Maresin 1 (BioDeep_00000409879)

   


代谢物信息卡片


7S,14S-dihydroxy-4Z,8E,10E,12E,16Z,19Z-docosahexaenoic acid

化学式: C22H32O4 (360.2300472)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@H](C/C=C\C/C=C\CC)O)(O)=O
InChI: InChI=1S/C22H32O4/c1-2-3-4-5-6-10-15-20(23)16-11-7-8-12-17-21(24)18-13-9-14-19-22(25)26/h3-4,6-13,16-17,20-21,23-24H,2,5,14-15,18-19H2,1H3,(H,25,26)/b4-3-,8-7+,10-6-,13-9-,16-11-,17-12+/t20-,21-/m0/s1

描述信息

CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001319.mzML; PROCESSING averaging of repeated ion fragments at 30.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001319.mzML; PROCESSING averaging of repeated ion fragments at 20.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001319.mzML; PROCESSING averaging of repeated ion fragments at 10.0 eV within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001319.mzML; PROCESSING averaging of repeated ion fragments at 40.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001319.mzML; PROCESSING averaging of repeated ion fragments at 30.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]
CONFIDENCE standard compound; NATIVE_RUN_ID QExHF03_NM_0001319.mzML; PROCESSING averaging of repeated ion fragments at 20.0 NCE within 5 ppm window [MS, MS:1000575, mean of spectra, ]

同义名列表

2 个代谢物同义名

Maresin 1; 7S,14S-dihydroxy-4Z,8E,10E,12E,16Z,19Z-docosahexaenoic acid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huiping Wu, Na Li, Shuang Peng, Haiyan Fu, Zhansheng Hu, Longxiang Su. Maresin1 improves hippocampal neuroinflammation and cognitive function in septic rats by activating the SLC7A11 / GPX4 ferroptosis signaling pathway. International immunopharmacology. 2024 Apr; 131(?):111792. doi: 10.1016/j.intimp.2024.111792. [PMID: 38484667]
  • Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji. Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. The Journal of clinical investigation. 2024 Mar; 134(9):. doi: 10.1172/jci173537. [PMID: 38530364]
  • Jesus A Castor-Macias, Jacqueline A Larouche, Emily C Wallace, Bonnie D Spence, Alec Eames, Pamela Duran, Benjamin A Yang, Paula M Fraczek, Carol A Davis, Susan V Brooks, Krishna Rao Maddipati, James F Markworth, Carlos A Aguilar. Maresin 1 repletion improves muscle regeneration after volumetric muscle loss. eLife. 2023 Dec; 12(?):. doi: 10.7554/elife.86437. [PMID: 38131691]
  • Laura M Laiglesia, Xavier Escoté, Neira Sáinz, Elisa Felix-Soriano, Eva Santamaría, María Collantes, Marta Fernández-Galilea, Ignacio Colón-Mesa, Leyre Martínez-Fernández, Tania Quesada-López, Sergio Quesada-Vázquez, Carlos Rodríguez-Ortigosa, José M Arbones-Mainar, Ángela M Valverde, J Alfredo Martínez, Jesmond Dalli, Laura Herrero, Silvia Lorente-Cebrián, Francesc Villarroya, María J Moreno-Aliaga. Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice. Molecular metabolism. 2023 Jun; ?(?):101749. doi: 10.1016/j.molmet.2023.101749. [PMID: 37271337]
  • Leyre Martínez-Fernández, Miguel Burgos, Neira Sáinz, Laura M Laiglesia, José Miguel Arbones-Mainar, Pedro González-Muniesa, María J Moreno-Aliaga. Maresin 1 Exerts a Tissue-Specific Regulation of Adipo-Hepato-Myokines in Diet-Induced Obese Mice and Modulates Adipokine Expression in Cultured Human Adipocytes in Basal and Inflammatory Conditions. Biomolecules. 2023 05; 13(6):. doi: 10.3390/biom13060919. [PMID: 37371501]
  • Luísa Teixeira-Santos, Sandra Martins, Teresa Sousa, António Albino-Teixeira, Dora Pinho. The pro-resolving lipid mediator Maresin 1 ameliorates pain responses and neuroinflammation in the spared nerve injury-induced neuropathic pain: A study in male and female mice. PloS one. 2023; 18(6):e0287392. doi: 10.1371/journal.pone.0287392. [PMID: 37347750]
  • Victoria Leroy, Jun Cai, Zhenxiao Tu, Alexander McQuiston, Simrun Sharma, Amir Emtiazjoo, Carl Atkinson, Gilbert R Upchurch, Ashish K Sharma. Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2022 Dec; ?(?):. doi: 10.1016/j.healun.2022.12.013. [PMID: 36628837]
  • Hui Li, Xinyu Li, Yu Hao, Chenghua Wu, Yuhao Fu, Nana Su, Houlin Chen, Binyu Ying, Haixing Wang, Lihuang Su, Haijian Cai, Qinlian He, Mengsi Cai, Junwei Sun, Jing Lin, Aaron Scott, Fanggao Smith, Xiaoying Huang, Shengwei Jin. Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice. British journal of pharmacology. 2022 11; 179(22):5132-5147. doi: 10.1111/bph.15906. [PMID: 35764296]
  • Dongdong Yao, Yang Zou, Yonggang Lv. Maresin 1 enhances osteogenic potential of mesenchymal stem cells by modulating macrophage peroxisome proliferator-activated receptor-γ-mediated inflammation resolution. Biomaterials advances. 2022 Oct; 141(?):213116. doi: 10.1016/j.bioadv.2022.213116. [PMID: 36115155]
  • Zhanwei Zhang, Chonghao Ji, Ya-Nan Wang, Shiyue Liu, Maoshan Wang, Xin Xu, Dongjiao Zhang. Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis. Cells. 2022 08; 11(16):. doi: 10.3390/cells11162560. [PMID: 36010637]
  • Inês Ferreira, Filipa Falcato, Narcisa Bandarra, Amélia P Rauter. Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation. Molecules (Basel, Switzerland). 2022 Mar; 27(5):. doi: 10.3390/molecules27051677. [PMID: 35268778]
  • Xinyue Li, Butuo Xu, Jing Wu, Yueli Pu, Shengrong Wan, Yan Zeng, Mei Wang, Lifang Luo, Fanjie Zhang, Zongzhe Jiang, Yong Xu. Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway. Oxidative medicine and cellular longevity. 2022; 2022(?):7177889. doi: 10.1155/2022/7177889. [PMID: 35498124]
  • Ellen C Keeley, Han J Li, Christopher R Cogle, Eileen M Handberg, C Noel Bairey Merz, Carl J Pepine. Specialized Proresolving Mediators in Symptomatic Women With Coronary Microvascular Dysfunction (from the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD [WARRIOR] Trial). The American journal of cardiology. 2022 01; 162(?):1-5. doi: 10.1016/j.amjcard.2021.09.015. [PMID: 34728061]
  • María José Rodríguez, Matías Sabaj, Gerardo Tolosa, Francisca Herrera Vielma, María José Zúñiga, Daniel R González, Jessica Zúñiga-Hernández. Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation. Cells. 2021 12; 10(12):. doi: 10.3390/cells10123406. [PMID: 34943914]
  • Xia Fang, Hongya Wang, Ting Ye, Xiaolan Fu, Xiaozhen Tan, Yan Zeng, Jiahao Fan, Yong Xu. Low serum Maresin-1 levels are associated with non-alcoholic fatty liver disease: a cross-sectional study. Lipids in health and disease. 2021 Aug; 20(1):96. doi: 10.1186/s12944-021-01518-5. [PMID: 34461919]
  • Craig T Elder, Amanda C Filiberto, Gang Su, Zachary Ladd, Victoria Leroy, Eric Y Pruitt, Guanyi Lu, Zhihua Jiang, Ashish K Sharma, Gilbert R Upchurch. Maresin 1 activates LGR6 signaling to inhibit smooth muscle cell activation and attenuate murine abdominal aortic aneurysm formation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 08; 35(8):e21780. doi: 10.1096/fj.202100484r. [PMID: 34320253]
  • Dan Li, Menglong Wang, Jing Ye, Jishou Zhang, Yao Xu, Zhen Wang, Mengmeng Zhao, Di Ye, Jun Wan. Maresin 1 alleviates the inflammatory response, reduces oxidative stress and protects against cardiac injury in LPS-induced mice. Life sciences. 2021 Jul; 277(?):119467. doi: 10.1016/j.lfs.2021.119467. [PMID: 33811894]
  • Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio. Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway. American journal of physiology. Cell physiology. 2021 07; 321(1):C82-C93. doi: 10.1152/ajpcell.00568.2020. [PMID: 34038245]
  • Dominika Maciejewska-Markiewicz, Ewa Stachowska, Viktoria Hawryłkowicz, Laura Stachowska, Piotr Prowans. The Role of Resolvins, Protectins and Marensins in Non-Alcoholic Fatty Liver Disease (NAFLD). Biomolecules. 2021 06; 11(7):. doi: 10.3390/biom11070937. [PMID: 34202667]
  • Da Tang, Guang Fu, Wenbo Li, Ping Sun, Patricia A Loughran, Meihong Deng, Melanie J Scott, Timothy R Billiar. Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway. Molecular medicine (Cambridge, Mass.). 2021 02; 27(1):18. doi: 10.1186/s10020-021-00280-9. [PMID: 33632134]
  • L Martínez-Fernández, P González-Muniesa, N Sáinz, X Escoté, J A Martínez, J M Arbones-Mainar, M J Moreno-Aliaga. Maresin 1 regulates insulin signaling in human adipocytes as well as in adipose tissue and muscle of lean and obese mice. Journal of physiology and biochemistry. 2021 Feb; 77(1):167-173. doi: 10.1007/s13105-020-00775-9. [PMID: 33206345]
  • Issa Beegun, Duco S Koenis, Ghassan Alusi, Jesmond Dalli. Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis. Frontiers in immunology. 2021; 12(?):733019. doi: 10.3389/fimmu.2021.733019. [PMID: 34531873]
  • Ying Wang, Axel Leppert, Shuai Tan, Bram van der Gaag, Nailin Li, Marianne Schultzberg, Erik Hjorth. Maresin 1 attenuates pro-inflammatory activation induced by β-amyloid and stimulates its uptake. Journal of cellular and molecular medicine. 2021 01; 25(1):434-447. doi: 10.1111/jcmm.16098. [PMID: 33225628]
  • Guochun Ou, Qin Liu, Chengxiu Yu, Xiaoju Chen, Wenbo Zhang, Yong Chen, Tao Wang, Yongqiang Luo, Guolu Jiang, Mingmei Zhu, Hongmei Li, Mei Zeng. The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model. Mediators of inflammation. 2021; 2021(?):4131420. doi: 10.1155/2021/4131420. [PMID: 33628113]
  • Yingying Lu, Guotao Lu, Lin Gao, Qingtian Zhu, Jing Xue, Jingzhu Zhang, Xiaojie Ma, Nan Ma, Qi Yang, Jie Dong, Weijuan Gong, Weiqin Li, Zhihui Tong. The Proresolving Lipid Mediator Maresin1 Alleviates Experimental Pancreatitis via Switching Macrophage Polarization. Mediators of inflammation. 2021; 2021(?):6680456. doi: 10.1155/2021/6680456. [PMID: 33776575]
  • Fabian Schulte, Abdul Aziz Asbeutah, Peter N Benotti, G Craig Wood, Christopher Still, Bruce R Bistrian, Markus Hardt, Francine K Welty. The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery. Scientific reports. 2020 11; 10(1):20128. doi: 10.1038/s41598-020-75353-6. [PMID: 33208757]
  • Hui Li, Yu Hao, Li-Li Yang, Xin-Yang Wang, Xin-Yu Li, Suwas Bhandari, Jun Han, Yong-Jian Liu, Yu-Qiang Gong, Aaron Scott, Fang Gao Smith, Sheng-Wei Jin. MCTR1 alleviates lipopolysaccharide-induced acute lung injury by protecting lung endothelial glycocalyx. Journal of cellular physiology. 2020 10; 235(10):7283-7294. doi: 10.1002/jcp.29628. [PMID: 32037554]
  • Sisi Zheng, Minqi Ma, Zhongwang Li, Yu Hao, Hui Li, Panhan Fu, Shengwei Jin. Posttreatment of Maresin1 Inhibits NLRP3 inflammasome activation via promotion of NLRP3 ubiquitination. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 09; 34(9):11944-11956. doi: 10.1096/fj.202000665rr. [PMID: 32667092]
  • Keishi Miyazawa, Hisanori Fukunaga, Yasuko Tatewaki, Yumi Takano, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki. Alzheimer's Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?. International journal of molecular sciences. 2020 Aug; 21(16):. doi: 10.3390/ijms21165783. [PMID: 32806612]
  • Huayi Ma, Song Mo, Qushen Yi, Junhua Lai, Huan Liu, Zhanying Shi. Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock. Medical science monitor : international medical journal of experimental and clinical research. 2020 Aug; 26(?):e923518. doi: 10.12659/msm.923518. [PMID: 32750045]
  • Yi-Hao Wang, Yan Li, Jun-Nan Wang, Qing-Xiang Zhao, Shuang Wen, Si-Cong Wang, Tao Sun. A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome. Neurochemical research. 2020 Aug; 45(8):1860-1869. doi: 10.1007/s11064-020-03050-x. [PMID: 32410045]
  • C W Wang, S H Yu, T Fretwurst, L Larsson, J V Sugai, J Oh, K Lehner, Q Jin, W V Giannobile. Maresin 1 Promotes Wound Healing and Socket Bone Regeneration for Alveolar Ridge Preservation. Journal of dental research. 2020 07; 99(8):930-937. doi: 10.1177/0022034520917903. [PMID: 32384864]
  • Q-F Li, H Hao, W-S Tu, N Guo, X-Y Zhou. Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential. European review for medical and pharmacological sciences. 2020 07; 24(13):7442-7453. doi: 10.26355/eurrev_202007_21913. [PMID: 32706084]
  • Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska. Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092026. [PMID: 32349225]
  • Dong-Soon Im. Maresin-1 resolution with RORα and LGR6. Progress in lipid research. 2020 04; 78(?):101034. doi: 10.1016/j.plipres.2020.101034. [PMID: 32360520]
  • Luiza Oliveira Perucci, Talita Adriana Pereira Santos, Patrícia Campi Santos, Lívia Cristina Ribeiro Teixeira, Patrícia Nessralla Alpoim, Karina Braga Gomes, Lirlândia Pires Sousa, Luci Maria Sant'Ana Dusse, André Talvani. Pre-eclampsia is associated with reduced resolvin D1 and maresin 1 to leukotriene B4 ratios in the plasma. American journal of reproductive immunology (New York, N.Y. : 1989). 2020 02; 83(2):e13206. doi: 10.1111/aji.13206. [PMID: 31679164]
  • Gonzalo Soto, María José Rodríguez, Roberto Fuentealba, Adriana V Treuer, Iván Castillo, Daniel R González, Jessica Zúñiga-Hernández. Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats. International journal of molecular sciences. 2020 Jan; 21(2):. doi: 10.3390/ijms21020540. [PMID: 31952110]
  • Shujin Qiu, Ping Li, Hengfang Zhao, Xiaofang Li. Maresin 1 alleviates dextran sulfate sodium-induced ulcerative colitis by regulating NRF2 and TLR4/NF-kB signaling pathway. International immunopharmacology. 2020 Jan; 78(?):106018. doi: 10.1016/j.intimp.2019.106018. [PMID: 31780371]
  • Emmanuel Albuquerque-Souza, Fabian Schulte, Tsute Chen, Markus Hardt, Hatice Hasturk, Thomas E Van Dyke, Marinella Holzhausen, Alpdogan Kantarci. Maresin-1 and Resolvin E1 Promote Regenerative Properties of Periodontal Ligament Stem Cells Under Inflammatory Conditions. Frontiers in immunology. 2020; 11(?):585530. doi: 10.3389/fimmu.2020.585530. [PMID: 33101318]
  • Ping Yin, Shuang Wang, Yafen Wei, Xu Wang, Jingdian Zhang, Xiang Yin, Jiachun Feng, Mingqin Zhu. Maresin1 Decreased Microglial Chemotaxis and Ameliorated Inflammation Induced by Amyloid-β42 in Neuron-Microglia Co-Culture Models. Journal of Alzheimer's disease : JAD. 2020; 73(2):503-515. doi: 10.3233/jad-190682. [PMID: 31796671]
  • Tian Miao, Bangliang Huang, Niexia He, Lihua Sun, Guangsheng Du, Xiaoli Gong, Yong Xu, Yi Zheng, Hongting Zheng, Hua Qu. Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. Mediators of inflammation. 2020; 2020(?):4539035. doi: 10.1155/2020/4539035. [PMID: 32377160]
  • L Martínez-Fernández, P González-Muniesa, N Sáinz, L M Laiglesia, X Escoté, J A Martínez, M J Moreno-Aliaga. Maresin 1 Regulates Hepatic FGF21 in Diet-Induced Obese Mice and in Cultured Hepatocytes. Molecular nutrition & food research. 2019 12; 63(24):e1900358. doi: 10.1002/mnfr.201900358. [PMID: 31576649]
  • Chengjie Lv, Qi Jin. Maresin-1 Inhibits Oxidative Stress and Inflammation and Promotes Apoptosis in a Mouse Model of Caerulein-Induced Acute Pancreatitis. Medical science monitor : international medical journal of experimental and clinical research. 2019 10; 25(?):8181-8189. doi: 10.12659/msm.917380. [PMID: 31671079]
  • Fahad Munir, Muhammad Babar Jamshed, Numan Shahid, Syed Aun Muhammad, Adheesh Bhandari, QiYu Zhang. Protective effects of maresin 1 against inflammation in experimentally induced acute pancreatitis and related lung injury. American journal of physiology. Gastrointestinal and liver physiology. 2019 09; 317(3):G333-G341. doi: 10.1152/ajpgi.00078.2019. [PMID: 31125268]
  • Stephanie G Dakin, Romain A Colas, Julia Newton, Stephen Gwilym, Natasha Jones, Hamish A B Reid, Simon Wood, Louise Appleton, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J Carr. 15-Epi-LXA4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 07; 33(7):8043-8054. doi: 10.1096/fj.201900196r. [PMID: 30916999]
  • Victor Fattori, Felipe A Pinho-Ribeiro, Larissa Staurengo-Ferrari, Sergio M Borghi, Ana C Rossaneis, Rubia Casagrande, Waldiceu A Verri. The specialised pro-resolving lipid mediator maresin 1 reduces inflammatory pain with a long-lasting analgesic effect. British journal of pharmacology. 2019 06; 176(11):1728-1744. doi: 10.1111/bph.14647. [PMID: 30830967]
  • Qing Tang, Chengye Che, Jing Lin, Hong He, Wenyi Zhao, Leyu Lv, Guiqiu Zhao. Maresin1 regulates neutrophil recruitment and IL-10 expression in Aspergillus fumigatus keratitis. International immunopharmacology. 2019 Apr; 69(?):103-108. doi: 10.1016/j.intimp.2019.01.032. [PMID: 30690344]
  • Matthew Spite. Resolving inflammation in nonalcoholic steatohepatitis. The Journal of clinical investigation. 2019 03; 129(4):1524-1526. doi: 10.1172/jci127583. [PMID: 30855277]
  • T Yang, G Xu, P T Newton, A S Chagin, S Mkrtchian, M Carlström, X-M Zhang, R A Harris, M Cooter, M Berger, K R Maddipati, K Akassoglou, N Terrando. Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. British journal of anaesthesia. 2019 Mar; 122(3):350-360. doi: 10.1016/j.bja.2018.10.062. [PMID: 30770053]
  • Talita L C Cezar, Renata M Martinez, Camila da Rocha, Cristina P B Melo, David L Vale, Sergio M Borghi, Victor Fattori, Josiane A Vignoli, Doumit Camilios-Neto, Marcela M Baracat, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrande. Treatment with maresin 1, a docosahexaenoic acid-derived pro-resolution lipid, protects skin from inflammation and oxidative stress caused by UVB irradiation. Scientific reports. 2019 02; 9(1):3062. doi: 10.1038/s41598-019-39584-6. [PMID: 30816324]
  • Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun, Sumin Gao. Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/NF-κB pathways and activation of the Nrf2 pathway. Drug design, development and therapy. 2019; 13(?):739-745. doi: 10.2147/dddt.s188654. [PMID: 30863013]
  • Yu Hao, Hong Zheng, Ruo-Han Wang, Hui Li, Li-Li Yang, Suwas Bhandari, Yong-Jian Liu, Jun Han, Fang Gao Smith, Hong-Chang Gao, Sheng-Wei Jin. Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis. Mediators of inflammation. 2019; 2019(?):2309175. doi: 10.1155/2019/2309175. [PMID: 30800000]
  • Kazuki Ohuchi, Yoko Ono, Mina Joho, Kazuhiro Tsuruma, Shiho Ogami, Shinsaku Yamane, Michinori Funato, Hideo Kaneko, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa. A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death. Neurochemical research. 2018 Jul; 43(7):1413-1423. doi: 10.1007/s11064-018-2556-1. [PMID: 29797139]
  • Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M Hodgson, Ian Puddey, Trevor A Mori. The effects of alcohol on plasma lipid mediators of inflammation resolution in patients with Type 2 diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids. 2018 06; 133(?):29-34. doi: 10.1016/j.plefa.2018.04.004. [PMID: 29789130]
  • Natsuko Saito-Sasaki, Yu Sawada, Emi Mashima, Takashi Yamaguchi, Shun Ohmori, Haruna Yoshioka, Sanehito Haruyama, Etsuko Okada, Motonobu Nakamura. Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression. Scientific reports. 2018 04; 8(1):5522. doi: 10.1038/s41598-018-23623-9. [PMID: 29615641]
  • Tae Woo Jung, Hyoung-Chun Kim, A M Abd El-Aty, Ji Hoon Jeong. Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK-SERCA2b pathway. The Journal of biological chemistry. 2018 03; 293(11):3981-3988. doi: 10.1074/jbc.ra117.000885. [PMID: 29414781]
  • L M Laiglesia, S Lorente-Cebrián, L Martínez-Fernández, N Sáinz, P L Prieto-Hontoria, M A Burrell, C M Rodríguez-Ortigosa, J A Martínez, M J Moreno-Aliaga. Maresin 1 mitigates liver steatosis in ob/ob and diet-induced obese mice. International journal of obesity (2005). 2018 03; 42(3):572-579. doi: 10.1038/ijo.2017.226. [PMID: 28895586]
  • Li Du, Yucheng Li, Weifeng Liu. Maresin 1 regulates autophagy and inflammation in human periodontal ligament cells through glycogen synthase kinase-3β/β-catenin pathway under inflammatory conditions. Archives of oral biology. 2018 Mar; 87(?):242-247. doi: 10.1016/j.archoralbio.2017.12.023. [PMID: 29331511]
  • Laura M Laiglesia, Silvia Lorente-Cebrián, Miguel López-Yoldi, Raquel Lanas, Neira Sáinz, Jose Alfredo Martínez, Maria J Moreno-Aliaga. Maresin 1 inhibits TNF-alpha-induced lipolysis and autophagy in 3T3-L1 adipocytes. Journal of cellular physiology. 2018 Mar; 233(3):2238-2246. doi: 10.1002/jcp.26096. [PMID: 28703289]
  • Isaac Francos-Quijorna, Eva Santos-Nogueira, Karsten Gronert, Aaron B Sullivan, Marcel A Kopp, Benedikt Brommer, Samuel David, Jan M Schwab, Ruben López-Vales. Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Nov; 37(48):11731-11743. doi: 10.1523/jneurosci.1395-17.2017. [PMID: 29109234]
  • Stephanie G Dakin, Lucy Ly, Romain A Colas, Udo Oppermann, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J Carr. Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy. Scientific reports. 2017 09; 7(1):11009. doi: 10.1038/s41598-017-11188-y. [PMID: 28887458]
  • Quanchao Sun, You Wu, Feng Zhao, Jianjun Wang. Maresin 1 inhibits transforming growth factor-β1-induced proliferation, migration and differentiation in human lung fibroblasts. Molecular medicine reports. 2017 Aug; 16(2):1523-1529. doi: 10.3892/mmr.2017.6711. [PMID: 29067437]
  • Jun-Li Zhang, Xiao-Jun Zhuo, Jing Lin, Ling-Chun Luo, Wei-Yang Ying, Xiang Xie, Hua-Wei Zhang, Jing-Xiang Yang, Dan Li, Fang Gao Smith, Sheng-Wei Jin. Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway. Laboratory investigation; a journal of technical methods and pathology. 2017 05; 97(5):543-554. doi: 10.1038/labinvest.2016.150. [PMID: 28218740]
  • Leyre Martínez-Fernández, Pedro González-Muniesa, Laura M Laiglesia, Neira Sáinz, Pedro L Prieto-Hontoria, Xavier Escoté, Leticia Odriozola, Fernando J Corrales, Jose M Arbones-Mainar, José A Martínez, María J Moreno-Aliaga. Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation in ob/ob and diet-induced obese mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 05; 31(5):2135-2145. doi: 10.1096/fj.201600859r. [PMID: 28188173]
  • K L Lannan, S L Spinelli, N Blumberg, R P Phipps. Maresin 1 induces a novel pro-resolving phenotype in human platelets. Journal of thrombosis and haemostasis : JTH. 2017 04; 15(4):802-813. doi: 10.1111/jth.13620. [PMID: 28079976]
  • Shi Tang, Chenlin Gao, Yang Long, Wei Huang, Jiao Chen, Fang Fan, Chunxia Jiang, Yong Xu. Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis. Mediators of inflammation. 2017; 2017(?):2438247. doi: 10.1155/2017/2438247. [PMID: 28182085]
  • Jesmond Dalli, Iliyan Vlasakov, Ian R Riley, Ana R Rodriguez, Bernd W Spur, Nicos A Petasis, Nan Chiang, Charles N Serhan. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2016 10; 113(43):12232-12237. doi: 10.1073/pnas.1607003113. [PMID: 27791009]
  • Joana R Viola, Patricia Lemnitzer, Yvonne Jansen, Gergely Csaba, Carla Winter, Carlos Neideck, Carlos Silvestre-Roig, Gunnar Dittmar, Yvonne Döring, Maik Drechsler, Christian Weber, Ralf Zimmer, Nicolas Cenac, Oliver Soehnlein. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circulation research. 2016 Oct; 119(9):1030-1038. doi: 10.1161/circresaha.116.309492. [PMID: 27531933]
  • Valerio Chiurchiù, Alessandro Leuti, Jesmond Dalli, Anders Jacobsson, Luca Battistini, Mauro Maccarrone, Charles N Serhan. Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Science translational medicine. 2016 08; 8(353):353ra111. doi: 10.1126/scitranslmed.aaf7483. [PMID: 27559094]
  • Hildur Arnardottir, Sarah K Orr, Jesmond Dalli, Charles N Serhan. Human milk proresolving mediators stimulate resolution of acute inflammation. Mucosal immunology. 2016 05; 9(3):757-766. doi: 10.1038/mi.2015.99. [PMID: 26462421]
  • Wenjing Xian, Yan Wu, Wei Xiong, Longyan Li, Tong Li, Shangwen Pan, Limin Song, Lisha Hu, Lei Pei, Shanglong Yao, You Shang. The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response. Biochemical and biophysical research communications. 2016 Mar; 472(1):175-81. doi: 10.1016/j.bbrc.2016.02.090. [PMID: 26915798]
  • Ruidong Li, Yaxin Wang, Ende Zhao, Ke Wu, Wei Li, Liang Shi, Di Wang, Gengchen Xie, Yuping Yin, Meizhou Deng, Peng Zhang, Kaixiong Tao. Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. Oxidative medicine and cellular longevity. 2016; 2016(?):9203716. doi: 10.1155/2016/9203716. [PMID: 26881046]
  • Ruidong Li, Yaxin Wang, Zhijun Ma, Muyuan Ma, Di Wang, Gengchen Xie, Yuping Yin, Peng Zhang, Kaixiong Tao. Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. Mediators of inflammation. 2016; 2016(?):3798465. doi: 10.1155/2016/3798465. [PMID: 28042205]
  • Chin-Wei Wang, Romain A Colas, Jesmond Dalli, Hildur H Arnardottir, Daniel Nguyen, Hatice Hasturk, Nan Chiang, Thomas E Van Dyke, Charles N Serhan. Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. Infection and immunity. 2015 Dec; 84(3):658-65. doi: 10.1128/iai.01131-15. [PMID: 26667839]
  • Yaxin Wang, Ruidong Li, Lin Chen, Wen Tan, Zhipeng Sun, Haifa Xia, Bo Li, Yuan Yu, Jie Gong, Min Tang, Yudong Ji, Shiying Yuan, Shanglong Yao, You Shang. Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. Shock (Augusta, Ga.). 2015 Nov; 44(5):496-502. doi: 10.1097/shk.0000000000000446. [PMID: 26196843]
  • Tara M Nordgren, Christopher D Bauer, Art J Heires, Jill A Poole, Todd A Wyatt, William W West, Debra J Romberger. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. Translational research : the journal of laboratory and clinical medicine. 2015 Jul; 166(1):57-69. doi: 10.1016/j.trsl.2015.01.001. [PMID: 25655838]
  • Daisuke Akagi, Mian Chen, Robert Toy, Anuran Chatterjee, Michael S Conte. Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Jun; 29(6):2504-13. doi: 10.1096/fj.14-265363. [PMID: 25777995]
  • Ji Yeon Lim, Chul-Kyu Park, Sun Wook Hwang. Biological Roles of Resolvins and Related Substances in the Resolution of Pain. BioMed research international. 2015; 2015(?):830930. doi: 10.1155/2015/830930. [PMID: 26339646]
  • Raja-Elie E Abdulnour, Jesmond Dalli, Jennifer K Colby, Nandini Krishnamoorthy, Jack Y Timmons, Sook Hwa Tan, Romain A Colas, Nicos A Petasis, Charles N Serhan, Bruce D Levy. Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. Proceedings of the National Academy of Sciences of the United States of America. 2014 Nov; 111(46):16526-31. doi: 10.1073/pnas.1407123111. [PMID: 25369934]
  • Song Hong, Yan Lu, Haibin Tian, Bhagwat V Alapure, Quansheng Wang, Bruce A Bunnell, James Monroe Laborde. Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. Chemistry & biology. 2014 Oct; 21(10):1318-1329. doi: 10.1016/j.chembiol.2014.06.010. [PMID: 25200603]
  • Charles N Serhan. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014 Jun; 510(7503):92-101. doi: 10.1038/nature13479. [PMID: 24899309]
  • Marius Aursnes, Jørn E Tungen, Anders Vik, Romain Colas, Chien-Yee C Cheng, Jesmond Dalli, Charles N Serhan, Trond V Hansen. Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions. Journal of natural products. 2014 Apr; 77(4):910-6. doi: 10.1021/np4009865. [PMID: 24576195]
  • Gandrath Dayaker, Thierry Durand, Laurence Balas. A versatile and stereocontrolled total synthesis of dihydroxylated docosatrienes containing a conjugated E,E,Z-triene. Chemistry (Weinheim an der Bergstrasse, Germany). 2014 Mar; 20(10):2879-87. doi: 10.1002/chem.201304526. [PMID: 24520010]
  • Anuran Chatterjee, Anjali Sharma, Mian Chen, Robert Toy, Giorgio Mottola, Michael S Conte. The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. PloS one. 2014; 9(11):e113480. doi: 10.1371/journal.pone.0113480. [PMID: 25409514]
  • Rodrigo Marcon, Allisson F Bento, Rafael C Dutra, Maira A Bicca, Daniela F P Leite, João B Calixto. Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. Journal of immunology (Baltimore, Md. : 1950). 2013 Oct; 191(8):4288-98. doi: 10.4049/jimmunol.1202743. [PMID: 24038091]
  • Charles N Serhan, Jesmond Dalli, Sergey Karamnov, Alexander Choi, Chul-Kyu Park, Zhen-Zhong Xu, Ru-Rong Ji, Min Zhu, Nicos A Petasis. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Apr; 26(4):1755-65. doi: 10.1096/fj.11-201442. [PMID: 22253477]
  • Charles N Serhan, Rong Yang, Kimberly Martinod, Kie Kasuga, Padmini S Pillai, Timothy F Porter, Sungwhan F Oh, Matthew Spite. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. The Journal of experimental medicine. 2009 Jan; 206(1):15-23. doi: 10.1084/jem.20081880. [PMID: 19103881]