Galbanic acid (BioDeep_00000410511)

   

natural product


代谢物信息卡片


Galbanic acid

化学式: C24H30O5 (398.209313)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)=C1CC[C@H](C)[C@](C)(COc2ccc3ccc(=O)oc3c2)[C@H]1CCC(=O)O
InChI: InChI=1S/C24H30O5/c1-15(2)19-9-5-16(3)24(4,20(19)10-11-22(25)26)14-28-18-8-6-17-7-12-23(27)29-21(17)13-18/h6-8,12-13,16,20H,5,9-11,14H2,1-4H3,(H,25,26)/t16-,20-,24-/m0/s1

描述信息

Origin: Plant, Coumarins, Coumarin terpenoids, Sesquiterpenoids, Ferula terpenoids

同义名列表

1 个代谢物同义名

Galbanic acid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elahe Raji, Vahid Vahedian, Pezhman Golshanrad, Reza Nahavandi, Parisa Behshood, Nahal Soltani, Mahdi Gharibi, Mohsen Rashidi, Nazila Fathi Maroufi. The potential therapeutic effects of Galbanic acid on cancer. Pathology, research and practice. 2023 Aug; 248(?):154686. doi: 10.1016/j.prp.2023.154686. [PMID: 37487315]
  • Faegheh Farhadi, Javad Asili, Milad Iranshahy, Mehrdad Iranshahi. NMR-based metabolomic study of asafoetida. Fitoterapia. 2019 Nov; 139(?):104361. doi: 10.1016/j.fitote.2019.104361. [PMID: 31629871]
  • Maryam Sajjadi, Ehsan Karimi, Ehsan Oskoueian, Mehrdad Iranshahi, Ali Neamati. Galbanic acid: Induced antiproliferation in estrogen receptor-negative breast cancer cells and enhanced cellular redox state in the human dermal fibroblasts. Journal of biochemical and molecular toxicology. 2019 Nov; 33(11):e22402. doi: 10.1002/jbt.22402. [PMID: 31576639]
  • Yoon Hyeon Kim, Eun Ah Shin, Ji Hoon Jung, Ji Eon Park, Jinsuk Koo, Ja Il Koo, Bum Sang Shim, Sung-Hoon Kim. Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5. European journal of pharmacology. 2019 Mar; 847(?):91-96. doi: 10.1016/j.ejphar.2019.01.028. [PMID: 30689998]
  • F Ahmadi, Y Shokoohinia, Sh Javaheri, H Azizian. Proposed binding mechanism of galbanic acid extracted from Ferula assa-foetida to DNA. Journal of photochemistry and photobiology. B, Biology. 2017 Jan; 166(?):63-73. doi: 10.1016/j.jphotobiol.2016.11.011. [PMID: 27886594]
  • Morteza Eskandani, Jalal Abdolalizadeh, Hamed Hamishehkar, Hossein Nazemiyeh, Jaleh Barar. Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells. Fitoterapia. 2015 Mar; 101(?):1-11. doi: 10.1016/j.fitote.2014.12.003. [PMID: 25510323]
  • Morteza Eskandani, Jaleh Barar, Jafar Ezzati Nazhad Dolatabadi, Hamed Hamishehkar, Hossein Nazemiyeh. Formulation, characterization, and geno/cytotoxicity studies of galbanic acid-loaded solid lipid nanoparticles. Pharmaceutical biology. 2015; 53(10):1525-38. doi: 10.3109/13880209.2014.991836. [PMID: 25853953]
  • Mohammad Yahya Hanafi-Bojd, Mehrdad Iranshahi, Fatemeh Mosaffa, Shahireh Omidvar Tehrani, Fatemeh Kalalinia, Javad Behravan. Farnesiferol A from Ferula persica and galbanic acid from Ferula szowitsiana inhibit P-glycoprotein-mediated rhodamine efflux in breast cancer cell lines. Planta medica. 2011 Sep; 77(14):1590-3. doi: 10.1055/s-0030-1270987. [PMID: 21484672]
  • Kwan-Hyun Kim, Hyo-Jung Lee, Soo-Jin Jeong, Hyo-Jeong Lee, Eun-Ok Lee, Hyun-Seok Kim, Yong Zhang, Shi-Yong Ryu, Min-Ho Lee, Junxuan Lü, Sung-Hoon Kim. Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation. Pharmaceutical research. 2011 Mar; 28(3):597-609. doi: 10.1007/s11095-010-0311-7. [PMID: 21063754]
  • Ahmad Reza Shahverdi, Ali Fakhimi, Gholamreza Zarrini, Gholamreza Dehghan, Mehrdad Iranshahi. Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus. Biological & pharmaceutical bulletin. 2007 Sep; 30(9):1805-7. doi: 10.1248/bpb.30.1805. [PMID: 17827745]
  • V N Syrov, Z A Khushbaktova, A N Nabiev. [The effect of galbanic acid on the course of experimental hepatitis]. Farmakologiia i toksikologiia. 1990 Mar; 53(2):41-3. doi: NULL. [PMID: 2369953]
  • A E BEDNIAK. [On the problem of the isolation of galbanic acid from Ferula gumosa Boiss. roots]. Aptechnoe delo. 1962 May; 12(?):28-34. doi: ". [PMID: 13866469]