Fluoromethalone (BioDeep_00000409849)

   


代谢物信息卡片


Fluoromethalone

化学式: C22H29FO4 (376.2049766)
中文名称: 氟米龙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2C3CCC(C3(CC(C2(C4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O
InChI: InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1

描述信息

D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XB - Corticosteroids, moderately potent, other combinations
S - Sensory organs > S01 - Ophthalmologicals > S01C - Antiinflammatory agents and antiinfectives in combination > S01CB - Corticosteroids/antiinfectives/mydriatics in combination
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii)
D - Dermatologicals > D10 - Anti-acne preparations > D10A - Anti-acne preparations for topical use > D10AA - Corticosteroids, combinations for treatment of acne
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
D018926 - Anti-Allergic Agents
CONFIDENCE standard compound; INTERNAL_ID 1168; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8875; ORIGINAL_PRECURSOR_SCAN_NO 8870
CONFIDENCE standard compound; INTERNAL_ID 1168; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8811; ORIGINAL_PRECURSOR_SCAN_NO 8809
CONFIDENCE standard compound; INTERNAL_ID 1168; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8911; ORIGINAL_PRECURSOR_SCAN_NO 8909
CONFIDENCE standard compound; INTERNAL_ID 1168; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8940; ORIGINAL_PRECURSOR_SCAN_NO 8939
CONFIDENCE standard compound; INTERNAL_ID 1168; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8959; ORIGINAL_PRECURSOR_SCAN_NO 8957
CONFIDENCE standard compound; INTERNAL_ID 1168; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8931; ORIGINAL_PRECURSOR_SCAN_NO 8930
CONFIDENCE standard compound; INTERNAL_ID 2811

同义名列表

2 个代谢物同义名

Fluoromethalone; Fluorometholone



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qinhua Zheng, Weijian Tan, Xiaolin Feng, Kexin Feng, Wenting Zhong, Caiyu Liao, Yuntong Liu, Shangjian Li, Wenzhong Hu. Protective Effect of Flavonoids from Mulberry Leaf on AAPH-Induced Oxidative Damage in Sheep Erythrocytes. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217625. [PMID: 36364452]
  • Wenqiang Jiang, Yan Lin, Linjie Qian, Linghong Miao, Bo Liu, Xianping Ge, Huaishun Shen. Mulberry leaf meal: A potential feed supplement for juvenile Megalobrama amblycephala 'Huahai No. 1'. Fish & shellfish immunology. 2022 Sep; 128(?):279-287. doi: 10.1016/j.fsi.2022.07.022. [PMID: 35870747]
  • Taher K Eleiwa, Ayman Elmaghrabi, Hend G Helal, Samar N Abdelrahman, Reem H ElSheikh, Abdelrahman M Elhusseiny. Phlyctenular Keratoconjunctivitis in a Patient With COVID-19 Infection. Cornea. 2021 Nov; 40(11):1502-1504. doi: 10.1097/ico.0000000000002789. [PMID: 34320598]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Carlos Méndez Mangana, Anton Barraquer Kargacin, Rafael I Barraquer. Episcleritis as an ocular manifestation in a patient with COVID-19. Acta ophthalmologica. 2020 Dec; 98(8):e1056-e1057. doi: 10.1111/aos.14484. [PMID: 32483943]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Aileen Sy, Kieran S O'Brien, Margaret P Liu, Puja A Cuddapah, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer. Expert opinion in the management of aqueous Deficient Dry Eye Disease (DED). BMC ophthalmology. 2015 Oct; 15(?):133. doi: 10.1186/s12886-015-0122-z. [PMID: 26462481]
  • Thu P Huynh, Sonali P Barwe, Seung J Lee, Ryan McSpadden, Omar E Franco, Simon W Hayward, Robert Damoiseaux, Stephen S Grubbs, Nicholas J Petrelli, Ayyappan K Rajasekaran. Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression. PloS one. 2015; 10(4):e0122442. doi: 10.1371/journal.pone.0122442. [PMID: 25836370]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Ramon C Ghanem, Vinícius C Ghanem, Gustavo Victor, Milton Ruiz Alves. Bilateral progressive idiopathic annular lipid keratopathy. Case reports in ophthalmological medicine. 2012; 2012(?):731413. doi: 10.1155/2012/731413. [PMID: 22649744]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Bing Shao, Xiaoliang Cui, Yi Yang, Jing Zhang, Yongnin Wu. Validation of a solid-phase extraction and ultra-performance liquid chromatographic tandem mass spectrometric method for the detection of 16 glucocorticoids in pig tissues. Journal of AOAC International. 2009 Mar; 92(2):604-11. doi: . [PMID: 19485221]
  • Lingyi Liang, Mei Zhang, Wenjin Zou, Zuguo Liu. Aggravated dry eye after laser in situ keratomileusis in patients with Sjögren syndrome. Cornea. 2008 Jan; 27(1):120-3. doi: 10.1097/ico.0b013e318158312f. [PMID: 18245981]
  • Louis Wang, Hughie Tsang, Minas Coroneo. Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. Clinical & experimental ophthalmology. 2008 Jan; 36(1):8-12. doi: 10.1111/j.1442-9071.2007.01648.x. [PMID: 18290949]
  • Robert L Taylor, Stefan K Grebe, Ravinder J Singh. Quantitative, highly sensitive liquid chromatography-tandem mass spectrometry method for detection of synthetic corticosteroids. Clinical chemistry. 2004 Dec; 50(12):2345-52. doi: 10.1373/clinchem.2004.033605. [PMID: 15486026]
  • M Shimabukuro, N Iwasaki, Y Nagae, Y Nakagawa, Y Ohtori, Y Inoue, Y Tano. Ligneous conjunctivitis: a case report. Japanese journal of ophthalmology. 2001 Jul; 45(4):375-7. doi: 10.1016/s0021-5155(01)00342-2. [PMID: 11485769]
  • M Kubo, T Sakuraba, Y Arai, M Nakazawa. [A case of suspected drug-induced ocular pemphigoid]. Nippon Ganka Gakkai zasshi. 2001 Mar; 105(3):189-92. doi: . [PMID: 11280879]
  • N J van Haeringen, N L Verbey, J L van Delft. Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea. Journal of ocular pharmacology. 1993; 9(4):365-72. doi: 10.1089/jop.1993.9.365. [PMID: 8106842]
  • H Yamauchi, T Iso, H Iwata. Ocular anti-inflammatory and systemic immunosuppressive effects of topically applied fluorometholone. Japanese journal of pharmacology. 1979 Feb; 29(1):87-92. doi: 10.1254/jjp.29.87. [PMID: 459159]