11-HETE (BioDeep_00000409906)

代谢物信息卡片

5,8,12,14-Eicosatetraenoic acid, 11-hydroxy-, (E,Z,Z,Z)-

化学式: C20H32O3 (320.2351)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 83.33%

分子结构信息

SMILES: C(CCC/C=C/C/C=C\CC(O)/C=C\C=C/CCCCC)(=O)O
InChI: InChI=1S/C20H32O3/c1-2-3-4-5-7-10-13-16-19(21)17-14-11-8-6-9-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b9-6+,10-7-,14-11-,16-13-

描述信息

A HETE that is (5Z,8Z,12E,14Z)-icosa-5,8,12,14-tetraenoic acid substituted at position 11 by a hydroxy group.
CONFIDENCE standard compound; NATIVE_RUN_ID STD_neg_MSMS_1min0081.mzML; PROCESSING averaging of repeated ion fragments at 30.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID STD_neg_MSMS_1min0081.mzML; PROCESSING averaging of repeated ion fragments at 20.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID STD_neg_MSMS_1min0081.mzML; PROCESSING averaging of repeated ion fragments at 10.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001289.mzML; PROCESSING averaging of repeated ion fragments at 30.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001289.mzML; PROCESSING averaging of repeated ion fragments at 20.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001289.mzML; PROCESSING averaging of repeated ion fragments at 10.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001289.mzML; PROCESSING averaging of repeated ion fragments at 40.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001289.mzML; PROCESSING averaging of repeated ion fragments at 30.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001289.mzML; PROCESSING averaging of repeated ion fragments at 20.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]

同义名列表

6 个代谢物同义名

11-HETE; 5,8,12,14-Eicosatetraenoic acid, 11-hydroxy-, (E,Z,Z,Z)-; 11-hydroxy-5E,8Z,12Z,14Z-eicosatetraenoic acid; FA 20:4;O; 11-hydroxy-5E,8Z,12Z,14Z-eicosatetraenoic acid;11-HETE; 11-hydroxy-5Z,8Z,12E,14Z-eicosatetraenoic acid

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:72606
PubChem: 5312982
Metlin: METLIN75010
LipidMAPS: LMFA03060062
LipidMAPS: LMFA03060085
MoNA: IA000426
MoNA: IA000425
MoNA: IA000424
MoNA: IA000297
MoNA: IA000296
MoNA: IA000295
MoNA: IA000123
MoNA: IA000122
MoNA: IA000121
MetaboLights: MTBLC72606
RefMet: 11-HETE

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Charles Austin Pickens, Lorraine M Sordillo, Chen Zhang, Jenifer I Fenton. Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE). Metabolism: clinical and experimental. 2017 05; 70(?):177-191. doi: 10.1016/j.metabol.2017.01.034. [PMID: 28403941]
Jelena Klawitter, Kim McFann, Alexander T Pennington, Wei Wang, Jost Klawitter, Uwe Christians, Robert W Schrier, Berenice Gitomer, Melissa A Cadnapaphornchai. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clinical journal of the American Society of Nephrology : CJASN. 2015 Sep; 10(9):1534-41. doi: 10.2215/cjn.11331114. [PMID: 26224879]
M A Fernández-Peralbo, C Ferreiro Vera, F Priego-Capote, M D Luque de Castro. Stable isotopic internal standard correction for quantitative analysis of hydroxyeicosatetraenoic acids (HETEs) in serum by on-line SPE-LC-MS/MS in selected reaction monitoring mode. Talanta. 2014 Aug; 126(?):170-6. doi: 10.1016/j.talanta.2014.03.038. [PMID: 24881549]
H J Brinkman, M F van Buul-Wortelboer, J A van Mourik. Involvement of cyclooxygenase- and lipoxygenase-mediated conversion of arachidonic acid in controlling human vascular smooth muscle cell proliferation. Thrombosis and haemostasis. 1990 Apr; 63(2):291-7. doi: . [PMID: 2114045]
A R Morrison, J R Crowley. Identification of an unusual cyclooxygenase metabolite of arachidonic acid in rabbit renal medulla. Archives of biochemistry and biophysics. 1984 Nov; 234(2):413-7. doi: 10.1016/0003-9861(84)90287-x. [PMID: 6437329]
C E Low, M B Pupillo, R W Bryant, J M Bailey. Inhibition of phytohemagglutinin-induced lymphocyte mitogenesis by lipoxygenase metabolites of arachidonic acid: structure-activity relationships. Journal of lipid research. 1984 Oct; 25(10):1090-5. doi: NULL. [PMID: 6439809]
D A Bass, P Szejda, E J Goetzl, S Love, J T O'Flaherty, C E McCall. Stimulation of hexose uptake by human eosinophils with chemotactic factors. The Journal of infectious diseases. 1981 May; 143(5):719-25. doi: 10.1093/infdis/143.5.719. [PMID: 7240808]
E J Goetzl. Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes. Nature. 1980 Nov; 288(5787):183-5. doi: 10.1038/288183a0. [PMID: 6253824]