhimin Hu, Ying Ma, Jian Wang, Yatian Cheng, Baolong Jin, Tong Chen, Jinfu Tang, Guanghong Cui, Juan Guo, Luqi Huang. Functional characterization of CYP81C16 involved in the tanshinone biosynthetic pathway in Salvia miltiorrhiza.
Chinese journal of natural medicines.
2023 Dec; 21(12):938-949. doi:
10.1016/s1875-5364(23)60484-4. [PMID: 38143107] - Lu Ma, Lei Yang, Chang-Qing Deng, Wei Zhang, Huang Ding, Xiao-Dan Liu, Wan-Yu Li, Jiang Wen, Wei Tan, Yan-Ling Li, Yan-Yan Zhang, Xin-Ying Fu, Lin-Quan Liu, Cai-Xia Liu, Zhao-Wen Zeng. [EPCs-exos combined with tanshinone Ⅱ_A protect vascular endothelium cells from oxidative damage via PI3K/Akt pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Dec; 48(23):6423-6433. doi:
10.19540/j.cnki.cjcmm.20230828.701. [PMID: 38212000] - Qi Wu, Yu-Bo Guan, Ke-Jia Zhang, Li Li, Yao Zhou. Tanshinone IIA mediates protection from diabetes kidney disease by inhibiting oxidative stress induced pyroptosis.
Journal of ethnopharmacology.
2023 Nov; 316(?):116667. doi:
10.1016/j.jep.2023.116667. [PMID: 37257702] - Zhuixing Liu, Jie Zhang, Jinpeng Liu, Lihong Guo, Guangwei Chen, Yu Fang, Yang Yang. Combining Network Pharmacology, Molecular Docking and Preliminary Experiments to Explore the Mechanism of Action of FZKA Formula on Non-small Cell Lung Cancer.
Protein and peptide letters.
2023 Nov; ?(?):. doi:
10.2174/0109298665268153231024111622. [PMID: 37962044] - Tongtong Zhang, Xinglin Chen, Xiran Ju, Jixiang Yuan, Jielong Zhou, Zhihang Zhang, Guanqun Ju, Dongliang Xu. PPARG is a potential target of Tanshinone IIA in prostate cancer treatment: a combination study of molecular docking and dynamic simulation based on transcriptomic bioinformatics.
European journal of medical research.
2023 Nov; 28(1):487. doi:
10.1186/s40001-023-01477-w. [PMID: 37932808] - Lin Bai, Yaping Zhang, Changmin Zheng, Shifu Xu, Yining He, Guangqiang Yu, Delun Huang, Yulin Huang, Mingxing Li, Changlong Xu. Tanshinone IIA protects mouse testes from heat stress injury by inhibiting apoptosis and TGFβ1/Smad2/Smad3 signaling pathway.
Cell stress & chaperones.
2023 11; 28(6):749-759. doi:
10.1007/s12192-023-01367-4. [PMID: 37610501] - Yan Xuan, Cai Yu, Kang Ni, Lou Congcong, Qiu Lixin, Luan Qingxian. Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway.
Microbes and infection.
2023 Nov; 25(8):105177. doi:
10.1016/j.micinf.2023.105177. [PMID: 37392987] - Xiangke Ma, Lei Zhang, Fujun Gao, Weihua Jia, Chao Li. Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Nov; 167(?):115501. doi:
10.1016/j.biopha.2023.115501. [PMID: 37713995] - Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kong. [Research progress in mechanism of puerarin in treating vascular dementia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Nov; 48(22):5993-6002. doi:
10.19540/j.cnki.cjcmm.20230718.401. [PMID: 38114205] - Xiaoxiao Zhang, Shumiao Li, Zhenzhen Chen, Wei Liang, Shuting Pei, Feiyue Gou, Zhicheng Jia, Zhaoyang Geng, Xin Gong. Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway.
Molecular medicine reports.
2023 Nov; 28(5):. doi:
10.3892/mmr.2023.13108. [PMID: 37800602] - Tie Hu, Hua-Xi Zou, Shu-Yu Le, Ya-Ru Wang, Ya-Mei Qiao, Yong Yuan, Ji-Chun Liu, Song-Qing Lai, Huang Huang. Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1.
International journal of molecular medicine.
2023 Nov; 52(5):. doi:
10.3892/ijmm.2023.5312. [PMID: 37800609] - Zhuo Xu, Ke Cai, Shu-Lan Su, Yue Zhu, Feng Liu, Jin-Ao Duan. Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.
Journal of ethnopharmacology.
2023 Oct; 319(Pt 3):117356. doi:
10.1016/j.jep.2023.117356. [PMID: 37890803] - Xinyu He, Yiwen Chen, Yuting Xia, Xinyu Hong, Huaqian You, Rui Zhang, Zongsuo Liang, Qi Cui, Shuncang Zhang, Ming Zhou, Dongfeng Yang. DNA methylation regulates biosynthesis of tanshinones and phenolic acids during growth of Salvia miltiorrhiza.
Plant physiology.
2023 Oct; ?(?):. doi:
10.1093/plphys/kiad573. [PMID: 37879117] - Wang Lili, Feng Ju, Zhan Daqian, Wang Junshuai, Zhou Daixing. Protective effects of tanshinone ⅡA on sepsis-induced multiple organ dysfunction: a literature review.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 10; 43(5):1040-1046. doi:
10.19852/j.cnki.jtcm.20230727.003. [PMID: 37679993] - Chaofeng Niu, Peiyu Zhang, Lijing Zhang, Dingfeng Lin, Haixia Lai, Di Xiao, Yong Liu, Rui Zhuang, Meng Li, Liyong Ma, Jiaqi Ye, Yi Pan. Molecular targets and mechanisms of Guanxinning tablet in treating atherosclerosis: Network pharmacology and molecular docking analysis.
Medicine.
2023 Sep; 102(39):e35106. doi:
10.1097/md.0000000000035106. [PMID: 37773840] - Bin Wu, Jia Li, Hongjie Kuang, Yuxian Shangguan, Jianbing Chen. Mercapto-based palygorskite modified soil micro-biology and reduced the uptake of heavy metals by Salvia miltiorrhiza in cadmium and lead co-contaminated soil.
Journal of environmental management.
2023 Aug; 345(?):118859. doi:
10.1016/j.jenvman.2023.118859. [PMID: 37647730] - Donia M Hassan, Amal H El-Kamel, Eman A Allam, Basant A Bakr, Asmaa A Ashour. Chitosan-coated nanostructured lipid carriers for effective brain delivery of Tanshinone IIA in Parkinson's disease: interplay between nuclear factor-kappa β and cathepsin B.
Drug delivery and translational research.
2023 Aug; ?(?):. doi:
10.1007/s13346-023-01407-7. [PMID: 37598133] - Yahui Hu, Shasha He, Xiaolong Xu, Xuran Cui, Yiming Wei, Chunxia Zhao, Haoran Ye, Jingxia Zhao, Qingquan Liu. Shenhuangdan decoction alleviates sepsis-induced lung injury through inhibition of GSDMD-mediated pyroptosis.
Journal of ethnopharmacology.
2023 Aug; 318(Pt B):117047. doi:
10.1016/j.jep.2023.117047. [PMID: 37586442] - Jiayan Huang, Jiaojiao Zhang, Chengtao Sun, Ruiwen Yang, Miaomiao Sheng, Jiangning Hu, Guoyin Kai, Bing Han. Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: A review of its bioactive components, health-promotion effect and mechanisms.
Journal of ethnopharmacology.
2023 Aug; ?(?):117022. doi:
10.1016/j.jep.2023.117022. [PMID: 37572929] - Syed Sahajada Mahafujul Alam, Arijit Samanta, Faizan Uddin, Safdar Ali, Mehboob Hoque. Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy.
Pharmacological reports : PR.
2023 Aug; 75(4):907-922. doi:
10.1007/s43440-023-00507-y. [PMID: 37440106] - Qingfa Tang, Yao Chen, Yusheng Zhang, Kewei Wang, Li Liu, Dongmei Pan, Qiang Liu, Cuiping Jiang. ROS-Responsive Prodrug Micelle Co-Delivery System for Synergistic Antiatherosclerotic Therapy.
Molecular pharmaceutics.
2023 Jul; ?(?):. doi:
10.1021/acs.molpharmaceut.3c00127. [PMID: 37524050] - Yueting Yu, Jia Wang, Qingze Liu, Fangyong Wei, Xuejun Xie, Mei Zhang. Integrated serum pharmacochemistry and serum pharmacology to investigate the active components and mechanism of Bushen Huoxue Prescription in the treatment of diabetic retinopathy.
Journal of pharmaceutical and biomedical analysis.
2023 Jul; 235(?):115586. doi:
10.1016/j.jpba.2023.115586. [PMID: 37494766] - Jia Zhao, Hongbin Liu, Zhixian Hong, Wei Luo, Wenqing Mu, Xiaorong Hou, Guang Xu, Zhie Fang, Lutong Ren, Tingting Liu, Jincai Wen, Wei Shi, Ziying Wei, Yongping Yang, Wenjun Zou, Jun Zhao, Xiaohe Xiao, Zhaofang Bai, Xiaoyan Zhan. Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC.
Molecular medicine (Cambridge, Mass.).
2023 07; 29(1):84. doi:
10.1186/s10020-023-00671-0. [PMID: 37400760] - Shuncang Zhang, Lin Qiu, Yuwei Zheng, Wei Wang, Hongguang Zhao, Dongfeng Yang. Comparative transcriptome analysis reveals the regulatory effects of exogenous auxin on lateral root development and tanshinone accumulation in Salvia miltiorrhiza.
Planta.
2023 Jun; 258(2):33. doi:
10.1007/s00425-023-04193-1. [PMID: 37378716] - Miao-Ching Chi, Zih-Chan Lin, Chiang-Wen Lee, Cathy Chia-Yu Huang, Kuo-Ti Peng, Chieh-Mo Lin, Hui-Chun Lee, Mei-Ling Fang, Yao-Chang Chiang. Tanshinone IIA suppresses burning incense-induced oxidative stress and inflammatory pathways in astrocytes.
Ecotoxicology and environmental safety.
2023 Jun; 258(?):114987. doi:
10.1016/j.ecoenv.2023.114987. [PMID: 37172407] - Zhenyu Zhao, Dongfeng Yang, Juan Guo, Xiuyu Liu, Qishuang Li, Ping Su, Jian Wang, Ying Ma, Luqi Huang. Functional Study and Efficient Catalytic Element Mining of CYP76AHs in Salvia Plants.
Molecules (Basel, Switzerland).
2023 Jun; 28(12):. doi:
10.3390/molecules28124711. [PMID: 37375266] - Ya-Chao Wang, Huan Wang, Chang-le Shao, Xiu-Ya Li, Ji Cui, Hai-Dong Guo. Screening and identification of effective components from modified Taohong Siwu decoction for protecting H9c2 cells from damage.
In vitro cellular & developmental biology. Animal.
2023 Jun; ?(?):. doi:
10.1007/s11626-023-00773-3. [PMID: 37294373] - Baoyu Wei, Chengtao Sun, Haitong Wan, Qiyang Shou, Bing Han, Miaomiao Sheng, Liqing Li, Guoyin Kai. Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis.
Journal of ethnopharmacology.
2023 Jun; ?(?):116697. doi:
10.1016/j.jep.2023.116697. [PMID: 37295577] - Wenwen Zhang, Meihua Liu, Yurou Ji, Dake Yu, Chuanrui Ma, Jianguo Zhao, Pengpeng Qu. Tanshinone IIA inhibits endometrial carcinoma growth through the MAPK/ERK/TRIB3 pathway.
Archives of biochemistry and biophysics.
2023 Jun; 743(?):109655. doi:
10.1016/j.abb.2023.109655. [PMID: 37285895] - Jian-Shuang Jiang, Quan-Chang Gu, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang, Ya-Nan Yang. The tanshinones from the plant of Salvia miltiorrhiza.
Phytochemistry.
2023 Jun; 210(?):113673. doi:
10.1016/j.phytochem.2023.113673. [PMID: 37030588] - Sheng Li, Ke Yang, Weilong Cao, Rui Guo, Zhihao Liu, Jing Zhang, Aodi Fan, Yuting Huang, Chuanrui Ma, Lan Li, Guanwei Fan. Tanshinone IIA enhances the therapeutic efficacy of mesenchymal stem cells derived exosomes in myocardial ischemia/reperfusion injury via up-regulating miR-223-5p.
Journal of controlled release : official journal of the Controlled Release Society.
2023 06; 358(?):13-26. doi:
10.1016/j.jconrel.2023.04.014. [PMID: 37086952] - Jianchao Si, Bingbing Liu, Kerong Qi, Xue Chen, Dongli Li, Shengchang Yang, Ensheng Ji. Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway.
Journal of ethnopharmacology.
2023 May; ?(?):116677. doi:
10.1016/j.jep.2023.116677. [PMID: 37268259] - Jingwen Xu, Zhenhua Tian, Zhe Li, Xiaoshi Du, Yansong Cui, Jiangrong Wang, Mei Gao, Yinglong Hou. Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis.
Journal of ethnopharmacology.
2023 May; ?(?):116675. doi:
10.1016/j.jep.2023.116675. [PMID: 37257708] - Xiao-Qing Cao, Xiao-Hui Ma, Ya-Tian Cheng, Qi-Shuang Li, Jun-Ling Bu, Ying Ma, Juan Guo. [Modification of C20 oxidase in tanshinone biosynthesis pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 May; 48(9):2298-2306. doi:
10.19540/j.cnki.cjcmm.20230215.102. [PMID: 37282858] - Zahra Sadeghi, Antonietta Cerulli, Stefania Marzocco, Mahdi Moridi Farimani, Milena Masullo, Sonia Piacente. Anti-inflammatory Activity of Tanshinone-Related Diterpenes from Perovskia artemisioides Roots.
Journal of natural products.
2023 04; 86(4):812-821. doi:
10.1021/acs.jnatprod.2c01004. [PMID: 37040078] - Xinxing Li, Haixin Qiu, Jinyue Gan, Zhenjie Liu, Shilin Yang, Renyikun Yuan, Hongwei Gao. Total tanshinones protect against acute lung injury through the PLCγ2/NLRP3 inflammasome signaling pathway.
Journal of ethnopharmacology.
2023 Apr; ?(?):116478. doi:
10.1016/j.jep.2023.116478. [PMID: 37121449] - Kajal Sherawat, Sidharth Mehan. Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Apr; ?(?):. doi:
10.1007/s00210-023-02476-8. [PMID: 37010572] - Jiaqi Zhang, Haole Qi, Mingxia Wang, Yongqin Wei, Hao Liang. Enzymatically hydrolyzed sodium caseinate nanoparticles efficiently enhancing the solubility, stability, and antioxidant and anti-biofilm activities of hydrophobic Tanshinone IIA.
Journal of materials chemistry. B.
2023 03; 11(11):2440-2454. doi:
10.1039/d2tb02263j. [PMID: 36810656] - Wei Wang, Lu Cao, Peng Ren, Bei-Bei Zhu, Kai Liu. [Network Meta-analysis of Chinese medicine injection combined with conventional western medicine in treatment of stable angina pectoris].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Mar; 48(6):1652-1663. doi:
10.19540/j.cnki.cjcmm.20220907.503. [PMID: 37005853] - Zhengtao Chen, Haoyue Feng, Chuan Peng, Zehua Zhang, Qianghua Yuan, Hong Gao, Shiyun Tang, Chunguang Xie. Renoprotective Effects of Tanshinone IIA: A Literature Review.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041990. [PMID: 36838978] - Yue Li, Qian Wang, Jingyi Jin, Bo Tan, Jie Ren, Guochao Song, Bin Zou, Fengyi Weng, Dongming Yan, Furong Qiu. 15,16-dihydrotanshinone I in Danshen ethanol extract aggravated cholestasis by inhibiting Cyp3a11 mediated bile acids hydroxylation.
Toxicology letters.
2023 Feb; 377(?):62-70. doi:
10.1016/j.toxlet.2023.02.005. [PMID: 36804361] - Annika Roth, Piwen Zhao, Sebastian T Soukup, Claudia Guigas, Joachim Stärke, Sabine E Kulling, Patrick Diel. Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems.
Toxicology letters.
2023 Feb; 375(?):21-28. doi:
10.1016/j.toxlet.2022.12.002. [PMID: 36563867] - Jiahao Fang, Yuzhen He, Yuhong Cao, Yiwei Shi, Hui Wang, Zhanying Hong, Yifeng Chai. Effect of P-Glycoprotein on the Blood-Brain Barrier Transport of the Major Active Constituents of Salvia miltiorrhiza Based on the MDCK-MDR1 Cell Model.
ACS chemical neuroscience.
2023 02; 14(4):766-772. doi:
10.1021/acschemneuro.2c00757. [PMID: 36704945] - Ronghui Tan, Min Chen, Lu Wang, Jinjia Zhang, Shujuan Zhao. A tracking work on how Sm4CL2 re-directed the biosynthesis of salvianolic acids and tanshinones in Salvia miltiorrhiza hairy roots.
Plant cell reports.
2023 Feb; 42(2):297-308. doi:
10.1007/s00299-022-02957-9. [PMID: 36459184] - Xia Li, Hong Guo, Deng-Xuan Mao, Yu-Ping Liu, Yan Chen. [Preparation of two tanshinone Ⅱ_A-astragaloside Ⅳ co-loaded nano-delivery systems and in vitro antitumor activity comparison].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Feb; 48(3):672-680. doi:
10.19540/j.cnki.cjcmm.20221127.302. [PMID: 36872230] - Jinfeng Liu, Chang Zhang, Shuang Liu, Xiaokang Wang, Xiongzhi Wu, Jian Hao. Tanshinone IIA promotes apoptosis by downregulating BCL2 and upregulating TP53 in triple-negative breast cancer.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 02; 396(2):365-374. doi:
10.1007/s00210-022-02316-1. [PMID: 36374307] - Ling-Ling Zheng, Mei-Lan Chen, Li-Ping Kang, Ying-Li Wang, Xiu-Teng Zhou. [Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jan; 48(2):349-355. doi:
10.19540/j.cnki.cjcmm.20221017.101. [PMID: 36725224] - Ye Yang, Mingyan Shao, Wenkun Cheng, Junkai Yao, Lin Ma, Yong Wang, Wei Wang. A Pharmacological Review of Tanshinones, Naturally Occurring Monomers from Salvia miltiorrhiza for the Treatment of Cardiovascular Diseases.
Oxidative medicine and cellular longevity.
2023; 2023(?):3801908. doi:
10.1155/2023/3801908. [PMID: 36793978] - Tian-Xiang Wang, Kun-Long Duan, Zi-Xuan Huang, Zi-An Xue, Jun-Yun Liang, Yongjun Dang, Ao Zhang, Yue Xiong, Chunyong Ding, Kun-Liang Guan, Hai-Xin Yuan. Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.
Life science alliance.
2023 01; 6(1):. doi:
10.26508/lsa.202201667. [PMID: 36319062] - Jun Qian, Yi Cao, Junfeng Zhang, Lingchang Li, Juan Wu, Jialin Yu, Jiege Huo. Tanshinone IIA Alleviates the Biological Characteristics of Colorectal Cancer via Activating the ROS/JNK Signaling Pathway.
Anti-cancer agents in medicinal chemistry.
2023; 23(2):227-236. doi:
10.2174/1871520622666220421093430. [PMID: 35593352] - Yu Qian, Youfu He, Aili Qiong, Wenhang Zhang. Tanshinone IIA Regulates MAPK/mTOR Signal-Mediated Autophagy to Alleviate Atherosclerosis through the miR-214-3p/ATG16L1 Axis.
International heart journal.
2023; 64(5):945-954. doi:
10.1536/ihj.23-087. [PMID: 37778998] - Yanhong Bai, Ying Zhou, Qiaoqi Lei, Yu Wang, Gaobin Pu, Zhenhua Liu, Xue Chen, Qian Liu. Analysis of the HD-Zip I transcription factor family in Salvia miltiorrhiza and functional research of SmHD-Zip12 in tanshinone synthesis.
PeerJ.
2023; 11(?):e15510. doi:
10.7717/peerj.15510. [PMID: 37397009] - Fei Sun, Xiaoli Yang, Wei Song, Nan Yu, Qingyi Lin. Tanshinone IIA (TSIIA) represses the progression of non-small cell lung cancer by the circ_0020123/miR-1299/HMGB3 pathway.
Molecular and cellular biochemistry.
2022 Dec; ?(?):. doi:
10.1007/s11010-022-04646-3. [PMID: 36586093] - Hui Zhong, Dai-Ying Li, Su-Ying Wang, Jie-Yi Chen, Jia-Xin Chen, Xiao Tan, Yue-Heng Wang, Yu-Chen Xie, Dong-Xing Zhu. [Tanshinone IIa attenuates vascular calcification through inhibition of NF-κB and β-catenin signaling pathways].
Sheng li xue bao : [Acta physiologica Sinica].
2022 Dec; 74(6):949-958. doi:
. [PMID: 36594383] - Linzhou Yin, Pengyu Liu, Yue Jin, Zunxi Ning, Yiren Yang, Huiyuan Gao. Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications.
European journal of medicinal chemistry.
2022 Dec; 244(?):114861. doi:
10.1016/j.ejmech.2022.114861. [PMID: 36332549] - Qing Chen, Liping Shao, Yong Li, Mian Dai, He Liu, Nan Xiang, Hui Chen. Tanshinone IIA alleviates ovalbumin-induced allergic rhinitis symptoms by inhibiting Th2 cytokine production and mast cell histamine release in mice.
Pharmaceutical biology.
2022 Dec; 60(1):326-333. doi:
10.1080/13880209.2022.2034894. [PMID: 35167426] - Ling Xu, Mengting Cao, Qichao Wang, Jiahao Xu, Chenglin Liu, Najeeb Ullah, Juanjuan Li, Zhuoni Hou, Zongsuo Liang, Weijun Zhou, Ake Liu. Insights into the plateau adaptation of Salvia castanea by comparative genomic and WGCNA analyses.
Journal of advanced research.
2022 12; 42(?):221-235. doi:
10.1016/j.jare.2022.02.004. [PMID: 36089521] - Teng Ma, Li-Ting Mu, Xin-Tong Tian, Ji Yang, Ying-Qiang Zhao. [Systematic review and sequential analysis of Tanshinone Ⅱ_A Sodium Sulfonate Injection combined with enalapril in treatment of acute exacerbation of pulmonary heart disease].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Dec; 47(24):6794-6802. doi:
10.19540/j.cnki.cjcmm.20220830.501. [PMID: 36604928] - Jiao Wang, Liang Kong, Rui-Bo Guo, Si-Yu He, Xin-Ze Liu, Lu Zhang, Yang Liu, Yang Yu, Xue-Tao Li, Lan Cheng. Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease.
Drug delivery.
2022 Dec; 29(1):1648-1662. doi:
10.1080/10717544.2022.2072543. [PMID: 35616263] - Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment.
Drug delivery.
2022 Dec; 29(1):2815-2823. doi:
10.1080/10717544.2022.2118401. [PMID: 36047255] - Caicai Lin, Lin Zhang, Xia Zhang, Xin Wang, Chaoyang Wang, Yufeng Zhang, Jianhua Wang, Xingfeng Li, Zhenqiao Song. Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis in Salvia miltiorrhiza Roots.
International journal of molecular sciences.
2022 Nov; 23(21):. doi:
10.3390/ijms232113607. [PMID: 36362395] - Yanyun Zhou, Hong Zhang, Yitong Huang, Shengyun Wu, Zongjun Liu. Tanshinone IIA regulates expression of glucose transporter 1 via activation of the HIF‑1α signaling pathway.
Molecular medicine reports.
2022 11; 26(5):. doi:
10.3892/mmr.2022.12844. [PMID: 36069225] - Qianqian Jiang, Xu Chen, Xue Tian, Jingmei Zhang, Siming Xue, Yanyan Jiang, Tiantian Liu, Xiaoping Wang, Qianbin Sun, Yiqin Hong, Chun Li, Dongqing Guo, Yong Wang, Qiyan Wang. Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154439. doi:
10.1016/j.phymed.2022.154439. [PMID: 36108374] - Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded mitochondria targeted lipid-polymer hybrid nano-system: Preparation, characterization, and anti myocardial infarction activity assessment.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Nov; 155(?):113650. doi:
10.1016/j.biopha.2022.113650. [PMID: 36130421] - He Tai, Xiao-Zheng Cui, Jia He, Zhi-Ming Lan, Shun-Min Li, Ling-Bing Li, Si-Cheng Yao, Xiao-Lin Jiang, Xian-Sheng Meng, Jin-Song Kuang. Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Aging.
2022 10; 14(20):8302-8320. doi:
10.18632/aging.204304. [PMID: 36279396] - Shuo Liu, Xi-Yun Zhao, Jin-Feng Li, Zeng-Peng Lu, Xiao-Gang Zhang. [Network Meta-analysis of Chinese medicine injections in treatment of rheumatoid arthritis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Oct; 47(20):5627-5641. doi:
10.19540/j.cnki.cjcmm.20220727.501. [PMID: 36471981] - Ping Huang, Weifeng Jin, Shouchao Xu, Lei Jin, Jianzhen Chen, Ting Zhang, Kunjun Mao, Haitong Wan, Yu He. Optimization of smashing tissue and ultrasonic extraction of tanshinones and their neuroprotective effect on cerebral ischemia/reperfusion injury by inhibiting parthanatos.
Food & function.
2022 Sep; 13(18):9658-9673. doi:
10.1039/d2fo01902g. [PMID: 36040108] - Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza.
Metabolic engineering.
2022 09; 73(?):182-191. doi:
10.1016/j.ymben.2022.08.002. [PMID: 35934177] - Xu Chen, Zhi-Fang Huang, Yun-Hua Liu, Yu-Hong Liu, Yan Chen, Deng-Yun Qin, Jin-Hai Yi. [Study on metabolites in vivo of Dangefentong Capsules based on UHPLC-Q/Orbitrap-MS/MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(18):5052-5063. doi:
10.19540/j.cnki.cjcmm.20220421.703. [PMID: 36164915] - Xiu-Rong Zhang, Tao Lin, Xiu-Li Wang, Xiao-Jie Wang, Heng Gu. [Preparation of salvianolic acid B, tanshinone Ⅱ_A, and glycyrrhetinic acid lipid emulsion and its protective effect against acute liver injury induced by acetaminophen].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4634-4642. doi:
10.19540/j.cnki.cjcmm.20220705.302. [PMID: 36164869] - Si-Jia Wu, Xing-Guang Xie, Kun-Miao Feng, Xin Zhai, Qian-Liang Ming, Lu-Ping Qin, Khalid Rahman, Zhen-Zhen Zhang, Ting Han. Transcriptome sequencing and signal transduction for the enhanced tanshinone production in Salvia miltiorrhiza hairy roots induced by Trichoderma atroviride D16 polysaccharide fraction.
Bioscience, biotechnology, and biochemistry.
2022 Jul; 86(8):1049-1059. doi:
10.1093/bbb/zbac088. [PMID: 35675224] - Małgorzata Majewska, Piotr Szymczyk, Jan Gomulski, Agnieszka Jeleń, Renata Grąbkowska, Ewa Balcerczak, Łukasz Kuźma. The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of Tanshinones.
Molecules (Basel, Switzerland).
2022 Jul; 27(14):. doi:
10.3390/molecules27144354. [PMID: 35889227] - Dongdong Tian, Yingchun Miao, Wendong Hao, Ning Yang, Ping Wang, Qingyi Ge, Cailian Zhang. Tanshinone IIA protects against chronic obstructive pulmonary disease via exosome‑shuttled miR‑486‑5p.
International journal of molecular medicine.
2022 Jul; 50(1):. doi:
10.3892/ijmm.2022.5153. [PMID: 35621142] - Lin Bai, Guozhen He, Chenghai Gao, Hua Yang, Mingxing Li, Yulin Huang, Mahmoud Moussa, Changlong Xu. Tanshinone IIA enhances the ovarian reserve and attenuates ovarian oxidative stress in aged mice.
Veterinary medicine and science.
2022 Jul; 8(4):1617-1625. doi:
10.1002/vms3.811. [PMID: 35451235] - Xiqian Zhang, Fangyi Long, Ruina Li, Yujie Yang, Ting Wang, Qin He, Min Xu, Ling Wang, Xuehua Jiang. Tanshinone IIA prevents acetaminophen-induced nephrotoxicity through the activation of the Nrf2-Mrp2/4 pathway in mice.
Environmental toxicology.
2022 Jul; 37(7):1618-1628. doi:
10.1002/tox.23511. [PMID: 35243748]