Enzacamene (BioDeep_00000409811)

   


代谢物信息卡片


3-(4-Methylbenzylidene)camphor

化学式: C18H22O (254.1670562)
中文名称: 3-(4-甲基苯亚甲基)-樟脑, 3-(对甲苯基亚甲基)樟脑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)C=C2C3CCC(C2=O)(C3(C)C)C
InChI: InChI=1S/C18H22O/c1-12-5-7-13(8-6-12)11-14-15-9-10-18(4,16(14)19)17(15,2)3/h5-8,11,15H,9-10H2,1-4H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 2452

同义名列表

3 个代谢物同义名

3-(4-Methylbenzylidene)camphor; Enzacamene; 4-Methylbenzylidene camphor



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hongyi Xian, Zhiming Li, Rongyi Ye, Mingzhu Dai, Yu Feng, Ruobing Bai, Jie Guo, Xiliang Yan, Xingfen Yang, Da Chen, Zhenlie Huang. 4-Methylbenzylidene camphor triggers estrogenic effects via the brain-liver-gonad axis in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 2023 Oct; 335(?):122260. doi: 10.1016/j.envpol.2023.122260. [PMID: 37506809]
  • Aline Murawski, Maria I H Schmied-Tobies, Enrico Rucic, Christoph Schmidtkunz, Katja Küpper, Gabriele Leng, Elisabeth Eckert, Laura Kuhlmann, Thomas Göen, Anja Daniels, Gerda Schwedler, Marike Kolossa-Gehring. Metabolites of 4-methylbenzylidene camphor (4-MBC), butylated hydroxytoluene (BHT), and tris(2-ethylhexyl) trimellitate (TOTM) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey GerES V (2014-2017). Environmental research. 2021 01; 192(?):110345. doi: 10.1016/j.envres.2020.110345. [PMID: 33096061]
  • Mengmeng Liang, Saihong Yan, Rui Chen, Xiangsheng Hong, Jinmiao Zha. 3-(4-Methylbenzylidene) camphor induced reproduction toxicity and antiandrogenicity in Japanese medaka (Oryzias latipes). Chemosphere. 2020 Jun; 249(?):126224. doi: 10.1016/j.chemosphere.2020.126224. [PMID: 32088463]
  • Elissa O'Malley, Jake W O'Brien, Rory Verhagen, Jochen F Mueller. Annual release of selected UV filters via effluent from wastewater treatment plants in Australia. Chemosphere. 2020 May; 247(?):125887. doi: 10.1016/j.chemosphere.2020.125887. [PMID: 31978656]
  • Changwon Yang, Whasun Lim, Seungkwon You, Gwonhwa Song. 4-Methylbenzylidene-camphor inhibits proliferation and induces reactive oxygen species-mediated apoptosis of human trophoblast cells. Reproductive toxicology (Elmsford, N.Y.). 2019 03; 84(?):49-58. doi: 10.1016/j.reprotox.2018.12.011. [PMID: 30597193]
  • M J Araújo, R J M Rocha, A M V M Soares, J L Benedé, A Chisvert, M S Monteiro. Effects of UV filter 4-methylbenzylidene camphor during early development of Solea senegalensis Kaup, 1858. The Science of the total environment. 2018 Jul; 628-629(?):1395-1404. doi: 10.1016/j.scitotenv.2018.02.112. [PMID: 30045559]
  • Diana Martins, Marta S Monteiro, Amadeu M V M Soares, Carla Quintaneiro. Effects of 4-MBC and triclosan in embryos of the frog Pelophylax perezi. Chemosphere. 2017 Jul; 178(?):325-332. doi: 10.1016/j.chemosphere.2017.03.038. [PMID: 28334672]
  • Gabriele Leng, Wolfgang Gries. New specific and sensitive biomonitoring methods for chemicals of emerging health relevance. International journal of hygiene and environmental health. 2017 03; 220(2 Pt A):113-122. doi: 10.1016/j.ijheh.2016.09.014. [PMID: 27692573]
  • Hamidreza Sharifan, David Klein, Audra N Morse. UV filters interaction in the chlorinated swimming pool, a new challenge for urbanization, a need for community scale investigations. Environmental research. 2016 07; 148(?):273-276. doi: 10.1016/j.envres.2016.04.002. [PMID: 27088731]
  • NULL. [Monograph for 3-(4-methylbenzylidene)camphor (4-MBC)--HBM values for the sum of metabolites 3-(4-carboxybenzylidene)camphor (3-4CBC) and 3-(4-carboxybenzylidene)-6-hydroxycamphor (3-4 CBHC) in the urine of adults and children. Statement of the HBM Commission of the German Federal Environment Agency]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 2016 Jan; 59(1):132-49. doi: 10.1007/s00103-015-2272-9. [PMID: 26721474]
  • Qinan Yin, Lara Fischer, Claudia Noethling, Wolfgang R Schaefer. In vitro-assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial Ishikawa cells. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2015 Jul; 31(7):578-81. doi: 10.3109/09513590.2015.1047448. [PMID: 26036805]
  • Franziska D Fleischli, Fabienne Morf, Christian Adlhart. Skin Concentrations of Topically Applied Substances in Reconstructed Human Epidermis (RHE) Compared with Human Skin Using in vivo Confocal Raman Microscopy. Chimia. 2015; 69(3):147-51. doi: 10.2533/chimia.2015.147. [PMID: 26507219]
  • M Krause, A Klit, M Blomberg Jensen, T Søeborg, H Frederiksen, M Schlumpf, W Lichtensteiger, N E Skakkebaek, K T Drzewiecki. Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters. International journal of andrology. 2012 Jun; 35(3):424-36. doi: 10.1111/j.1365-2605.2012.01280.x. [PMID: 22612478]
  • You-Sheng Liu, Guang-Guo Ying, Ali Shareef, Rai S Kookana. Occurrence and removal of benzotriazoles and ultraviolet filters in a municipal wastewater treatment plant. Environmental pollution (Barking, Essex : 1987). 2012 Jun; 165(?):225-32. doi: 10.1016/j.envpol.2011.10.009. [PMID: 22019204]
  • Marina Komrakova, Stephan Sehmisch, Mohammad Tezval, Ulrich Schmelz, Holm Frauendorf, Thomas Grueger, Thomas Wessling, Carolin Klein, Miriam Birth, Klaus M Stuermer, Ewa K Stuermer. Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats. The Journal of endocrinology. 2011 Nov; 211(2):157-68. doi: 10.1530/joe-11-0096. [PMID: 21803835]
  • Karl Fent, Armin Zenker, Maja Rapp. Widespread occurrence of estrogenic UV-filters in aquatic ecosystems in Switzerland. Environmental pollution (Barking, Essex : 1987). 2010 May; 158(5):1817-24. doi: 10.1016/j.envpol.2009.11.005. [PMID: 20004505]
  • M E Carou, B Szwarcfarb, M L Deguiz, R Reynoso, S Carbone, J A Moguilevsky, P Scacchi, O J Ponzo. Impact of 4-methylbenzylidene-camphor (4-MBC) during embryonic and fetal development in the neuroendocrine regulation of testicular axis in prepubertal and peripubertal male rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2009 Oct; 117(9):449-54. doi: 10.1055/s-0028-1112153. [PMID: 19885997]
  • Santo Scalia, Matteo Mezzena. Co-loading of a photostabilizer with the sunscreen agent, butyl methoxydibenzoylmethane in solid lipid microparticles. Drug development and industrial pharmacy. 2009 Feb; 35(2):192-8. doi: 10.1080/03639040802244300. [PMID: 18785040]
  • Armin Zenker, Hansruedi Schmutz, Karl Fent. Simultaneous trace determination of nine organic UV-absorbing compounds (UV filters) in environmental samples. Journal of chromatography. A. 2008 Aug; 1202(1):64-74. doi: 10.1016/j.chroma.2008.06.041. [PMID: 18632108]
  • Antonia M Calafat, Lee-Yang Wong, Xiaoyun Ye, John A Reidy, Larry L Needham. Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003--2004. Environmental health perspectives. 2008 Jul; 116(7):893-7. doi: 10.1289/ehp.11269. [PMID: 18629311]
  • N R Janjua, B Kongshoj, A-M Andersson, H C Wulf. Sunscreens in human plasma and urine after repeated whole-body topical application. Journal of the European Academy of Dermatology and Venereology : JEADV. 2008 Apr; 22(4):456-61. doi: 10.1111/j.1468-3083.2007.02492.x. [PMID: 18221342]
  • Helena Gonzalez, Carl-Eric Jacobson, Ann-Marie Wennberg, Olle Larkö, Anne Farbrot. Solid-phase extraction and reverse-phase HPLC: application to study the urinary excretion pattern of benzophenone-3 and its metabolite 2,4-dihydroxybenzophenone in human urine. Analytical chemistry insights. 2008 Jan; 3(?):1-7. doi: 10.4137/aci.s396. [PMID: 19609385]
  • Elisabete Silva, Martin Scholze, Andreas Kortenkamp. Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay. Environmental health perspectives. 2007 Dec; 115 Suppl 1(?):91-7. doi: 10.1289/ehp.9363. [PMID: 18174956]
  • Santo Scalia, Matteo Mezzena, Valentina Iannuccelli. Influence of solid lipid microparticle carriers on skin penetration of the sunscreen agent, 4-methylbenzylidene camphor. The Journal of pharmacy and pharmacology. 2007 Dec; 59(12):1621-7. doi: 10.1211/jpp.59.12.0003. [PMID: 18053323]
  • Weihong Li, Yongmin Ma, Changsheng Guo, Wei Hu, Keming Liu, Yuqiu Wang, Tan Zhu. Occurrence and behavior of four of the most used sunscreen UV filters in a wastewater reclamation plant. Water research. 2007 Aug; 41(15):3506-12. doi: 10.1016/j.watres.2007.05.039. [PMID: 17597178]
  • Wolfgang Völkel, Thomas Colnot, Ute M D Schauer, Thomas H Broschard, Wolfgang Dekant. Toxicokinetics and biotransformation of 3-(4-methylbenzylidene)camphor in rats after oral administration. Toxicology and applied pharmacology. 2006 Oct; 216(2):331-8. doi: 10.1016/j.taap.2006.05.012. [PMID: 16806338]
  • Ute M D Schauer, Wolfgang Völkel, Alexander Heusener, Thomas Colnot, Thomas H Broschard, Friedrich von Landenberg, Wolfgang Dekant. Kinetics of 3-(4-methylbenzylidene)camphor in rats and humans after dermal application. Toxicology and applied pharmacology. 2006 Oct; 216(2):339-46. doi: 10.1016/j.taap.2006.05.011. [PMID: 16814339]
  • Dana Seidlová-Wuttke, Julie Christoffel, Guillermo Rimoldi, Hubertus Jarry, Wolfgang Wuttke. Comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones. Toxicology and applied pharmacology. 2006 Jul; 214(1):1-7. doi: 10.1016/j.taap.2005.11.002. [PMID: 16368123]
  • Hans-Rudolf Buser, Marianne E Balmer, Peter Schmid, Martin Kohler. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants. Environmental science & technology. 2006 Mar; 40(5):1427-31. doi: 10.1021/es052088s. [PMID: 16568752]
  • D Seidlová-Wuttke, H Jarry, J Christoffel, G Rimoldi, W Wuttke. Comparison of effects of estradiol (E2) with those of octylmethoxycinnamate (OMC) and 4-methylbenzylidene camphor (4MBC)--2 filters of UV light - on several uterine, vaginal and bone parameters. Toxicology and applied pharmacology. 2006 Feb; 210(3):246-54. doi: 10.1016/j.taap.2005.05.006. [PMID: 15979666]
  • Marjoke Heneweer, Martine Muusse, Martin van den Berg, J Thomas Sanderson. Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells. Toxicology and applied pharmacology. 2005 Oct; 208(2):170-7. doi: 10.1016/j.taap.2005.02.006. [PMID: 16183391]
  • Marianne E Balmer, Hans-Rudolf Buser, Markus D Müller, Thomas Poiger. Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss Lakes. Environmental science & technology. 2005 Feb; 39(4):953-62. doi: 10.1021/es040055r. [PMID: 15773466]
  • Nadeem Rezaq Janjua, Brian Mogensen, Anna-Maria Andersson, Jørgen Holm Petersen, Mette Henriksen, Niels E Skakkebaek, Hans Christian Wulf. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. The Journal of investigative dermatology. 2004 Jul; 123(1):57-61. doi: 10.1111/j.0022-202x.2004.22725.x. [PMID: 15191542]
  • Madoka Inui, Tetsuya Adachi, Shigeo Takenaka, Hiroshi Inui, Masami Nakazawa, Mitsuhiro Ueda, Hajime Watanabe, Chisato Mori, Taisen Iguchi, Kazutaka Miyatake. Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes). Toxicology. 2003 Dec; 194(1-2):43-50. doi: 10.1016/s0300-483x(03)00340-8. [PMID: 14636695]
  • Stefan O Mueller, Margret Kling, Poppy Arifin Firzani, Astrid Mecky, Eric Duranti, Jacqueline Shields-Botella, Remi Delansorne, Thomas Broschard, Peter-Jürgen Kramer. Activation of estrogen receptor alpha and ERbeta by 4-methylbenzylidene-camphor in human and rat cells: comparison with phyto- and xenoestrogens. Toxicology letters. 2003 Apr; 142(1-2):89-101. doi: 10.1016/s0378-4274(03)00016-x. [PMID: 12765243]